Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease

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Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease is …
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P356DOI10.1177/154411130201300304
P698PubMed publication ID12090464
P5875ResearchGate publication ID11286065

P2093author name stringDickinson DP
P2860cites workHuman cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterizationQ22008028
Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinaseQ22008032
Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in boneQ24309351
Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal locationQ24310097
Human dipeptidyl-peptidase I. Gene characterization, localization, and expressionQ24311837
Cystatin F Is a Glycosylated Human Low Molecular Weight Cysteine Proteinase InhibitorQ24312357
Evolutionary families of peptidasesQ24527684
Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin SQ24528220
Caspases: the executioners of apoptosisQ24530218
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and LQ24531160
Secreted cathepsin L generates endostatin from collagen XVIIIQ24599981
Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophagesQ24676370
Two distinct gene subfamilies within the family of cysteine protease genesQ36216964
An acid protease secreted by transformed cells interferes with antigen processingQ36218951
Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.Q36301521
The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractantQ36354993
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentationQ36475793
Direct evidence for the elevated synthesis and secretion of procathepsin L in the distal caput epididymis of boarQ36671752
Cloning and expression of a rat placental cDNA encoding a novel cathepsin L-related proteinQ36705688
Cathepsin B, a cysteine protease implicated in metastatic progression, is also expressed during regression of the rat prostate and mammary glands.Q36731034
Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclastsQ36800896
Alterations in phagocyte function and periodontal infectionQ36831541
Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase I.Q36853423
The neutrophil: mechanisms of controlling periodontal bacteriaQ36894586
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cellsQ37384330
Tissue destruction by neutrophilsQ38264463
Neutrophil Migration Into the Gingival Sulcus Is Associated With Transepithelial Gradients of Interleukin‐8 and ICAM‐1Q38578614
Lysosomal enzymes and their receptorsQ39479416
Cytokines: making the right choiceQ39696739
Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteasesQ35691389
Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cellsQ35787073
Elevated levels of cysteine protease activity in saliva and salivary glands of the nonobese diabetic (NOD) mouse model for Sjögren syndromeQ36158535
Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregionsQ36198437
Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutationQ24681399
Basic local alignment search toolQ25938991
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.Q27617244
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAPQ27620280
The crystal structure of human procathepsin KQ27766712
Structure and chromosomal assignment of the human cathepsin K geneQ28117956
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localizationQ28137688
Cathepsin expression during skeletal developmentQ28138976
Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosisQ28139155
Immunocytochemical localization of cathepsins B and G in odontoclasts of human deciduous teethQ28207591
Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2Q28236726
Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated formsQ28238221
Cathepsin BQ28245818
The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20Q28253236
Cross-Class Inhibition of the Cysteine Proteinases Cathepsins K, L, and S by the Serpin Squamous Cell Carcinoma Antigen 1: A Kinetic AnalysisQ28268059
The structure of the mouse cathepsin B gene and its putative promoterQ28272190
Inactivation of human cystatin C and kininogen by human cathepsin DQ28272426
Cathepsin B, Cathepsin H, and cathepsin LQ28277583
Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identificationQ28280533
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiencyQ28284581
Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)Q28286845
Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distributionQ28290432
Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin LQ28290438
Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2Q28304561
Emerging roles for cysteine proteases in human biologyQ28306260
Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomasQ28307471
The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin LQ28361595
The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinasesQ28367093
Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and PQ28509398
Cathepsin Q, a novel lysosomal cysteine protease highly expressed in placentaQ28570157
