Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium.

scientific article

Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2009PLoSO...4.7836A
P356DOI10.1371/JOURNAL.PONE.0007836
P932PMC publication ID2775162
P698PubMed publication ID19924306
P5875ResearchGate publication ID38100037

P50authorWendy BarclayQ20005716
Ian M JonesQ55313194
Holly SheltonQ56706745
Margaret A ScullQ61992320
Raymond J. PicklesQ114519286
P2093author name stringJunyuan Ren
Guadalupe Ayora-Talavera
P2860cites workHuman and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammalsQ22255464
Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificityQ24646829
Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret modelQ24670511
Inefficient transmission of H5N1 influenza viruses in a ferret contact modelQ24684249
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemiaQ28262914
Evolution of the receptor binding phenotype of influenza A (H5) virusesQ28277115
A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmissionQ28286390
Human-like receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza virusesQ28472513
Avian flu: influenza virus receptors in the human airwayQ29619374
Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptorsQ30230269
Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammalsQ30327124
1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants.Q30336398
Human and avian influenza viruses target different cell types in cultures of human airway epithelium.Q30341182
Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities.Q30352169
Infection of human airway epithelium by human and avian strains of influenza a virus.Q30355972
Avian-virus-like receptor specificity of the hemagglutinin impedes influenza virus replication in cultures of human airway epithelium.Q30359078
An avian influenza H5N1 virus that binds to a human-type receptor.Q30362874
Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses.Q30367860
Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A virusesQ30369536
Positive selection at the receptor-binding site of haemagglutinin H5 in viral sequences derived from human tissues.Q30370726
Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity.Q30371137
Replication and transmission of H9N2 influenza viruses in ferrets: evaluation of pandemic potential.Q30371348
Role of sialic acid binding specificity of the 1918 influenza virus hemagglutinin protein in virulence and pathogenesis for mice.Q30374894
Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airwaysQ33444633
The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties.Q33640697
Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathologyQ34364942
Evolving complexities of influenza virus and its receptorsQ34765597
Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cellsQ35023814
Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility.Q36676836
Role of interferon in the replication of human parainfluenza virus type 1 wild type and mutant viruses in human ciliated airway epitheliumQ36845674
Measurement of the mutation rates of animal viruses: influenza A virus and poliovirus type 1.Q36864763
Reassortment between avian H5N1 and human H3N2 influenza viruses in ferrets: a public health risk assessmentQ37275055
Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epitheliumQ37743793
Probing the receptor interactions of an H5 avian influenza virus using a baculovirus expression system and functionalised poly(acrylic acid) ligandsQ38302467
Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells.Q40099360
Restrictions to the adaptation of influenza a virus h5 hemagglutinin to the human host.Q40377049
Amino acid 226 in the hemagglutinin of H4N6 influenza virus determines binding affinity for alpha2,6-linked sialic acid and infectivity levels in primary swine and human respiratory epithelial cellsQ42406925
Amino acid 226 in the hemagglutinin of H9N2 influenza viruses determines cell tropism and replication in human airway epithelial cellsQ42737927
Genetic characterization and protective immunity of cold-adapted attenuated avian H9N2 influenza vaccineQ43175382
Host species barriers to influenza virus infectionsQ43220385
Human-specific Regulation of α2–6-linked Sialic AcidsQ44590822
Glycan topology determines human adaptation of avian H5N1 virus hemagglutininQ45398016
Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.Q45401402
Purification and Properties of Cloned Salmonella typhimurium LT2 Sialidase with Virus-Typical Kinetic Preference for Sialyl α2→3 Linkages1Q45857252
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e7836
P577publication date2009-11-18
P1433published inPLOS OneQ564954
P1476titleMutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium.
P478volume4

Reverse relations

cites work (P2860)
Q46242247A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic?
Q30417784A review of influenza haemagglutinin receptor binding as it relates to pandemic properties
Q30408155A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets
Q30403405Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt.
Q27005668Adaptive pathways of zoonotic influenza viruses: from exposure to establishment in humans
Q39614628Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines
Q90419546Alternative Experimental Models for Studying Influenza Proteins, Host-Virus Interactions and Anti-Influenza Drugs
Q38865842Amino acid substitution D222N from fatal influenza infection affects receptor-binding properties of the influenza A(H1N1)pdm09 virus
Q30426011An overview of the highly pathogenic H5N1 influenza virus
Q35107548Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins
Q30412089Contemporary epidemiology of North American lineage triple reassortant influenza A viruses in pigs.
Q34190552Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures
Q41873650Differentiated swine airway epithelial cell cultures for the investigation of influenza A virus infection and replication
Q40158695Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin
Q30429141Emergence of influenza viruses with zoonotic potential: open issues which need to be addressed. A review
Q35745427Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence
Q35018600Evaluation of live attenuated H7N3 and H7N7 vaccine viruses for their receptor binding preferences, immunogenicity in ferrets and cross reactivity to the novel H7N9 virus
Q40064175First genome report and analysis of chicken H7N9 influenza viruses with poly-basic amino acids insertion in the hemagglutinin cleavage site
Q35436397Frequency and fitness consequences of bacteriophage φ6 host range mutations
Q30397785Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008.
Q39709717Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferrets
Q30429803H5N1 receptor specificity as a factor in pandemic risk
Q42251539Hemagglutinin variants of influenza A(H1N1)pdm09 virus with reduced affinity for sialic acid receptors
Q97436123Human Bocavirus 1 Infection of Well-Differentiated Human Airway Epithelium
Q35013810Identification of an H6N6 swine influenza virus in southern China
Q30388086In vitro assessment of attachment pattern and replication efficiency of H5N1 influenza A viruses with altered receptor specificity
Q38077952Influenza a virus entry: implications in virulence and future therapeutics
Q37962433Influenza pandemics
Q30390262Influenza virus evolution, host adaptation, and pandemic formation
Q92717896Inventory of molecular markers affecting biological characteristics of avian influenza A viruses
Q46242252Molecular Markers for Interspecies Transmission of Avian Influenza Viruses in Mammalian Hosts.
Q28385604Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility
Q64094586Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding
Q30400058Neuraminidase inhibitor sensitivity and receptor-binding specificity of Cambodian clade 1 highly pathogenic H5N1 influenza virus
Q30393675Neutralizing Epitopes of Influenza Virus Hemagglutinin: Target for the Development of a Universal Vaccine against H5N1 Lineages
Q30396667Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential
Q57285033Risk Assessment of Fifth-Wave H7N9 Influenza A Viruses in Mammalian Models.
Q39707715The influenza A virus hemagglutinin glycosylation state affects receptor-binding specificity
Q30410954The receptor binding specificity of the live attenuated influenza H2 and H6 vaccine viruses contributes to vaccine immunogenicity and protection in ferrets
Q28390168The short stalk length of highly pathogenic avian influenza H5N1 virus neuraminidase limits transmission of pandemic H1N1 virus in ferrets
Q27016093Transmission of influenza A viruses
Q30370928Validation of normal human bronchial epithelial cells as a model for influenza A infections in human distal trachea
Q30353598Virus-specific factors associated with zoonotic and pandemic potential.
Q57093653Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Search more.