Formins as effector proteins of Rho GTPases

scientific article

Formins as effector proteins of Rho GTPases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.4161/SGTP.29513
P932PMC publication ID4111664
P698PubMed publication ID24914801
P5875ResearchGate publication ID262977534

P50authorMatthias GeyerQ63363890
P2093author name stringSonja Kühn
P2860cites workCharacterization of Diaphanous-related formin FMNL2 in human tissuesQ21284188
Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in plateletsQ24307657
The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cellsQ24309382
Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesisQ24310527
Bi-modal regulation of a formin by srGAP2Q24315079
Structure of the autoinhibitory switch in formin mDia1.Q34493635
RhoB and the mammalian Diaphanous-related formin mDia2 in endosome traffickingQ34596684
The formin DAD domain plays dual roles in autoinhibition and actin nucleation.Q34683336
FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasionQ35005232
The formin mDia regulates GSK3beta through novel PKCs to promote microtubule stabilization but not MTOC reorientation in migrating fibroblastsQ35190950
RhoA and RhoC have distinct roles in migration and invasion by acting through different targetsQ35196063
Dynamic remodeling of the actin cytoskeleton by FMNL1γ is required for structural maintenance of the Golgi complexQ35210823
Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cordQ35690673
mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formationQ35763102
Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochordQ35800339
The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombeQ36323291
Cellular functions of the Spir actin-nucleation factorsQ36562415
Comparative gene expression analysis of the fmnl family of formins during zebrafish development and implications for tissue specific functionsQ36581924
Two distinct phosphorylation events govern the function of muscle FHOD3.Q36968593
Apical targeting of the formin Diaphanous in Drosophila tubular epitheliaQ36998821
IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusionsQ37063714
Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowthQ37177993
Spire and Cordon-bleu: multifunctional regulators of actin dynamicsQ37262049
Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.Q37446184
Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenanceQ24315677
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilinQ24316148
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formationQ24318404
The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamicsQ24319184
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migrationQ24321510
The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbingQ24322829
Planar cell polarity links axes of spatial dynamics in neural-tube closureQ24336656
FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophagesQ24551450
Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70Q24554501
A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilinQ24624729
Mechanism of activation of the Formin protein Daam1Q24657453
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-SrcQ24670372
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanismQ24679102
FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugationQ24680239
Structure of the FH2 domain of Daam1: implications for formin regulation of actin assemblyQ24681958
Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1.Q24682983
Stress fibers are generated by two distinct actin assembly mechanisms in motile cellsQ24683694
Formins at a glanceQ27009102
DAAM1 is a formin required for centrosome re-orientation during cell migrationQ27318753
Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cellsQ27333967
Diaphanous-related formin 2 and profilin I are required for gastrulation cell movementsQ27438166
The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activationQ27652093
Specificity of Interactions between mDia Isoforms and Rho ProteinsQ27652343
The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin ActivationQ27657671
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activationQ27659768
Crystal Structure of a Complex between Amino and Carboxy Terminal Fragments of mDia1: Insights into Autoinhibition of Diaphanous-Related ForminsQ27664937
Crystal Structure of the Formin mDia1 in Autoinhibited ConformationQ27664938
Structure, Dynamics, Lipid Binding, and Physiological Relevance of the Putative GTPase-binding Domain of Dictyostelium Formin CQ27671794
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsQ27860467
Formin Leaky Cap Allows Elongation in the Presence of Tight Capping ProteinsQ27935256
Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiaeQ27936679
RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation.Q45249865
Control of the assembly of ATP- and ADP-actin by formins and profilin.Q45345926
The filamentous actin cross-linking/bundling activity of mammalian formins.Q46331574
Structural and mechanistic insights into the interaction between Rho and mammalian Dia.Q46466555
The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia.Q46503087
Formin-induced actin cables are required for polarized recruitment of the Ste5 scaffold and high level activation of MAPK Fus3.Q46551366
Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filamentQ46556615
The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton.Q46937541
High expression of FMNL1 protein in T non-Hodgkin's lymphomasQ46957907
ForC lacks canonical formin activity but bundles actin filaments and is required for multicellular development of Dictyostelium cellsQ47882536
FMNL1 promotes proliferation and migration of leukemia cells.Q50337087
Structural basis of Rho GTPase-mediated activation of the formin mDia1.Q50337106
Mutations in the Rho1 small GTPase disrupt morphogenesis and segmentation during early Drosophila development.Q52173284
T cell responses in mammalian diaphanous-related formin mDia1 knock-out mice.Q52580057
Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis.Q53082928
WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2.Q53782742
FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibersQ56964060
The small GTPase Rho3 and the diaphanous/formin For3 function in polarized cell growth in fission yeastQ78470457
Dynamic localization and function of Bni1p at the sites of directed growth in Saccharomyces cerevisiaeQ27937372
Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeastQ27939574
Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiaeQ27940300
Aurora B regulates formin mDia3 in achieving metaphase chromosome alignmentQ28119054
Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2Q28144520
Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42Q28188673
The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response elementQ28190692
Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cellsQ28199851
mDia mediates Rho-regulated formation and orientation of stable microtubulesQ28210597
Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formationQ28212226
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1Q28214701
Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architectureQ28248937
Cdc42 and mDia3 regulate microtubule attachment to kinetochoresQ28256623
Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulationQ28267022
Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7Q28267048
Formin-like 2 drives amoeboid invasive cell motility downstream of RhoCQ28271418
Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1Q28287470
Mechanism and function of formins in the control of actin assemblyQ28293947
FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movementQ28505650
Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heartQ28513956
Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated musclesQ28571176
Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2Q28586161
The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibitionQ28586353
Cooperation between mDia1 and ROCK in Rho-induced actin reorganizationQ28587275
Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signalingQ28646114
Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesisQ29347301
Regulation of actin filament assembly by Arp2/3 complex and forminsQ29615161
A nucleator arms race: cellular control of actin assemblyQ29616146
The BAR domain superfamily: membrane-molding macromoleculesQ30014845
Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex.Q30158011
Regulation of the formin for3p by cdc42p and bud6pQ30480139
Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and CappuccinoQ30480159
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cellsQ30481840
Regulation and targeting of the fission yeast formin cdc12p in cytokinesisQ30481843
The microtubule-binding protein CLIP-170 coordinates mDia1 and actin reorganization during CR3-mediated phagocytosisQ30485142
Characterization of the biochemical properties and biological function of the formin homology domains of Drosophila DAAM.Q30494160
Assembly of filopodia by the formin FRL2 (FMNL3)Q30497461
The formin FRL1 (FMNL1) is an essential component of macrophage podosomesQ30505923
RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.Q30528815
Rocket launcher mechanism of collaborative actin assembly defined by single-molecule imagingQ30538297
The formins FMNL1 and mDia1 regulate coiling phagocytosis of Borrelia burgdorferi by primary human macrophagesQ30539638
The formin FMNL3 is a cytoskeletal regulator of angiogenesisQ30539874
Directing exocrine secretory vesicles to the apical membrane by actin cables generated by the formin mDia1.Q30541010
Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.Q30541101
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motilityQ30547698
Analysis of the local organization and dynamics of cellular actin networksQ30547708
Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domainQ31465756
Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.Q34043243
RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinaseQ34176256
The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed endsQ34233588
Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt.Q34273594
The mouse formin, FRLalpha, slows actin filament barbed end elongation, competes with capping protein, accelerates polymerization from monomers, and severs filamentsQ34301887
An 8.9 Mb 19p13 duplication associated with precocious puberty and a sporadic 3.9 Mb 2q23.3q24.1 deletion containing NR4A2 in mentally retarded members of a family with an intrachromosomal 19p-into-19q between-arm insertionQ34326690
EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migrationQ34341177
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesisQ34422795
Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domainsQ34489876
FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migrationQ37473452
The role of formins in human disease.Q37639554
Fifteen formins for an actin filament: a molecular view on the regulation of human formins.Q37681690
WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyondQ37796281
Structural and functional insights into the Spir/formin actin nucleator complexQ38122288
Physiological roles of Rho and Rho effectors in mammalsQ38158776
Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity.Q38460722
FMNL2 is a positive regulator of cell motility and metastasis in colorectal carcinomaQ38502636
FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers.Q39028670
Formin-mediated actin polymerization promotes Salmonella invasionQ39123404
Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase.Q39289697
Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1.Q39372922
The multiplicity of human formins: Expression patterns in cells and tissuesQ39427797
Enhancement of mDia2 activity by Rho-kinase-dependent phosphorylation of the diaphanous autoregulatory domainQ39519441
Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapseQ39546199
FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transitionQ39632868
The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structuresQ39851210
Filopodia formation induced by active mDia2/Drf3.Q39858881
Formin proteins of the DAAM subfamily play a role during axon growth.Q39909551
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2.Q40014693
The diaphanous inhibitory domain/diaphanous autoregulatory domain interaction is able to mediate heterodimerization between mDia1 and mDia2.Q40089959
Identification of genes downregulated in tumor cells expressing antisense glutaminase mRNA by differential displayQ40350138
RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1.Q40412034
Structure and activity of full-length formin mDia1Q41762564
Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons.Q41830984
Rho and anillin-dependent control of mDia2 localization and function in cytokinesisQ41854360
FMNL2 drives actin-based protrusion and migration downstream of Cdc42.Q42188467
FORMIN stable kinetochore-microtubule attachmentsQ42534187
The basic region of the diaphanous-autoregulatory domain (DAD) is required for autoregulatory interactions with the diaphanous-related formin inhibitory domainQ42675963
Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene.Q42687958
Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movementsQ42791086
Activation of the Rac-binding partner FHOD1 induces actin stress fibers via a ROCK-dependent mechanismQ42799513
Interaction of the N- and C-terminal autoregulatory domains of FRL2 does not inhibit FRL2 activity.Q42807829
The Rho family GTPase Rif induces filopodia through mDia2.Q42818923
Nuclear actin network assembly by formins regulates the SRF coactivator MAL.Q42823636
Phospholipids regulate localization and activity of mDia1 forminQ42824761
Actin filament bundling and different nucleating effects of mouse Diaphanous-related formin FH2 domains on actin/ADF and actin/cofilin complexesQ42876929
The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2.Q43056651
The regulation of mDia1 by autoinhibition and its release by Rho*GTP.Q43192533
Formin mDia1 senses and generates mechanical forces on actin filamentsQ44189807
The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxisQ44312178
F- and G-actin homeostasis regulates mechanosensitive actin nucleation by forminsQ44627297
Actin polymerization-driven molecular movement of mDia1 in living cellsQ44814909
Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysisQ45126402
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P921main subjectenzymeQ8047
fetal proteinsQ5445910
peptideQ172847
transport proteinQ2111029
nuclear proteinQ16860021
cytoskeletal proteinsQ66563066
macromolecular substanceQ75174158
P304page(s)e29513
P577publication date2014-06-10
P1433published inSmall GTPases (journal)Q15709529
P1476titleFormins as effector proteins of Rho GTPases
P478volume5

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