Rat testin is a newly identified component of the junctional complexes in various tissues whose mRNA is predominantly expressed in the testis and ovaryQ28572184
Characterization of mouse cathepsin R, a new member of a family of placentally expressed cysteine proteasesQ28585681
Cathepsin J, a novel murine cysteine protease of the papain family with a placenta-restricted expressionQ28586755
Surface activation of pro-cathepsin LQ28592047
Cathepsin S required for normal MHC class II peptide loading and germinal center developmentQ28611850
Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the ThymusQ28613227
Caspases: Enemies WithinQ29547315
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosisQ29617776
Matrix metalloproteinases: a reviewQ29620220
Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cellsQ30321132
Cathepsin S and related lysosomal endopeptidases.Q30321425
Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.Q30321506
Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domainQ30696787
Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorptionQ30773401
Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor geneQ30854542
Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblastsQ31417108
Human cathepsin X: A novel cysteine protease of the papain family with a very short proregion and unique insertions1Q32021129
Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activationQ40096626
Human plasma proteinase inhibitorsQ40107740
Regulation of proteolytic activity in tissuesQ40575091
Role of suspected periodontopathogens in microbiological monitoring of periodontitisQ40789891
Interferon-gamma down-regulates gene expression of cathepsin K in osteoclasts and inhibits osteoclast formationQ40818408
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.Q40925415
Expression of cathepsin K in lung epithelial cellsQ40963587
Inhibition of tumour cell invasion by protease inhibitors: correlation with the protease profileQ40986849
How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathwayQ41020969
Cytokine-inducing components of periodontopathogenic bacteriaQ41180923
Neural crest apoptosis and the establishment of craniofacial pattern: an honorable deathQ41212560
Expression of rat cathepsin S in phagocytic cellsQ41226814
Alpha 2-macroglobulin in gingival fluid: correlation with alveolar bone loss in periodontal diseaseQ41247703
Identification on melanoma cells of p39, a cysteine proteinase that cleaves C3, the third component of complement: amino-acid-sequence identities with procathepsin LQ41259127
Giant cells in arthritic synoviumQ41260586
Differential recognition of alpha 1-antitrypsin-elastase and alpha 1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related proteinQ41370261
Multi-step processing of procathepsin L in vitroQ41436588
The proregion of cathepsin L is required for proper folding, stability, and ER exitQ41467775
Cytokines and the hepatic acute phase responseQ41474260
Proenzyme from of cathepsin L produced by thymic epithelial cells promotes proliferation of immature thymocytes in the presence of IL-1, IL-7, and anti-CD3 antibodyQ41536790
Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA.Q41555093
Caspases: Intracellular Signaling by ProteolysisQ41656258
Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motifQ41668260
MHC class II molecules, cathepsins, and La/SSB proteins in lacrimal acinar cell endomembranesQ41702760
Stimulation with carbachol alters endomembrane distribution and plasma membrane expression of intracellular proteins in lacrimal acinar cellsQ41712044
Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissuesQ41849893
Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzymeQ42064898
Quantification of cathepsins B and L in cellsQ42537421
Primary structure of bovine cathepsin S. Comparison to cathepsins L, H, B and papainQ42622492
Expression of cysteine proteases in extraembryonic tissues during mouse embryogenesisQ42807530
Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell linesQ42813782
A partial catalog of proteins secreted by epidermal keratinocytes in cultureQ42816120
Analysis of where and which types of proteinases participate in lysosomal proteinase processing using bafilomycin A1 and Helicobacter pylori Vac A toxinQ42817555
Procathepsin L degrades extracellular matrix proteins in the presence of glycosaminoglycans in vitroQ42819271
Multiple processing of procathepsin L to cathepsin L in vivoQ42824669
Elastinolytic activity of human cathepsin L.Q42867583
Mode of activation of the precursor to cathepsin L: implication for matrix degradation in arthritisQ44855335
Neutrophil chemotactic activity is modulated by human cystatin C, an inhibitor of cysteine proteasesQ45262126
Cytokine Expression in Periodontal Health and DiseaseQ45297941
Purification and characterization of cathepsin J from rat liverQ46117343
Gene structure and 5'-upstream sequence of rat cathepsin L.Q46984019
Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain reaQ47685856
Testin Secreted by Sertoli Cells Is Associated with the Cell Surface, and Its Expression Correlates with the Disruption of Sertoli-Germ Cell Junctions but Not the Inter-Sertoli Tight JunctionQ47724366
