Cysteine cathepsins: from structure, function and regulation to new frontiers

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Cysteine cathepsins: from structure, function and regulation to new frontiers is …
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scholarly articleQ13442814

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P356DOI10.1016/J.BBAPAP.2011.10.002
P8608Fatcat IDrelease_3kobyvwwwvdoxmygzeeakgyg3e
P3181OpenCitations bibliographic resource ID456691
P932PMC publication ID7105208
P698PubMed publication ID22024571
P5875ResearchGate publication ID51742804

P2093author name stringVito Turk
Tao Sun
Dušan Turk
Miha Renko
Boris Turk
Veronika Stoka
Olga Vasiljeva
P2860cites workHuman cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterizationQ22008028
Hallmarks of Cancer: The Next GenerationQ22252312
Cloning a synthetic gene for human stefin B and its expression in E. coliQ22254878
Structural basis for the recognition and cleavage of histone H3 by cathepsin LQ24293301
Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluidsQ24299090
The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitorsQ24300962
Cystatin C modulates cerebral beta-amyloidosisQ24300978
The proteome of lysosomesQ24303943
Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosisQ24305291
Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal locationQ24310097
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomasQ24310447
Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitorQ24312357
Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidinQ24527331
Evolutionary families of peptidase inhibitorsQ24530704
Lysosomal cysteine proteases: facts and opportunitiesQ24535678
The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interactionQ24556546
Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegmentQ24561952
Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysisQ24632017
MEROPS: the peptidase databaseQ24644757
Friends and relations of the cystatin superfamily--new members and their evolutionQ24673719
Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophagesQ24676370
Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin LQ24678337
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.Q27617244
Crystal structure of wild-type human procathepsin KQ27617382
Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.Q33843319
Lysosomal cysteine proteases: more than scavengersQ33857460
Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogenQ33858403
Human cathepsin X: A cysteine protease with unique carboxypeptidase activityQ33875510
Proteolysis in MHC class II antigen presentation: who's in charge?Q33885986
Boophilus microplus cathepsin L-like (BmCL1) cysteine protease: specificity study using a peptide phage display libraryQ33887709
Cysteine proteinases and their inhibitors in extracellular fluids: markers for diagnosis and prognosis in cancer.Q33890759
Hereditary cystatin C amyloid angiopathyQ33937075
Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficitsQ33973023
Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi.Q34102897
Protease degradomics: a new challenge for proteomicsQ34136618
Lysosomes revisitedQ34255304
Human cystatin, a new protein inhibitor of cysteine proteinasesQ34257291
Protein inhibitors of cysteine proteinases. III. Amino-acid sequence of cystatin from chicken egg whiteQ34265764
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesisQ34320916
Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.Q34326413
Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different familiesQ34396220
The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeuticsQ34416331
Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytesQ34422070
The lysosome turns fiftyQ34447595
Distinct roles for cysteine cathepsin genes in multistage tumorigenesisQ34471105
Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formationQ34478046
Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfateQ34523628
Molecular genetics of the NCLs -- status and perspectivesQ34545774
Targeting proteases: successes, failures and future prospectsQ34563752
Structural organization of the human kininogen gene and a model for its evolutionQ34564387
RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive propertiesQ34576631
Cysteine cathepsins and the cutting edge of cancer invasionQ34605340
Cathepsin L activity controls adipogenesis and glucose toleranceQ34654358
Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and diseaseQ34713891
Delivering nanomedicine to solid tumorsQ34726981
Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulatorsQ34754105
Imaging proteolysis by living human breast cancer cellsQ34786084
Determination of cathepsins B and H in sera and synovial fluids of patients with different joint diseasesQ68760971
Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatinQ68822977
Collagenolytic cathepsins of rabbit spleen: a kinetic analysis of collagen degradation and inhibition by chicken cystatinQ69420750
Evidence that aspartic proteinase is involved in the proteolytic processing event of procathepsin L in lysosomesQ69505828
Genealogy of mammalian cysteine proteinase inhibitors. Common evolutionary origin of stefins, cystatins and kininogensQ69913137
Mechanism of inhibition of papain by chicken egg white cystatin. Inhibition constants of N-terminally truncated forms and cyanogen bromide fragments of the inhibitorQ69948361
Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitroQ70136099
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivoQ70136102
Bovine stefin C, a new member of the stefin familyQ70636054
Participation of cathepsin L on bone resorptionQ70670024
Lysosomal cathepsin B: correlation with metastatic potentialQ70777196
Rheumatoid arthritisQ71046923
Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine proteasesQ71185919
Conserved cystatin segments as models for designing specific substrates and inhibitors of cysteine proteinasesQ71365991
Lysosomal proteases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancerQ71782469
Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatinsQ71935429
Role of the occluding loop in cathepsin B activityQ71973705
Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamilyQ71994730
Kinetics of the pH-induced inactivation of human cathepsin LQ72067273
Structural dissection of the multidomain kininogens. Fine mapping of the target epitopes of antibodies interfering with their functional propertiesQ72077110
