A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2

scientific article published on 11 February 2015

A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00169-15
P932PMC publication ID4442396
P698PubMed publication ID25673704
P5875ResearchGate publication ID272176053

P50authorMichael Henry MalimQ21166756
P2093author name stringCaroline Goujon
Rebecca A Greenbury
Stelios Papaioannou
Tomas Doyle
P2860cites workPositional cloning of the mouse retrovirus restriction gene Fv1.Q36812909
Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activityQ37821936
Mx GTPases: dynamin-like antiviral machines of innate immunityQ38312100
Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitroQ40067568
Transduction of nondividing human macrophages with gammaretrovirus-derived vectorsQ41889493
The interferon-inducible MxB protein inhibits HIV-1 infection.Q42267969
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infectionQ24336824
MX2 is an interferon-induced inhibitor of HIV-1 infectionQ24338311
Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral functionQ27674633
Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power strokeQ27695693
Crystal structure of an isoleucine-zipper trimerQ27730889
A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutantsQ27731470
Interferons at age 50: past, current and future impact on biomedicineQ28259312
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasuresQ29615028
Use of a transient assay for studying the genetic determinants of Fv1 restrictionQ33809632
Host and viral determinants of Mx2 antiretroviral activityQ33900299
Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factorQ34059183
MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1Q34091405
Host and viral determinants for MxB restriction of HIV-1 infectionQ34422979
Structural insight into HIV-1 restriction by MxB.Q34615762
Effect of Fv-1 gene product on proviral DNA formation and integration in cells infected with murine leukemia virusesQ35008273
Characterization of an amino-terminal dimerization domain from retroviral restriction factor Fv1Q35023942
Contribution of MxB oligomerization to HIV-1 capsid binding and restrictionQ35111033
Interferon-stimulated genes and their antiviral effector functionsQ35742006
IFN-inducible GTPases in host cell defenseQ36374867
Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.Q36520909
P433issue8
P407language of work or nameEnglishQ1860
P1104number of pages5
P304page(s)4676-4680
P577publication date2015-02-11
P1433published inJournal of VirologyQ1251128
P1476titleA triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2
P478volume89

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cites work (P2860)
Q99550896A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat
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Q47146547Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?
Q39320682Capsid-Dependent Host Factors in HIV-1 Infection
Q40107041Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.
Q58693128Equine Myxovirus Resistance Protein 2 Restricts Lentiviral Replication by Blocking Nuclear Uptake of Capsid Protein
Q28551681Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction
Q91887203HIV-1 is more dependent on the K182 capsid residue than HIV-2 for interactions with CPSF6
Q59351855Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1
Q59358015Human MxB Protein Is a Pan-herpesvirus Restriction Factor
Q58546274Human MxB inhibits the replication of HCV
Q52576485MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.
Q26801484Misdelivery at the Nuclear Pore Complex-Stopping a Virus Dead in Its Tracks
Q59349565Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction
Q38834397Mx oligomer: a novel capsid pattern sensor?
Q38807646MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells
Q92471253MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid
Q54207401MxB is an interferon-induced restriction factor of human herpesviruses.
Q56530177Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2
Q36433874Oligomerization Requirements for MX2-Mediated Suppression of HIV-1 Infection
Q90689409Pro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid
Q35914350Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal
Q59358399Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection

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