Wendy Barclay

British virologist

DBpedia resource is: http://dbpedia.org/resource/Wendy_Barclay

Abstract is: Wendy Sue Fox CBE FMedSci (née Barclay) is a British virologist. She is currently head of Department of Infectious Disease and Chair in Influenza Virology at Imperial College London. She leads a team of scientists studying the influenza virus and its physiology and morphology to discover novel vaccines. In particular, they are trying to understand more about influenza virus mutations, and how they can allow scientists to create new vaccines against possible flu pandemics.

Born 2000-01-01

Wendy Barclay is …
instance of (P31):
humanQ5

External links are
P646Freebase ID/m/0138n3k7
P269IdRef ID252350162
P345IMDb IDnm3857949
P213ISNI000000012441234X
P856official websitehttps://www.imperial.ac.uk/people/w.barclay
P496ORCID iD0000-0002-3948-0895
P1153Scopus author ID7005440974
P214VIAF ID272161272151747441236
P2002X usernamewendybarclay11

P1416affiliationImperial College LondonQ189022
P6424affiliation stringImperial College London
P166award receivedCommander of the Order of the British EmpireQ12201477
P69educated atUniversity of ReadingQ1432632
Blackheath High SchoolQ4922996
P108employerImperial College LondonQ189022
P734family nameBarclayQ16243195
BarclayQ16243195
BarclayQ16243195
P101field of workvirologyQ7215
P735given nameWendyQ4018995
WendyQ4018995
P737influenced byPeter PaleseQ1795041
P463member ofScientific Advisory Group for EmergenciesQ88096332
New and Emerging Respiratory Virus Threats Advisory GroupQ88099150
P106occupationvirologistQ15634281
P1344participant inWorld Economic Forum Annual Meeting 2019Q114717235
P21sex or genderfemaleQ6581072

