| scholarly article | Q13442814 |
| P50 | author | Avinash Shenoy | Q42680127 |
| P2093 | author name string | Pradeep Kumar | |
| John D MacMicking | |||
| Bae-Hoon Kim | |||
| Clinton J Bradfield | |||
| P2860 | cites work | Death and resurrection of the human IRGM gene | Q21092466 |
| The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage | Q21184175 | ||
| Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains | Q21559416 | ||
| Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death | Q21559499 | ||
| IFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagy | Q21562514 | ||
| Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases. | Q22255523 | ||
| Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant | Q24300925 | ||
| GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals | Q24310380 | ||
| Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor | Q24529563 | ||
| Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls | Q24550675 | ||
| Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole | Q24614550 | ||
| Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence | Q24617053 | ||
| Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls | Q24628710 | ||
| Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria | Q24631535 | ||
| Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria | Q24644997 | ||
| Disease tolerance as a defense strategy | Q26828371 | ||
| Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it | Q27321401 | ||
| The Evolutionarily Dynamic IFN-Inducible GTPase Proteins Play Conserved Immune Functions in Vertebrates and Cephalochordates | Q27506698 | ||
| Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins | Q27621403 | ||
| Structural basis of oligomerization in the stalk region of dynamin-like MxA | Q27660998 | ||
| Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function | Q27674633 | ||
| The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking | Q28204529 | ||
| IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3 | Q28255726 | ||
| Plant and animal sensors of conserved microbial signatures | Q28298959 | ||
| A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease | Q28304318 | ||
| Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii | Q28476607 | ||
| A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins | Q28481222 | ||
| Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosis | Q28505187 | ||
| Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma | Q28505888 | ||
| Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii | Q28506496 | ||
| Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense | Q28512319 | ||
| Inactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivo | Q28587410 | ||
| The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection | Q28589928 | ||
| A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection | Q28593668 | ||
| IIGP1, an Interferon-γ-inducible 47-kDa GTPase of the Mouse, Showing Cooperative Enzymatic Activity and GTP-dependent Multimerization | Q28595035 | ||
| Intrinsic antiviral immunity | Q28709929 | ||
| Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages | Q29547420 | ||
| Human IRGM induces autophagy to eliminate intracellular mycobacteria | Q29614486 | ||
| Positive natural selection in the human lineage | Q29614585 | ||
| Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility | Q29614872 | ||
| Genetics and pathogenesis of inflammatory bowel disease | Q29616350 | ||
| An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis | Q29618105 | ||
| Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies | Q33327569 | ||
| Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large | Q33342232 | ||
| Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gamma | Q33490124 | ||
| Human RAS superfamily proteins and related GTPases | Q33689727 | ||
| Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages | Q33766719 | ||
| Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner | Q33769297 | ||
| Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans | Q33809035 | ||
| Guanylate-binding protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon-gamma and regulates barrier function through effects on apoptosis. | Q33879907 | ||
| Chlamydial IFN-gamma immune evasion is linked to host infection tropism | Q33906721 | ||
| Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis | Q33951982 | ||
| IRGM is a common target of RNA viruses that subvert the autophagy network. | Q34102728 | ||
| Interferon-inducible effector mechanisms in cell-autonomous immunity | Q34114819 | ||
| Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis | Q34120776 | ||
| Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47 | Q34272123 | ||
| The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. | Q34325516 | ||
| Unique features of different members of the human guanylate-binding protein family. | Q34607986 | ||
| Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. | Q34771892 | ||
| The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice | Q35080460 | ||
| Commensal Escherichia coli reduces epithelial apoptosis through IFN-alphaA-mediated induction of guanylate binding protein-1 in human and murine models of developing intestine | Q35132878 | ||
| p47 GTPases: regulators of immunity to intracellular pathogens | Q35709631 | ||
| IFN-inducible GTPases and immunity to intracellular pathogens | Q35920524 | ||
| Immune control of phagosomal bacteria by p47 GTPases | Q36032380 | ||
| IFN-γ elicits macrophage autophagy via the p38 MAPK signaling pathway. | Q36083662 | ||
| Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages | Q36228861 | ||
| IFN-γ and TNF-α-induced GBP-1 inhibits epithelial cell proliferation through suppression of β-catenin/TCF signaling | Q36346795 | ||
| Dynamin, a membrane-remodelling GTPase | Q36460251 | ||
| The interferon-inducible GTPases. | Q36528795 | ||
| Lipid domains in bacterial membranes | Q36573948 | ||
| PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane | Q36630120 | ||
| Induction of guanylate binding protein 5 by gamma interferon increases susceptibility to Salmonella enterica serovar Typhimurium-induced pyroptosis in RAW 264.7 cells | Q36710611 | ||
| Fresh approaches to anti-infective therapies | Q37015858 | ||
| Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families. | Q37034561 | ||
| Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens | Q37193067 | ||
| Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease | Q37318174 | ||
| It takes two to tango: regulation of G proteins by dimerization | Q37474358 | ||
| Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity | Q37821936 | ||
| Emerging roles for lipid droplets in immunity and host-pathogen interactions | Q37848832 | ||
| Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy | Q38263938 | ||
| A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication | Q39439015 | ||
| Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly | Q39800747 | ||
| Salmonella modulates vesicular traffic by altering phosphoinositide metabolism | Q40531614 | ||
| The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii. | Q41880176 | ||
| A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells | Q42088817 | ||
