A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

scientific article

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NG.762
P8608Fatcat IDrelease_xrgbsmatjzdhnp6htt46rlrpxi
P3181OpenCitations bibliographic resource ID738767
P698PubMed publication ID21278745
P5875ResearchGate publication ID49796073

P50authorArlette Darfeuille-MichaudQ16526102
Baharia MograbiQ30111794
Valérie Vouret-CraviariQ30111948
Patrick BrestQ30225254
Paul HofmanQ30507739
Bernard MariQ38800681
Pascal BarbryQ39775090
Annick Harel-BellanQ41607045
Pierre LapaquetteQ47502214
Jean-François MosnierQ95648053
Kevin LebrigandQ98394752
P2093author name stringXavier Hébuterne
Annabelle Cesaro
Mouloud Souidi
P2860cites workDeath and resurrection of the human IRGM geneQ21092466
The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineageQ21184175
Independent and population-specific association of risk variants at the IRGM locus with Crohn's diseaseQ22242868
MicroRNA-155 is induced during the macrophage inflammatory responseQ24683841
Interferon modulation of cellular microRNAs as an antiviral mechanismQ27489711
Sequence variants in SLITRK1 are associated with Tourette's syndromeQ28276961
Human IRGM induces autophagy to eliminate intracellular mycobacteriaQ29614486
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cellsQ29614565
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityQ29614872
NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responsesQ30972954
Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancersQ33288464
Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoidsQ33291235
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variantQ33375721
Tandem affinity purification of miRNA target mRNAs (TAP-Tar).Q33700124
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47Q34272123
Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicentre study. Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du Tube Digestif (GETAID)Q34532419
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitisQ35596103
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's diseaseQ37318174
Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancerQ37764367
Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's diseaseQ39511730
Amplification loop of the inflammatory process is induced by P2X7R activation in intestinal epithelial cells in response to neutrophil transepithelial migrationQ39735000
Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularlyQ39800747
Differential expression and regulation of ADAM17 and TIMP3 in acute inflamed intestinal epitheliaQ39870713
Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileumQ74133428
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectCrohn's diseaseQ1472
P304page(s)242-5
P577publication date2011-03-01
P1433published inNature GeneticsQ976454
P1476titleA synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
P478volume43

Reverse relations

cites work (P2860)
Q91814033A Functional 3' UTR Polymorphism of FADS2 Affects Cow Milk Composition through Modifying Mir-744 Binding
Q90746215A Functional Synonymous Variant in PDGFRA Is Associated with Better Survival in Acral Melanoma
Q36247314A Large-Scale Analysis of the Relationship of Synonymous SNPs Changing MicroRNA Regulation with Functionality and Disease
Q50922084A Massively Parallel Fluorescence Assay to Characterize the Effects of Synonymous Mutations on TP53 Expression.
Q49851013A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality
Q87224216A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis
Q90133294A miR-18a binding-site polymorphism in CDC42 3'UTR affects CDC42 mRNA expression in placentas and is associated with litter size in pigs
Q28393278A multi-targeted approach to suppress tumor-promoting inflammation
Q46931778A passenger strand variant in miR-196a2 contributes to asthma severity in children and adolescents: A preliminary study
Q40751695Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection
Q38194867Advances in IBD genetics
Q36826856Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.
Q33620861Allele-specific regulation of DISC1 expression by miR-135b-5p
Q38928108Alterations in microRNA expression profiles in inflamed and non-inflamed ascending colon mucosae of patients with active Crohn';s disease
Q35819085Altered Gene Expression Associated with microRNA Binding Site Polymorphisms
Q50592002Altered expression of microRNAs in patients with pouchitis after restorative proctocolectomy.
Q33734495Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia
Q41353960Analysis of Newly Identified and Rare Synonymous Genetic Variants in the RET Gene in Patients with Medullary Thyroid Carcinoma in Polish Population.
Q41606948Analysis of population-specific pharmacogenomic variants using next-generation sequencing data.
Q39249155Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression
Q52562962Ankyrin repeat and Single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs.
Q34624885Approaches for establishing the function of regulatory genetic variants involved in disease
Q29305518Are synonymous codons indeed synonymous?
Q38440865Association between genetic variants in the IRGM gene and tuberculosis in a Korean population.
Q34142595Association of IRGM gene mutations with inflammatory bowel disease in the Indian population.
