Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity

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Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity is …
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scholarly articleQ13442814

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P356DOI10.1126/SCISIGNAL.2000370
P932PMC publication ID2850287
P698PubMed publication ID19755710
P5875ResearchGate publication ID26813532

P50authorBegoña DíazQ57080149
P2093author name stringDavide Gianni
Gary M Bokoch
Nicolas Taulet
Sara A Courtneidge
Bruce Fowler
P2860cites workCell transformation by the superoxide-generating oxidase Mox1Q22010372
Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1Q24291189
Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH OxidasesQ24300616
Nox1-dependent superoxide production controls colon adenocarcinoma cell migrationQ24300861
Src family kinases in tumor progression and metastasisQ24311656
Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanismQ24311930
Nox1-dependent reactive oxygen generation is regulated by Rac1Q24320021
A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivoQ24322028
A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrateQ24533279
Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidasesQ24548021
The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formationQ24647032
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiologyQ27860991
The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cellsQ28180409
p40phox: the last NADPH oxidase subunitQ28267507
Assembly and biological role of podosomes and invadopodiaQ28272503
NOX3, a superoxide-generating NADPH oxidase of the inner earQ28278418
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen speciesQ28282131
The matrix corroded: podosomes and invadopodia in extracellular matrix degradationQ28286690
Activation and assembly of the NADPH oxidase: a structural perspectiveQ28297425
NOX enzymes and the biology of reactive oxygenQ29547517
Reactive oxygen species in cell signalingQ29615243
A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidaseQ30157443
Sequential signals toward podosome formation in NIH-src cells.Q30157646
The SRC substrate Tks5, podosomes (invadopodia), and cancer cell invasionQ30159706
The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cellsQ30160317
Dynamin participates in focal extracellular matrix degradation by invasive cellsQ30477655
A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phoxQ30478913
Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosomeQ30484229
Reactive oxygen species regulate F-actin dynamics in neuronal growth cones and neurite outgrowthQ30497525
Isolation of novel Src substratesQ30883343
Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1.Q30961526
Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymesQ33300608
Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexesQ34233390
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cellsQ34283019
Assembly of the phagocyte NADPH oxidaseQ34338562
Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteinsQ34411802
The Phox (PX) domain proteins and membrane trafficQ34539521
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
The superoxide-generating NADPH oxidase: structural aspects and activation mechanismQ35003216
The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cellsQ35221860
NADPH oxidases: not just for leukocytes anymore!Q35296159
Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidasesQ35829421
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropyQ36052377
Specificity in reactive oxidant signaling: think globally, act locallyQ36118494
Redox redux: revisiting PTPs and the control of cell signalingQ36151514
Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.Q36301037
Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networksQ36319228
Subcellular targeting of oxidants during endothelial cell migrationQ36320521
Redox signaling in angiogenesis: role of NADPH oxidaseQ36509981
Localizing NADPH oxidase-derived ROS.Q36574300
NADPH oxidases in the gastrointestinal tract: a potential role of Nox1 in innate immune response and carcinogenesisQ36598808
The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1.Q36739856
Role of the small GTPase Rac in p22phox-dependent NADPH oxidasesQ36855140
Regulation of Nox and Duox enzymatic activity and expressionQ36865824
NOX enzymes as novel targets for drug developmentQ37176104
Reactive oxygen species regulate a slingshot-cofilin activation pathwayQ37207711
Compartmentalization of redox signaling through NADPH oxidase-derived ROS.Q37322476
Inhibitors of the leukocyte superoxide generating oxidase: mechanisms of action and methods for their elucidationQ37876022
Sequential binding of cytosolic Phox complex to phagosomes through regulated adaptor proteins: evaluation using the novel monomeric Kusabira-Green System and live imaging of phagocytosisQ39970291
Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidaseQ40047105
Molecular imaging of hydrogen peroxide produced for cell signalingQ40151095
Redox changes of cultured endothelial cells and actin dynamicsQ40893463
Superoxide production and expression of NAD(P)H oxidases by transformed and primary human colonic epithelial cellsQ42113918
The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cellsQ42487257
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells.Q42513515
A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cellsQ42931877
Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling.Q43755949
Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migrationQ44826979
NADPH oxidase mediates vascular endothelial cadherin phosphorylation and endothelial dysfunctionQ44991524
IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2.Q46716879
Airway epithelial cell migration and wound repair by ATP-mediated activation of dual oxidase 1.Q54569525
P433issue88
P407language of work or nameEnglishQ1860
P921main subjectSH3 and PX domains 2AQ21113815
SH3 and PX domains 2BQ21135654
NADPH oxidase 1Q21149712
NADPH oxidase organizer 1Q21245847
NADPH oxidase activator 1Q21245957
P304page(s)ra54
P577publication date2009-09-15
P1433published inScience SignalingQ7433604
P1476titleNovel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity
P478volume2

Reverse relations

cites work (P2860)
Q33660799A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells
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Q24338017Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation
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Q34361024c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells

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