Activation and assembly of the NADPH oxidase: a structural perspective

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Activation and assembly of the NADPH oxidase: a structural perspective is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1042/BJ20041835
P8608Fatcat IDrelease_hksujqtdmjbdta7tnaybasy4bq
P3181OpenCitations bibliographic resource ID3302452
P932PMC publication ID1134858
P698PubMed publication ID15588255

P50authorKatrin RittingerQ21264208
P2093author name stringYvonne Groemping
P2860cites workThe structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathwaysQ24291216
Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactionsQ24291510
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphateQ24291846
Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking"Q24291961
Killing activity of neutrophils is mediated through activation of proteases by K+ fluxQ24292504
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for RacQ24294423
Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 functionQ24298671
Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interactionQ24307993
PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62Q24312088
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous diseaseQ24319232
Modulation of p47 PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidaseQ34982130
The superoxide-generating NADPH oxidase: structural aspects and activation mechanismQ35003216
Oxidant signals and oxidative stressQ35089394
NADPH oxidases: not just for leukocytes anymore!Q35296159
Oxidative killing of microbes by neutrophilsQ35582200
GTPases and reactive oxygen species: switches for killing and signalingQ35607959
The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesisQ35763251
The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systemsQ35828194
Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidasesQ35829421
The Nox family of NAD(P)H oxidases: host defense and beyondQ35886272
Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidaseQ36165558
A structural model for the nucleotide binding domains of the flavocytochrome b-245 beta-chainQ36277673
A domain of p47phox that interacts with human neutrophil flavocytochrome b558.Q36685379
Topological mapping of neutrophil cytochrome b epitopes with phage-display librariesQ36688465
Regulation of NADPH oxidase activity by Rac GTPase activating protein(s).Q37376598
Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox).Q38336129
Continuous Translocation of Rac2 and the NADPH Oxidase Component p67 during PhagocytosisQ40615763
Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phoxQ40674156
Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiencyQ40816848
Biosynthesis of flavocytochrome b558 . gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum.Q40975170
Electron transfer in the superoxide-generating NADPH oxidase complex reconstituted in vitroQ41116252
The GTP binding motif: variations on a themeQ41198113
The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteinsQ41603615
Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase.Q41620128
NADPH dehydrogenase activity of p67PHOX, a cytosolic subunit of the leukocyte NADPH oxidaseQ41650267
Simultaneous presence of p47(phox) and flavocytochrome b-245 are required for the activation of NADPH oxidase by anionic amphiphiles. Evidence for an intermediate state of oxidase activationQ41666467
Analysis of glycosylation sites on gp91phox, the flavocytochrome of the NADPH oxidase, by site-directed mutagenesis and translation in vitroQ41840237
p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domainsQ24324646
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targetsQ24328957
Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophilsQ24329084
Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phoxQ24528599
The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactionsQ24533152
The Phox homology (PX) domain, a new player in phosphoinositide signallingQ24533547
Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phoxQ24534192
A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phoxQ24603771
Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?Q24674641
156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phoxQ24679525
Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activationQ24681540
The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDIQ27621179
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDIQ27621400
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machineQ27622332
Structure of the TPR domain of p67phox in complex with Rac.GTPQ27628646
The active N-terminal region of p67phox. Structure at 1.8 A resolution and biochemical characterizations of the A128V mutant implicated in chronic granulomatous diseaseQ27630753
Solution structure of the PX domain, a target of the SH3 domainQ27632043
Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13pQ27639477
Molecular basis of phosphorylation-induced activation of the NADPH oxidaseQ27641143
The PB1 domain and the PC motif-containing region are structurally similar protein binding modulesQ27642246
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogueQ27734818
The GTPase superfamily: conserved structure and molecular mechanismQ27860524
Rho GTPases in cell biologyQ27860969
Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.Q27933674
The guanine nucleotide-binding switch in three dimensionsQ28131710
The tetratricopeptide repeat: a structural motif mediating protein-protein interactionsQ28145758
Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phoxQ28205560
The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domainQ28206438
Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidasesQ28213110
Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phoxQ28215817
A novel cytosolic component, p40phox, of respiratory burst oxidase associates with p67phox and is absent in patients with chronic granulomatous disease who lack p67phoxQ28251613
Regulation of the human neutrophil NADPH oxidase by rho-related G-proteinsQ28269651
Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox)Q28273527
p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation processQ28287891
Topology of cytochrome b558 in neutrophil membrane analyzed by anti-peptide antibodies and proteolysisQ28288636
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptorsQ28293826
The GTPase superfamily: a conserved switch for diverse cell functionsQ28302983
p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domainQ28306699
Phosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activityQ28349250
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defenseQ28609612
Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidaseQ28609613
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2Q28609631
The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinasesQ28609645
NADPH oxidase: an updateQ28611494
Rho GTPases and signaling networksQ28646215
NOX enzymes and the biology of reactive oxygenQ29547517
TPR proteins: the versatile helixQ29547585
Rho GTPases and their effector proteinsQ29547740
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivoQ29615579
G protein mechanisms: insights from structural analysisQ29618461
The PX domains of p47phox and p40phox bind to lipid products of PI(3)KQ30016925
A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidaseQ30164072
Solution structure of the tandem Src homology 3 domains of p47phox in an autoinhibited formQ30164100
PX domain takes shapeQ30165014
The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.Q30165057
Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidaseQ30175140
Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby actiQ30175312
Activation of the phagocyte NADPH oxidase protein p47(phox). Phosphorylation controls SH3 domain-dependent binding to p22(phox).Q30175411
The PC motif: a novel and evolutionarily conserved sequence involved in interaction between p40phox and p67phox, SH3 domain-containing cytosolic factors of the phagocyte NADPH oxidaseQ30176279
Specificity of p47phox SH3 domain interactions in NADPH oxidase assembly and activationQ30176592
NADPH oxidase activity is independent of p47phox in vitroQ30176826
Assembly and activation of the phagocyte NADPH oxidase. Specific interaction of the N-terminal Src homology 3 domain of p47phox with p22phox is required for activation of the NADPH oxidaseQ30176829
Interactions between cytosolic components of the NADPH oxidase: p40phox interacts with both p67phox and p47phoxQ30176875
Topological organization of the cytosolic activating complex of the superoxide-generating NADPH-oxidase. Pinpointing the sites of interaction between p47phoz, p67phox and p40phox using the two-hybrid system.Q30176942
An SH3 domain-mediated interaction between the phagocyte NADPH oxidase factors p40phox and p47phoxQ30176967
Mapping the domains of interaction of p40phox with both p47phox and p67phox of the neutrophil oxidase complex using the two-hybrid system.Q30193582
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidaseQ30194274
An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complexQ30194338
Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase componentsQ30195706
Chronic granulomatous disease.Q30335769
Phage display epitope mapping of human neutrophil flavocytochrome b558. Identification of two juxtaposed extracellular domainsQ30940086
Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burstQ31806719
Molecular basis for Rac2 regulation of phagocyte NADPH oxidaseQ32063730
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activityQ33292285
Potential drug targets: small GTPases that regulate leukocyte functionQ33720590
Phagocytes and oxidative stressQ33998363
Assembly of the neutrophil respiratory burst oxidase: a direct interaction between p67PHOX and cytochrome b558 II.Q34047289
Mapping sites of interaction of p47-phox and flavocytochrome b with random-sequence peptide phage display librariesQ34104041
Regulation of neutrophil function by Rac GTPasesQ34164956
Evaluation of the process for superoxide production by NADPH oxidase in human neutrophils: evidence for cytoplasmic origin of superoxideQ34238897
Assembly of the phagocyte NADPH oxidaseQ34338562
Location, location, location: membrane targeting directed by PX domainsQ34453921
Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factorQ34471453
The PX domain: a new phosphoinositide-binding moduleQ34555240
Assembly of the neutrophil respiratory burst oxidase: a direct interaction between p67PHOX and cytochrome b558.Q34689181
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
Stoichiometry of p22-phox and gp91-phox in phagocyte cytochrome b558Q70801464
Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65Q71245916
Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNKQ71743139
The cytosolic component p47(phox) is not a sine qua non participant in the activation of NADPH oxidase but is required for optimal superoxide productionQ71825234
Reconstitution of Flavin-depleted Neutrophil Flavocytochrome b558 with 8-Mercapto-FAD and Characterization of the Flavin-reconstituted EnzymeQ71869440
The mechanism of electron donation to molecular oxygen by phagocytic cytochrome b558Q72149265
Photoaffinity labeling and photoinactivation of the O2(-)-generating oxidase of neutrophils by an azido derivative of FADQ72528351
Superoxide production by cytochrome b559. Mechanism of cytosol-independent activationQ72771070
Critical assessment of the presence of an NADPH binding site on neutrophil cytochrome b558 by photoaffinity and immunochemical labelingQ72908801
Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assemblyQ73010796
The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophilsQ73112969
A phosphatidic acid-activated protein kinase and conventional protein kinase C isoforms phosphorylate p22(phox), an NADPH oxidase componentQ73263512
Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assemblyQ73337967
