Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms

scientific article published on 7 November 2011

Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1365-2958.2011.07877.X
P932PMC publication ID3225693
P698PubMed publication ID22014092
P5875ResearchGate publication ID51734018

P50authorYadunanda KumarQ38329780
P2093author name stringLaura G Dubois
Raphael H Valdivia
M Arthur Moseley
J Will Thompson
Yi-Shan Chen
Hector A Saka
P2860cites workStructural characterization of a type III secretion system filament protein in complex with its chaperoneQ81199232
Two-dimensional separation of peptides using RP-RP-HPLC system with different pH in first and second separation dimensionsQ81351422
The global burden of trachoma: a reviewQ21562267
Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatisQ22065557
Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the ChlamydiaceaeQ22065992
Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39.Q22065998
Chlamydia trachomatis Infections in Neonates and Young ChildrenQ22250933
A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actinQ24564460
Effective--a database of predicted secreted bacterial proteinsQ24611732
The expression, processing and localization of polymorphic membrane proteins in Chlamydia pneumoniae strain CWL029Q24795016
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Inter-subunit interaction and quaternary rearrangement defined by the central stalk of prokaryotic V1-ATPaseQ27657556
A statistical model for identifying proteins by tandem mass spectrometryQ28186251
Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database searchQ28211385
Protein delivery into eukaryotic cells by type III secretion machinesQ28276443
Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodiesQ28280558
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiologyQ29614686
Mechanisms of host cell exit by the intracellular bacterium ChlamydiaQ30480273
Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuoleQ30482674
Proteome analysis of the Chlamydia pneumoniae elementary bodyQ30669016
Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisitionQ30800087
Comparative proteome analysis of Chlamydia trachomatis serovar A, D and L2.Q31038366
Action and reaction: Chlamydophila pneumoniae proteome alteration in a persistent infection induced by iron deficiencyQ31113864
Expression, processing, and localization of PmpD of Chlamydia trachomatis Serovar L2 during the chlamydial developmental cycleQ33288962
The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS/MS.Q33419188
Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixturesQ33419191
Analysis of pmpD expression and PmpD post-translational processing during the life cycle of Chlamydia trachomatis serovars A, D, and L2Q33430259
The Chlamydia type III secretion system C-ring engages a chaperone-effector protein complexQ33502747
Chlamydia trachomatis infections: progress and problemsQ33542366
Type V protein secretion pathway: the autotransporter storyQ33559645
Deep sequencing-based discovery of the Chlamydia trachomatis transcriptomeQ33633681
The conserved Tarp actin binding domain is important for chlamydial invasionQ33640294
Molecular cloning and characterization of the genes coding for the highly immunogenic cluster of 90-kilodalton envelope proteins from the Chlamydia psittaci subtype that causes abortion in sheepQ33752022
Multiple host proteins that function in phosphatidylinositol-4-phosphate metabolism are recruited to the chlamydial inclusion.Q33825984
Proteome of the large Pseudomonas myovirus 201 phi 2-1: delineation of proteolytically processed virion proteinsQ33855002
Biological characterization of Chlamydia trachomatis plasticity zone MACPF domain family protein CT153.Q33877165
Chlamydia trachomatis YtgA is an iron-binding periplasmic protein induced by iron restrictionQ33923221
Two nucleotide transport proteins in Chlamydia trachomatis, one for net nucleoside triphosphate uptake and the other for transport of energyQ33991260
Characterization of outer membrane proteins in Chlamydia trachomatis LGV serovar L2.Q33996097
Expression of Chlamydia pneumoniae polymorphic membrane protein family genesQ34006871
Mass spectrometry–based proteomics in cell biologyQ34083139
Polymorphisms in the nine polymorphic membrane proteins of Chlamydia trachomatis across all serovars: evidence for serovar Da recombination and correlation with tissue tropism.Q34233262
Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigenQ34478609
Identification and characterization of a Chlamydia trachomatis early operon encoding four novel inclusion membrane proteins.Q37877960
Immunoreactivity of the 60 kDa cysteine-rich proteins of Chlamydia trachomatis, Chlamydia psittaci and Chlamydia pneumoniae expressed in Escherichia coliQ37888611
The obligate intracellular bacterium Chlamydia trachomatis is auxotrophic for three of the four ribonucleoside triphosphatesQ37890890
