| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Takehiko Ueyama | Q88081912 |
| P2093 | author name string | Takehiko Ueyama | |
| P2860 | cites work | Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation | Q24290357 |
| Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity | Q24306096 | ||
| Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia | Q24317492 | ||
| Nox1-dependent reactive oxygen generation is regulated by Rac1 | Q24320021 | ||
| Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous | Q24324252 | ||
| RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis | Q24531821 | ||
| Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9 | Q24534496 | ||
| Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases | Q24548021 | ||
| Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages | Q24557445 | ||
| The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis | Q24596918 | ||
| Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia | Q24601390 | ||
| A landscape of driver mutations in melanoma | Q24603357 | ||
| Immunological function in mice lacking the Rac-related GTPase RhoG | Q24603992 | ||
| The 'invisible hand': regulation of RHO GTPases by RHOGDIs | Q24606819 | ||
| Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma | Q24607661 | ||
| Identification of four new susceptibility loci for testicular germ cell tumour | Q36839486 | ||
| Role of the small GTPase Rac in p22phox-dependent NADPH oxidases | Q36855140 | ||
| Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis. | Q37031442 | ||
| Cdc42 deficiency causes ciliary abnormalities and cystic kidneys. | Q37119933 | ||
| Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation | Q37139797 | ||
| Deregulation of Rho GTPases in cancer | Q37214445 | ||
| Rac1 GTPase: a "Rac" of all trades. | Q37371665 | ||
| Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. | Q37373023 | ||
| Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss | Q37386996 | ||
| Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas | Q37612511 | ||
| Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas | Q37658327 | ||
| The diverse roles of Rac signaling in tumorigenesis | Q37863400 | ||
| Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis. | Q38131795 | ||
| Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task | Q38193605 | ||
| Neuronal polarization in vivo: Growing in a complex environment | Q38209719 | ||
| Formins as effector proteins of Rho GTPases | Q38219067 | ||
| Nox family NADPH oxidases: Molecular mechanisms of activation | Q38243365 | ||
| I'm coming to GEF you: Regulation of RhoGEFs during cell migration | Q38284377 | ||
| Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. | Q38307191 | ||
| Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation | Q24678428 | ||
| Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis | Q26744456 | ||
| Photoreceptor Sensory Cilium: Traversing the Ciliary Gate | Q26778955 | ||
| Modulation of osteoclast differentiation and bone resorption by Rho GTPases | Q26851553 | ||
| G17V RHOA: Genetic evidence of GTP-unbound RHOA playing a role in tumorigenesis in T cells | Q26863411 | ||
| Conditional gene expression in the mouse inner ear using Cre-loxP. | Q26991845 | ||
| Vav family exchange factors: an integrated regulatory and functional view | Q27026905 | ||
| Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks | Q27302773 | ||
| HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice. | Q27311312 | ||
| The small GTPase Rif is dispensable for platelet filopodia generation in mice | Q27318487 | ||
| A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase | Q27713259 | ||
| Regulation of phagocytosis by Rho GTPases | Q28081285 | ||
| Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency | Q28144652 | ||
| Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas | Q28207345 | ||
| RhoG regulates the neutrophil NADPH oxidase | Q28235204 | ||
| GDIs: central regulatory molecules in Rho GTPase activation | Q28253312 | ||
| Polyglycine expansions in eRF3/GSPT1 are associated with gastric cancer susceptibility | Q28259039 | ||
| Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase | Q28269266 | ||
| Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update) | Q28273669 | ||
| Hematologically important mutations: X-linked chronic granulomatous disease (third update) | Q28291147 | ||
| The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface | Q28506128 | ||
| Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons | Q28506696 | ||
| FGFR1 is required for the development of the auditory sensory epithelium | Q28513526 | ||
| Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion | Q28574211 | ||
| RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development | Q28585313 | ||
| Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit | Q28585974 | ||
| Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin | Q28587207 | ||
| Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain | Q28588826 | ||
| RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells | Q28589451 | ||
| The small GTPase Rac1 regulates auditory hair cell morphogenesis | Q28591364 | ||
| Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense | Q28609612 | ||
| The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes | Q77801010 | ||
| Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases | Q79176492 | ||
| Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells | Q79862685 | ||
| Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development | Q83565934 | ||
| ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing | Q84368835 | ||
| Translation Termination and Ribosome Recycling in Eukaryotes | Q88595715 | ||
| RHO GTPases in cancer: known facts, open questions, and therapeutic challenges | Q89000020 | ||
| Rho GTPases and their downstream effectors in megakaryocyte biology | Q89137902 | ||
| The Rac1 splice form Rac1b favors mouse colonic mucosa regeneration and contributes to intestinal cancer progression | Q89472949 | ||
| Cytoplasmic p27Kip1 promotes tumorigenesis via suppression of RhoB activity | Q91397072 | ||
| Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells. | Q50425907 | ||
| Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. | Q50695424 | ||
| Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets. | Q50710667 | ||
| miRNA-144 suppresses proliferation and migration of colorectal cancer cells through GSPT1. | Q51726569 | ||
| Progressive macrothrombocytopenia and hearing loss in a large family with DIAPH1 related disease. | Q53107734 | ||
| P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. | Q53240397 | ||
| GGCn polymorphism of eRF3a/GSPT1 gene and breast cancer susceptibility. | Q54338136 | ||
| Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia. | Q55059493 | ||
| Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay | Q55670363 | ||
| RecurrentRHOAmutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols | Q57270481 | ||
| Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice | Q58586679 | ||
| Phenotype description and response to thrombopoietin receptor agonist in -related disorder | Q58717272 | ||
| Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1 | Q59053220 | ||
| Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions | Q60220834 | ||
| Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling | Q63408326 | ||
| Rho signaling research: history, current status and future directions. | Q64884251 | ||
| Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma | Q35166408 | ||
| The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release | Q35173004 | ||
| Nox4: a hydrogen peroxide-generating oxygen sensor | Q35213232 | ||
| The Rho GTPase Cdc42 regulates hair cell planar polarity and cellular patterning in the developing cochlea. | Q35453418 | ||
| Gene Expression by Mouse Inner Ear Hair Cells during Development | Q35515541 | ||
| Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding | Q35562465 | ||
| Rac deletion in osteoclasts causes severe osteopetrosis | Q35576455 | ||
| RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency | Q35589474 | ||
| Cdc42 and sec10 Are Required for Normal Retinal Development in Zebrafish | Q35678795 | ||
| Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood | Q36469565 | ||
| Regulation of cell fate in the sensory epithelia of the inner ear. | Q36629867 | ||
| Transforming mutations of RAC guanosine triphosphatases in human cancers | Q36637506 | ||
| Studies on human eRF3-PABP interaction reveal the influence of eRF3a N-terminal glycin repeat on eRF3-PABP binding affinity and the lower affinity of eRF3a 12-GGC allele involved in cancer susceptibility | Q36791625 | ||
| Fluctuation of Rac1 activity is associated with the phenotypic and transcriptional heterogeneity of glioma cells | Q38479861 | ||
| Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein | Q38484900 | ||
| The cuticular plate: a riddle, wrapped in a mystery, inside a hair cell | Q38536077 | ||
| The Small Rho GTPase TC10 Modulates B Cell Immune Responses. | Q38659465 | ||
| The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer | Q38846822 | ||
| Stereocilia morphogenesis and maintenance through regulation of actin stability | Q38938244 | ||
| Inhibition of Rac1 activity induces G1/S phase arrest through the GSK3/cyclin D1 pathway in human cancer cells | Q38967474 | ||
| Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling | Q39085280 | ||
| A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma | Q39241800 | ||
| In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion | Q39383454 | ||
| Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia | Q39695439 | ||
| CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex | Q39797161 | ||
| eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development | Q39855036 | ||
| Sequential binding of cytosolic Phox complex to phagosomes through regulated adaptor proteins: evaluation using the novel monomeric Kusabira-Green System and live imaging of phagocytosis | Q39970291 | ||
| Membrane phosphatidylserine regulates surface charge and protein localization | Q40026492 | ||
| Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome | Q40388422 | ||
| Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. | Q40646102 | ||
| Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma | Q40881085 | ||
| Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma. | Q41004137 | ||
| Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP. | Q41262163 | ||
| Cytoskeletal Stability in the Auditory Organ In Vivo: RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development | Q41720505 | ||
| Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures | Q41739151 | ||
| Rho GTPases: Regulation and roles in cancer cell biology | Q41751754 | ||
| Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly | Q41772077 | ||
| RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes | Q41918465 | ||
| Cdc42 is crucial for facial and palatal formation during craniofacial development. | Q42254357 | ||
| Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. | Q42808195 | ||
| Rac1 regulates neuronal polarization through the WAVE complex | Q43059450 | ||
| A new locus for nonsyndromic hereditary hearing impairment, DFNA17, maps to chromosome 22 and represents a gene for cochleosaccular degeneration | Q43218224 | ||
| The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA. | Q43607245 | ||
| The GTP-binding release factor eRF3 as a key mediator coupling translation termination to mRNA decay | Q45037139 | ||
| Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. | Q45345920 | ||
| Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome | Q46063842 | ||
| Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. | Q46196991 | ||
| Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation. | Q46430126 | ||
| Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid | Q46795047 | ||
| Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish. | Q47074233 | ||
| Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis. | Q47239179 | ||
| Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. | Q47257087 | ||
| RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis | Q47637185 | ||
| Negative charges in the flexible N-terminal domain of Rho GDP-dissociation inhibitors (RhoGDIs) regulate the targeting of the RhoGDI-Rac1 complex to membranes | Q47849199 | ||
| Novel role of Rac-Mid1 signaling in medial cerebellar development. | Q48135016 | ||
| A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury | Q48166066 | ||
| Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas. | Q48177867 | ||
| Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma. | Q48197344 | ||
| RhoB: Team Oncogene or Team Tumor Suppressor? | Q49550467 | ||
| A hot-spot mutation in CDC42 (p.Tyr64Cys) and novel phenotypes in the third patient with Takenouchi-Kosaki syndrome. | Q50042736 | ||
| Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes. | Q50210065 | ||
| Identification of novel genetic causes of Rett syndrome-like phenotypes. | Q50307278 | ||
| Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2 | Q28609631 | ||
| Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function. | Q29347270 | ||
| GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors | Q29547630 | ||
| Mammalian Rho GTPases: new insights into their functions from in vivo studies | Q29615191 | ||
| A nucleator arms race: cellular control of actin assembly | Q29616146 | ||
| The interdependence of the Rho GTPases and apicobasal cell polarity | Q30009264 | ||
| Cochlear hair cells: The sound-sensing machines. | Q30370018 | ||
| Genetics of auditory mechano-electrical transduction | Q30421422 | ||
| Redundant functions of Rac GTPases in inner ear morphogenesis | Q30422406 | ||
| Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis | Q30478066 | ||
| A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox | Q30478913 | ||
| Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases | Q30491877 | ||
| PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils | Q30514916 | ||
| Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear. | Q30644335 | ||
| Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins. | Q30659759 | ||
| A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss. | Q30668593 | ||
| Nonmuscle myosin heavy chain IIA mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fechtner, Sebastian, Epstein, and Alport-like syndromes. | Q33339198 | ||
| Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. | Q33376049 | ||
| Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. | Q33388172 | ||
| Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias | Q33395195 | ||
| Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. | Q33397943 | ||
| Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. | Q33409152 | ||
| Extension of the clinical and molecular phenotype of DIAPH1-associated autosomal dominant hearing loss (DFNA1). | Q33436505 | ||
| Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization | Q33882828 | ||
| Generation and characterization of Atoh1-Cre knock-in mouse line | Q33912847 | ||
| Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner | Q34000136 | ||
| Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells | Q34160731 | ||
| Regulation of neutrophil function by Rac GTPases | Q34164956 | ||
| Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. | Q34276621 | ||
| Stem cell depletion through epidermal deletion of Rac1. | Q34440522 | ||
| Signaling role of Cdc42 in regulating mammalian physiology | Q34509197 | ||
| RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes | Q34611649 | ||
| The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4 | Q34787163 | ||
| Current molecular models for NADPH oxidase regulation by Rac GTPase | Q34915029 | ||
| Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly | Q35133906 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell polarity | Q189100 |
| neoplasm | Q1216998 | ||
| P304 | page(s) | 92 | |
| P577 | publication date | 2019-01-28 | |
| P1433 | published in | Cells | Q27724621 |
| P1476 | title | Rho-Family Small GTPases: From Highly Polarized Sensory Neurons to Cancer Cells | |
| P478 | volume | 8 |
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