Current molecular models for NADPH oxidase regulation by Rac GTPase

scientific article

Current molecular models for NADPH oxidase regulation by Rac GTPase is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1182/BLOOD-2002-04-1149
P698PubMed publication ID12351373
P5875ResearchGate publication ID11105867

P2093author name stringGary M Bokoch
Becky A Diebold
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2692-2696
P577publication date2002-10-01
P1433published inBloodQ885070
P1476titleCurrent molecular models for NADPH oxidase regulation by Rac GTPase
P478volume100

Reverse relations

cites work (P2860)
Q33300467A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity
Q30478913A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox
Q42496593A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation.
Q28297425Activation and assembly of the NADPH oxidase: a structural perspective
Q24816906Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
Q40392011Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming growth factor-beta. Evidence for oxidative signaling through NADPH oxidase
Q28509300Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor
Q36445350Angiotensin II (AT1) receptors and NADPH oxidase regulate Cl- current elicited by beta1 integrin stretch in rabbit ventricular myocytes
Q39392738Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway
Q40516112Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2.
Q34338562Assembly of the phagocyte NADPH oxidase
Q35068684AtROP1 negatively regulates potato resistance to Phytophthora infestans via NADPH oxidase-mediated accumulation of H2O2.
Q36094307Bacterial cytotoxins: targeting eukaryotic switches
Q37141649Biological roles for the NOX family NADPH oxidases
Q39797161CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex
Q37031442Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis.
Q44693557Comparative functional analysis of the Rac GTPases
Q45940843Comparison of proton channel, phagocyte oxidase, and respiratory burst levels between human eosinophil and neutrophil granulocytes.
Q33360225Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway
Q40615763Continuous Translocation of Rac2 and the NADPH Oxidase Component p67 during Phagocytosis
Q36516796Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation?
Q39777000Cytotoxic necrotizing factor 1 enhances reactive oxygen species-dependent transcription and secretion of proinflammatory cytokines in human uroepithelial cells
Q34034054Cytotoxic necrotizing factor type 1 production by uropathogenic Escherichia coli modulates polymorphonuclear leukocyte function.
Q36809477Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases
Q36569018Dendritic cells and tumor microenvironment: a dangerous liaison
Q39533795Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1.
Q37600276Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells
Q44859194Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia
Q47282229Down-regulation of metallothionein, a reactive oxygen scavenger, by the small GTPase OsRac1 in rice
Q46370097Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos
Q33649841Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases
Q57372482Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis
Q35775396Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes
Q40303488FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways
Q42096094FcγR-driven release of IL-6 by macrophages requires NOX2-dependent production of reactive oxygen species
Q34186778Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes
Q34623486Function and design of the Nox1 system in vascular smooth muscle cells
Q33195014Functional analysis of barley RAC/ROP G‐protein family members in susceptibility to the powdery mildew fungus
Q46415573Heart failure and statins--why do we need a clinical trial?
Q42131004Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis
Q36492507Hyperosmotic activation of the CD95 death receptor system
Q36944179Hyperosmotic activation of the CD95 system
Q42163271Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
Q24311930Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism
Q38334917Identification of a novel tumor necrosis factor alpha-responsive region in the NCF2 promoter
Q45065483Important role for Rac1 in regulating reactive oxygen species generation and pulmonary arterial smooth muscle cell growth
Q35644145Inflammation and repeated infections in CGD: two sides of a coin
Q45154749Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle
Q37117160Inhibition of Rac1 reduces store overload-induced calcium release and protects against ventricular arrhythmia
Q83317779Inhibition of ceramide-redox signaling pathway blocks glomerular injury in hyperhomocysteinemic rats
Q35856880Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation
Q36436666Interactions between electron and proton currents in excised patches from human eosinophils
Q26775228Intracellular replication of the well-armed pathogen Burkholderia pseudomallei
Q24548021Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases
Q36200269Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity
Q36994594Lactosylceramide: a lipid second messenger in neuroinflammatory disease
Q57374193Leishmania donovani lipophosphoglycan blocks NADPH oxidase assembly at the phagosome membrane
Q21131305Leishmania promastigotes: building a safe niche within macrophages
Q91619991Life-span extension by pigmented rice bran in the model yeast Saccharomyces cerevisiae
Q37951442Lipid rafts and redox regulation of cellular signaling in cholesterol induced atherosclerosis
Q44172726Malaria circumsporozoite protein inhibits the respiratory burst in Kupffer cells
