IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver

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IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver is …
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scholarly articleQ13442814

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P356DOI10.1016/J.EXPPARA.2015.07.005
P932PMC publication ID4640457
P698PubMed publication ID26208780

P2093author name stringXiaojing Ma
Gregory A Taylor
Henry W Murray
Marisa Mitchell-Flack
P2860cites workThe molecular cell biology of interferon-gamma and its receptorQ40898233
The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.Q44527568
Prevention of relapse after chemotherapy in a chronic intracellular infection: mechanisms in experimental visceral leishmaniasisQ46425891
Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47).Q50067094
Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthaseQ83947223
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTPQ24679086
Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cellsQ27315334
Pentavalent antimonials: new perspectives for old drugsQ28253055
Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasisQ28343835
Deficiency of p110δ isoform of the phosphoinositide 3 kinase leads to enhanced resistance to Leishmania donovaniQ28539842
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infectionQ28586576
A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infectionQ28593668
Regulation of macrophage motility by Irgm1Q30492916
p47 GTPases regulate Toxoplasma gondii survival in activated macrophagesQ33788028
Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP.Q34008942
Interferon-inducible effector mechanisms in cell-autonomous immunityQ34114819
Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinomaQ34215458
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47Q34272123
Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.Q34287918
Tissue granuloma structure-function in experimental visceral leishmaniasisQ34434760
Requirement for T cells and effect of lymphokines in successful chemotherapy for an intracellular infection. Experimental visceral leishmaniasisQ34570535
Balancing immunity and pathology in visceral leishmaniasisQ34587432
p47 GTPases: regulators of immunity to intracellular pathogensQ35709631
The immunopathology of experimental visceral leishmaniasisQ35884243
Progress in the treatment of a neglected infectious disease: visceral leishmaniasisQ35917392
The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogensQ36222916
Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovaniQ36367801
IFN-inducible GTPases in host cell defenseQ36374867
Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liverQ36970905
In vitro antileishmanial properties of tri- and pentavalent antimonial preparationsQ39779821
P921main subjectmacrophageQ184204
Leishmania donovaniQ1950752
P304page(s)103-109
P577publication date2015-07-21
P1433published inExperimental ParasitologyQ15754029
P1476titleIFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver
P478volume157