Q40754199Association of autophagy-related IRGM polymorphisms with latent versus active tuberculosis infection in a Chinese population
Q47142918Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn's disease.
Q44576607Association study of 71 European Crohn's disease susceptibility loci in a Japanese population
Q38463457Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population.
Q38074783Autophagy and Crohn's disease.
Q37429062Autophagy and human diseases
Q38065286Autophagy and intestinal homeostasis
Q26822919Autophagy and the regulation of the immune response
Q35785827Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors.
Q45324093Autophagy in Measles Virus Infection.
Q36235457Autophagy in immunity: implications in etiology of autoimmune/autoinflammatory diseases
Q29248363Autophagy in infection, inflammation, and immunity
Q35309849Autophagy, viruses, and intestinal immunity
Q40403804Autophagy-related IRGM genes confer susceptibility to ankylosing spondylitis in a Chinese female population: a case-control study.
Q35120236Autophagy-related IRGM polymorphism is associated with mortality of patients with severe sepsis
Q35683041Autophagy: a core cellular process with emerging links to pulmonary disease
Q37969122Autophagy: a primer for the gastroenterologist/hepatologist
Q64243021Autophagy: roles in intestinal mucosal homeostasis and inflammation
Q91865303Benefits and limitations of genome-wide association studies
Q37572837Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics.
Q36306493Bicodon bias can determine the role of synonymous SNPs in human diseases
Q34721125Biological basis of miRNA action when their targets are located in human protein coding region
Q21129422Biopersistence and brain translocation of aluminum adjuvants of vaccines
Q38667805Breaking fat: The regulation and mechanisms of lipophagy.
Q82831590Breaking the silence
Q28727290Building a robust a-p axis
Q34003160Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium
Q26798207Cellular and Molecular Connections between Autophagy and Inflammation
Q35562931Circulating microRNAs as potential biomarkers for endometriosis
Q38938480Circulating microRNAs in Inflammatory Bowel Diseases
Q35590466Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging
Q34669910Clinical implications of copy number variations in autoimmune disorders
Q38026391Commensal-innate immune miscommunication in IBD pathogenesis
Q35155368Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy).
Q38869610Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death
Q30378925Computational approaches to study the effects of small genomic variations.
Q37261147Contribution of higher risk genes and European admixture to Crohn's disease in African Americans
Q38032203Copy number variation in autoimmunity--importance hidden in complexity?
Q28273481Crohn's disease
Q58592067Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues
Q38059440Database tools in genetic diseases research
Q26821951Decoding mechanisms by which silent codon changes influence protein biogenesis and function
Q35804603Decoding the cardiac message: the 2011 Thomas W. Smith Memorial Lecture
Q50503026Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response.
Q33968000Different types of secondary information in the genetic code.
Q50114013Differential expression of microRNAs in peripheral blood mononuclear cells identifies autophagy and TGF-beta related signatures aberrantly expressed in inflammatory bowel disease
Q90004373Differential miRNA Expression in Ileal and Colonic Tissues Reveals an Altered Immunoregulatory Molecular Profile in Individuals With Crohn's Disease versus Healthy Subjects
Q35633085Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes
Q34540581Duplication of C7orf58, WNT16 and FAM3C in an obese female with a t(7;22)(q32.1;q11.2) chromosomal translocation and clinical features resembling Coffin-Siris Syndrome
Q90999466Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
Q91877866Effects of microRNAs polymorphism in cancer progression
Q38974926Emerging connections between RNA and autophagy.
Q58781739Epigenetic Regulation of Autophagy: A Path to the Control of Autoimmunity
Q61253263Epigenetik bei entzündlichen Systemerkrankungen
Q34288268Etiology of Crohn's disease: many roads lead to autophagy
Q38026389Evidence from genetics for a role of autophagy and innate immunity in IBD pathogenesis
Q42212982Evolution. The hidden codes that shape protein evolution
Q56000614Exploratory re-encoding of yellow fever virus genome: new insights for the design of live-attenuated viruses
Q58606351Exploring the Role of Autophagy-Related Gene 5 () Yields Important Insights Into Autophagy in Autoimmune/Autoinflammatory Diseases
Q34270516Extent, causes, and consequences of small RNA expression variation in human adipose tissue
Q41183433Functional Implications of MicroRNAs in Crohn's Disease Revealed by Integrating MicroRNA and Messenger RNA Expression Profiling
Q50102071Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease
Q34037058Genetic and functional profiling of Crohn's disease: autophagy mechanism and susceptibility to infectious diseases
Q38149113Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease
Q54577917Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.