Overexpression and surface localization of the Chlamydia trachomatis major outer membrane protein in Escherichia coliQ37893301
Protective monoclonal antibodies recognize epitopes located on the major outer membrane protein of Chlamydia trachomatis.Q37901943
Ultrastructure of Chlamydia trachomatis infection of the mouse oviductQ37905345
MxiK and MxiN interact with the Spa47 ATPase and are required for transit of the needle components MxiH and MxiI, but not of Ipa proteins, through the type III secretion apparatus of Shigella flexneriQ41466218
Flagellar formation in C-ring-defective mutants by overproduction of FliI, the ATPase specific for flagellar type III secretionQ41832635
Shigella Spa33 is an essential C-ring component of type III secretion machineryQ42485719
Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cellsQ42643543
Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high resolution differential mass spectrometryQ43185959
Simultaneous qualitative and quantitative analysis of the Escherichia coli proteome: a sweet taleQ46884609
Interactions between C ring proteins and export apparatus components: a possible mechanism for facilitating type III protein exportQ50081214
Orthogonality of separation in two-dimensional liquid chromatography.Q51963424
Mass spectrometry in high-throughput proteomics: ready for the big time.Q54676816
Quantitative analysis of complex peptide mixtures using FTMS and differential mass spectrometryQ79310635
Biophysical characterization of Chlamydia trachomatis CT584 supports its potential role as a type III secretion needle tip proteinQ34851073
Effector protein modulation of host cells: examples in the Chlamydia spp. arsenalQ34920157
Global Stage-Specific Gene Regulation during the Developmental Cycle of Chlamydia trachomatisQ34977705
The Chlamydial Type III Secretion Mechanism: Revealing Cracks in a Tough Nut.Q35075114
Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatisQ35168447
C-ring requirement in flagellar type III secretion is bypassed by FlhDC upregulation.Q35357107
Immunity and vaccines against sexually transmitted Chlamydia trachomatis infectionQ35536190
Chlamydial type III secretion system is encoded on ten operons preceded by sigma 70-like promoter elementsQ35634235
Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification.Q35961641
Protein identification using 2D-LC-MS/MS.Q36049614
Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolatesQ36259301
Structural and polypeptide differences between envelopes of infective and reproductive life cycle forms of Chlamydia sppQ36294869
Recent insights into the mechanisms of Chlamydia entryQ36322949
Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatisQ36445214
Characterization of fifty putative inclusion membrane proteins encoded in the Chlamydia trachomatis genomeQ36710662
The chlamydial plasmid-encoded protein pgp3 is secreted into the cytosol of Chlamydia-infected cellsQ36804245
Type III secretion à la ChlamydiaQ36812549
Comparison of two-dimensional fractionation techniques for shotgun proteomicsQ36901541
Developmental-form-specific DNA-binding proteins in Chlamydia spp.Q36997246
Chlamydia effector proteins and new insights into chlamydial cellular microbiologyQ37094438
Genital Chlamydia trachomatis infectionsQ37394173
Acquisition of nutrients by Chlamydiae: unique challenges of living in an intracellular compartmentQ37652709
Proteomics as a probe of microbial pathogenesis and its molecular boundariesQ37689718
Risk of sequelae after Chlamydia trachomatis genital infection in womenQ37752412
Proteomic analysis reveals a virtually complete set of proteins for translation and energy generation in elementary bodies of the amoeba symbiont Protochlamydia amoebophilaQ37851007
Identification of Chlamydia trachomatis outer membrane complex proteins by differential proteomicsQ37853351
Variable expression of surface-exposed polymorphic membrane proteins in in vitro-grown Chlamydia trachomatisQ37854196
Bacterial secretion systems with an emphasis on the chlamydial Type III secretion system.Q37854601
Analysis of proteins in Chlamydia trachomatis L2 outer membrane complex, COMC.Q37855589
Characterization of the putative type III secretion ATPase CdsN (Cpn0707) of Chlamydophila pneumoniaeQ37856790
Interactions between CdsD, CdsQ, and CdsL, three putative Chlamydophila pneumoniae type III secretion proteinsQ37858039
Identification of an iron-responsive protein that is antigenic in patients with Chlamydia trachomatis genital infectionsQ37858760
A plasmid-cured Chlamydia muridarum strain displays altered plaque morphology and reduced infectivity in cell culture.Q37862161
Ultrastructural analysis of chlamydial antigen-containing vesicles everting from the Chlamydia trachomatis inclusionQ37862277
Shotgun proteomic analysis of Chlamydia trachomatisQ37865040
