Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor

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Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01269-14
P932PMC publication ID4136259
P698PubMed publication ID24899177

P50authorWendy BarclayQ20005716
Michael Henry MalimQ21166756
Olivier MoncorgéQ55743797
P2093author name stringCaroline Goujon
Tomas Doyle
Hélène Bauby
P2860cites workMechanisms for the Inhibition of HIV Replication by Interferons-α, -β, and -γ, in Primary Human MacrophagesQ42278001
GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae).Q42819861
Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses.Q54456249
Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro.Q55245135
Regulation of HIV replication in infected monocytes by IFN-alpha. Mechanisms for viral restrictionQ68158031
Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxBQ24295362
HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiencyQ24300016
Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensingQ24318920
Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelopeQ24321804
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infectionQ24336824
MX2 is an interferon-induced inhibitor of HIV-1 infectionQ24338311
Antiviral actions of interferonsQ24550676
cDNA structures and regulation of two interferon-induced human Mx proteinsQ24631222
Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA proteinQ24649045
Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activityQ24677786
Regulation of type I interferon responsesQ26853177
Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA proteinQ27480330
Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral functionQ27674633
Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomersQ28201712
Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodiesQ28206468
Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell linesQ28339753
Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin AQ28379060
Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsidsQ29040504
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeysQ29547689
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasuresQ29615028
The viral nucleoprotein determines Mx sensitivity of influenza A virusesQ30403933
Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoproteinQ30429005
Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integrationQ30452981
Interferon-Alpha Mediates Restriction of Human Immunodeficiency Virus Type-1 Replication in Primary Human Macrophages at an Early Stage of ReplicationQ33728042
Flexible use of nuclear import pathways by HIV-1.Q33739260
Inhibition of hepatitis B virus replication by the interferon-inducible MxA proteinQ33865474
Mechanism of human MxA protein action: variants with changed antiviral propertiesQ33937693
Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexesQ34016778
Characterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cellsQ34120302
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1Q34140181
Comparison of gene transfer efficiencies and gene expression levels achieved with equine infectious anemia virus- and human immunodeficiency virus type 1-derived lentivirus vectorsQ34328548
Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infectionQ35018048
Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivityQ35018068
Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loopQ35424269
IFN-inducible GTPases in host cell defenseQ36374867
Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.Q36520909
Myxovirus resistance gene A (MxA) expression suppresses influenza A virus replication in alpha interferon-treated primate cellsQ36559577
Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activityQ37821936
Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexesQ38150610
Interferon-stimulated genes: roles in viral pathogenesisQ38203069
A functional GTP-binding motif is necessary for antiviral activity of Mx proteinsQ38314550
Mouse Mx2 protein inhibits vesicular stomatitis virus but not influenza virusQ38329807
Protein transfer into human cells by VSV-G-induced nanovesicles.Q38585869
The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm.Q39094210
Evidence for a different susceptibility of primate lentiviruses to type I interferons.Q39223017
Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cellsQ39250932
The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating.Q39253660
Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteinsQ39419407
Complementation of vif-defective human immunodeficiency virus type 1 by primate, but not nonprimate, lentivirus vif genesQ39870640
Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genomeQ40695371
Transduction of nondividing human macrophages with gammaretrovirus-derived vectorsQ41889493
Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virusQ41984285
The interferon-inducible MxB protein inhibits HIV-1 infection.Q42267969
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)9017-9026
P577publication date2014-06-04
P1433published inJournal of VirologyQ1251128
P1476titleTransfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor
P478volume88

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cites work (P2860)
Q99550896A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat
Q35641044A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2
Q37034818Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations
Q39320682Capsid-Dependent Host Factors in HIV-1 Infection
Q35111033Contribution of MxB oligomerization to HIV-1 capsid binding and restriction
Q59355127Equine MX2 is a restriction factor of equine infectious anemia virus (EIAV)
Q58693128Equine Myxovirus Resistance Protein 2 Restricts Lentiviral Replication by Blocking Nuclear Uptake of Capsid Protein
Q28551681Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction
Q37037995Expression levels of Fv1: effects on retroviral restriction specificities
Q57043865From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections
Q38457723HIV suppression by host restriction factors and viral immune evasion
Q34473801HIV-1 and interferons: who's interfering with whom?
Q34422979Host and viral determinants for MxB restriction of HIV-1 infection
Q59351855Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1
Q59358015Human MxB Protein Is a Pan-herpesvirus Restriction Factor
Q58546274Human MxB inhibits the replication of HCV
Q38816438Interferon but not MxB inhibits foamy retroviruses
Q59356261MXB inhibits murine cytomegalovirus
Q26801484Misdelivery at the Nuclear Pore Complex-Stopping a Virus Dead in Its Tracks
Q64247477Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle
Q59349565Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction
Q38834397Mx oligomer: a novel capsid pattern sensor?
Q38807646MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells
Q92471253MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid
Q54207401MxB is an interferon-induced restriction factor of human herpesviruses.
Q96585128MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface
Q47555067Naturally occurring mutations in HIV-1 CRF01_AE capsid affect viral sensitivity to restriction factors
Q56530177Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2
Q36433874Oligomerization Requirements for MX2-Mediated Suppression of HIV-1 Infection
Q90689409Pro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid
Q38899780Promotion of expression of interferon-stimulated genes in U937 monocytic cells by HIV RNAs, measured using stable isotope labeling with amino acids in cell culture (SILAC).
Q35914350Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal
Q59358399Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection
Q37335524Soybean-derived Bowman-Birk Inhibitor (BBI) Inhibits HIV Replication in Macrophages
Q36121243Structural analysis of tumor-related single amino acid mutations in human MxA protein
Q34615762Structural insight into HIV-1 restriction by MxB.
Q56467498The 125th Lys and 145th Thr Amino Acids in the GTPase Domain of Goose Mx Confer Its Antiviral Activity against the Tembusu Virus
Q35639494The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition
Q64100581The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB
Q41019959Transcription profiling of CD4⁺ T cells in rhesus macaques that infected with simian-human immunodeficiency virus and re-challenged with SIVmac251.

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