Q33358591Genetic polymorphisms altering microRNA activity in psoriasis--a key to solve the puzzle of missing heritability?
Q37074271Genetic variants associated with Crohn's disease
Q29616350Genetics and pathogenesis of inflammatory bowel disease
Q37880890Genetics of infectious diseases: hidden etiologies and common pathways
Q38063274Genetics of inflammatory bowel diseases: a comparison between Western and Eastern perspectives
Q38001243Genetics of spondyloarthritis--beyond the MHC.
Q90238984Genome wide analyses uncover allele-specific RNA editing in human and mouse
Q50317203Genome-wide association studies in Crohn's disease: Past, present and future.
Q38500260Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway
Q47171648Ginsenoside Rg3 Decreases Fibrotic and Invasive Nature of Endometriosis by Modulating miRNA-27b: In Vitro and In Vivo Studies
Q40381056GipA Factor Supports Colonization of Peyer's Patches by Crohn's Disease-associated Escherichia Coli.
Q21996341Guidelines for the use and interpretation of assays for monitoring autophagy
Q22676705Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Q40073307Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.
Q54318310H-ras mutation detection in bladder cancer by COLD-PCR analysis and direct sequencing.
Q35852993HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC).
Q89475561Host-microbiota interactions in inflammatory bowel disease
Q36355547Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior
Q33831324Human autophagy gene ATG16L1 is post-transcriptionally regulated by MIR142-3p
Q38170524Human diseases caused by germline and somatic abnormalities in microRNA and microRNA-related genes
Q36374867IFN-inducible GTPases in host cell defense
Q29029813IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense
Q54304352IRGM gene polymorphisms and risk of gastric cancer.
Q41914825IRGM in autophagy and viral infections.
Q34102728IRGM is a common target of RNA viruses that subvert the autophagy network.
Q34568290IRGM variants and susceptibility to inflammatory bowel disease in the German population
Q35881151IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition
Q36860169IRGM1 regulates oxidized LDL uptake by macrophage via actin-dependent receptor internalization during atherosclerosis
Q91728040Identification and characterization of differentially expressed exosomal microRNAs in bovine milk infected with Staphylococcus aureus
Q36674906Identification of OCTN2 variants and their association with phenotypes of Crohn's disease in a Korean population
Q51119596Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis.
Q42276802Identification of genome-wide non-canonical spliced regions and analysis of biological functions for spliced sequences using Read-Split-Fly
Q34143465Immune and genetic gardening of the intestinal microbiome.
Q34444900Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota
Q34545252Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice
Q38217235Implication of miRNAs for inflammatory bowel disease treatment: Systematic review
Q42223480In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts
Q34168490Infectious etiopathogenesis of Crohn's disease
Q28066443Inflammatory Bowel Disease Drugs: A Focus on Autophagy
Q34036608Inflammatory bowel disease in pediatric and adolescent patients: a biomolecular and histopathological review
Q38072219Inflammatory bowel disease: dysfunction of autophagy?
Q57253397Innate immunity in the small intestine
Q34784772Integrated miRNA and mRNA expression profiling in inflamed colon of patients with ulcerative colitis
Q58587095Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity
Q38834935Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.
Q34114819Interferon-inducible effector mechanisms in cell-autonomous immunity
Q37205898Intestinal epithelium and autophagy: partners in gut homeostasis
Q38337742Intestinal fibrosis in Crohn's disease: role of microRNAs as fibrogenic modulators, serum biomarkers, and therapeutic targets
Q45946946Investigating DNA-, RNA-, and protein-based features as a means to discriminate pathogenic synonymous variants.
Q21198790Involvement of autophagy in ovarian cancer: a working hypothesis
Q49576355Lack of association of mirSNP rs11174811 in AVPR1A gene with arterial blood pressure and hypertension in South Indian population.
Q33631309Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'.
Q89978366Long Term Pharmacological Perturbation of Autophagy in Mice: Are HCQ Injections a Relevant Choice?
Q36669409MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer
Q37407940MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy
Q41520395MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5.
Q39036477MIR7-3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1.
Q98205235Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
Q28243138MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells
Q64967770MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women.
Q42806693MiR-449a regulates autophagy to inhibit silica-induced pulmonary fibrosis through targeting Bcl2.