Analysis of altered protein expression patterns of Chlamydia pneumoniae by an integrated proteome-works systemQ37866515
Prevalence of chlamydial and gonococcal infections among young adults in the United StatesQ37867157
Proteome analysis of Chlamydia pneumoniaeQ37870594
A secondary structure motif predictive of protein localization to the chlamydial inclusion membraneQ37874933
P4510describes a project that usesImageQuantQ112270642
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectChlamydia trachomatisQ131065
P304page(s)1185-1203
P577publication date2011-11-07
P1433published inMolecular MicrobiologyQ6895967
P1476titleQuantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms
P478volume82

Reverse relations

cites work (P2860)
Q30420776A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis
Q26775890A Coming of Age Story: Chlamydia in the Post-Genetic Era
Q60302097A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion
Q36094676A Proteomic Investigation of Hepatic Resistance to Ascaris in a Murine Model
Q36594034A working model for the type III secretion mechanism in Chlamydia
Q34870145All subtypes of the Pmp adhesin family are implicated in chlamydial virulence and show species-specific function
Q36134315Analysis of Polymorphic Membrane Protein Expression in Cultured Cells Identifies PmpA and PmpH of Chlamydia psittaci as Candidate Factors in Pathogenesis and Immunity to Infection
Q35741537Application of β-lactamase reporter fusions as an indicator of effector protein secretion during infections with the obligate intracellular pathogen Chlamydia trachomatis
Q27684803Biochemical and Structural Insights into Microtubule Perturbation by CopN from Chlamydia pneumoniae
Q35679647Bioinformatic Analysis of Chlamydia trachomatis Polymorphic Membrane Proteins PmpE, PmpF, PmpG and PmpH as Potential Vaccine Antigens
Q37834004Biphasic Metabolism and Host Interaction of a Chlamydial Symbiont
Q37002228CTL0511 from Chlamydia trachomatis Is a Type 2C Protein Phosphatase with Broad Substrate Specificity
Q36950792Chlamydia cell biology and pathogenesis
Q30389751Chlamydia pneumoniae effector chlamydial outer protein N sequesters fructose bisphosphate aldolase A, providing a benefit to bacterial growth
Q27680973Chlamydia trachomatis CT771 ( nudH ) Is an Asymmetric Ap 4 A Hydrolase
Q35536134Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells
Q37847527Chlamydia trachomatis Tarp harbors distinct G and F actin binding domains that bundle actin filaments
Q36070071Chlamydia trachomatis Type III Secretion Proteins Regulate Transcription
Q89267432Chlamydia trachomatis paralyses neutrophils to evade the host innate immune response
Q44059252Chlamydia trachomatis regulates growth and development in response to host cell fatty acid availability in the absence of lipid droplets
Q37035936Chlamydia trachomatis transports NAD via the Npt1 ATP/ADP translocase
Q37292262Chlamydial Protease-Like Activity Factor and Type III Secreted Effectors Cooperate in Inhibition of p65 Nuclear Translocation
Q36683752Chlamydial metabolism revisited: interspecies metabolic variability and developmental stage-specific physiologic activities
Q37834482Comparison of the nine polymorphic membrane proteins of Chlamydia trachomatis for their ability to induce protective immune responses in mice against a C. muridarum challenge
Q26998512Conserved type III secretion system exerts important roles in Chlamydia trachomatis
Q91711374Early Transcriptional Landscapes of Chlamydia trachomatis-Infected Epithelial Cells at Single Cell Resolution
Q38063574Exoproteomics: exploring the world around biological systems
Q44058928Fluorescence-Reported Allelic Exchange Mutagenesis Reveals a Role for Chlamydia trachomatis TmeA in Invasion That Is Independent of Host AHNAK.
Q36281253Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
Q37127539Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii
Q37839872Hypothetical protein CT398 (CdsZ) interacts with σ(54) (RpoN)-holoenzyme and the type III secretion export apparatus in Chlamydia trachomatis
Q34595020Identification of novel type III secretion chaperone-substrate complexes of Chlamydia trachomatis
Q35574539Identification of the base-pairing requirements for repression of hctA translation by the small RNA IhtA leads to the discovery of a new mRNA target in Chlamydia trachomatis
Q37844382Imaging of Chlamydia and host cell metabolism
Q88983828In silico prediction of T- and B-cell epitopes in PmpD: First step towards to the design of a Chlamydia trachomatis vaccine
Q57159008Inhibition of the Protein Phosphatase CppA Alters Development of Chlamydia trachomatis
Q58610716Initial Characterization of the Two ClpP Paralogs of Suggests Unique Functionality for Each
Q54237349Insights Into Vaginal Bacterial Communities and Metabolic Profiles of Chlamydia trachomatis Infection: Positioning Between Eubiosis and Dysbiosis.