Phosphorylation of the respiratory burst oxidase subunit p67(phox) during human neutrophil activation. Regulation by protein kinase C-dependent and independent pathwaysQ73456376
Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidaseQ73520876
Phosphorylation of p22phox is mediated by phospholipase D-dependent and -independent mechanisms. Correlation of NADPH oxidase activity and p22phox phosphorylationQ73993853
Indication of a protein kinase C-independent pathway for NADPH oxidase activation in human neutrophilsQ74079178
P67-phox-mediated NADPH oxidase assembly: imaging of cytochrome b558 liposomes by atomic force microscopyQ74103991
The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558)Q78101657
Activation domain in P67phox regulates the steady state reduction of FAD in gp91phoxQ79286389
Direct interaction between p47phox and protein kinase C: evidence for targeting of protein kinase C by p47phox in neutrophilsQ41968271
The major phosphorylation site of the NADPH oxidase component p67phox is Thr233.Q42123357
Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptidesQ42163381
Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.Q42509458
Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunitsQ42835038
Cytochrome b-245 from human neutrophils is a glycoproteinQ42849534
p40(phox) Participates in the activation of NADPH oxidase by increasing the affinity of p47(phox) for flavocytochrome b(558).Q42996911
Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox).Q43645354
The cytosolic components of the respiratory burst oxidase exist as a M(r) approximately 240,000 complex that acquires a membrane-binding site during activation of the oxidase in a cell-free systemQ43680605
The PX domain as a novel phosphoinositide- binding moduleQ43742589
Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1.Q43809961
The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides.Q43812779
Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent.Q43918731
A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheismQ43918747
Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail.Q43984235
Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activationQ44022525
Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors.Q44172192
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidaseQ44283104
Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity.Q44287543
Phosphorylation of the NADPH Oxidase Component p67PHOX by ERK2 and P38MAPK: Selectivity of Phosphorylated Sites and Existence of an Intramolecular Regulatory Domain in the Tetratricopeptide-Rich RegionQ44402446
Akt Phosphorylates p47phoxand Mediates Respiratory Burst Activity in Human NeutrophilsQ44432151
Functional epitope on human neutrophil flavocytochrome b558.Q44470204
Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.Q44581701
The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functionsQ44608965
Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimerasQ44755199
Phosphorylated p40PHOX as a negative regulator of NADPH oxidaseQ44808558
Isolation of a complex of respiratory burst oxidase components from resting neutrophil cytosolQ44914871
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.Q44915718
p47(phox) PX domain of NADPH oxidase targets cell membrane via moesin-mediated association with the actin cytoskeletonQ44947580
Phosphorylation of p40-phox during activation of neutrophil NADPH oxidase.Q46145994
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.Q46196991
Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide adenine dinucleotide phosphate (reduced) oxidaseQ46412280
Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic oxidase components p47phox and p67phox to the submembranous actin cytoskeleton during oQ46450269
Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinaseQ46600114
Continuous phosphorylation of both the 47 and the 49 kDa proteins occurs during superoxide production by neutrophilsQ46771064
Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304.Q46874695
Purification of the 260 kDa cytosolic complex involved in the superoxide production of guinea pig neutrophilsQ46981093
Electron transfer across the O2- generating flavocytochrome b of neutrophils. Evidence for a transition from a low-spin state to a high-spin state of the heme iron component.Q50535182
Asparagine-linked glycosylation of cytochrome b558 large subunit varies in different human phagocytic cells.Q54338827
OPR, PC and AID: all in the PB1 familyQ57024881
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phoxQ57057849
The phagocyte 47-kilodalton cytosolic oxidase protein is an early reactant in activation of the respiratory burstQ57908457
Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558Q57908472
Activation of bovine neutrophil oxidase in a cell free system. GTP-dependent formation of a complex between a cytosolic factor and a membrane proteinQ57973982
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1Q59053220
Phosphorylation of p67 phox in the neutrophil occurs in the cytosol and is independent of p47 phoxQ59512310
Chronic granulomatous diseaseQ59512386
Processing and Maturation of Flavocytochromeb558Include Incorporation of Heme as a Prerequisite for Heterodimer AssemblyQ59942392
Chronic granulomatous diseaseQ67488183
Cytochrome b558, a component of the phagocyte NADPH oxidase, is a flavoproteinQ67502906
Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirementQ67598655
Activation of O2.- generating oxidase of bovine neutrophils in a cell-free system. Interaction of a cytosolic factor with the plasma membrane and control by G nucleotidesQ69359722
P433issuePt 3
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)401-16
P577publication date2005-03-15
P1433published inBiochemical JournalQ864221
P1476titleActivation and assembly of the NADPH oxidase: a structural perspective
P478volume386

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cites work (P2860)
Q499103382,5-Hexanedione induces dopaminergic neurodegeneration through integrin αMβ2/NADPH oxidase axis-mediated microglial activation.
