In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B

scientific article

In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.00869-13
P932PMC publication ID3811747
P698PubMed publication ID23897615

P50authorJason A. PapinQ37369558
Glynis L KollingQ56888940
Cirle Alcantara WarrenQ62070954
P2093author name stringErik L Hewlett
Mary C Gray
Gina M Donato
Kevin M D'Auria
P2860cites workBinding kinetics of Clostridium difficile toxins A and B to intestinal brush border membranes from infant and adult hamstersQ36961946
Markers of intestinal inflammation, not bacterial burden, correlate with clinical outcomes in Clostridium difficile infectionQ36999988
Cell surface binding site for Clostridium difficile enterotoxin: evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta 1-4GlcNAcQ37025852
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The economic burden of Clostridium difficileQ37147648
Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A.Q37358133
Economic healthcare costs of Clostridium difficile infection: a systematic reviewQ37691876
The enterotoxicity of Clostridium difficile toxinsQ37954308
Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.Q38334527
Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasomeQ39713999
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.Q39757721
Comparison of two toxins produced by Clostridium difficileQ40612560
Tissue eosinophilia in a mouse model of colitis is highly dependent on TLR2 and independent of mast cells.Q42045236
Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injury.Q42140145
Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cellsQ47936620
Immunoglobulin and non-immunoglobulin components of human milk inhibit Clostridium difficile toxin A-receptor bindingQ49187253
Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis.Q51024811
Neuronal involvement in the intestinal effects of Clostridium difficile toxin A and Vibrio cholerae enterotoxin in rat ileum.Q51626531
Fatal enterocolitis in hamsters given lincomycin hydrochloride.Q54693976
Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamstersQ67697866
A human antibody binds to alpha-galactose receptors and mimics the effects of Clostridium difficile toxin A in rat colonQ71884807
Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in miceQ77718421
Substrate specificity of clostridial glucosylating toxins and their function on colonocytes analyzed by proteomics techniquesQ86073305
Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cellsQ24561508
Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbitQ24607564
Toxin B is essential for virulence of Clostridium difficileQ24647539
Exploration, normalization, and summaries of high density oligonucleotide array probe level dataQ27861098
An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizersQ28508414
A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changesQ29618085
Immune responses to Clostridium difficile infectionQ30416692
Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle controlQ30428655
Murine model of Clostridium difficile infection with aged gnotobiotic C57BL/6 mice and a BI/NAP1 strainQ30429490
Epithelial cell apoptosis facilitates Entamoeba histolytica infection in the gutQ30433009
Angiotensin II subtype 1 receptor blockade inhibits Clostridium difficile toxin A-induced intestinal secretion in a rabbit modelQ30436846
Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.Q30973103
Binding of Clostridium difficile toxins to human milk oligosaccharides.Q33910800
The role of toxin A and toxin B in Clostridium difficile infectionQ34138233
Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammationQ34236680
The role of toxin A and toxin B in the virulence of Clostridium difficileQ34239367
p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritisQ34432263
Comparative sequence analysis of the Clostridium difficile toxins A and B.Q34435318
Toxin A-negative, toxin B-positive Clostridium difficileQ34549681
Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in miceQ34678754
Structure and mode of action of clostridial glucosylating toxins: the ABCD modelQ34768469
Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal modelsQ35669017
Burden of Clostridium difficile on the healthcare systemQ36071497
Camera: a competitive gene set test accounting for inter-gene correlationQ36280584
IFN-inducible GTPases in host cell defenseQ36374867
Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposureQ36396899
Effects of the two toxins of Clostridium difficile in antibiotic-associated cecitis in hamsters.Q36441243
Toxin A of Clostridium difficile binds to the human carbohydrate antigens I, X, and YQ36958780
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectClostridium difficileQ310543
P304page(s)3814-3824
P577publication date2013-07-29
P1433published inInfection and ImmunityQ6029193
P1476titleIn vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B
P478volume81

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