Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential

scientific article published on April 2009

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.22753
P932PMC publication ID2670444
P698PubMed publication ID19116891
P5875ResearchGate publication ID23714093

P50authorJosé C Fernández-ChecaQ38544954
Montserrat MaríQ56872493
Anna MolesQ58992193
P2093author name stringNúria Tarrats
P2860cites workCathepsin D targeted by acid sphingomyelinase-derived ceramideQ24529823
History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cellsQ28190388
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activationQ28240307
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosisQ28263747
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cellsQ28295485
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymusQ28613227
Liver fibrosisQ29547449
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liverQ29616840
Cathepsin D in cancer metastasis: a protease and a ligandQ33586471
Unraveling the role of proteases in cancerQ33838143
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesisQ34320916
Cathepsin L is required for endothelial progenitor cell-induced neovascularizationQ34387265
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome cQ34457741
The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicityQ34512981
Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesisQ35595788
Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organQ35649446
Extracellular proteases as targets for treatment of cancer metastasesQ35881244
Lysosomes as targets for cancer therapyQ36099892
Mechanisms of liver fibrosisQ36247948
Catalytically inactive human cathepsin D triggers fibroblast invasive growthQ36321336
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammationQ36509878
Hepatic stellate cells and the reversal of fibrosisQ36588244
Cysteine cathepsins: multifunctional enzymes in cancerQ36600996
Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B.Q36646524
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.Q38333252
Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent.Q38358348
Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradationQ38533885
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasisQ39785797
Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell lineQ40910869
Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substratesQ42119374
Increased activities of liver cathepsins T and D in carbon tetrachloride-treated ratsQ42250707
Regulation of cell growth by redox-mediated extracellular proteolysis of platelet-derived growth factor receptor betaQ43603110
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.Q43744841
Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancerQ44068250
Pepstatin A attenuates the inhibitory effect of N-acetyl-L-cysteine on proliferation of hepatic myofibroblasts (stellate cells).Q44145455
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient miceQ44391043
Cysteine cathepsins (proteases)--on the main stage of cancer?Q44897180
Histone h3 modifications in rat hepatic stellate cells by ethanolQ46531252
Contact of high-invasive, but not low-invasive, melanoma cells to native collagen I induces the release of mature cathepsin B.Q46870610
Lysosomal Cathepsins B and L and Stef in A Blood Levels in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis: Potential Clinical ImplicationsQ60245921
Kinetics of in vivo inhibition of tissue cathepsin D by pepstatin AQ67979755
Collagenolytic cathepsin B and L activity in experimental fibrotic liver and human liverQ68036770
Identification of latent procathepsins B and L in microsomal lumen: characterization of enzymatic activation and proteolytic processing in vitroQ68265043
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosisQ71669546
Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repairQ73285228
Proteome analysis of rat hepatic stellate cellsQ74071343
Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepaticQ74292004
Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2Q80853276
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1297-1307
P577publication date2009-04-01
P1433published inHepatologyQ15724398
P1476titleCathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential
P478volume49

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cites work (P2860)
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