Expression in Escherichia coli, refolding, and purification of human procathepsin K, an osteoclast-specific proteaseQ47851649
Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.Q47872621
Calpain: a protease in search of a function?Q47923112
Processing of the papain precursor. The ionization state of a conserved amino acid motif within the Pro region participates in the regulation of intramolecular processingQ48073777
A novel family of cathepsin L-like (CTSLL) sequences on human chromosome 10q and related transcriptsQ48077716
Differential distribution of messenger RNAs for cathepsins B, L and S in adult rat brain: an in situ hybridization studyQ48150354
Cyclic protein-2, a secretory product of rat Sertoli cells, is the proenzyme form of cathepsin L.Q48197841
Cathepsin B-mediated activation of the proinflammatory caspase-11.Q49171734
Investigations into the cellular contribution to host tissue proteases and inhibitors in gingival crevicular fluidQ50528244
A possible association of α1‐antitrypsin deficiency with the periodontal condition in adultsQ50868482
Developmental expression of cathepsin L and c-rasHa in the mouse placentaQ51196704
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.Q52190101
Testin is tightly associated with testicular cell membrane upon its secretion by sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctionsQ52195730
Ultrastructural localization of cathepsin B in gingival tissue from chronic periodontitis patientsQ53994638
Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not DemineralizationQ57272396
Prolactin Up-Regulates Cathepsin B and D Expression in Minor Salivary Glands of Patients with Sjögren's SyndromeQ58862290
Cathepsin K mRNA Detection Is Restricted to Osteoclasts During Fetal Mouse DevelopmentQ32066782
The potential role of chemokines and inflammatory cytokines in periodontal disease progressionQ33588763
Activation of the plasma kallikrein/kinin system on endothelial cellsQ33650374
Suicidal tendencies: apoptotic cell death by caspase family proteinasesQ33684353
The lysosomal cysteine proteasesQ33689936
Making sense of the limb-girdle muscular dystrophiesQ33701932
Osteopetrosis and osteoporosis: two sides of the same coinQ33724069
Proteolysis and cell migration: creating a path?Q33744936
Clinical, molecular, and cell biological aspects of Chediak-Higashi syndromeQ33755016
Unraveling the role of proteases in cancerQ33838143
Lysosomal cysteine proteases: more than scavengersQ33857460
Caspases - controlling intracellular signals by protease zymogen activationQ33857511
Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogenQ33858403
Human cathepsins F and W: A new subgroup of cathepsinsQ33864371
Genomic organization and chromosomal localization of the human cathepsin L2 gene.Q33866167
Human cathepsin X: A cysteine protease with unique carboxypeptidase activityQ33875510
Proteolysis in MHC class II antigen presentation: who's in charge?Q33885986
Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain familyQ33888252
Tissue expression and immunolocalization of a novel human cathepsin P.Q33888257
Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspasesQ33889747
Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localizationQ33897792
Noncaspase proteases in apoptosisQ34037785
Role of bacterial proteinases in matrix destruction and modulation of host responsesQ34200755
Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophagesQ34255942
Biochemical composition of human saliva in relation to other mucosal fluidsQ34294679
Families of cysteine peptidases.Q34317817
Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophagesQ34385281
Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytesQ34422070
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome cQ34457741
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidasesQ34487989
Genomic Structure, Chromosomal Localization, and Expression of Human Cathepsin WQ34749685
Human cystatin C. role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastaseQ35016459
Cystatins--inhibitors of cysteine proteinasesQ35361416
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivoQ35558255
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)238-275
P577publication date2002-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inJournal of Dental ResearchQ6295082
P1476titleCysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease
P478volume13

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cites work (P2860)
Q50948847A New Sugarcane Cystatin Strongly Binds to Dental Enamel and Reduces Erosion
Q35085725A snapshot of the Ixodes scapularis degradome
Q35630007Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis.
Q36227942Analysis of the human saliva proteome.
Q33693412Analysis of the transcriptome of adult Dictyocaulus filaria and comparison with Dictyocaulus viviparus, with a focus on molecules involved in host-parasite interactions
Q36543714Anti-serpin Antibody-mediated Regulation of Proteases in Autoimmune Diabetes
Q34377103Biochemistry and clinical role of human cystatin C.