Q36561540MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells
Q64884469Micro-RNAs -106a and -362-3p in Peripheral Blood of Inflammatory Bowel Disease Patients.
Q38082379Micro-RNAs in inflammatory diseases and as a link between inflammation and cancer
Q35200081MicroRNA control of high-density lipoprotein metabolism and function
Q37992401MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction
Q26775937MicroRNA in inflammatory bowel disease: Translational research and clinical implication
Q35763174MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy
Q41228757MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3'-UTR via altered RNA structure
Q39117431MicroRNAs at the epicenter of intestinal homeostasis
Q40849959MicroRNAs enrichment in GWAS of complex human phenotypes
Q26824814MicroRNAs in autoimmune diseases
Q27008099MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis
Q27025092MicroRNAs in inflammatory bowel disease--pathogenesis, diagnostics and therapeutics
Q38407040MicroRNAs in inflammatory bowel diseases: paradoxes and possibilities.
Q38095501MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer
Q26777313MicroRNAs, TGF-β signaling, and the inflammatory microenvironment in cancer
Q38052464MicroRNAs--novel regulators of systemic lupus erythematosus pathogenesis
Q38219024MicroRNAs: New therapeutic targets for intestinal barrier dysfunction
Q38823581MicroRNAs: how many in inflammatory bowel disease?
Q35135542MicroRNAs: new players in IBD.
Q35801931Microbiota in Inflammatory Bowel Disease Pathogenesis and Therapy: Is It All About Diet?
Q35205924Mitoxosome: a mitochondrial platform for cross-talk between cellular stress and antiviral signaling.
Q60954864Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells
Q28082840Modulation of inflammation by autophagy: Consequences for human disease
Q38492052Molecular Analysis of Inflammatory Bowel Disease: Clinically Useful Tools for Diagnosis, Response Prediction, and Monitoring of Targeted Therapy
Q64071922Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer
Q48233408Mutagenic primer-based PCR-RFLP assay for genotyping IRGM gene promoter variant rs4958843 (C/T).
Q38076049Negative regulation of human mononuclear phagocyte function
Q36053989Network Modeling of Crohn's Disease Incidence
Q44434274Noisy silent polymorphisms
Q29618039Non-coding RNAs in human disease
Q35882722Novel players in inflammatory bowel disease pathogenesis
Q38921593Oxygen metabolism and barrier regulation in the intestinal mucosa
Q43827753PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis
Q59357405Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense
Q96950920Pathogen-associated selection on innate immunity genes (TLR4, TLR7) in a neotropical rodent in landscapes differing in anthropogenic disturbance
Q35659341Pathogenesis of Crohn's disease
Q43829519Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II).
Q36828596Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk
Q37218177Post-transcriptional Regulation of BRCA2 through Interactions with miR-19a and miR-19b
Q28542768Pre-miR-146a (rs2910164 G>C) single nucleotide polymorphism is genetically and functionally associated with leprosy
Q39433651Prioritization of genetic variants in the microRNA regulome as functional candidates in genome-wide association studies
Q36256402Professor Arlette Darfeuille-Michaud: the discovery of adherent-invasive Escherichia coli
Q30657282Protein functional features are reflected in the patterns of mRNA translation speed
Q33741954RNase-mediated protein footprint sequencing reveals protein-binding sites throughout the human transcriptome
Q38725402Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition.
Q42781142Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases
Q34169930Reconsidering association testing methods using single-variant test statistics as alternatives to pooling tests for sequence data with rare variants
Q38273211Regenerative inflammation: lessons from Drosophila intestinal epithelium in health and disease
Q40268401Regulation of immunity and inflammation by autophagy: « All is well, all is fine, all goes as well as possible»
Q47134262Relation between NOD2 genotype and changes in innate signaling in Crohn's disease on mRNA and miRNA levels
Q39449979Replication of Crohn's disease-associated AIEC within macrophages is dependent on TNF-α secretion
Q61448750Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages
Q35998480Role of Autophagy in the Maintenance of Intestinal Homeostasis
Q39229393Role of MiRNAs in Inflammatory Bowel Disease
Q38110271Role of microRNAs in the immune system, inflammation and cancer
Q61812275Roles of Autophagy-Related Genes in the Pathogenesis of Inflammatory Bowel Disease
Q28384314S-Nitrosylation of Bcl-2 Negatively Affects Autophagy in Lung Epithelial Cells
Q33640984SNPs in microRNA binding sites as prognostic and predictive cancer biomarkers
Q28652564Selective autophagy: xenophagy
Q38070134Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity.