Reverse relations

author (P50)
Q112710104A common TMPRSS2 variant has a protective effect against severe COVID-19
Q37275127A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA.
Q40532455A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria
Q30228084A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine
Q39685928A reverse genetics approach for recovery of recombinant influenza B viruses entirely from cDNA.
Q30408155A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets
Q96291833ACE2: The Only Thing That Matters?
Q92883453ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells
Q30366662Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.
Q39614628Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines
Q40099360Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells.
Q38865842Amino acid substitution D222N from fatal influenza infection affects receptor-binding properties of the influenza A(H1N1)pdm09 virus
Q38758122An engineered avian-origin influenza A virus for pancreatic ductal adenocarcinoma virotherapy
Q30412888An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo
Q108819011Antibody prevalence for SARS-CoV-2 following the peak of the pandemic in England: REACT2 study in 100,000 adults
Q36438526Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape
Q39227786Antiviral Screening of Multiple Compounds against Ebola Virus
Q35605579Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry
Q59353775Assays to Measure the Activity of Influenza Virus Polymerase
Q99610109Assessing a novel, lab-free, point-of-care test for SARS-CoV-2 (CovidNudge): a diagnostic accuracy study
Q63408422Attenuating mutations in the influenza virus genome which may increase the safety of vaccine production
Q61228840Avian ANP32B does not support influenza A virus polymerase and influenza A virus relies exclusively on ANP32A in chicken cells.: Supplementary Information
Q33444633Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways
Q91955949Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission
Q47573057Can defective interfering RNAs affect the live attenuated influenza vaccine? - Authors' reply
Q30353819Cellular immune correlates of protection against symptomatic pandemic influenza.
Q40577158Changes in in vitro susceptibility of influenza A H3N2 viruses to a neuraminidase inhibitor drug during evolution in the human host
Q89876357Characterising viable virus from air exhaled by H1N1 influenza-infected ferrets reveals the importance of haemagglutinin stability for airborne infectivity
Q40467433Characterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations.
Q98470301Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey
Q37238003Computational and molecular analysis of conserved influenza A virus RNA secondary structures involved in infectious virion production
Q28384431Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance
Q58089569Determining the Mutation Bias of Favipiravir in Influenza Using Next-generation Sequencing
Q62898069Determining the Mutation Bias of Favipiravir in Influenza Using Next-generation Sequencing
Q40134334Development of a reverse genetics system enabling the rescue of recombinant avian influenza virus A/Turkey/England/50-92/91 (H5N1).
Q92997467Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study
Q91151083Elucidating the Interactions between Influenza Virus Polymerase and Host Factor ANP32A
Q92267294Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor
Q112722302Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model
Q39680151Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase
Q33513974Fatal cases of influenza a in childhood
Q41249449Ferret airway epithelial cell cultures support efficient replication of influenza B virus but not mumps virus
Q55399537Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments.
Q30376964Generation of candidate human influenza vaccine strains in cell culture - rehearsing the European response to an H7N1 pandemic threat
Q125880271Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential
Q34317413Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies
Q33865132HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation
Q108819005High and increasing prevalence of SARS-CoV-2 swab positivity in England during end September beginning October 2020: REACT-1 round 5 updated report
Q104659121High prevalence of SARS-CoV-2 swab positivity and increasing R number in England during October 2020: REACT-1 round 6 interim report
Q108819007High prevalence of SARS-CoV-2 swab positivity in England during September 2020: interim report of round 5 of REACT-1 study
Q102152437Host ANP32A mediates the assembly of the influenza virus replicase
Q100315715Host Cell Factors That Interact with Influenza Virus Ribonucleoproteins
Q91707062Host Determinants of Influenza RNA Synthesis
Q59349660Host and viral determinants of influenza A virus species specificity
Q24336824Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection
Q59569190Identification of novel expressed sequences, up-regulated in the leucocytes of chronic fatigue syndrome patients
Q30401640Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics
Q34199805Immune responses in pigs vaccinated with adjuvanted and non-adjuvanted A(H1N1)pdm/09 influenza vaccines used in human immunization programmes
Q108818986Increasing SARS-CoV-2 antibody prevalence in England at the start of the second wave: REACT-2 Round 4 cross-sectional study in 160,000 adults
Q30355972Infection of human airway epithelium by human and avian strains of influenza a virus.
Q39044498Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
Q38325400Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase
Q40563817Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window
Q92689668Influenza Virus with Increased pH of Hemagglutinin Activation Has Improved Replication in Cell Culture but at the Cost of Infectivity in Human Airway Epithelium
Q37962433Influenza pandemics
Q38768547Influenza: a world of discoveries, outbreaks and controversy
Q47210087Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice.
Q36506769Investigation of influenza virus polymerase activity in pig cells
Q38673915Knowns and unknowns of influenza B viruses
Q39555531Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo
Q30361125Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir.
Q37730817M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza
Q45421935Molecular characterization of Iranian wheat stripe virus shows its taxonomic position as a distinct species in the genus Tenuivirus.
Q37798373Molecular studies of influenza B virus in the reverse genetics era.
Q49409333Mouse Models of Influenza Infection with Circulating Strains to Test Seasonal Vaccine Efficacy
Q30382671Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium.
