| scholarly article | Q13442814 |
| P2093 | author name string | C Peters | |
| C Sandberg | |||
| J Brunner | |||
| J Gahr | |||
| M Heinrich | |||
| M Krönke | |||
| M Wickel | |||
| P Saftig | |||
| R Schwandner | |||
| S Schütze | |||
| T Weber | |||
| W Schneider-Brachert | |||
| P433 | issue | 19 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ceramides | Q424213 |
| P304 | page(s) | 5252-63 | |
| P577 | publication date | 1999-10-01 | |
| P1433 | published in | The EMBO Journal | Q1278554 |
| P1476 | title | Cathepsin D targeted by acid sphingomyelinase-derived ceramide | |
| P478 | volume | 18 |
| Q26866012 | A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression |
| Q24675372 | A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death |
| Q47712397 | A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7. |
| Q44693510 | Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L. |
| Q46606270 | Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging |
| Q40125869 | Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma |
| Q34086900 | Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis |
| Q39405747 | Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease |
| Q37403072 | Apoptosis and necrosis in the liver |
| Q34736760 | Apoptotic sphingolipid ceramide in cancer therapy |
| Q38361932 | Autophagic flux and autophagosome morphogenesis require the participation of sphingolipids. |
| Q34665604 | Bax inhibition protects against free fatty acid-induced lysosomal permeabilization |
| Q34883222 | Bioactive sphingolipids: metabolism and function |
| Q94571502 | C24 -Ceramide Drives Gallbladder Cancer Progression through Directly Targeting PIP4K2C to Facilitate mTOR Signaling Activation |
| Q93551560 | CORRIGENDUM |
| Q34790629 | Cancer treatment strategies targeting sphingolipid metabolism |
| Q38025001 | Cancer-associated lysosomal changes: friends or foes? |
| Q40448258 | Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis. |
| Q24316264 | Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes |
| Q91976213 | Cathepsin D Expression and Gemcitabine Resistance in Pancreatic Cancer |
| Q28240307 | Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation |
| Q28267787 | Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux |
| Q28275626 | Cathepsin D--many functions of one aspartic protease |
| Q37161711 | Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential |
| Q38979542 | Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1. |
| Q90010368 | Ceramide Domains in Health and Disease: A Biophysical Perspective |
| Q37708912 | Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells |
| Q37344754 | Ceramide and mitochondria in ischemia/reperfusion |
| Q34040269 | Ceramide as a second messenger: sticky solutions to sticky problems |
| Q38021345 | Ceramide function in the brain: when a slight tilt is enough. |
| Q24646847 | Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells |
| Q35047136 | Ceramide in apoptosis: an overview and current perspectives |
| Q37265533 | Ceramide in bacterial infections and cystic fibrosis |
| Q37797406 | Ceramide in stress response |
| Q57351173 | Ceramide inPseudomonas aeruginosa infections |
| Q28384389 | Ceramide induced mitophagy and tumor suppression |
| Q40241323 | Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells. |
| Q39807508 | Ceramide metabolism determines glioma cell resistance to chemotherapy |
| Q36803735 | Ceramide signaling in cancer and stem cells |
| Q37619251 | Ceramide signaling in mammalian epidermis |
| Q37894760 | Ceramide transfer protein and cancer |
| Q38067062 | Ceramide-orchestrated signalling in cancer cells. |
| Q35633883 | Ceramide-rich platforms in transmembrane signaling |
| Q34500904 | Ceramide: does it matter for T cells? |
| Q34984863 | Ceramide: second messenger or modulator of membrane structure and dynamics? |
| Q36313910 | Constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar Typhimurium |
| Q73716557 | Control of apoptotic DNA degradation |
| Q35022529 | Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide |
| Q35549436 | Destination 'lysosome': a target organelle for tumour cell killing? |
| Q57375071 | Development and characterization of a novel anti-ceramide antibody |
| Q57372648 | Differential Regulation of ATP Binding Cassette Protein A1 Expression and ApoA-I Lipidation by Niemann-Pick Type C1 in Murine Hepatocytes and Macrophages |
| Q37123974 | Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling |
| Q44023205 | Disialoganglioside GD3 is released by microglia and induces oligodendrocyte apoptosis |
| Q33876969 | Does ceramide play a role in neural cell apoptosis? |
| Q92891409 | Endoplasmic reticulum stress induces liver cells apoptosis after brain death by suppressing the phosphorylation of protein phosphatase 2A |
| Q44219914 | Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D. |
| Q34121060 | Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons |
| Q57040370 | GBA-Associated Parkinson's Disease and Other Synucleinopathies |
| Q35884004 | Glycogen Synthase Kinase-3β and Caspase-2 Mediate Ceramide- and Etoposide-Induced Apoptosis by Regulating the Lysosomal-Mitochondrial Axis |
| Q53669198 | Identification of ceramide binding proteins in neuronal cells: a critical point of view. |
| Q44203329 | Identification of the LIM kinase-1 as a ceramide-regulated gene in renal mesangial cells |
| Q39956645 | Immunomagnetic isolation of tumor necrosis factor receptosomes |
| Q44131884 | Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells |
| Q35911354 | Increased apoptosis in cancer cells in vitro and in vivo by ceramides in transferrin-modified liposomes |
| Q26852322 | Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons |
| Q33938298 | Inhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid |
| Q34373466 | Interdiction of sphingolipid metabolism to improve standard cancer therapies |
| Q45919951 | Intracellular IL-15 controls mast cell survival. |
| Q40650255 | Intracellular delivery of ceramide lipids via liposomes enhances apoptosis in vitro |
| Q28343424 | Involvement of FAN in TNF-induced apoptosis |
| Q40240793 | Involvement of sphingolipids in apoptin-induced cell killing |
| Q34361344 | Keeping TNF-induced apoptosis under control in astrocytes: PEA-15 as a 'double key' on caspase-dependent and MAP-kinase-dependent pathways. |
