Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases

scientific article

Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.26.6.2160-2174.2006
P3181OpenCitations bibliographic resource ID1813375
P932PMC publication ID1430270
P698PubMed publication ID16507994

P2093author name stringThomas L Leto
Miklós Geiszt
Takehiko Ueyama
P2860cites workCell transformation by the superoxide-generating oxidase Mox1Q22010372
Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH OxidasesQ24300616
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targetsQ24328957
Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutationQ24678428
Structure of the TPR domain of p67phox in complex with Rac.GTPQ27628646
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide productionQ28114945
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and GolgiQ28140190
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5Q28190953
Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidaseQ28249779
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidaseQ28277982
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.Q46196991
NAD(P)H oxidases in rat basilar arterial endothelial cells.Q46450271
Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.Q46887698
Characterization of neutrophil NADPH oxidase factors p47-phox and p67-phox from recombinant baculoviruses.Q52447388
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1Q59053220
Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophilsQ69063590
The cytosolic component p47(phox) is not a sine qua non participant in the activation of NADPH oxidase but is required for optimal superoxide productionQ71825234
Characterization of the effector-specifying domain of Rac involved in NADPH oxidase activationQ71996707
Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assemblyQ73010796
NADPH oxidaseQ75301478
NOX3, a superoxide-generating NADPH oxidase of the inner earQ28278418
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathwaysQ28571066
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1Q28585409
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defenseQ28609612
Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidaseQ28609613
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2Q28609631
NOX enzymes and the biology of reactive oxygenQ29547517
NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) DomainQ30164408
Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cellsQ30164806
Specificity of p47phox SH3 domain interactions in NADPH oxidase assembly and activationQ30176592
NADPH oxidase activity is independent of p47phox in vitroQ30176826
Assembly and activation of the phagocyte NADPH oxidase. Specific interaction of the N-terminal Src homology 3 domain of p47phox with p22phox is required for activation of the NADPH oxidaseQ30176829
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidaseQ30194274
The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activatorsQ33213948
The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophilsQ33630157
NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cellsQ33916755
NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytesQ34207369
Ultrastructural localization of cytochrome b in the membranes of resting and phagocytosing human granulocytesQ34245500
Nox3 regulation by NOXO1, p47phox, and p67phox.Q34324985
Assembly of the phagocyte NADPH oxidaseQ34338562
Analysis of mRNA transcripts from the NAD(P)H oxidase 1 (Nox1) gene. Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variantQ34349277
Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3.Q34425599
Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.Q34430784
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
Molecular mechanism for activation of superoxide-producing NADPH oxidases.Q35638899
The Nox family of NAD(P)H oxidases: host defense and beyondQ35886272
Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2.Q37732032
Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosomeQ40388422
Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cellsQ40587011
Biosynthesis of flavocytochrome b558 . gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum.Q40975170
Two forms of autosomal chronic granulomatous disease lack distinct neutrophil cytosol factors.Q42001699
Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunitsQ42835038
A fusion protein between rac and p67phox (1-210) reconstitutes NADPH oxidase with higher activity and stability than the individual componentsQ43797270
Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1.Q43809961
A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheismQ43918747
Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimerasQ44755199
Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cellsQ45094684
Functional association of nox1 with p22phox in vascular smooth muscle cellsQ45100914
Expression and localization of NOX2 and NOX4 in primary human endothelial cellsQ45261476
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)2160-74
P577publication date2006-03-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleInvolvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases
P478volume26

Reverse relations

cites work (P2860)
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