| A giant GTPase, very large inducible GTPase-1, is inducible by IFNs | Q42604043 | ||
| Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein | Q42991703 | ||
| Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana | Q44963941 | ||
| Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases | Q45045871 | ||
| New insight into the everlasting host-pathogen arms race | Q50054066 | ||
| A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii | Q60621617 | ||
| In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters | Q83321178 | ||
| NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humans | Q83985694 | ||
| Immunology. Select inflammasome assembly | Q84008780 | ||
| Guanylate-binding proteins: niche recruiters for antimicrobial effectors | Q84867551 | ||
| P433 | issue | 4 | |
| P304 | page(s) | 432-444 | |
| P577 | publication date | 2012-10-01 | |
| P1433 | published in | Cell Host & Microbe | Q5058153 |
| P1476 | title | IFN-inducible GTPases in host cell defense | |
| P478 | volume | 12 |
| Q36862416 | A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP. |
| Q35674567 | A de novo Assembly of the Common Frog (Rana temporaria) Transcriptome and Comparison of Transcription Following Exposure to Ranavirus and Batrachochytrium dendrobatidis |
| Q35641044 | A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2 |
| Q38105072 | Age-dependent differences in systemic and cell-autonomous immunity to L. monocytogenes |
| Q97568152 | An Important Role for CD4+ T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3 |
| Q48245742 | Analysis of host-pathogen modulators of autophagy during Mycobacterium Tuberculosis infection and therapeutic repercussions |
| Q46161927 | Association between IRGM polymorphisms and tuberculosis risk: A meta-analysis |
| Q40754199 | Association of autophagy-related IRGM polymorphisms with latent versus active tuberculosis infection in a Chinese population |
| Q86825903 | Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines |
| Q33819237 | Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System |
| Q41864323 | Broad recruitment of mGBP family members to Chlamydia trachomatis inclusions |
| Q36053123 | Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium |
| Q34287676 | Cell-autonomous effector mechanisms against mycobacterium tuberculosis |
| Q26864521 | Cellular self-defense: how cell-autonomous immunity protects against pathogens |
| Q37836009 | Chlamydia-host cell interaction not only from a bird's eye view: some lessons from Chlamydia psittaci |
| Q90224185 | Common Host Responses in Murine Aerosol Models of Infection Caused by Highly Virulent Gram-Negative Bacteria from the Genera Burkholderia, Francisella and Yersinia |
| Q64094875 | Comparative virulence of Caribbean, Brazilian and European isolates of Toxoplasma gondii |
| Q47821617 | Constitutive NLRP3 activation: too much of a bad thing. |
| Q36974221 | Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ΔureC::hly Improves Protection against Tuberculosis |
| Q54244659 | Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. |
| Q55178733 | Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma. |
| Q47556585 | Eat Prey, Live: Dictyostelium discoideum As a Model for Cell-Autonomous Defenses. |
| Q41365577 | Elevated expression of immunity-related GTPase family M in gastric cancer |
| Q48183815 | Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. |
| Q28559840 | Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells |
| Q64112675 | Exosome-Mediated Delivery of Inducible miR-423-5p Enhances Resistance of MRC-5 Cells to Rabies Virus Infection |
| Q42363573 | Facilitation of Endosomal Recycling by an IRG Protein Homolog Maintains Apical Tubule Structure in Caenorhabditis elegans |
| Q49925707 | For when bacterial infections persist: Toll-like receptor-inducible direct antimicrobial pathways in macrophages. |
| Q59550075 | Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection |
| Q42379443 | GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8. |
| Q38844789 | Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection. |
| Q41008219 | Global transcriptomic profiling of bovine endometrial immune response in vitro. II. Effect of bovine viral diarrhea virus on the endometrial response to lipopolysaccharide. |
| Q30827681 | Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death |
| Q98158485 | Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting |
| Q40640876 | Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins |
| Q38700921 | Guanylate-Binding Protein 1 Inhibits Nuclear Delivery of Kaposi's Sarcoma-Associated Herpesvirus Virions by Disrupting Formation of Actin Filament |
| Q34697891 | Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii |
| Q41429405 | Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida |
| Q64972531 | HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion. |
| Q29871458 | Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M. |
| Q92956896 | Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii |
| Q39224888 | Host genetics of response to porcine reproductive and respiratory syndrome in nursery pigs |
| Q41684078 | Host-Toxoplasma gondii Coadaptation Leads to Fine Tuning of the Immune Response |
| Q24336824 | Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection |
| Q36267823 | IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver |
| Q35187600 | IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria |
| Q35616862 | Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses |
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| Q30414030 | In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B |
| Q33646948 | Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design. |
| Q92093394 | Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense |
| Q92028460 | Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets |
| Q51148229 | Integrative Approaches to Understand the Mastery in Manipulation of Host Cytokine Networks by Protozoan Parasites with Emphasis on Plasmodium and Leishmania Species. |
| Q58754083 | Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver |
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| Q48123228 | Loss of CNFY toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency. |
| Q57286623 | Macrophage-microbe interaction: lessons learned from the pathogen Mycobacterium tuberculosis |
| Q27025164 | Maintenance of vacuole integrity by bacterial pathogens |
| Q53811462 | Mechanisms of interferon-beta-induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: role of immunity-related GTPase M1. |
| Q40348070 | Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages |
| Q40218226 | Mice lack of LRG-47 display the attenuated outcome of infection with Schistosoma japonicum |
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| Q87174491 | Mycobacterium leprae upregulates IRGM expression in monocytes and monocyte-derived macrophages |
| Q37700122 | Mycobacterium tuberculosis replicates within necrotic human macrophages |
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| Q50306049 | Regulation of Effector Treg Cells in Murine Lupus. |
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