Potent inactivation of cathepsins S and L by peptidyl (acyloxy)methyl ketonesQ72159778
Identification of bovine stefin A, a novel protein inhibitor of cysteine proteinasesQ72589659
The affinity-labelling of cathepsin S with peptidyl diazomethyl ketones. Comparison with the inhibition of cathepsin L and calpainQ72615845
Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidneyQ72709864
Kinetics of inhibition of bovine cathepsin S by bovine stefin BQ72787152
Serum cathepsin B levels and urinary excretion of cathepsin B in the cancer patients with remote metastasisQ72828702
Human cathepsin B is a metastable enzyme stabilized by specific ionic interactions associated with the active siteQ72891339
Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptidesQ73023870
Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complexQ27620728
Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteineQ27621210
Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the proteaseQ27622021
Crystal structure of human cathepsin VQ27627428
Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swappingQ27630854
Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domainQ27635416
Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteasesQ27636471
Structure of a Cys25-->Ser mutant of human cathepsin SQ27637974
The crystal structure of human cathepsin F and its implications for the development of novel immunomodulatorsQ27639638
Crystal structure of Stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidasesQ27640485
Essential role of proline isomerization in stefin B tetramer formationQ27643513
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor familyQ27644771
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificityQ27651464
The crystal and molecular structures of a cathepsin K:chondroitin sulfate complexQ27651504
Dipeptidyl nitrile inhibitors of Cathepsin LQ27655858
Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleftQ27664635
Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate InteractionsQ27666421
The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinasesQ27728538
Structure of papain refined at 1.65 A resolutionQ27729147
Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitorsQ27730182
The three-dimensional solution structure of human stefin AQ27730383
Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptideQ27732677
Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregionQ27733264
Crystal structure of human cathepsin K complexed with a potent inhibitorQ27734780
Crystal structure of human osteoclast cathepsin K complex with E-64Q27734783
Crystal structure of the wild-type human procathepsin B at 2.5 A resolution reveals the native active site of a papain-like cysteine protease zymogenQ27743415
Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B.Q31130955
Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertionsQ32021129
Expression of cathepsins B and S in the progression of prostate carcinomaQ32160033
Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitorsQ33226393
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificitiesQ33235638
Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chainQ33262483
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sitesQ33337380
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.Q33350682
Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditionsQ33505847
Novel peptidyl aryl vinyl sulfones as highly potent and selective inhibitors of cathepsins L and B.Q33638719
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.Q33664639
Stefin B interacts with histones and cathepsin L in the nucleusQ33744431
Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic miceQ33749964
How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamicsQ33787274
Regulation of proteolytic activity in tissuesQ40575091
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsinsQ40622338
Functional involvement of cathepsin W in the cytotoxic activity of NK‐92 cellsQ40629022
Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitorsQ40652154
Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B.Q40754112
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotypeQ40787027
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely routeQ40843079
Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell lineQ40910869
Invariant chain structure and MHC class II functionQ40968427
The discovery of lysosomesQ41438482
Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitorsQ41482008
Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranesQ41541087
Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activityQ41710645
Thyropins--new structurally related proteinase inhibitors.Q41730400
Revised definition of substrate binding sites of papain-like cysteine proteasesQ41730414
Calpain inhibition by peptide epoxidesQ41761276
Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissueQ41845012
Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.Q41845464
Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissuesQ41849893
Quantifying cathepsin S activity in antigen presenting cells using a novel specific substrateQ41852752
Cathepsin K: a cysteine protease with unique kinin-degrading propertiesQ41873108
Interaction of chicken cystatin with inactivated papainsQ41878875
S3 to S3' subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substratesQ41888215
Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzymeQ42064898
E64 [trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactionsQ42084932
The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagentsQ42112501
Histone H3 tail clipping regulates gene expressionQ42159557
The S2 subsites of cathepsins K and L and their contribution to collagen degradationQ42160204
Resistance of cathepsin L compared to elastase to proteolysis when complexed with the serpin endopin 2C, and recovery of cathepsin L activityQ42171555
The combined action of two enzymes in human serum can mimic the activity of cathepsin B.Q42248043
Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells.Q42508689
The occluding loop of cathepsin B prevents its effective inhibition by human kininogens.Q42663543
Cathepsin L increases invasion and migration of B16 melanomaQ42757004
Dynamic imaging of protease activity with fluorescently quenched activity-based probes.Q42806191
An intracellular form of cathepsin B contributes to invasiveness in cancer.Q42829858