Q36035656Interrogating Genes That Mediate Chlamydia trachomatis Survival in Cell Culture Using Conditional Mutants and Recombination
Q37050178Lactobacillus crispatus inhibits the infectivity of Chlamydia trachomatis elementary bodies, in vitro study.
Q37419731Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase
Q34945481Metabolic features of Protochlamydia amoebophila elementary bodies--a link between activity and infectivity in Chlamydiae.
Q28248842Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9
Q101237382Modeling of variables in cellular infection reveals CXCL10 levels are regulated by human genetic variation and the Chlamydia-encoded CPAF protease
Q37847213Molecular cartography in acute Chlamydia pneumoniae infections--a non-targeted metabolomics approach
Q38642072Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp.
Q34170841Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum.
Q37548120New frontiers in type III secretion biology: the Chlamydia perspective
Q43409968New insights into Chlamydiae persistence: an energy metabolism strategy?
Q37846210Novel HLA-B27-restricted epitopes from Chlamydia trachomatis generated upon endogenous processing of bacterial proteins suggest a role of molecular mimicry in reactive arthritis
Q37836353One Face of Chlamydia trachomatis: The Infectious Elementary Body
Q35329559Outer membrane proteins preferentially load MHC class II peptides: implications for a Chlamydia trachomatis T cell vaccine
Q90178754Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development
Q60958289Persistence: A Survival Strategy to Evade Antimicrobial Effects and
Q44059365Phosphatidylserine decarboxylase CT699, lysophospholipid acyltransferase CT775, and acyl-ACP synthase CT776 provide membrane lipid diversity to Chlamydia trachomatis
Q36376542Phosphoproteomic analysis of the Chlamydia caviae elementary body and reticulate body forms
Q36690689Proteomic analysis of an unculturable bacterial endosymbiont (Blochmannia) reveals high abundance of chaperonins and biosynthetic enzymes
Q37839078Proteomic analysis of the Simkania-containing vacuole: the central role of retrograde transport
Q33599524Proteomic differences between male and female anterior cruciate ligament and patellar tendon
Q64058737Ptr/CTL0175 Is Required for the Efficient Recovery of From Stress Induced by Gamma-Interferon
Q37479083Quantitative Protein Profiling of Chlamydia trachomatis Growth Forms Reveals Defense Strategies Against Tryptophan Starvation
Q35922044Quantitative Proteomics of the Infectious and Replicative Forms of Chlamydia trachomatis
Q30405911Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches
Q34433420Reconceptualizing the chlamydial inclusion as a pathogen-specified parasitic organelle: an expanded role for Inc proteins
Q37842209Remodeling of host phosphatidylcholine by Chlamydia acyltransferase is regulated by acyl-CoA binding protein ACBD6 associated with lipid droplets
Q90645841Role for GrgA in Regulation of σ28-Dependent Transcription in the Obligate Intracellular Bacterial Pathogen Chlamydia trachomatis
Q36872696STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.
Q36791942Sequestration of host metabolism by an intracellular pathogen
Q35865404Shotgun proteomics of bacterial pathogens: advances, challenges and clinical implications
Q57751827Spectroscopic Analysis of Chlamydial Major Outer Membrane Protein in Support of Structure Elucidation
Q37837221Subunit vaccines for the prevention of mucosal infection with Chlamydia trachomatis
Q37835815The Chlamydia pneumoniae Adhesin Pmp21 Forms Oligomers with Adhesive Properties
Q36237241The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs
Q28539981The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signaling
Q37318059The DUF582 Proteins of Chlamydia trachomatis Bind to Components of the ESCRT Machinery, Which Is Dispensable for Bacterial Growth In vitro
Q37833743The Effector TepP Mediates Recruitment and Activation of Phosphoinositide 3-Kinase on Early Chlamydia trachomatis Vacuoles
Q37525397The Impact of Protein Phosphorylation on Chlamydial Physiology
Q55344798The Loss of Expression of a Single Type 3 Effector (CT622) Strongly Reduces Chlamydia trachomatis Infectivity and Growth.
Q35652665The Proteome of the Isolated Chlamydia trachomatis Containing Vacuole Reveals a Complex Trafficking Platform Enriched for Retromer Components
Q37846201The chlamydial OTU domain-containing protein ChlaOTU is an early type III secretion effector targeting ubiquitin and NDP52.
Q90138180The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg
Q34430716Uptake of biotin by Chlamydia Spp. through the use of a bacterial transporter (BioY) and a host-cell transporter (SMVT).
Q54250859Urine metabolome in women with Chlamydia trachomatis infection.
Q58803216Virulence-related comparative transcriptomics of infectious and non-infectious chlamydial particles

Search more.