Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells

scientific article (publication date: December 2016)

Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MICROBIOLSPEC.MCHD-0050-2016
P932PMC publication ID5244469
P698PubMed publication ID28087931

P2093author name stringJohn D MacMicking
Clinton J Bradfield
Ryan G Gaudet
P2860cites workAncient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new optionsQ21091000
Comparing the Dictyostelium and Entamoeba genomes reveals an ancient split in the Conosa lineageQ21092583
The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineageQ21184175
Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Q22255523
Innate Immunity in Lophotrochozoans: The AnnelidsQ22305794
Superoxide radical production by sponges Sycon spQ22330810
The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysisQ24296252
Ubiquitin is phosphorylated by PINK1 to activate parkinQ24296532
Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variantQ24300925
Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasionQ24301905
The proteome of lysosomesQ24303943
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growthQ24304447
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationQ24310115
GBP5 promotes NLRP3 inflammasome assembly and immunity in mammalsQ24310380
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagyQ24312147
A role for NBR1 in autophagosomal degradation of ubiquitinated substratesQ24316135
Tetramerization of human guanylate-binding protein 1 is mediated by coiled-coil formation of the C-terminal α-helicesQ24323235
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infectionQ24336824
MX2 is an interferon-induced inhibitor of HIV-1 infectionQ24338311
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid productionQ24338884
Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactorQ24529563
The analysis of 100 genes supports the grouping of three highly divergent amoebae: Dictyostelium, Entamoeba, and MastigamoebaQ24533391
Endogenous nitric oxide protects bacteria against a wide spectrum of antibioticsQ24623506
Immune-like phagocyte activity in the social amoebaQ24628848
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathwaysQ24629208
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondriaQ24631535
Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteriaQ24644997
Origin and evolution of the slime molds (Mycetozoa)Q24646167
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosisQ24650149
Inhibitory action of NoxA1 on dual oxidase activity in airway cellsQ24655002
Cellular self-defense: how cell-autonomous immunity protects against pathogensQ26864521
Self and nonself: how autophagy targets mitochondria and bacteriaQ27012602
ATM functions at the peroxisome to induce pexophagy in response to ROS.Q27312743
Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control itQ27321401
Social amoebae trap and kill bacteria by casting DNA netsQ27324670
Identification and expression analysis of hepcidin-like antimicrobial peptides in bony fishQ47971859
Nitric oxide synthase sequences in the marine fish Stenotomus chrysops and the sea urchin Arbacia punctulata, and phylogenetic analysis of nitric oxide synthase calmodulin-binding domainsQ48334933
Metchnikoff and the phagocytosis theoryQ48678873
Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteinsQ48826829
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomesQ50335815
Effect of gamma-interferon on phagosome-lysosome fusion in Salmonella typhimurium-infected murine macrophages.Q50464090
Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila.Q51003621
In vitro superoxide activity in the haemolymph of the West Indian leaf cockroach, Blaberus discoidalis.Q51671543
The Nramp (Slc11) proteins regulate development, resistance to pathogenic bacteria and iron homeostasis in Dictyostelium discoideum.Q52629925
Antifungal defense in Drosophila.Q52679938
Horizontal gene transfer of "prototype" Nramp in bacteria.Q53850355
Transient kinetic investigation of GTP hydrolysis catalyzed by interferon-gamma-induced hGBP1 (human guanylate binding protein 1).Q54458808
Evidence for nitric oxide production and utilization as a bacteriocidal agent by invertebrate immunocytes.Q54647447
A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondiiQ60621617
Presence of coelomocytes in the primitive chordate amphioxus (Branchiostoma lanceolatum)Q70383989
Characterization of lysosomes isolated from Dictyostelium discoideum by magnetic fractionationQ72077113
Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytesQ72081999
Isolation of a gene encoding a developmentally regulated T cell-specific protein with a guanine nucleotide triphosphate-binding motifQ72467785
Peroxynitrite-mediated cytotoxicity to Trypanosoma cruziQ72810879
Dictyostelium lysosomal proteins with different sugar modifications sort to functionally distinct compartmentsQ73899763
Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cellsQ77899643
Immune responses of mussel hemocyte subpopulations are differentially regulated by enzymes of the PI 3-K, PKC, and ERK kinase familiesQ80111718
Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal systemQ81300400
In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clustersQ83321178
Mutations in the Aeromonas salmonicida subsp. salmonicida type III secretion system affect Atlantic salmon leucocyte activation and downstream immune responsesQ84557296
The Evolutionarily Dynamic IFN-Inducible GTPase Proteins Play Conserved Immune Functions in Vertebrates and CephalochordatesQ27506698
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteinsQ27621403
RING domain E3 ubiquitin ligasesQ27860546
Innate immune recognitionQ27860721
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiologyQ27860991
Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathwayQ27930427
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiaeQ27935838
Structural features and biological activities of the cathelicidin-derived antimicrobial peptidesQ28142912
Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defenseQ28181893
Defensins: antimicrobial peptides of innate immunityQ28204453
A direct role for dual oxidase in Drosophila gut immunityQ28280565
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen speciesQ28282131