High-affinity binding of two molecules of cysteine proteinases to low-molecular-weight kininogen.Q42844879
Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinasesQ42852932
Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin.Q42853691
Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.Q42981725
Probing cathepsin K activity with a selective substrate spanning its active site.Q43003155
Conformational flexibility and allosteric regulation of cathepsin K.Q43070071
Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritisQ43151758
Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulationQ43158721
Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substratesQ43203232
Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 bindingQ43277216
Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation.Q43507844
Cyclic ketone inhibitors of the cysteine protease cathepsin K.Q43550009
Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritisQ43591458
Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processingQ43591595
Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitorQ43660551
Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening methodQ43773668
Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancerQ44068250
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.Q44103830
Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patientsQ44219922
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitroQ44312060
Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.Q44442851
Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B.Q44639948
Regulation of collagenase activities of human cathepsins by glycosaminoglycansQ44674022
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.Q44732185
Cysteine cathepsins (proteases)--on the main stage of cancer?Q44897180
Comprehensive search for cysteine cathepsins in the human genomeQ44935351
Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteasesQ45047073
Expresso: automatic incorporation of structural information in multiple sequence alignments using 3D-CoffeeQ34974325
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets functionQ34996827
Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.Q35021901
Development of activity-based probes for cathepsin X.Q35053426
A new subgroup of the family 2 cystatinsQ35088033
High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cellsQ35107342
Functions of Propeptide Parts in Cysteine ProteasesQ35552225
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivoQ35558255
Papain-like lysosomal cysteine proteases and their inhibitors: drug discovery targets?Q35572201
Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradationQ35747144
Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survivalQ35833961
Cysteine cathepsins in human cancerQ35970409
Autocatalytic processing of procathepsin B is triggered by proenzyme activityQ36001094
Lysosomal cysteine proteases: structural features and their role in apoptosisQ36203712
Two distinct gene subfamilies within the family of cysteine protease genesQ36216964
The lysosomal cysteine proteases in MHC class II antigen presentationQ36266499
Drug delivery strategies for cathepsin inhibitors in joint diseasesQ36316921
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligandsQ36370268
Cysteine cathepsins in the immune responseQ36467439
Cysteine cathepsins: multifunctional enzymes in cancerQ36600996
The molecular understanding of osteoclast differentiationQ36650749
Inhibition of bone resorption by selective inactivators of cysteine proteinasesQ36710669
Role of cathepsin K in normal joints and in the development of arthritisQ36737790
Emerging roles of cysteine cathepsins in disease and their potential as drug targets.Q36740577
Emerging role of cathepsin S in obesity and its associated diseasesQ36766860
Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclastsQ36800896
Cathepsin cysteine proteases in cardiovascular disease.Q36830621
Protease signalling in cell death: caspases versus cysteine cathepsins.Q36838143
Lysosomal cysteine cathepsins: signaling pathways in apoptosisQ36841861
Autocatalytic activation of human cathepsin K.Q36861164
Nuclear cathepsin F regulates activation markers in rat hepatic stellate cellsQ36914323
Cysteine cathepsins: cellular roadmap to different functionsQ36934250
Biochemical properties and regulation of cathepsin K activityQ36970827
Two decades of thyroglobulin type-1 domain research.Q36988309
A fragment of the major histocompatibility complex class II-associated p41 invariant chain inhibits cruzipain, the major cysteine proteinase from Trypanosoma cruziQ73025834
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
Equistatin, a new inhibitor of cysteine proteinases from Actinia equina, is structurally related to thyroglobulin type-1 domainQ73343314
Cathepsin B-like activity as a serum tumour marker in ovarian carcinomaQ73374461
Binding mode of CA074, a specific irreversible inhibitor, to bovine cathepsin B as determined by X-ray crystal analysis of the complexQ73436746
Structure-based development of pyridoxal propionate derivatives as specific inhibitors of cathepsin K in vitro and in vivoQ73445387
Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicatorsQ73483295
Equistatin, a protease inhibitor from the sea anemone actinia equina, is composed of three structural and functional domainsQ73556510
Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cellsQ73582840
Cathepsins B and L in synovial fluids from patients with rheumatoid arthritis and the effect of cathepsin B on the activation of pro-urokinaseQ73601904
Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formationQ73723925
E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl groupQ73837899
The inhibition of cathepsin S by its propeptide--specificity and mechanism of actionQ74166240
Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitorsQ74173020
Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidaseQ74198942
Cathepsin B and tumor-associated laminin expression in the progression of colorectal adenoma to carcinomaQ77162078
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorptionQ77449793
MEROPS: the peptidase databaseQ77660649
Cystatin B: mutation detection, alternative splicing and expression in progressive myclonus epilepsy of Unverricht-Lundborg type (EPM1) patientsQ79144720
Selective inhibition of the collagenase activity of cathepsin KQ80140006
Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity-binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexesQ80207375
Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammationQ82733740
A structural network associated with the kallikrein-kinin and renin-angiotensin systemsQ83017881
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targetingQ83704514
Serum cathepsin-B levels and urinary-excretion of cathepsin-B in the patients with colorectal-cancer - possible indicators for tumor malignancyQ84089175
Azepanone-based inhibitors of human cathepsin S: optimization of selectivity via the P2 substituentQ84512759
Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L.Q45060723
Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivoQ45231987
Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycansQ45264641
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.Q46006433
Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLsQ46187663
Cathepsin X binds to cell surface heparan sulfate proteoglycansQ46409838
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysmsQ46477376
Localization of DNA sequences governing alternative mRNA production of rat kininogen genesQ46571738
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologuesQ46603171
Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation.Q46686104
Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins.Q46808877
Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L.Q46819743
Destabilizing role of cathepsin S in murine atherosclerotic plaquesQ46893001
Total and lipid-bound plasma sialic acid as diagnostic markers in colorectal cancer patients: correlation with cathepsin B expression in progression to Dukes stage.Q46984342
Selective cysteine protease inhibition contributes to blood-feeding success of the tick Ixodes scapularis.Q47840644
Autocatalytic processing of recombinant human procathepsin B is a bimolecular processQ47851086
Rat procathepsin B. Proteolytic processing to the mature form in vitro.Q47856856
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinomaQ47907185
Modulation of hypotensive effects of kinins by cathepsin K.Q51092421
Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts.Q52528116
Acidic pH as a physiological regulator of human cathepsin L activity.Q52534368
Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells.Q53257403
Thyroglobulin type-1 domains in equistatin inhibit both papain-like cysteine proteinases and cathepsin D.Q53744558
Modification of S1 subsite specificity in the cysteine protease cathepsin B.Q54186211
Maturation of human procathepsin B. Proenzyme activation and proteolytic processing of the precursor to the mature proteinase, in vitro, are primarily unimolecular processes.Q54760063
Neuronal ceroid lipofuscinosesQ56566989
Serum cysteine proteases and their inhibitors in rheumatoid arthritis: relation to disease activity and radiographic progressionQ56974060
Multifunctional Roles for Serum Protein Fetuin-A in Inhibition of Human Vascular Smooth Muscle Cell CalcificationQ56999742
pH-induced conformational transitions of the propeptide of human cathepsin L. A role for a molten globule state in zymogen activationQ57220930
Conformational Variability of Chicken CystatinQ57902438
Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA)Q59287810
Lysosomal Cathepsins B and L and Stef in A Blood Levels in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis: Potential Clinical ImplicationsQ60245921
Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironmentQ63965514
Structural basis for specificity of papain-like cysteine protease proregions toward their cognate enzymesQ64038856
Biosynthesis of leupeptinQ67276489
Cathepsins B, H and L in human breast carcinomaQ67848008
Potent slow-binding inhibition of cathepsin B by its propeptideQ67974285
Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseasesQ68100706
Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion.Q36996823
Lung cysteine cathepsins: intruders or unorthodox contributors to the kallikrein-kinin system?Q37038006
Proteases for processing proneuropeptides into peptide neurotransmitters and hormonesQ37053834
Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationshipQ37076723
Activity-based protein profiling: from enzyme chemistry to proteomic chemistryQ37119021
Cystatins: biochemical and structural properties, and medical relevanceQ37175525
Proteases: multifunctional enzymes in life and diseaseQ37225060
Cathepsins: key modulators of cell death and inflammatory responsesQ37257916
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cellsQ37384330
Lysosomes as "suicide bags" in cell death: myth or reality?Q37497722
Structure and functions of human kininogensQ37506097
Diverse regulatory roles for lysosomal proteases in the immune responseQ37564269
Intracellular trafficking of lysosomal proteins and lysosomesQ37664183
Development of nitrile-based peptidic inhibitors of cysteine cathepsinsQ37694669
Kininogens: More than cysteine protease inhibitors and kinin precursorsQ37719822
Cathepsins and cystatin C in atherosclerosis and obesityQ37736846
Peptidase inhibitors in the MEROPS databaseQ37739525
Cathepsins and their involvement in immune responsesQ37774592
Specialized roles for cysteine cathepsins in health and disease.Q37797839
Mechanisms of amyloid fibril formation--focus on domain-swappingQ37871074
Falcipains and other cysteine proteases of malaria parasitesQ37887586
Cystatins of parasitic organismsQ37887599
The endosome-lysosome pathway and information generation in the immune systemQ37904214
The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expressionQ37909147
Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactionsQ38298816
Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificityQ38301566
Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization.Q38322542
Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusionQ39571113
Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide.Q40002125
Selective activity-based probes for cysteine cathepsinsQ40049363
Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis.Q40268385
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cellsQ40341738
Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C).Q40545373
Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase functionQ27748903
The crystal structure of human procathepsin KQ27766712
On the size of the active site in proteases. I. PapainQ27860826
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localizationQ28137688
Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosisQ28139155
Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosisQ28145435
CystatinsQ28180897
Human and mouse proteases: a comparative genomic approachQ28184208
Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human diseaseQ28215150
Irreversible inhibitors of serine, cysteine, and threonine proteasesQ28217093
The crystal structure of human cathepsin L complexed with E-64Q28237390
Histidine-rich glycoprotein: A novel adaptor protein in plasma that modulates the immune, vascular and coagulation systemsQ28238035
Structure of papainQ28255054
Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitroQ28262233
Sorting of non-glycosylated human procathepsin S in mammalian cellsQ28266262
Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysisQ28268059
Inactivation of human cystatin C and kininogen by human cathepsin DQ28272426
The cystatins: Protein inhibitors of cysteine proteinasesQ28283958
High-molecular-weight kininogen binds two molecules of cysteine proteinases with different rate constantsQ28284858
Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review)Q28285195
Molecular cloning and sequence analysis of human preprocathepsin CQ28295805
Evolution of proteins of the cystatin superfamilyQ28298204
The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin BQ28359859
Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytesQ28473458
Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidasesQ28512369
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiationQ28590081
A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factorQ28592058
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymusQ28613227
Friends or foes - bipolar effects of the tumour stroma in cancerQ29619348
Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.Q30321506
Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological diseaseQ30477117
Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblastsQ30491065
Imaging proteolysis by living human glioma cellsQ30703032
Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotesQ30888032
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)68-88
P577publication date2012-01-01
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleCysteine cathepsins: from structure, function and regulation to new frontiers
P478volume1824

Reverse relations

cites work (P2860)
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Q47849287Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation
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Q56535621Cathepsins: Proteases that are vital for survival but can also be fatal
Q27704273Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L
Q36266181Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells
Q34443252Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1.
Q28079032Cellular proteostasis: degradation of misfolded proteins by lysosomes
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Q96301222Characterization of a Trichinella spiralis cathepsin X and its promotion for the larval invasion of mouse intestinal epithelial cells
Q91831377Characterization of proteolysis in muscle tissues of sea cucumber Stichopus japonicus
Q47867122Chemical introduction of the green fluorescence: imaging of cysteine cathepsins by an irreversibly locked GFP fluorophore
Q41116581Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats.
Q36480910Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer
Q38644377Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases
Q47228764Computational predictions of cysteine cathepsin-mediated fibrinogen proteolysis
Q38871517Conformational changes required for reovirus cell entry are sensitive to pH.
Q47926090Copper(ii)-benzimidazole complexes as efficient fluorescent probes for l-cysteine in water
Q91995280Covalent Inhibition in Drug Discovery
Q61444815Curcumin inhibits the TGF-β1-dependent differentiation of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L
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Q46797867Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells.
Q38341202Cystatin C is a disease-associated protein subject to multiple regulation
Q38835714Cystatin D locates in the nucleus at sites of active transcription and modulates gene and protein expression.
Q92853428Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer
Q35592746Cysteine Cathepsins Activate ELR Chemokines and Inactivate Non-ELR Chemokines
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Q38182521Cysteine cathepsins and their potential in clinical therapy and biomarker discovery
Q35910069Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
Q38292676Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells.
Q26827307Cysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probes
Q34333230Cysteine peptidases and their inhibitors in Tetranychus urticae: a comparative genomic approach.
Q26771736Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors
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Q91690107Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions
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Q26700100Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability
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Q41143858Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes
Q36469004Development of α-helical calpain probes by mimicking a natural protein-protein interaction
Q36087869Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.
Q52685987Differential Protein Profiling of Cerebrospinal Fluid in Piglets with Severe Meningoencephalitis Caused by Streptococcus suis Type 2 Compared to Controls.
Q36577139Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway
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Q26825638Disruptions of Host Immunity and Inflammation by Giardia Duodenalis: Potential Consequences for Co-Infections in the Gastro-Intestinal Tract
Q34271356Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.
Q35092804Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development
Q43874096Dynamic identification of H2 epitopes from Leishmania (Leishmania) amazonensis cysteine proteinase B with potential immune activity during murine infection.
Q47664632Dysfunction of Membrane Trafficking Leads to Ischemia-Reperfusion Injury After Transient Cerebral Ischemia
Q64991702Ectromelia virus suppresses expression of cathepsins and cystatins in conventional dendritic cells to efficiently execute the replication process.