Q34413796Bovipain-2, the falcipain-2 ortholog, is expressed in intraerythrocytic stages of the tick-transmitted hemoparasite Babesia bovis
Q36640223Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles
Q24336204Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells
Q38420668Cathepsin S: therapeutic, diagnostic, and prognostic potential.
Q34631788Clinical Efficacy of a Specifically Targeted Antimicrobial Peptide Mouth Rinse: Targeted Elimination of <i>Streptococcus mutans</i> and Prevention of Demineralization
Q41994145Crystallization and preliminary X-ray diffraction studies of the precursor protein of a thermostable variant of papain
Q90669948Cystatins in Health and Diseases
Q35129249Cysteine cathepsins in human carious dentin
Q26860406Cysteine cathepsins: from structure, function and regulation to new frontiers
Q38169006Dentin biomodification: strategies, renewable resources and clinical applications
Q43575189Development of a saliva collection device for use in the field
Q38712591Effect of pH on dentin protease inactivation by carbodiimide.
Q34361835Evolution of C, D and S-type cystatins in mammals: an extensive gene duplication in primates
Q44433403Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment
Q24303274Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor
Q40285536Identification and characterization of a cathepsin L-like cysteine protease from Rhipicephalus (Boophilus) annulatus.
Q42025701Identification of parasite-responsive cysteine proteases in Manduca sexta.
Q35684193Identification, Characterization and Down-Regulation of Cysteine Protease Genes in Tobacco for Use in Recombinant Protein Production
Q36902096Immune and regulatory functions of neutrophils in inflammatory bone loss
Q35052350Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus
Q93198245Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis
Q43144436Involvement of a cysteine protease in the secretion process of human xylosyltransferase I.
Q28741956Limitations in bonding to dentin and experimental strategies to prevent bond degradation
Q37147938Long-lasting tissue inflammatory processes trigger autoimmune responses to extracellular matrix molecules.
Q92153915Molecular Signaling Regulating Endometrium-Blastocyst Crosstalk
Q33505847Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions
Q37594566Neutrophil homeostasis and periodontal health in children and adults
Q33638719Novel peptidyl aryl vinyl sulfones as highly potent and selective inhibitors of cathepsins L and B.
Q36914323Nuclear cathepsin F regulates activation markers in rat hepatic stellate cells
Q26866319Optimizing dentin bond durability: control of collagen degradation by matrix metalloproteinases and cysteine cathepsins
Q49335018Overexpression of asparaginyl endopeptidase is significant for esophageal carcinoma metastasis and predicts poor patient prognosis
Q38092835Overview of Clinical Alternatives to Minimize the Degradation of the Resin-dentin Bonds
Q39937000P. gingivalis regulates the expression of Cathepsin B and Cystatin C.
Q47135856Particular gene upregulation and p53 heterogeneous expression in TP53-mutated maxillary carcinoma
Q36401848Proteinases in the joint: clinical relevance of proteinases in joint destruction
Q49612416Recent Advances in Adhesive Bonding - The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates
Q47843867Role of Cathepsin S in Periodontal Inflammation and Infection
Q54241034Role of cathepsin S In periodontal wound healing-an in vitro study on human PDL cells.
Q38204999Role of genetic factors in the pathogenesis of aggressive periodontitis.
Q35033473Salivary (SD-type) cystatins: over one billion years in the making--but to what purpose?
Q53573454Salivary glutathione and uric acid levels in patients with head and neck squamous cell carcinoma.
Q37802873Salivary peptidomics.
Q27652649Structural elucidation of the Cys-His-Glu-Asn proteolytic relay in the secreted CHAP domain enzyme from the human pathogenStaphylococcus saprophyticus
Q52334096Targeted proteomics guided by label-free global proteome analysis in saliva reveal transition signatures from health to periodontal disease.
Q92150617The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
Q37406971The biology of cystatin M/E and its cognate target proteases.
Q39775765The effects of host derived metalloproteinases on dentin bond and the role of MMPs inhibitors on dentin matrix degradation
Q35000607The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction
Q58040472Towards defining the whole salivary peptidome
Q34399545Transcriptional profiling of bone marrow stromal cells in response to Porphyromonas gingivalis secreted products

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