| Q38843156 | LAPTM4B facilitates late endosomal ceramide export to control cell death pathways. |
| Q38308411 | Lipid metabolism, apoptosis and cancer therapy |
| Q37920895 | Lipids in cystic fibrosis |
| Q89879079 | Lysosomal Ceramide Metabolism Disorders: Implications in Parkinson's Disease |
| Q91674752 | Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99) |
| Q28204360 | Lysosomal Enzymes Are Released From Cultured Human Macrophages, Hydrolyze LDL In Vitro, and Are Present Extracellularly in Human Atherosclerotic Lesions |
| Q26749121 | Lysosomal cathepsins and their regulation in aging and neurodegeneration |
| Q38889429 | Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis |
| Q39798053 | Lysosomal ceramide mediates gemcitabine-induced death of glioma cells |
| Q36370419 | Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion |
| Q27026045 | Lysosomal proteins in cell death and autophagy |
| Q36292872 | Lysosomes and autophagy in cell death control |
| Q40510257 | Mannose 6-phosphorylated proteins are required for tumor necrosis factor-induced apoptosis: defective response in I-cell disease fibroblasts |
| Q38401864 | Metabolic Modifications in Human Biofluids Suggest the Involvement of Sphingolipid, Antioxidant, and Glutamate Metabolism in Alzheimer's Disease Pathogenesis |
| Q57364601 | Metabolism and physiological functions of sphingolipids |
| Q34503377 | Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. |
| Q34504957 | Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism |
| Q55716612 | Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans. |
| Q34975049 | New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer |
| Q34443559 | Organelle-specific initiation of cell death pathways |
| Q54956762 | Palmitoyl-ceramide accumulation with necrotic cell death in A549 cells, followed by a steep increase in sphinganine content. |
| Q101461779 | Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells |
| Q36341274 | Physiological and pathophysiological aspects of ceramide |
| Q33930354 | Physiology and pathophysiology of sphingolipid metabolism and signaling |
| Q35974137 | Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes. |
| Q91131091 | Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans |
| Q40856159 | Posttranslational regulation of acid sphingomyelinase in niemann-pick type C1 fibroblasts and free cholesterol-enriched chinese hamster ovary cells |
| Q37878301 | Procathepsin D and cancer: From molecular biology to clinical applications |
| Q44104453 | Propapoptotic effects of NF-kappaB in LNCaP prostate cancer cells lead to serine protease activation |
| Q41841689 | Protein kinase C-δ isoform mediates lysosome labilization in DNA damage-induced apoptosis |
| Q35884862 | Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing |
| Q41868050 | Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells |
| Q30845700 | Purification and characterization of a magnesium-dependent neutral sphingomyelinase from bovine brain |
| Q33204778 | Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation |
| Q33830140 | Redox control of liver function in health and disease |
| Q37188507 | Regulation of TNFR1 and CD95 signalling by receptor compartmentalization |
| Q41995031 | Relating toxicity to transfection: using sphingosine to maintain prolonged expression in vitro |
| Q36562936 | Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway |
| Q48301421 | Role of the Lysosomal Membrane Protein, CLN3, in the Regulation of Cathepsin D Activity |
| Q38414026 | SapC-DOPS nanovesicles: a novel targeted agent for the imaging and treatment of glioblastoma |
| Q40571355 | Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity |
| Q36778330 | Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology |
| Q34534466 | Small-molecule therapeutics for the treatment of glycolipid lysosomal storage disorders |
| Q37808219 | Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance |
| Q44965785 | Sphingolipids in the lungs. |
| Q36462123 | Sphingolipids: regulators of crosstalk between apoptosis and autophagy |
| Q53085881 | Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells. |
| Q28215624 | Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase |
| Q35047156 | Sphingosine in apoptosis signaling |
| Q28360876 | Sphingosine-induced apoptosis is dependent on lysosomal proteases |
| Q47586716 | Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide |
| Q44559484 | Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D. |
| Q34924126 | Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling |
| Q47558991 | TARGETED AND OFF-TARGET (BYSTANDER AND ABSCOPAL) EFFECTS OF RADIATION THERAPY: REDOX MECHANISMS AND RISK-BENEFIT ANALYSIS. |
| Q93043730 | TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit |
| Q42317467 | TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death |
| Q39379449 | Targeting sphingosine-1-phosphate signaling for cancer therapy |
| Q38618873 | The Role of Ceramide in the Pathogenesis of Alcoholic Liver Disease |
| Q89551770 | The Squeaky Yeast Gets Greased: The Roles of Host Lipids in the Clearance of Pathogenic Fungi |
| Q108831791 | The acid sphingomyelinase/ceramide system in COVID-19 |
| Q34074186 | The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review |
| Q37900689 | The new faces of endocytosis in signaling |
| Q41065534 | The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis |
| Q50098238 | The role of sphingolipids in psychoactive drug use and addiction. |
| Q24642219 | The sphingolipid salvage pathway in ceramide metabolism and signaling |
| Q34717833 | The therapeutic potential of modulating the ceramide/sphingomyelin pathway |
| Q36119393 | The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease |
| Q34688272 | Triggering caspase-independent cell death to combat cancer. |
| Q34185821 | Tumor necrosis factor signaling. |
| Q44132425 | Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent |
| Q38348743 | Two Faces of Cathepsin D: Physiological Guardian Angel and Pathological Demon |
| Q73170887 | Use of affinity chromatography and TID-ceramide photoaffinity labeling for detection of ceramide-binding proteins |
| Q38096833 | Using ASMase knockout mice to model human diseases |
| Q91857226 | Visualizing bioactive ceramides |
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