IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.

scientific article published on 2 October 2017

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PPAT.1006630
P932PMC publication ID5624647
P698PubMed publication ID28968459

P50authorBénédicte PyQ30158338
Thomas HenryQ57716997
Sophia DjebaliQ58330213
Pierre WalletQ63968643
Igor GolovliovQ89121856
Fanny MichalQ89121858
Masahiro YamamotoQ89121862
Petr BrozQ37378371
Anders SjöstedtQ42406311
P2093author name stringEric Faudry
Pauline Basso
Omran Allatif
Etienne Meunier
Helena Lindgren
Amandine Martin
Brice Lagrange
Amandine Mosnier
Angelina Provost
Sacha Benaoudia
P2860cites workThe interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineageQ21184175
Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell deathQ21559499
Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Q22255523
GBP5 promotes NLRP3 inflammasome assembly and immunity in mammalsQ24310380
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteinsQ27621403
Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 ReceptorQ27678368
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophagesQ28250671
The dynamin superfamily: universal membrane tubulation and fission molecules?Q28252404
Cryopyrin activates the inflammasome in response to toxins and ATPQ28291313
Non-canonical inflammasome activation targets caspase-11Q28506831
The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in miceQ28511677
Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defenseQ28512319
A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infectionQ28593668
Interferon-induced guanylate-binding proteins in inflammasome activation and host defenseQ28595838
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesQ29614469
The AIM2 inflammasome is critical for innate immunity to Francisella tularensisQ29622833
Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASCQ30278975
Construction of a reporter plasmid for screening in vivo promoter activity in Francisella tularensisQ30772154
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell deathQ30827681
Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studiesQ33327569
Restricted cytosolic growth of Francisella tularensis subsp. tularensis by IFN-gamma activation of macrophagesQ33931556
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.Q34006614
Interferon-inducible effector mechanisms in cell-autonomous immunityQ34114819
Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophagesQ34145815
Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.Q34414371
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPasesQ34415551
Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells.Q34793115
Production of anti-LPS IgM by B1a B cells depends on IL-1β and is protective against lung infection with Francisella tularensis LVSQ35175319
cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infectionQ35199121
Minimal requirements for murine resistance to infection with Francisella tularensis LVS.Q35512763
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infectionQ35528340
In vivo negative selection screen identifies genes required for Francisella virulenceQ35699734
Factors affecting the escape of Francisella tularensis from the phagolysosomeQ57441686
A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondiiQ60621617
In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clustersQ83321178
Survival of secondary lethal systemic Francisella LVS challenge depends largely on interferon gammaQ84587925
Cutting edge: nitric oxide inhibits the NLRP3 inflammasomeQ85277117
Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia.Q36215032
Type I interferon signaling is required for activation of the inflammasome during Francisella infectionQ36229342
Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.Q36281253
Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axisQ36403658
Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replicationQ36512191
Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β.Q37040409
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.Q37090120
Listeria monocytogenes and the Inflammasome: From Cytosolic Bacteriolysis to Tumor ImmunotherapyQ37265333
A Francisella tularensis pathogenicity island required for intramacrophage growthQ37513704
Caspase-8 and bid: caught in the act between death receptors and mitochondriaQ37835913
Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genesQ38387800
Interferon-inducible GTPases in cell autonomous and innate immunityQ38634433
Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.Q38834935
Salmonella and the Inflammasome: Battle for Intracellular DominanceQ38909265
Francisella Inflammasomes: Integrated Responses to a Cytosolic Stealth Bacterium.Q38909303
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells.Q39883754
An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cellsQ39913009
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.Q40520196
Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandinsQ40629931
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicidaQ41429405
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.Q41764481
Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shockQ41970918
AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages.Q42252067
The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell SignalingQ42732048
Multiple Pseudomonas species secrete exolysin-like toxins and provoke Caspase-1-dependent macrophage deathQ46343933
The requirement of tumour necrosis factor-alpha and interferon-gamma for the expression of protective immunity to secondary murine tularaemia depends on the size of the challenge inoculumQ47330762
ASC controls IFN-γ levels in an IL-18-dependent manner in caspase-1-deficient mice infected with Francisella novicidaQ47703279
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectinflammasome complexQ412405
Francisella novicidaQ16982112
P304page(s)e1006630
P577publication date2017-10-02
P1433published inPLOS PathogensQ283209
P1476titleIFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection
P478volume13