Application of β-lactamase reporter fusions as an indicator of effector protein secretion during infections with the obligate intracellular pathogen Chlamydia trachomatis

scientific article published on 10 August 2015

Application of β-lactamase reporter fusions as an indicator of effector protein secretion during infections with the obligate intracellular pathogen Chlamydia trachomatis is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1035295M
P356DOI10.1371/JOURNAL.PONE.0135295
P932PMC publication ID4530969
P698PubMed publication ID26258949
P5875ResearchGate publication ID281478262

P2093author name stringKenneth A Fields
Konrad E Mueller
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Expression of the effector protein IncD in Chlamydia trachomatis mediates recruitment of the lipid transfer protein CERT and the endoplasmic reticulum-resident protein VAPB to the inclusion membraneQ37713377
The transcriptional repressor EUO regulates both subsets of Chlamydia late genesQ37843504
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Reversal of the antichlamydial activity of putative type III secretion inhibitors by ironQ37859892
A directed screen for chlamydial proteins secreted by a type III mechanism identifies a translocated protein and numerous other new candidatesQ37864748
Requirement for the Rac GTPase in Chlamydia trachomatis invasion of non-phagocytic cells.Q37867232
Evidence for the secretion of Chlamydia trachomatis CopN by a type III secretion mechanism.Q37875136
Identification and characterization of a Chlamydia trachomatis early operon encoding four novel inclusion membrane proteins.Q37877960
Tracking bacterial pathogens with genetically-encoded reporters.Q38214489
Real-time analysis of effector translocation by the type III secretion system of enteropathogenic Escherichia coliQ40007146
The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signalingQ28539981
Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivityQ30449313
Mechanisms of host cell exit by the intracellular bacterium ChlamydiaQ30480273
Chlamydia trachomatis type III secretion: evidence for a functional apparatus during early-cycle development.Q30916655
Multifunctional analysis of Chlamydia-specific genes in a yeast expression systemQ31034927
Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection modelQ33285974
The Chlamydia type III secretion system C-ring engages a chaperone-effector protein complexQ33502747
Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genesQ33578702
Deep sequencing-based discovery of the Chlamydia trachomatis transcriptomeQ33633681
The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replicationQ33921269
Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vectorQ34037667
Analysis of putative Chlamydia trachomatis chaperones Scc2 and Scc3 and their use in the identification of type III secretion substrates.Q34048332
Alveolar macrophages and neutrophils are the primary reservoirs for Legionella pneumophila and mediate cytosolic surveillance of type IV secretion.Q34298593
Evidence that CT694 is a novel Chlamydia trachomatis T3S substrate capable of functioning during invasion or early cycle developmentQ34383783
Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteinsQ34491620
Identification of novel type III secretion chaperone-substrate complexes of Chlamydia trachomatisQ34595020
Role for chlamydial inclusion membrane proteins in inclusion membrane structure and biogenesisQ34733854
The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substratesQ34740733
The trans-Golgi SNARE syntaxin 6 is recruited to the chlamydial inclusion membrane.Q34837395
Effector protein modulation of host cells: examples in the Chlamydia spp. arsenalQ34920157
Characterization of interactions between inclusion membrane proteins from Chlamydia trachomatisQ35072279
The Chlamydial Type III Secretion Mechanism: Revealing Cracks in a Tough Nut.Q35075114
Identification of type III secretion substrates of Chlamydia trachomatis using Yersinia enterocolitica as a heterologous systemQ35095777
Advances in genetic manipulation of obligate intracellular bacterial pathogensQ35155325
Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatisQ35168447
Plague bacteria target immune cells during infectionQ35535438
The Chlamydia trachomatis parasitophorous vacuolar membrane is not passively permeable to low-molecular-weight compoundsQ35544513
Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental formsQ35577557
Chlamydial type III secretion system is encoded on ten operons preceded by sigma 70-like promoter elementsQ35634235
Rapid, accurate, computational discovery of Rho-independent transcription terminators illuminates their relationship to DNA uptakeQ35751629
Domain analyses reveal that Chlamydia trachomatis CT694 protein belongs to the membrane-localized family of type III effector proteinsQ36201930
Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatisQ36445214
Induction of type III secretion by cell-free Chlamydia trachomatis elementary bodiesQ36992556
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectChlamydia trachomatisQ131065
P304page(s)e0135295
P577publication date2015-08-10
P1433published inPLOS OneQ564954
P1476titleApplication of β-lactamase reporter fusions as an indicator of effector protein secretion during infections with the obligate intracellular pathogen Chlamydia trachomatis
P478volume10

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