Q64930732Effect of Non-Vital Bleaching on the Durability of Resin⁻Dentin Bond with an Ethanol-Based Etch-And-Rinse Adhesive.
Q28069869Effects of Glycosylation on the Enzymatic Activity and Mechanisms of Proteases
Q38647522Effects of Vacuolar H(+)-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells.
Q38714350Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells.
Q36682721Effects of open versus laparoscopic nephrectomy techniques on oxidative stress markers in patients with renal cell carcinoma
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Q36264141Enhanced transcriptomic responses in the Pacific salmon louse Lepeophtheirus salmonis oncorhynchi to the non-native Atlantic Salmon Salmo salar suggests increased parasite fitness
Q50216109Enzymatic modification by point mutation and functional analysis of an omega-6 fatty acid desaturase from Arctic Chlamydomonas sp.
Q26741532Enzymes in Fish and Seafood Processing
Q43185053EpCAM proteolysis: new fragments with distinct functions?
Q35914308Evidence of Alternative Cystatin C Signal Sequence Cleavage Which Is Influenced by the A25T Polymorphism
Q35891325Evolutionary History of Cathepsin L (L-like) Family Genes in Vertebrates
Q36505367Expression patterns of cysteine peptidase genes across the Tribolium castaneum life cycle provide clues to biological function
Q36502689Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients
Q36385028Expression, purification, and characterization of human cystatin C monomers and oligomers
Q50791577FPPS: Fast Profiling of Protease Specificity.
Q91026500Fasciola gigantica: Comparison of the tegumental ultrastructure in newly excysted metacercariae and in vitro penetrated juvenile flukes indicates intracellular sources of molecules with vaccinal and immunomodulatory potential
Q38417182Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S.
Q91709813Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples
Q98721032Food proteins are a potential resource for mining cathepsin L inhibitory drugs to combat SARS-CoV-2
Q41732169Foot-and-mouth disease virus leader proteinase: structural insights into the mechanism of intermolecular cleavage
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Q38465020Gene network and canonical pathway analysis in canine myxomatous mitral valve disease: a microarray study
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Q35762858Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase
Q42735511Giardia duodenalis cathepsin B proteases degrade intestinal epithelial interleukin-8 and attenuate interleukin-8-induced neutrophil chemotaxis
Q64982206Glucosamine prevents polarization of cytotoxic granules in NK-92 cells by disturbing FOXO1/ERK/paxillin phosphorylation.
Q40743173HIV Protease Inhibitor-Induced Cathepsin Modulation Alters Antigen Processing and Cross-Presentation
Q41121841High lumenal chloride in the lysosome is critical for lysosome function
Q47100235Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.
Q51763123Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression.
Q89259957Human cathepsins K, L, and S: Related proteases, but unique fibrinolytic activity
Q44870181Human cystatin C: a new biomarker of idiopathic pulmonary fibrosis?
Q37581801Identification and function of proteolysis regulators in seminal fluid
Q40747704Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus).
Q46828103In Search of a Converging Cellular Mechanism in Nanotoxicology and Nanomedicine in the Treatment of Cancer
Q64087585In Silico Analysis of Homologous Heterodimers of Cruzipain-Chagasin from Structural Models Built by Homology
Q47642547Inactivation of NSF ATPase Leads to Cathepsin B Release After Transient Cerebral Ischemia
Q89675940Increased Rate of Retinal Pigment Epithelial Cell Migration and Pro-Angiogenic Potential Ensuing From Reduced Cystatin C Expression
Q57025651Increasing time on target: utilization of inhibitors of cysteine cathepsins to enhance the tumor retention of receptor-targeted agents
Q52374264Indispensable Role of Proteases in Plant Innate Immunity.
Q42619504Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases
Q38943054Insights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor
Q50882222Insights into the mechanism of cystatin C oligomer and amyloid formation and its interaction with β-amyloid.
Q36806048Insufficient Generation of Mycobactericidal Mediators and Inadequate Level of Phagosomal Maturation Are Related with Susceptibility to Virulent Mycobacterium tuberculosis Infection in Mouse Macrophages
Q51747909Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity.
Q61959522Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone
Q33812663Investigating the Life Expectancy and Proteolytic Degradation of Engineered Skeletal Muscle Biological Machines.
Q42150501Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice
Q61805484Isolation and characterization of a tandem-repeated cysteine protease from the symbiotic dinoflagellate Symbiodinium sp. KB8
Q47384752Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages.
Q38557771Journey of cystatins from being mere thiol protease inhibitors to at heart of many pathological conditions
Q92030391KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation
Q35758680Kallikrein-8 Proteolytically Processes Human Papillomaviruses in the Extracellular Space To Facilitate Entry into Host Cells
Q38009194Killing a cancer: what are the alternatives?
