The proteome of lysosomes

scientific article published on October 19, 2010

The proteome of lysosomes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PMIC.201000196
P953full work available online athttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpmic.201000196
https://onlinelibrary.wiley.com/doi/full/10.1002/pmic.201000196
P3181OpenCitations bibliographic resource ID2103445
P698PubMed publication ID20957757

P50authorPaul SaftigQ28468939
Bernd SchröderQ89671442
P2093author name stringAndrej Hasilik
Christian Wrocklage
P2860cites workMass spectrometry-based protein profiling to determine the cause of lysosomal storage diseases of unknown etiologyQ37258104
Lysosomal involvement in cell death and cancer.Q37307183
Molecular and cellular basis of lysosomal transmembrane protein dysfunctionQ37369280
GLUT8, the enigmatic intracellular hexose transporter.Q37379522
Intracellular trafficking of lysosomal proteins and lysosomesQ37664183
Functional characterization of wild-type and mutant human sialinQ37671844
ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drugQ39780753
2-D DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cellsQ39957412
Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6.Q40030659
Modulation of the phagosome proteome by interferon-gamma.Q40031567
Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosomeQ40175915
Proteomic analysis of human lysosomes: application to monocytic and breast cancer cellsQ40707530
Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblastsQ40864003
Mouse transporter protein, a membrane protein that regulates cellular multidrug resistance, is localized to lysosomesQ40923295
Lipofuscin (aging) pigment granules of the newborn human liverQ41106603
The discovery of lysosomesQ41438482
Sorting of endocytosed transferrin and asialoglycoprotein occurs immediately after internalization in HepG2 cellsQ41517247
Two species of lysosomal organelles in cultured human fibroblastsQ41674466
The mannose 6-phosphate glycoprotein proteomeQ41820034
LAMP proteins are required for fusion of lysosomes with phagosomesQ41876261
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2Q41899742
Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha) requires two tandemly arranged tyrosine-based signals for sorting to lysosomesQ42157567
The human urine mannose 6-phosphate glycoproteomeQ42836499
Rate of accumulation of cardiac lipofuscin in the aging canineQ43989340
Potential role of retinal pigment epithelial lipofuscin accumulation in age-related macular degenerationQ44756796
Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranesQ45258087
Quantitative and dynamic assessment of the contribution of the ER to phagosome formationQ45345589
A new gene, encoding an anion transporter, is mutated in sialic acid storage diseasesQ22010865
Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cellsQ22253465
Identification of HE1 as the second gene of Niemann-Pick C diseaseQ24290663
Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.Q24292734
Integral and associated lysosomal membrane proteinsQ24295014
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 productionQ24296666
Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venulesQ24297211
Identification of a lysosomal peptide transport system induced during dendritic cell developmentQ24299256
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatasesQ24299329
Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomesQ24299648
Identification of sites of mannose 6-phosphorylation on lysosomal proteinsQ24300525
LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidaseQ24300793
Proteomic characterization of the human centrosome by protein correlation profilingQ24301045
Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregationQ24302007
Identification of a mammalian mitochondrial porphyrin transporterQ24305008
Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membraneQ24305928
Biosynthesis and Intracellular Targeting of the CLN3 Protein Defective in Batten DiseaseQ24310339
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomesQ24311444
Association of Mutations in a Lysosomal Protein with Classical Late-Infantile Neuronal Ceroid LipofuscinosisQ24311617
Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatusQ24314379
Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitinationQ24318243
Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membraneQ24322981
A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosisQ24322985
A gene network regulating lysosomal biogenesis and functionQ24339409
The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilinQ24594134
Identification and characterization of a lysosomal transporter for small neutral amino acidsQ24631129
Identification of a vesicular aspartate transporterQ24646582
Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosomeQ24670206
Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C)Q24671695
Mutations in TMEM76* cause mucopolysaccharidosis IIIC (Sanfilippo C syndrome)Q24672287
The phagosome proteome: insight into phagosome functionsQ24674883
Localisation of a gene for mucopolysaccharidosis IIIC to the pericentromeric region of chromosome 8Q24676012
The novel neuronal ceroid lipofuscinosis gene MFSD8 encodes a putative lysosomal transporterQ24676713
Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallographyQ27657154
Autophagy in the Pathogenesis of DiseaseQ27860558
Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporterQ27937730
TMEM74, a lysosome and autophagosome protein, regulates autophagyQ28114954
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPaseQ28116395
Proteomic analysis of early melanosomes: identification of novel melanosomal proteinsQ28184384
Lysosomal membrane proteinsQ28190556
Quantitative mass spectrometry in proteomics: a critical reviewQ28238800
Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagyQ28263676
Isolation of a novel gene underlying Batten disease, CLN3. The International Batten Disease ConsortiumQ28288921
Cloning of a lymphatic peptide/histidine transporterQ28364223
Isolation of the major subcellular organelles from mouse liver using Nycodenz gradients without the use of an ultracentrifugeQ45366480
"Subcellular proteomics" of neuromelanin granules isolated from the human brainQ46455513
Comparison of label-free methods for quantifying human proteins by shotgun proteomics.Q46568113
Isolation of Golgi membranes from tissues and cells by differential and density gradient centrifugationQ46785503