Q34764783Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress
Q44933466Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2.
Q37762865Mechanisms of degranulation in neutrophils
Q42132669Modulation of RhoGTPases improves the behavioral phenotype and reverses astrocytic deficits in a mouse model of Rett syndrome.
Q44550518Molecular recognition in dimerization between PB1 domains
Q54351044Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation.
Q33860500NADPH oxidase 1, a novel molecular source of ROS in hippocampal neuronal death in vascular dementia
Q30512262NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease
Q35296159NADPH oxidases: not just for leukocytes anymore!
Q24300616Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases
Q24316184Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity
Q37151978Nox enzymes in immune cells
Q28393242Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling
Q36110067Oxidative stress and cardiovascular risk: the role of vascular NAD(P)H oxidase and its genetic variants
Q38192646Oxidative stress-mediated effects of angiotensin II in the cardiovascular system
Q34414671PKCδ and θ possibly mediate FSH-induced mouse oocyte maturation via NOX-ROS-TACE cascade signaling pathway
Q34563843Phagocytosis of Leishmania donovani amastigotes is Rac1 dependent and occurs in the absence of NADPH oxidase activation
Q42697554Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis
Q36341274Physiological and pathophysiological aspects of ceramide
Q53582013Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation.
Q34430784Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.
Q39531687Polycyclic aromatic hydrocarbons induce migration in human hepatocellular carcinoma cells (HepG2) through reactive oxygen species-mediated p38 MAPK signal transduction
Q39684105Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase
Q42803988Rac signalling: a radical view
Q40349340Rac1-NADPH oxidase-regulated generation of reactive oxygen species mediates glutamate-induced apoptosis in SH-SY5Y human neuroblastoma cells
Q42609911Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.
Q36461947Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination
Q28388989Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Q36801016Reactive oxygen species in phagocytic leukocytes
Q46845199Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-gamma and attenuates the oxidative burst.
Q36456556Redox regulation of Ras and Rho GTPases: mechanism and function
Q42447237Reduced expression of flavocytochrome b558, a component of the NADPH oxidase complex, in neutrophils from patients with myelodysplasia
Q33753092Regulation of Adherens Junctions in Trabecular Meshwork Cells by Rac GTPase and their influence on Intraocular Pressure
Q26781628Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking
Q37179987Regulation of superoxide production in neutrophils: role of calcium influx
Q36857263Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance.
Q36912577Reperfusion syndrome: cellular mechanisms of microvascular dysfunction and potential therapeutic strategies
Q34552157Retracted: ATP Mediates NADPH Oxidase/ROS Generation and COX-2/PGE2 Expression in A549 Cells: Role of P2 Receptor-Dependent STAT3 Activation
Q64244340Rho-Family Small GTPases: From Highly Polarized Sensory Neurons to Cancer Cells
Q33689411Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat
Q30498776Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer.
Q37558943Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells
Q41080044Role of nucleotides and phosphoinositides in the stability of electron and proton currents associated with the phagocytic NADPH oxidase.
Q38193605Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task
Q36958966Selective Rac1 inhibition protects renal tubular epithelial cells from oxalate-induced NADPH oxidase-mediated oxidative cell injury
Q35165377Small GTPase 'Rop': molecular switch for plant defense responses.
Q58075704Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Q39466811Stable accumulation of p67phox at the phagosomal membrane and ROS production within the phagosome
Q36051340Synaptic localization of a functional NADPH oxidase in the mouse hippocampus
Q28264410TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF
Q97644542TaRac6 Is a Potential Susceptibility Factor by Regulating the ROS Burst Negatively in the Wheat-Puccinia striiformis f. sp. tritici Interaction
Q46427607The NADPH oxidase Cpnox1 is required for full pathogenicity of the ergot fungus Claviceps purpurea.
Q59326775The Plasma Membrane: A Platform for Intra- and Intercellular Redox Signaling
Q48347207The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1.
Q38301141The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome
Q34276805The general case for redox control of wound repair
Q33564954The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway
Q35132234The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease
Q33630157The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils
Q40591985The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly
Q37377623The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species
Q39850050The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death
Q33677016The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization
Q37694585Thiol redox systems and protein kinases in hepatic stellate cell regulatory processes
Q48083374Tobacco nectaries express a novel NADPH oxidase implicated in the defense of floral reproductive tissues against microorganisms
Q37779745Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment

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