Mechanisms and functions of guanylate-binding proteins and related interferon-inducible GTPases: roles in intracellular lysis of pathogens

scientific article published on 3 October 2017

Mechanisms and functions of guanylate-binding proteins and related interferon-inducible GTPases: roles in intracellular lysis of pathogens is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/CMI.12791
P698PubMed publication ID28975702

P50authorSi Ming ManQ42648826
P2093author name stringChinh C Ngo
P2860cites workTriphosphate induced dimerization of human guanylate binding protein 1 involves association of the C-terminal helices: a joint double electron-electron resonance and FRET studyQ44564916
Nucleotide dependent cysteine reactivity of hGBP1 uncovers a domain movement during GTP hydrolysis.Q45999872
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.Q48293410
Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell deathQ21559499
GBP5 promotes NLRP3 inflammasome assembly and immunity in mammalsQ24310380
Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactorQ24529563
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuoleQ24614550
Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteriaQ24644997
Converging roles of caspases in inflammasome activation, cell death and innate immunityQ26776532
Different subcellular localizations for the related interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for different functions?Q28138823
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and GolgiQ28140190
Mechanisms of type-I- and type-II-interferon-mediated signallingQ28247893
The dynamin superfamily: universal membrane tubulation and fission molecules?Q28252404
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMPQ28299939
Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosisQ28505187
Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiQ28506496
Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defenseQ28512319
Inactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivoQ28587410
A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infectionQ28593668
Interferon-induced guanylate-binding proteins in inflammasome activation and host defenseQ28595838
Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.Q29871458
Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studiesQ33327569
Purification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferaseQ33547011
Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical mannerQ33769297
TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles.Q33899190
Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1.Q33913562
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.Q34006614
Interferon-inducible effector mechanisms in cell-autonomous immunityQ34114819
Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.Q34414371
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPasesQ34415551
Unique features of different members of the human guanylate-binding protein family.Q34607986
Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondiiQ34697891
Murine guanylate-binding protein: incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding proteinQ34728624
IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteinsQ34778494
Self and non-self discrimination of intracellular membranes by the innate immune systemQ34998188
cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infectionQ35199121
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infectionQ35528340
Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagyQ35749637
IFN-inducible GTPases and immunity to intracellular pathogensQ35920524
RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondiiQ35989946
Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.Q35995190
Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteinsQ36179296
The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogensQ36222916
Type I interferon signaling is required for activation of the inflammasome during Francisella infectionQ36229342
The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activityQ36234104
Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.Q36281253
Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replicationQ36512191
The interferon-inducible GTPases.Q36528795
Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexesQ36673756
Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families.Q37034561
Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondiiQ37127539
Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systemsQ37682433
The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphataseQ37818303
Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation.Q37835983
Oligomerization of dynamin superfamily proteins in health and diseaseQ38105693
Interferon-inducible GTPases in cell autonomous and innate immunityQ38634433
Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.Q38697834
Guanylate-Binding Protein 1 Inhibits Nuclear Delivery of Kaposi's Sarcoma-Associated Herpesvirus Virions by Disrupting Formation of Actin FilamentQ38700921
Protein prenylation: unique fats make their mark on biologyQ38704283
Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.Q38834935
Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 InfectivityQ39147587
Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties.Q39837169
Molecular mechanisms of inflammasome signaling.Q40074125
Guanylate Binding Proteins regulate inflammasome activation in response to hyper-injected Yersinia translocon componentsQ40103031
Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondiiQ40358072
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.Q40520196
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicidaQ41429405
Caspase-11 protects against bacteria that escape the vacuoleQ41452200
P577publication date2017-10-03
P1433published inCellular MicrobiologyQ1921948
P1476titleMechanisms and functions of guanylate-binding proteins and related interferon-inducible GTPases: roles in intracellular lysis of pathogens

Reverse relations

cites work (P2860)
Q58202557Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action
Q92822226Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection
Q98158485Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting
Q91578550Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis
Q58202560Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis
Q89967237Mycobacterium tuberculosis PE31 (Rv3477) Attenuates Host Cell Apoptosis and Promotes Recombinant M. smegmatis Intracellular Survival via Up-regulating GTPase Guanylate Binding Protein-1
Q92877180Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8.

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