Q28385604Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility
Q112709659Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway
Q37738395NB protein does not affect influenza B virus replication in vitro and is not required for replication in or transmission between ferrets
Q35784659NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response.
Q30427526Obesity and susceptibility to severe outcomes following respiratory viral infection
Q30370246One-way trip: influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential.
Q116680016P251 The induction of early, dynamic airway mucosal and systemic immune responses following recent SARS-CoV-2 household exposure
Q30397718Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness
Q43138072Pandemic risks from bird flu.
Q91186385Passage of influenza A/H3N2 viruses in human airway cells removes artefactual variants associated with neuraminidase-mediated binding
Q37265666Pause on avian flu transmission research
Q30418993Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults
Q93013404Pregnancy-related immune suppression leads to altered influenza vaccine recall responses
Q104668085Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations.
Q38302467Probing the receptor interactions of an H5 avian influenza virus using a baculovirus expression system and functionalised poly(acrylic acid) ligands
Q90605918Publisher Correction: Host and viral determinants of influenza A virus species specificity
Q100955033Quantifying mechanistic traits of influenza viral dynamics using in vitro data
Q108818991REACT-1 round 10 report: Level prevalence of SARS-CoV-2 swab-positivity in England during third national lockdown in March 2021
Q108818988REACT-1 round 13 interim report: acceleration of SARS-CoV-2 Delta epidemic in the community in England during late June and early July 2021
Q108819001REACT-1 round 6 updated report: high prevalence of SARS-CoV-2 swab positivity with reduced rate of growth in England at the start of November 2020
Q108819000REACT-1 round 7 interim report: fall in prevalence of swab-positivity in England during national lockdown
Q108818998REACT-1 round 7 updated report: regional heterogeneity in changes in prevalence of SARS-CoV-2 infection during the second national COVID-19 lockdown in England
Q108818996REACT-1 round 8 final report: high average prevalence with regional heterogeneity of trends in SARS-CoV-2 infection in the community in England during January 2021
Q108818997REACT-1 round 8 interim report: SARS-CoV-2 prevalence during the initial stages of the third national lockdown in England
Q108818993REACT-1 round 9 final report: Continued but slowing decline of prevalence of SARS-CoV-2 during national lockdown in England in February 2021
Q108818995REACT-1 round 9 interim report: downward trend of SARS-CoV-2 in England in February 2021 but still at high prevalence
Q34097840RIG-I detects viral genomic RNA during negative-strand RNA virus infection
Q64082340RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals
Q39734394Rapid generation of a well-matched vaccine seed from a modern influenza A virus primary isolate without recourse to eggs.
Q30396667Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential
Q92063002Receptor for bat influenza virus uncovers potential risk to humans
Q40562546Reduced incorporation of the influenza B virus BM2 protein in virus particles decreases infectivity
Q92604841Regulation of influenza A virus mRNA splicing by CLK1
Q40377049Restrictions to the adaptation of influenza a virus h5 hemagglutinin to the human host.
Q108819008Resurgence of SARS-CoV-2 in England: detection by community antigen surveillance
Q108818989Resurgence of SARS-CoV-2: Detection by community viral surveillance
Q107473201SARS-CoV-2 one year on: evidence for ongoing viral adaptation
Q126871061Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults
Q98384023Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza
Q36456422Species difference in ANP32A underlies influenza A virus polymerase host restriction
Q83232819Species specific differences in use of ANP32 proteins by influenza A virus
Q27650988Structure of an avian influenza A virus NS1 protein effector domain
Q30376923Suitability of PER.C6 cells to generate epidemic and pandemic influenza vaccine strains by reverse genetics.
Q91738175Swine ANP32A supports avian influenza virus polymerase
Q57094088The 1918 Influenza Pandemic: one hundred years of progress, but where now?
Q98664923The Emergence of H7N7 Highly Pathogenic Avian Influenza Virus from Low Pathogenicity Avian Influenza Virus Using an in ovo Embryo Culture Model
Q35773994The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein
Q61229032The MHC class-II HLA-DR receptor mediates bat influenza A-like H17N10 virus entry into mammalian cells
Q108177412The Origins of SARS-CoV-2: A Critical Review
Q110461150The SARS-CoV-2 variant, Omicron, shows rapid replication in human primary nasal epithelial cultures and efficiently uses the endosomal route of entry
Q91177233The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells
Q95260554The dynamics of humoral immune responses following SARS-CoV-2 infection and the potential for reinfection
Q37123100The effect of the PB2 mutation 627K on highly pathogenic H5N1 avian influenza virus is dependent on the virus lineage.
Q107473210The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
Q57799444The mechanism of resistance to favipiravir in influenza
Q28390168The short stalk length of highly pathogenic avian influenza H5N1 virus neuraminidase limits transmission of pandemic H1N1 virus in ferrets
Q34059183Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor
Q108819017Transient dynamics of SARS-CoV-2 as England exited national lockdown
Q21134081Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model
Q37338331Transmission studies resume for avian flu.
Q113269688Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England
Q99370208Ultrastructure of Cell Trafficking Pathways and Coronavirus: How to Recognise the Wolf Amongst the Sheep
Q63408423Unravelling the mysteries of influenza
Q39250932Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells
Q40093500Urgent challenges in implementing live attenuated influenza vaccine
Q98390814Usability and acceptability of home-based self-testing for SARS-CoV-2 antibodies for population surveillance
Q108818987Vaccine uptake and SARS-CoV-2 antibody prevalence among 207,337 adults during May 2021 in England: REACT-2 study
Q30400181Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion
Q40336119Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway.
Q38192476Viral determinants of influenza A virus host range
Q30275435Viral factors in influenza pandemic risk assessment.

The articles in Wikimedia projects and languages

      Wendy Barclaywikipedia

Search more.