Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. (scientific article)

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Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.

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Pathogenesis of fallopian tube damage caused by Chlamydia trachomatis infections

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Chlamydia pneumoniae: modern insights into an ancient pathogen.

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Genetic analysis of susceptibility to Chlamydia trachomatis in mouse

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Differential sensitivity of distinct Chlamydia trachomatis isolates to IFN-gamma-mediated inhibition

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Cellular Immunity to the Mouse Pneumonitis Agent

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Chlamydia trachomatis-induced salpingitis in mice

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A mouse model of Chlamydia trachomatis pneumonitis

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IL-18 in inflammatory and autoimmune disease

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Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

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Caspase-11 protects against bacteria that escape the vacuole

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Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock

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Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

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A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

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Non-canonical inflammasome activation targets caspase-11

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NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice

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Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense

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Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7

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A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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Activation and regulation of the inflammasomes

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The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance

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Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus

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Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome

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Chlamydial IFN-gamma immune evasion is linked to host infection tropism

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Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections

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Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

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Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector

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Inflammatory caspases are innate immune receptors for intracellular LPS.

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Comparison of gamma interferon-mediated antichlamydial defense mechanisms in human and mouse cells

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Chlamydia.

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The interleukin-1 family: back to the future

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Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

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Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria

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Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10.

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IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins

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Significant role of IL-1 signaling, but limited role of inflammasome activation, in oviduct pathology during Chlamydia muridarum genital infection

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The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice

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Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome

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Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection

Q35177551

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

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Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms

Q35577557

Chlamydia muridarum infection of macrophages elicits bactericidal nitric oxide production via reactive oxygen species and cathepsin B.

Q35833800

Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins

Q36179296

Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection

Q36421541

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

Q36583086

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

macrophage

Q184204

inflammasome complex

Q412405

P304

page(s)

4740-4749

P577

publication date

2015-09-28

P1433

published in

Infection and Immunity

Q6029193

P1476

title

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages

P478

volume

Reverse relations

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