Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B.

scientific article published on March 2006

Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/JB/MVJ037
P932PMC publication ID2376303
P698PubMed publication ID16567401
P5875ResearchGate publication ID7212683

P50authorEmmanuelle Liaudet-CoopmanQ74519771
P2093author name stringChristine Prébois
Nobuhiko Katunuma
Danielle Derocq
Valérie Laurent-Matha
P2860cites workIsolation and characterization of a stable activation intermediate of the lysosomal aspartyl protease cathepsin DQ28292267
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cellsQ28295485
Evolution in the structure and function of aspartic proteasesQ28300400
Neuronal loss and brain atrophy in mice lacking cathepsins B and LQ34030250
Enhanced degradation of cathepsin D synthesized in the presence of the threonine analog beta-hydroxynorvalineQ34259894
Multiple functions of pro-parts of aspartic proteinase zymogensQ34339858
Processing and activation of lysosomal proteinasesQ35055169
Catalytically inactive human cathepsin D triggers fibroblast invasive growthQ36321336
Proteolytic Activation of Human Procathepsin DQ37041771
Human proreninQ37687876
Lysosomal enzyme targetingQ37886057
Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cellsQ38331833
Structural evidence for gene duplication in the evolution of the acid proteasesQ39183165
Lysosomal enzymes and their receptorsQ39479416
A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cellsQ40701217
Specific mannose-6-phosphate receptor-independent sorting of pro-cathepsin D in breast cancer cellsQ41431024
Structural requirements of procathepsin D activation and maturationQ41467286
Autocrine growth stimulation of the MCF 7 breast cancer cells by the estrogen-regulated 52 K protein.Q41492398
Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.Q41926788
Effects of cysteine protease inhibitors on rabbit cathepsin D maturationQ41945044
Molecular aspects of the endocytic pathwayQ42992153
A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells.Q43785805
CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cellsQ44219923
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitroQ44312060
Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cellsQ45023221
Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors.Q47695846
Mechanisms and kinetics of procathepsin D activationQ47851176
Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2.Q47860602
Carboxyl-terminal proteolytic processing during biosynthesis of the lysosomal enzymes .beta.-glucuronidase and cathepsin DQ49487167
Processing of human cathepsin D in lysosomes in vitro.Q54453142
Proteolytic processing sites producing the mature form of human cathepsin DQ67576241
Effect of tunicamycin and endoglycosidase H and F on the estrogen regulated 52000-Mr protein secreted by breast cancer cellsQ69982982
Procathepsin D cannot autoactivate to cathepsin D at acid pHQ70612684
Role of glycosylation in the expression of human procathepsin DQ72017227
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
Proteases as prognostic markers in cancerQ77556803
Intramolecular activation of porcine pepsinogenQ93696517
P433issue3
P304page(s)363-371
P577publication date2006-03-01
P1433published inJournal of BiochemistryQ6294839
P1476titleProcessing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B
P478volume139

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cites work (P2860)
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Q47305008Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.
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