Subcellular targeting of oxidants during endothelial cell migration

scientific article

Subcellular targeting of oxidants during endothelial cell migration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.200507004
P932PMC publication ID2171295
P698PubMed publication ID16330715
P5875ResearchGate publication ID7438337

P2093author name stringFiemu E Nwariaku
George A Sarosi
Lance S Terada
Ru Feng Wu
Zhenyi Ma
You Cheng Xu
P2860cites workSrc-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1Q24300651
Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17Q24303880
Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape changeQ24313072
PAK kinases are directly coupled to the PIX family of nucleotide exchange factorsQ24313368
Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesionsQ24318621
Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.Q24534150
Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassemblyQ24552051
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motilityQ24554511
Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant productionQ24610688
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexesQ24647211
Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblastsQ24670333
Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodelingQ24682031
Cell migration: integrating signals from front to backQ27860670
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaQ27861126
Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domainQ28139714
Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblastsQ28189042
Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinaseQ28218739
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatasesQ28239642
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitmentQ28255124
RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent mannerQ28263831
Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2Q28363240
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migrationQ28505302
SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motilityQ28508471
Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesisQ28609623
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivoQ29615579
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassemblyQ29616029
TNFalpha activates c-Jun amino terminal kinase through p47(phox).Q30167744
Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activityQ30167760
A role for p21-activated kinase in endothelial cell migration.Q30175310
Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby actiQ30175312
Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulationQ30176025
Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1.Q30961526
Integrins regulate Rac targeting by internalization of membrane domainsQ34295045
Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.Q34451462
The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesisQ35203423
The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesisQ35763251
Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts.Q36322203
Discrete Functions of TRAF1 and TRAF2 in Drosophila melanogaster Mediated by c-Jun N-Terminal Kinase and NF-κB-Dependent Signaling PathwaysQ37057398
Calpain-mediated proteolysis of talin regulates adhesion dynamicsQ40510946
SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathwayQ40550696
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid raftsQ40572781
The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assemblyQ40591985
Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation.Q40737797
Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylationQ40808033
Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascadesQ40865574
Redox changes of cultured endothelial cells and actin dynamicsQ40893463
Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophagesQ41123408
Nanometer targeting of microtubules to focal adhesionsQ42014043
Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion.Q42048391
Interplay between Rac and Rho in the control of substrate contact dynamicsQ42814213
PTP-PEST controls motility through regulation of Rac1.Q44177182
Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathwayQ44212411
Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinaseQ44502573
A PTP-PEST-like protein affects alpha5beta1-integrin-dependent matrix assembly, cell adhesion, and migration in Xenopus gastrulaQ44734379
A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinaseQ47987718
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.Q52102307
Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn.Q54047415
Rac1 regulates stress-induced, redox-dependent heat shock factor activationQ64380518
Probing cellular protein targets of H2O2 with fluorescein-conjugated iodoacetamide and antibodies to fluoresceinQ77715240
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
cell migrationQ189092
P1104number of pages12
P304page(s)893-904
P577publication date2005-12-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleSubcellular targeting of oxidants during endothelial cell migration
P478volume171

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