Q38687454Significant impact of miRNA-target gene networks on genetics of human complex traits
Q39909346Significant selective constraint at 4-fold degenerate sites in the avian genome and its consequence for detection of positive selection
Q38779043Single synonymous mutation in factor IX alters protein properties and underlies haemophilia B.
Q90345417Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar)
Q34321074Sounds of silence: synonymous nucleotides as a key to biological regulation and complexity
Q35806902Sparse Modeling Reveals miRNA Signatures for Diagnostics of Inflammatory Bowel Disease
Q96576905Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency
Q51233548Synonymous Somatic Variants in Human Cancer Are Not Infamous: A Plea for Full Disclosure in Databases and Publications.
Q90477207Synonymous genome recoding: a tool to explore microbial biology and new therapeutic strategies
Q30378420Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling.
Q38129926Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAs
Q61807185The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy
Q90477075The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease
Q61810839The application of omics techniques to understand the role of the gut microbiota in inflammatory bowel disease
Q26753387The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations
Q34240770The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders
Q36388052The emerging importance of autophagy in pulmonary diseases
Q38305049The emerging role of miRNAs in inflammatory bowel disease: a review
Q36805023The functional relevance of somatic synonymous mutations in melanoma and other cancers
Q34624820The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease
Q28306099The long and winding road from correlation to causation
Q93079157The negative effect of lipid challenge on autophagy inhibits T cell responses
Q36079983The role of LRRK2 in inflammatory bowel disease
Q38202872The role of autophagy in Crohn's disease
Q39009636The roles of RNA processing in translating genotype to phenotype
Q59085777The sound of silence
Q37359270The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts
Q36028777TraceRNA: a web application for competing endogenous RNA exploration
Q34261528Transcriptional enhancers in protein-coding exons of vertebrate developmental genes
Q35883569Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells
Q35623787Transcriptomic landscape of lncRNAs in inflammatory bowel disease
Q36312175Translation Efficiency in Upstream Region of microRNA Targets in Arabidopsis thaliana
Q37924093Understanding the contribution of synonymous mutations to human disease
Q99572138Unique roles of rare variants in the genetics of complex diseases in humans
Q34534640VR09 cell line: an EBV-positive lymphoblastoid cell line with in vivo characteristics of diffuse large B cell lymphoma of activated B-cell type
Q47258057Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation
Q35261483Viruses, autophagy genes, and Crohn's disease
Q37104104Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma
Q35765125Why Selection Might Be Stronger When Populations Are Small: Intron Size and Density Predict within and between-Species Usage of Exonic Splice Associated cis-Motifs
Q37465525X-Linked miRNAs Associated with Gender Differences in Rheumatoid Arthritis.
Q52693138[Contribution of autophagy to intestinal homeostasis and pathology].
Q39788081dbDSM: a manually curated database for deleterious synonymous mutations
Q41462892miR-140-5p attenuates chemotherapeutic drug-induced cell death by regulating autophagy through inositol 1,4,5-trisphosphate kinase 2 (IP3k2) in human osteosarcoma cells
Q41868737miR-155 mediates drug resistance in osteosarcoma cells via inducing autophagy
Q38720692miR-196b regulates gastric cancer cell proliferation and invasion via PI3K/AKT/mTOR signaling pathway
Q37034009miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis
Q87725107miR-22 inhibits osteosarcoma cell proliferation and migration by targeting HMGB1 and inhibiting HMGB1-mediated autophagy
Q87416257miR-22 targets the 3' UTR of HMGB1 and inhibits the HMGB1-associated autophagy in osteosarcoma cells during chemotherapy
Q37232827miR-762 promotes porcine immature Sertoli cell growth via the ring finger protein 4 (RNF4) gene
Q35907923miR-Sens--a retroviral dual-luciferase reporter to detect microRNA activity in primary cells
Q26768556miRNAs as new molecular insights into inflammatory bowel disease: Crucial regulators in autoimmunity and inflammation
Q43040562miRNAs in precancerous lesions of the gastrointestinal tract
Q61965211miRNAs in the spotlight: Making 'silent' mutations speak up
Q60921916rs187960998 polymorphism in miR-211 prevents development of human colon cancer by deregulation of 3'UTR in CHD5