The crystal structure of human cathepsin L complexed with E-64

scientific article (publication date: 21 April 1997)

The crystal structure of human cathepsin L complexed with E-64 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0014-5793(97)00216-0
P698PubMed publication ID9141479
P5875ResearchGate publication ID14075922

P2093author name stringY Yamamoto
T Nomura
T Sugawara
Y Imai
Y Fujisawa
A Fujishima
P2860cites workStructure of human procathepsin L reveals the molecular basis of inhibition by the prosegmentQ24561952
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsitesQ27642171
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificityQ27651464
Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitorsQ27730182
Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor designQ27730414
Crystal structure of a papain-E-64 complexQ34524433
Crystal structure of an actinidin-E-64 complexQ46521277
Participation of cathepsin L on bone resorptionQ70670024
Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cellsQ71033250
Characterization and crystallization of recombinant human cathepsin LQ71829127
Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritisQ72296654
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcrystal structureQ895901
P304page(s)47-50
P577publication date1997-04-21
P1433published inFEBS LettersQ1388051
P1476titleThe crystal structure of human cathepsin L complexed with E-64
P478volume407

Reverse relations

cites work (P2860)
Q356835866. Cathepsin K inhibitors: their potential as anti-osteoporosis agents
Q89634052A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
Q52534368Acidic pH as a physiological regulator of human cathepsin L activity.
Q55474273Affinity-Enhanced Luminescent Re(I)- and Ru(II)-Based Inhibitors of the Cysteine Protease Cathepsin L.
Q28262233Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro
Q73669332Beta-cyclodextrin/epoxysuccinyl peptide conjugates: a new drug targeting system for tumor cells
Q108502694Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Q33200667Cloning and characterization of a gut-specific cathepsin L from the aphid Aphis gossypii.
Q27617244Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.
Q42846520Crystal structure of human cathepsin S.
Q27748903Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function
Q26860406Cysteine cathepsins: from structure, function and regulation to new frontiers
Q43610411Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors
Q42001497Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors
Q74151522Development of peptidyl alpha-keto-beta-aldehydes as new inhibitors of cathepsin L--comparisons of potency and selectivity profiles with cathepsin B
Q34855069Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica.
Q35826183Filoviruses require endosomal cysteine proteases for entry but exhibit distinct protease preferences
Q98721032Food proteins are a potential resource for mining cathepsin L inhibitory drugs to combat SARS-CoV-2
Q33920156Fractal intermediates in the self-assembly of silicatein filaments
Q30897474Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections
Q41728795Identification and characterization of a cathepsin-L-like peptidase in Eimeria tenella
Q39035003Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor
Q40747704Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus).
Q27315852In vivo imaging with fluorescent smart probes to assess treatment strategies for acute pancreatitis
Q77917014Inhibition of cysteine proteases by peptides containing aziridine-2,3-dicarboxylic acid building blocks
Q33327656Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L
Q26749121Lysosomal cathepsins and their regulation in aging and neurodegeneration
Q33857460Lysosomal cysteine proteases: more than scavengers
Q42611608Molecular and enzymatic properties of a cathepsin L-like proteinase with distinct substrate specificity from northern shrimp (Pandalus borealis).
Q43662638Molecular cloning and characterization of cathepsin L encoding genes from Fasciola gigantica
Q41889166Molecular docking of cathepsin L inhibitors in the binding site of papain
Q38551513Phage display selection can differentiate insecticidal activity of soybean cystatins
Q30848784Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates.
Q41710645Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity
Q37053834Proteases for processing proneuropeptides into peptide neurotransmitters and hormones
Q28612038Proteolysis and antigen presentation by MHC class II molecules
Q41730414Revised definition of substrate binding sites of papain-like cysteine proteases
Q27664560Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors
Q24293301Structural basis for the recognition and cleavage of histone H3 by cathepsin L
Q73077056Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo
Q43601519Synthesis and hydrolysis by cathepsin B of fluorogenic substrates with the general structure benzoyl-X-ARG-MCA containing non-natural basic amino acids at position X.
Q36281760The N-terminal region of cystatin A (stefin A) binds to papain subsequent to the two hairpin loops of the inhibitor. Demonstration of two-step binding by rapid-kinetic studies of cystatin A labeled at the N-terminus with a fluorescent reporter group
Q73526016The high stability of cruzipain against pH-induced inactivation is not dependent on its C-terminal domain
Q42549117The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry
Q61066436aziridinyl peptides as inhibitors of cysteine proteases: Effect of a free carboxylic acid function on inhibition

Search more.