Q38654407LLOMe does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes
Q34262192Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity
Q46572905Ligation of FcγR Alters Phagosomal Processing of Protein via Augmentation of NADPH Oxidase Activity
Q58920565Lithium chloride enhances cathepsin H expression and BMP-4 degradation in C3H10T1/2 cells
Q52864120Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe.
Q52725925Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals.
Q91784087Lysosomal Proteases Are a Determinant of Coronavirus Tropism
Q26749121Lysosomal cathepsins and their regulation in aging and neurodegeneration
Q34264949Lysosomal pathways to cell death and their therapeutic applications.
Q35116175Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells.
Q36357685Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis
Q93064841Lysosomes as a therapeutic target
Q64914067MAV_4644 Interaction with the Host Cathepsin Z Protects Mycobacterium avium subsp. hominissuis from Rapid Macrophage Killing.
Q27690658Macrocyclic protease inhibitors with reduced peptide character
Q61814442Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D₃
Q39003421Mammalian orthoreovirus T3D infects U-118 MG cell spheroids independent of junction adhesion molecule-A.
Q36593560Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy
Q34475790Mast cell proteases as pharmacological targets
Q50215750Measuring Phagosomal pH by Fluorescence Microscopy
Q38991409Mechanisms of buffer therapy resistance
Q47827985Meta-analysis of transcriptomic changes in optic nerve injury and neurodegenerative models reveals a fundamental response to injury throughout the central nervous system.
Q38799069Microbial inhibitors of cysteine proteases.
Q88670186Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth
Q41862863Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT.
Q39452252Molecular and immunological characterization of cathepsin L-like cysteine protease of Paragonimus pseudoheterotremus
Q35096243Molecular characterization and serological reactivity of a vacuolar ATP synthase subunit ε-like protein from Clonorchis sinensis
Q37526196Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection
Q47843948Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Q42428279Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation
Q111271454Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V
Q28552228Mutation in the Pro-Peptide Region of a Cysteine Protease Leads to Altered Activity and Specificity-A Structural and Biochemical Approach
Q50898615Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure.
Q90356650Myocardial cathepsin D is downregulated in sudden cardiac death
Q46200816Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion
Q41824919NLRP3 activation induces ASC-dependent programmed necrotic cell death, which leads to neutrophilic inflammation
Q36884629Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases
Q37691517Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer
Q28260087Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity
Q41455465Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin
Q50453909Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.
Q30389896Novel proteases from the genome of the carnivorous plant Drosera capensis: Structural prediction and comparative analysis
Q52591302Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability.
Q26866319Optimizing dentin bond durability: control of collagen degradation by matrix metalloproteinases and cysteine cathepsins
Q48014081PACMANS: A bioinformatically informed algorithm to predict, design, and disrupt protease-on-protease hydrolysis.
Q40470485PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment.
Q92828409Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization
Q37238697Pathogenesis of mitral valve disease in mucopolysaccharidosis VII dogs.
Q34635528Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects.
Q98158951Photoaging Skin Therapy with PRP and ADSC: A Comparative Study
Q90213483Plasma proteomic signature of the risk of developing mobility disability: A 9-year follow-up
Q38203114Podosomes in space: macrophage migration and matrix degradation in 2D and 3D settings
Q27677225Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases
Q95843513Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy?
Q111348329Potential roles of two Cathepsin genes, DcCath-L and DcCath-O in the innate immune response of Diaphorina citri
Q90310495Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis
Q92694063Prolines Affect the Nucleation Phase of Amyloid Fibrillation Reaction; Mutational Analysis of Human Stefin B
Q37022937Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation.
Q33734766Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction.
Q48364393Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain.
Q38663181Protease signaling in animal and plant-regulated cell death
Q48691301Protease-activated nanomaterials for targeted cancer theranostics
Q33795055Proteases Revisited: Roles and Therapeutic Implications in Fibrosis
Q38268345Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges
Q37629015Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer
Q36294814Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization
Q47271370Proteolytic systems' expression during myogenesis and transcriptional regulation by amino acids in gilthead sea bream cultured muscle cells.
Q38409707Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells.
Q35072858Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.
Q55131844Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes.
Q39259454RNA interference and dietary inhibitors induce a similar compensation response in Tribolium castaneum larvae
Q41181668Rational Design of Recombinant Papain-Like Cysteine Protease: Optimal Domain Structure and Expression Conditions for Wheat-Derived Enzyme Triticain-α.
Q26828960Reaching the melting point: Degradative enzymes and protease inhibitors involved in baculovirus infection and dissemination
Q93022937Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders
Q34905953Recognition of higher order patterns in proteins: immunologic kernels
Q64389267Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation
Q33718504Regulation of TGF-β1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C.