Dual oxidase2 is expressed all along the digestive tractQ28297773
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMPQ28299939
Interferon-induced Mx proteins in antiviral host defenseQ28306408
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiQ28476607
Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gammaQ28505888
Two families of GTPases dominate the complex cellular response to IFN-gammaQ28507786
Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defenseQ28512319
The proinflammatory cytokine-induced IRG1 protein associates with mitochondriaQ28512370
Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus RestrictionQ28551681
Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-MycQ28588435
A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infectionQ28593668
Interferon-induced guanylate-binding proteins in inflammasome activation and host defenseQ28595838
NADPH oxidase: an updateQ28611494
Regulation mechanisms and signaling pathways of autophagyQ29547416
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophagesQ29547420
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?Q29547675
Development by self-digestion: molecular mechanisms and biological functions of autophagyQ29547880
Functions of lysosomesQ29614182
Nitric oxide and macrophage functionQ29615327
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteriaQ29615619
The host defense of Drosophila melanogasterQ29617555
A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replicationQ39439015
Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: effects on macrophage growth and antimicrobial peptide gene expression.Q39518203
A carpet-based mechanism for direct antimicrobial peptide activity against vaccinia virus membranesQ39668222
Parkin-induced mitophagy in the pathogenesis of Parkinson diseaseQ39859240
Modulation of the phagosome proteome by interferon-gamma.Q40031567
Function and mechanism of action of Dictyostelium Nramp1 (Slc11a1) in bacterial infection.Q40323441
Indoleamine 2,3-dioxygenase mediates cell type-specific anti-measles virus activity of gamma interferonQ40416418
Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2,3-dioxygenaseQ40514876
Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandinsQ40629931
Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease.Q40988831
Nitric oxide: an ancestral immunocyte effector moleculeQ41069352
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicidaQ41429405
The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.Q41880176
The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway.Q42142128
Gene structure and polymorphism of an invertebrate nitric oxide synthase geneQ42601966
Bacterial autophagy: the trigger, the target and the timingQ42613816
Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within gamma interferon-activated macrophagesQ42727278
Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B proteinQ42991703
Heat stress-activated, calcium-dependent nitric oxide synthase in spongesQ43757031
Activation of lysosomal function during dendritic cell maturationQ44333919
The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenesQ44445269
Host responses to Renibacterium salmoninarum and specific components of the pathogen reveal the mechanisms of immune suppression and activationQ44474465
Evolution of the nitric oxide synthase family in metazoansQ44752568
Role of individual domains and identification of internal gap in human guanylate binding protein-1.Q45217339
Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase.Q45274479
Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infectionQ46490803
Toroidal pores formed by antimicrobial peptides show significant disorder.Q46500589
NADPH oxidase homologs are required for normal cell differentiation and morphogenesis in Dictyostelium discoideumQ46541212
Ancient weapons: NK-lysin, is a mammalian homolog to pore-forming peptides of a protozoan parasiteQ47193149
Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalentQ47208280
Hagfish intestinal antimicrobial peptides are ancient cathelicidinsQ47350244
Recognizing macrophage activation and host defenseQ47767041
Cathelicidins--a family of multifunctional antimicrobial peptides.Q34534231
Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agentsQ34556950
Evolution of vertebrate indoleamine 2,3-dioxygenasesQ34655410
Autophagy in immunity and cell-autonomous defense against intracellular microbesQ34673845
Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondiiQ34697891
IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteinsQ34778494
Nitric oxide and redox mechanisms in the immune responseQ35001939
GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusionQ35240046
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infectionQ35528340
Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophagesQ35564117
Opposing biological functions of tryptophan catabolizing enzymes during intracellular infectionQ35623712
Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cellsQ35671624
Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagyQ35749637
Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whalesQ35818853
IFN-inducible GTPases and immunity to intracellular pathogensQ35920524
The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashionQ35943304
Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila.Q35963562
RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondiiQ35989946
Ancient weapons: the three-dimensional structure of amoebapore A.Q36003742
Eating oneself and uninvited guests: autophagy-related pathways in cellular defenseQ36023948
The use of model systems to study biological functions of Nox/Duox enzymes.Q36074164
Phagocytosis: elegant complexityQ36127867
Nitric oxide in marine invertebrates: a comparative perspectiveQ36175287
Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophanQ36254619
A neuron-specific role for autophagy in antiviral defense against herpes simplex virusQ36266460
Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.Q36281253
Nitric Oxide Synthase in the Central Nervous System and Peripheral Organs of Stramonita haemastoma: Protein Distribution and Gene Expression in Response to Thermal StressQ36329678
Carbon metabolism of intracellular bacteriaQ36347854
