Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer

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Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0065-2571(01)00034-6
P698PubMed publication ID12123721

P2093author name stringJanko Kos
Vito Turk
Boris Turk
Dusan Turk
Gregor Guncar
P2860cites workCystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitorQ24312357
Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatinsQ24312902
Oligomeric Structure and Substrate Induced Inhibition of Human Cathepsin CQ24337142
Lysosomal cysteine proteases: facts and opportunitiesQ24535678
Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegmentQ24561952
Friends and relations of the cystatin superfamily--new members and their evolutionQ24673719
Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin LQ24678337
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.Q27617244
Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complexQ27620728
Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the proteaseQ27622021
Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteasesQ27636471
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificityQ27651464
Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitorsQ27730182
Crystal structure of human cathepsin K complexed with a potent inhibitorQ27734780
Crystal structure of human osteoclast cathepsin K complex with E-64Q27734783
Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase functionQ27748903
On the size of the active site in proteases. I. PapainQ27860826
The residual pro-part of cathepsin C fulfills the criteria required for an intramolecular chaperone in folding and stabilizing the human proenzymeQ28140187
The cystatins: Protein inhibitors of cysteine proteinasesQ28283958
The p41 isoform of invariant chain is a chaperone for cathepsin LQ28345078
Cathepsin S required for normal MHC class II peptide loading and germinal center developmentQ28611850
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymusQ28613227
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factorQ30481000
Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates.Q30848784
Expression of cathepsins B and S in the progression of prostate carcinomaQ32160033
Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motorsQ33815425
Unraveling the role of proteases in cancerQ33838143
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overviewQ33838156
Lysosomal cysteine proteases: more than scavengersQ33857460
Human cathepsin X: A cysteine protease with unique carboxypeptidase activityQ33875510
Cysteine proteinases and their inhibitors in extracellular fluids: markers for diagnosis and prognosis in cancer.Q33890759
The p41 fragment storyQ33904228
Antigen-processing machinery breakdown and tumor growthQ34011098
Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.Q36301521
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentationQ36475793
Cathepsin S activity regulates antigen presentation and immunityQ37382422
Cathepsin S in tumours, regional lymph nodes and sera of patients with lung cancer: relation to prognosisQ38281556
Intracellular proteasesQ39664942
Invasion of ras-transformed breast epithelial cells depends on the proteolytic activity of cysteine and aspartic proteinasesQ40784508
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely routeQ40843079
Lack of class II transactivator causes severe deficiency of HLA-DR expression in small cell lung cancerQ40948614
MHC class II restricted antigen presentationQ41353041
Endosomal proteolysis and MHC class II functionQ41729834
Revised definition of substrate binding sites of papain-like cysteine proteasesQ41730414
Characterization by spectroscopic, kinetic and equilibrium methods of the interaction between recombinant human cystatin A (stefin A) and cysteine proteinasesQ42160442
Crystal structure of human cathepsin S.Q42846520
Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytesQ43578153
Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processingQ43591595
Immunochemical localisation of cathepsin S, cathepsin L and MHC class II-associated p41 isoform of invariant chain in human lymph node tissueQ43716326
Cathepsin B/cystatin C complex levels in sera from patients with lung and colorectal cancer.Q43716328
Cancer. Proteases--invasion and moreQ47676048
Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.Q47872621
Acidic pH as a physiological regulator of human cathepsin L activity.Q52534368
Thyroglobulin type-1 domains in equistatin inhibit both papain-like cysteine proteinases and cathepsin D.Q53744558
Potent slow-binding inhibition of cathepsin B by its propeptideQ67974285
Participation of cathepsin L on bone resorptionQ70670024
Lymphoid monoclonal antibodies reactive with lung tumors. Diagnostic applicationsQ70835069
Lysosomal proteases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancerQ71782469
Kinetics of the pH-induced inactivation of human cathepsin LQ72067273
Peptidyl diazomethanes as inhibitors of cysteine and serine proteinasesQ72519434
CystatinsQ72519445
Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidneyQ72709864
Human cathepsin B is a metastable enzyme stabilized by specific ionic interactions associated with the active siteQ72891339
Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptidesQ73023870
A fragment of the major histocompatibility complex class II-associated p41 invariant chain inhibits cruzipain, the major cysteine proteinase from Trypanosoma cruziQ73025834
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64Q73135950
Fluorometric microassays for the determination of cathepsin L and cathepsin S activities in tissue extractsQ73137144
Anti-human procathepsin D activation peptide antibodies inhibit breast cancer developmentQ73316231
Saxiphilin, a saxitoxin-binding protein with two thyroglobulin type 1 domains, is an inhibitor of papain-like cysteine proteinasesQ73626504
Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidaseQ74198942
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null miceQ74595052
Interaction of cystatin C variants with papain and human cathepsins B, H and LQ78119067
P304page(s)285-303
P577publication date2002-01-01
P1433published inAdvances in Enzyme RegulationQ15756443
P1476titleLysosomal cathepsins: structure, role in antigen processing and presentation, and cancer
P478volume42

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