Q90363169Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants
Q38103557Relationship between the proteasomal system and autophagy
Q64248857Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer
Q89658859Revisiting the Roles of Pro-Metastatic EpCAM in Cancer
Q37215806Role of Cathepsins in Mycobacterium tuberculosis Survival in Human Macrophages
Q27026498Role of integrins in the periodontal ligament: organizers and facilitators
Q57584188Rotavirus Attachment, Internalization, and Vesicular Traffic
Q37713871Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell
Q28276622Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function
Q41434747STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation
Q40990114Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells
Q41334657Salvianolic acid B protects hepatocytes from H2O2 injury by stabilizing the lysosomal membrane
Q55023666Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.
Q93075496Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model
Q28829764Sequence comparison, molecular modeling, and network analysis predict structural diversity in cysteine proteases from the Cape sundew, Drosera capensis
Q64097586Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis
Q38971054Serpin1 and WSCP differentially regulate the activity of the cysteine protease RD21 during plant development in Arabidopsis thaliana
Q99635486Serum cystatin C is closely associated with euthyroid Hashimoto's thyroiditis in adult female Chinese patients
Q92609903Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Q96230684Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection
Q36743865Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis
Q91879301Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase
Q48533476Stat3 mediated alterations in lysosomal membrane protein composition
Q42275957Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model.
Q36169439Structural Dynamics Investigation of Human Family 1 & 2 Cystatin-Cathepsin L1 Interaction: A Comparison of Binding Modes
Q37065874Structural and Functional Characterization of the Major Allergen Amb a 11 from Short Ragweed Pollen
Q89392305Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states
Q34277879Structural basis for specificity of propeptide-enzyme interaction in barley C1A cysteine peptidases
Q27682067Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function
Q99587434Structure of the Plasmodium falciparum PfSERA5 pseudo-zymogen
Q41856866Studies of inhibitory mechanisms of propeptide-like cysteine protease inhibitors
Q39137404Synthesis and radiopharmacological characterisation of a fluorine-18-labelled azadipeptide nitrile as a potential PET tracer for in vivo imaging of cysteine cathepsins
Q94541646TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis
Q92373377TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin
Q52598834Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.
Q64234280The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
Q64248056The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells
Q41619854The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability
Q30936124The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution.
Q89966156The Functional Effects of Key Driver KRAS Mutations on Gene Expression in Lung Cancer
Q38357779The HIV protease inhibitor saquinavir inhibits HMGB1 driven inflammation by targeting the interaction of cathepsin V with TLR4/MyD88
Q97557237The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
Q47351855The Intra-Cellular Localization of the Vanillin Biosynthetic Machinery in Pods of Vanilla planifolia
Q60944020The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation
Q99413952The Potential Role of Cathepsin K in Non-Small Cell Lung Cancer
Q92150617The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
Q26799771The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung
Q29248184The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3
Q96954446The expression of Cathepsin L in oral lichen planus
Q37568511The function of cathepsins B, D, and X in atherosclerosis
Q38072995The role of cysteine proteinases and their inhibitors in the host-pathogen cross talk
Q27683442The structure of a thermostable mutant of pro-papain reveals its activation mechanism
Q39245158The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1.
Q27683866The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium
Q45760136Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives
Q37212428Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins
Q36534915Tooth bleaching increases dentinal protease activity.
Q36040040Transcriptome Analysis of the Sydney Rock Oyster, Saccostrea glomerata: Insights into Molluscan Immunity
Q92669055Transcriptome meta-analysis reveals differences of immune profile between eutopic endometrium from stage I-II and III-IV endometriosis independently of hormonal milieu
Q89449453Transcriptomic analysis of dead end knockout testis reveals germ cell and gonadal somatic factors in Atlantic salmon
Q40611895Transgenic Expression of a Viral Cystatin Gene CpBV-CST1 in Tobacco Confers Insect Resistance
Q46360939Tumor Necrosis Factor-α Induced Apoptosis in U937 Cells Promotes Cathepsin D-Independent Stefin B Degradation
Q34761929Uncovering the cathepsin system in heart failure patients submitted to Left Ventricular Assist Device (LVAD) implantation.
Q37998091Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease
Q89682842Utilizing Experimental Mouse Model to Identify Effectors of Hepatocellular Carcinoma Induced by HBx Antigen
Q28656193Vanillin formation from ferulic acid in Vanilla planifolia is catalysed by a single enzyme
Q30383716Vasohibins: new transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad
Q39208117Yeast as a tool to explore cathepsin D function
Q37691916c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer
Q98513731p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy-lysosomal pathway and coordinate cell cycle and cell growth

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