Isolation of lysosomes from tissues and cells by differential and density gradient centrifugationQ46785510
A method to assess the lysosomal residence of proteins in cultured cellsQ46848913
Characterisation of lipofuscin-like lysosomal inclusion bodies from human placentaQ52575698
Processing of human cathepsin D in lysosomes in vitro.Q54453142
Neuronal ceroid lipofuscinosesQ56566989
Isolation of a novel gene underlying batten disease, CLN3Q56804260
A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the OrganelleQ57372787
Chaperone-Mediated AutophagyQ57376122
Two-dimensional mapping and microsequencing of lysosomal proteins from human placentaQ58039502
Proteomic Analysis of Membrane-Associated Proteins from Rat Liver AutophagosomesQ63313636
Stimulation of the biosynthesis of lactosamine repeats in glycoproteins in differentiating U937 cells and its suppression in the presence of NH4ClQ67901622
Rupture of rat liver lysosomes mediated by L-amino acid estersQ69595430
Isolation of highly purified rat liver lysosomal membranes using two Percoll gradientsQ69810866
Method for the isolation of iron-loaded lysosomes from rat liverQ70037544
Purification of lysosomal membrane proteins from human placentaQ71757470
The preparation of subcellular organelles from mouse liver in self-generated gradients of iodixanolQ72851806
Lysosomal proteolysis of prosaposin, the precursor of saposins (sphingolipid activator proteins): its mechanism and inhibition by gangliosideQ73323611
Lysosomal membranes from beige mice contain higher than normal levels of endoplasmic reticulum proteinsQ79491764
The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptorQ79759115
A protocol for combined delipidation and subfractionation of membrane proteins using organic solventsQ80139032
Proteomics analysis of serum from mutant mice reveals lysosomal proteins selectively transported by each of the two mannose 6-phosphate receptorsQ81234547
Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveal a wide range of lysosomal and non-lysosomal proteinsQ83367020
An ascorbate-reducible cytochrome b561 is localized in macrophage lysosomesQ28505660
Intracellular localization of p40, a protein identified in a preparation of lysosomal membranesQ28507805
Molecular characterization of the hypothetical 66.3-kDa protein in mouse: lysosomal targeting, glycosylation, processing and tissue distributionQ28508163
NCU-G1 is a highly glycosylated integral membrane protein of the lysosomeQ28509778
ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal functionQ28512374
Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal MembraneQ28568133
Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosisQ28570730
Biochemical characterization and lysosomal localization of the mannose-6-phosphate protein p76 (hypothetical protein LOC196463)Q28588547
A model for random sampling and estimation of relative protein abundance in shotgun proteomicsQ29547316
Signals for sorting of transmembrane proteins to endosomes and lysosomesQ29547469
Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle ProteomesQ30445187
Towards a human repertoire of monocytic lysosomal proteinsQ30962551
High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexesQ31106305
The human brain mannose 6-phosphate glycoproteome: a complex mixture composed of multiple isoforms of many soluble lysosomal proteinsQ31155960
Proteome analysis of lipofuscin in human retinal pigment epithelial cellsQ33184588
Identification of novel lysosomal matrix proteins by proteome analysisQ33222882
Proteomic analysis of lysosomal acid hydrolases secreted by osteoclasts: implications for lytic enzyme transport and bone metabolismQ33224913
Examining the proteins of functional retinal lipofuscin using proteomic analysis as a guide for understanding its originQ33230359
High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing geneQ33386723
Mucolipins: Intracellular TRPML1-3 channelsQ33838349
Lysosomal transport disordersQ33948573
A mammalian organelle map by protein correlation profilingQ33995084
The structure and function of the Niemann-Pick C1 proteinQ34043087
The large-scale separation of peroxisomes, mitochondria, and lysosomes from the livers of rats injected with triton WR-1339. Improved isolation procedures, automated analysis, biochemical and morphological properties of fractionsQ34205999
???Q22254154
GEE MV: Rate and magnitude of age pigment accumulation in the human myocardiumQ34250756
LipofuscinQ34321294
An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motilityQ34502171
The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomesQ34519744
TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosisQ34626965
Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolismQ34919649
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets functionQ34996827
ER-mediated phagocytosis: a new membrane for new functionsQ35096184
Lysosomal storage disordersQ36027312
Isolation and preliminary characterization of the major membrane boundaries of the endocytic pathway in lymphocytes.Q36223921
The dynamic phagosomal proteome and the contribution of the endoplasmic reticulumQ36276856
You say lipofuscin, we say ceroid: defining autofluorescent storage materialQ36385244
The lysosomal-mitochondrial axis theory of postmitotic aging and cell deathQ36493763
TRPML and lysosomal functionQ36738367
Lysosome-related organelles: driving post-Golgi compartments into specialisationQ36880252
Lysosomes: fusion and functionQ36885390
Membrane proteomics of phagosomes suggests a connection to autophagyQ36964264
V-ATPase functions in normal and disease processesQ37008545
Autophagy, amyloidogenesis and Alzheimer diseaseQ37011121
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's diseaseQ37054679
Proteomic and phototoxic characterization of melanolipofuscin: correlation to disease and model for its originQ37097697
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal functionQ37099908
Molecular physiology and pathophysiology of lysosomal membrane transportersQ37143215
Autophagy in atherosclerosis.Q37167775
Proteomics of the lysosomeQ37196950
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectSolute carrier family 35 member F6Q21104967
Transmembrane protein 63AQ21112036
Solute carrier family 26 member 11Q21121330
P304page(s)4053-76
P577publication date2010-10-19
2010-11-01
P1433published inProteomicsQ15614164
P1476titleThe proteome of lysosomes
P478volume10

Reverse relations

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