IFN-inducible GTPases in host cell defenseQ36374867
Macrophage nutriprive antimicrobial mechanismsQ36444224
Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replicationQ36512191
The NRAMP family of metal-ion transportersQ36565388
Phagocytosis-coupled activation of the superoxide-producing phagocyte oxidase, a member of the NADPH oxidase (nox) familyQ36627802
Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family.Q36681990
Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transportersQ36704535
Induction of guanylate binding protein 5 by gamma interferon increases susceptibility to Salmonella enterica serovar Typhimurium-induced pyroptosis in RAW 264.7 cellsQ36710611
Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?Q36757725
Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infectionQ36822684
Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganismsQ36827957
Evolution of size and pattern in the social amoebas.Q36847195
CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteinsQ36911388
Autophagic control of listeria through intracellular innate immune recognition in drosophilaQ36925388
Mouse neutrophils lack defensinsQ36950015
Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families.Q37034561
The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and moreQ37158130
Proteomics of the lysosomeQ37196950
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagyQ37246125
Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouseQ37262073
Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistanceQ37318302
Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolismQ37349845
The roles of antimicrobial peptides in innate host defenseQ37361213
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of InflammationQ37412828
Autophagy in intracellular bacterial infection.Q37419944
Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killingQ37515820
Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virusQ37607765
The Anopheles innate immune system in the defense against malaria infectionQ37611725
Evolution of a cellular immune response in Drosophila: a phenotypic and genomic comparative analysis.Q37616498
The ancestry and cumulative evolution of immune reactionsQ37806637
Nutritional immunity: homology modeling of Nramp metal importQ37938961
Antimicrobial peptides: old molecules with new ideasQ37967109
Antimicrobial responses of teleost phagocytes and innate immune evasion strategies of intracellular bacteriaQ38129688
Bacteria-autophagy interplay: a battle for survivalQ38175276
Mast cell ontogeny: an historical overviewQ38188755
Evolution of Innate Immunity: Clues from Invertebrates via Fish to Mammals.Q38258083
Mx GTPases: dynamin-like antiviral machines of innate immunityQ38312100
Macrophage defense mechanisms against intracellular bacteria.Q38363796
Differential immune response of rainbow trout (Oncorhynchus mykiss) at early developmental stages (larvae and fry) against the bacterial pathogen Yersinia ruckeri.Q38426603
Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 InfectivityQ39147587
Nitric oxide synthases: Roles, tolls, and controlsQ29618629
A Unified Nomenclature for Yeast Autophagy-Related GenesQ29618950
Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophagesQ29871005
Structure and function of matrix metalloproteinases and TIMPsQ30014818
Chronic granulomatous disease.Q30335769
Intestinal epithelial autophagy is essential for host defense against invasive bacteriaQ30543790
Evidence that hsp90 is involved in the altered interactions of Acanthamoeba castellanii variants with bacteriaQ30763236
Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from woundsQ31775480
Amoebapores, archaic effector peptides of protozoan origin, are discharged into phagosomes and kill bacteria by permeabilizing their membranesQ33186099
Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gammaQ33490124
Purification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferaseQ33547011
A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activityQ33553377
Antimicrobial and cytolytic polypeptides of amoeboid protozoa--effector molecules of primitive phagocytesQ33699485
Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical mannerQ33769297
Inducible antibacterial defense system in C. elegansQ33960851
Phagocytosis and host-pathogen interactions in Dictyostelium with a look at macrophages.Q34015217
Interferon-inducible effector mechanisms in cell-autonomous immunityQ34114819
High-resolution dissection of phagosome maturation reveals distinct membrane trafficking phasesQ34168020
Mechanisms of antimicrobial peptide action and resistanceQ34181099
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47Q34272123
Cell-autonomous effector mechanisms against mycobacterium tuberculosisQ34287676
Tryptophan-catabolizing enzymes - party of threeQ34313731
Drosophila as a model system to unravel the layers of innate immunity to infectionQ34314541
Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactionsQ34341978
The IRG-47 gene is IFN-gamma induced in B cells and encodes a protein with GTP-binding motifsQ34405143
Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.Q34414371
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPasesQ34415551
SLC11A1 (formerly NRAMP1) and disease resistanceQ34459115
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agentQ34501431
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
P577publication date2016-12-01
P1433published inMicrobiology SpectrumQ27725717
P1476titleEvolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells
P478volume4

Reverse relations

cites work (P2860)
Q47551972Differential Effects of Iron, Zinc, and Copper on Dictyostelium discoideum Cell Growth and Resistance to Legionella pneumophila
Q47556585Eat Prey, Live: Dictyostelium discoideum As a Model for Cell-Autonomous Defenses.
Q91719344Glycoconjugates of Gram-negative bacteria and parasitic protozoa - are they similar in orchestrating the innate immune response?
Q92956896Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
Q92110459Innate Immune Recognition: An Issue More Complex Than Expected
Q40061452Modulation of Zinc Homeostasis in Acanthamoeba castellanii as a Possible Antifungal Strategy against Cryptococcus gattii
Q39129264Physiological roles of macrophages

Search more.