Physiological and pathophysiological aspects of ceramide

scientific article

Physiological and pathophysiological aspects of ceramide is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1152/AJPREGU.00416.2005
P698PubMed publication ID16352856
P5875ResearchGate publication ID7416886

P50authorErich GulbinsQ37611826
P2093author name stringPin Lan Li
P2860cites workReactive oxygen species limit neutrophil life span by activating death receptor signalingQ44967331
Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2*- production in the intact coronary endotheliumQ45096402
Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cellsQ45116558
Sphingosine 1-phosphate breakdown in plateletsQ45206456
Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphateQ45291431
Stimulation of erythrocyte ceramide formation by platelet-activating factorQ45291465
Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]Q46842083
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathwayQ46885906
CD95 rapidly clusters in cells of diverse originsQ47607398
Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell deathQ47954345
Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis.Q48970037
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.Q49165929
Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A.Q50527419
The active site of lysosomal sphingomyelinase: evidence for the involvement of hydrophobic and ionic groups.Q50931581
Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator.Q51662176
Ceramide enables fas to cap and kill.Q52542714
Host acid sphingomyelinase regulates microvascular function not tumor immunity.Q53879620
Observation of Topical Catalysis by Sphingomyelinase Coupled To MicrospheresQ57365739
Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteriaQ57369563
Ceramide-mediated clustering is required for CD95-DISC formationQ57369954
CD95 Signaling via Ceramide-rich Membrane RaftsQ57371964
UV-C Light Induces Raft-associated Acid Sphingomyelinase and JNK Activation and Translocation Independently on a Nuclear SignalQ57372335
Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patientsQ57375076
Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signallingQ58435118
Sphingosine Mediates the Immediate Negative Inotropic Effects of Tumor Necrosis Factor-α in the Adult Mammalian Cardiac MyocyteQ59192165
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutationsQ22254363
Cathepsin D targeted by acid sphingomyelinase-derived ceramideQ24529823
Cholesterol, lipid rafts, and diseaseQ24553188
Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosisQ24679716
Functional rafts in cell membranesQ27860768
Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase geneQ28116333
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapyQ28140319
Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell deathQ28213775
Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspringQ28219852
The fluid mosaic model of the structure of cell membranesQ28239890
Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblastsQ28241741
Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulationQ28284440
Kinase suppressor of Ras is ceramide-activated protein kinaseQ28307245
Involvement of the acid sphingomyelinase pathway in uva-induced apoptosisQ28361609
Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cellsQ28570949
Vav2 is an activator of Cdc42, Rac1, and RhoAQ28610652
The caveolae membrane systemQ29614726
NAD(P)H oxidase: role in cardiovascular biology and diseaseQ29616102
Functions of lipid rafts in biological membranesQ29616845
Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapyQ30044494
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout miceQ30881683
Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteineQ31145560
Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.Q31629166
Therapeutic strategies to reduce TNF-alpha mediated cardiac contractile depression following ischemia and reperfusionQ33640387
Apoptosis in myocardial ischemia-reperfusion.Q33692497
Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alphaQ42162100
Ceramide: a novel cell signaling mechanism for vasodilationQ42443114
LDLs impair vasomotor function of the coronary microcirculation: role of superoxide anionsQ42460475
Tumor necrosis factor inhibits stimulated but not basal release of nitric oxideQ42483715
Effects of neutral sphingomyelinase on phenylephrine-induced vasoconstriction and Ca(2+) mobilization in rat aortic smooth muscleQ42485139
Effects of tumor necrosis factor-alpha on basal and stimulated endothelium-dependent vasomotion in human resistance vesselQ42494359
Production and metabolism of ceramide in normal and ischemic-reperfused myocardium of ratsQ42505746
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.Q42555356
Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesiclesQ42825650
Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts.Q43508241
Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha. A novel feedback mechanism regulating cell deathQ43510191
Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteriesQ43590614
Molecular mechanisms of ceramide-mediated CD95 clusteringQ43642943
Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and effluxQ43752274
Differential NADPH- versus NADH-dependent superoxide production by phagocyte-type endothelial cell NADPH oxidaseQ43818610
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.Q43860697
PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cellsQ43997285
Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteriesQ44182978
Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteriesQ44210993
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane raftsQ44300453
Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cellsQ44539962
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.Q44712899
Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell deathQ44757012
Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramideQ33807705
Apoptotic mechanisms in acute renal failureQ33887907
Physiology and pathophysiology of sphingolipid metabolism and signalingQ33930354
Involvement of sphingomyelinases in TNF signaling pathwaysQ34042929
Participation of Rac GTPase activating proteins in the deactivation of the phagocytic NADPH oxidaseQ34145139
Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoproteinQ34206300
Membrane lipid microdomains and the role of PKCtheta in T cell activationQ34222554
Current perspective on the role of apoptosis in atherothrombotic diseaseQ34262829
Sphingolipid mediators in cardiovascular cell biology and pathologyQ34444896
Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aortaQ34555162
Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections.Q34731655
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
Pathogens: raft hijackersQ35183159
Function and regulation of the CD95 (APO-1/Fas) ligand in the immune systemQ35561571
Imaging immune cell interactions and functions: SMACs and the Immunological SynapseQ35682734
Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activityQ36048670
CD28 signals through acidic sphingomyelinaseQ36364947
Phospholipid unsaturation and plasma membrane organizationQ36406415
Calcium-independent activation of endothelial nitric oxide synthase by ceramideQ36546570
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglyceridesQ36657235
Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinasesQ36664164
Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids.Q36701948
Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activationQ38346649
Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramideQ39451271
Epidermal growth factor receptorsQ40124107
Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer (flip-flop) lipid motion in membranes.Q40311939
TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influxQ40437294
Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cellsQ40504942
Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts.Q40546049
Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells.Q40554384
Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomainsQ40559235
Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cellsQ40775470
CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosaQ40847899
Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cellsQ40853739
Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complexQ40858625
Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeaeQ40863681
Intracellular mechanisms of L-selectin induced cappingQ40947615
Interactions between the components of the human NADPH oxidase: intrigues in the phox familyQ41195261
Phosphorylation of Raf by ceramide-activated protein kinaseQ41270560
Role for ceramide in cell cycle arrest.Q41370969
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.Q41440948
Surgical implications of vascular endothelial physiologyQ41600713
Co-capping of ras proteins with surface immunoglobulins in B lymphocytesQ41721096
Role of acidic sphingomyelinase in Fas/CD95-mediated cell death.Q41725574
Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathwaysQ41846875
Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro.Q41855472
P433issue1
P921main subjectceramidesQ424213
pathophysiologyQ1135939
P304page(s)R11-26
P577publication date2006-01-01
P1433published inAmerican Journal of Physiology - Regulatory, Integrative and Comparative PhysiologyQ2201819
P1476titlePhysiological and pathophysiological aspects of ceramide
P478volume290

Reverse relations

cites work (P2860)
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