Q397185695-Lipoxygenase plays an essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase
Q34181387A Conserved Region between the TPR and Activation Domains of p67 Participates in Activation of the Phagocyte NADPH Oxidase
Q40661603A Founder Effect of c.257 + 2T > C Mutation in NCF2 Gene Underlies Severe Chronic Granulomatous Disease in Eleven Patients
Q33300467A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity
Q24314359A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis
Q35042069A metabolic biofuel cell: conversion of human leukocyte metabolic activity to electrical currents
Q35864241A nonpolar blueberry fraction blunts NADPH oxidase activation in neuronal cells exposed to tumor necrosis factor-α.
Q46794318A novel function for fibroblast growth factor 21: stimulation of NADPH oxidase-dependent ROS generation
Q34055834A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity
Q37190119A role for NADPH oxidase in antigen presentation.
Q35188154A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils
Q40266742A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites
Q46607752A whole genome bioinformatic approach to determine potential latent phase specific targets in Mycobacterium tuberculosis.
Q40047410ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling
Q38866879Actin filaments-A target for redox regulation
Q42734722Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism
Q38066514Activation of the neutrophil NADPH oxidase by Aspergillus fumigatus
Q42144524Anti-oxidative and anti-inflammatory effects of Tagetes minuta essential oil in activated macrophages
Q42403010Apocynin improves outcome in experimental stroke with a narrow dose range
Q36476821Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK
Q34138960Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production
Q39354924Aspirin-triggered lipoxin A₄ attenuates lipopolysaccharide-induced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase
Q42729199Blockage of NOX2/MAPK/NF-κB Pathway Protects Photoreceptors against Glucose Deprivation-Induced Cell Death
Q46591953Bone marrow chimeras in the study of experimental stroke
Q28394560Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors
Q39797161CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex
Q38799163CYBA encoding p22(phox), the cytochrome b558 alpha polypeptide: gene structure, expression, role and physiopathology
Q28384479Cancer cachexia: impact, mechanisms and emerging treatments
Q28566936Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth
Q36321683Cell signaling through protein kinase C oxidation and activation
Q37203208Cell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking
Q38856689Central Nervous System Injury and Nicotinamide Adenine Dinucleotide Phosphate Oxidase: Oxidative Stress and Therapeutic Targets
Q35918569Ceramide kinase regulates TNFα-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells
Q21564054Charge compensation during the phagocyte respiratory burst
Q41773170Cholesterol: A modulator of the phagocyte NADPH oxidase activity - A cell-free study
Q51226978Chronic Granulomatous Disease Due to Neutrophil Cytosolic Factor (NCF2) Gene Mutations in Three Unrelated Families.
Q43297511Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity
Q46532092Comparison of capillary and venous blood in the analysis of concentration and function of leucocyte sub-populations.
Q33647684Cooperative induction of CXCL10 involves NADPH oxidase: Implications for HIV dementia.
Q36516796Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation?
Q39277497Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells
Q39944302Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain
Q34316747DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome
Q35223974Decreased NADPH oxidase expression and antioxidant activity in cachectic skeletal muscle
Q35695135Defining the molecular role of gp91phox in the immune manifestation of acute allergic asthma using a preclinical murine model
Q28256579Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity
Q35895741Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing
Q45345920Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1.
Q38733068Dissecting the role of redox signaling in neuronal development
Q41262163Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.
Q50062562Down-regulation of NOX2 activity in phagocytes mediated by ATM-kinase dependent phosphorylation.
Q33818148Downstream targets and intracellular compartmentalization in Nox signaling
Q52717982Dual oxidase 2 and glutathione peroxidase gene expression are elevated in hyperimmunized sheep challenged with Haemonchus contortus.
Q36656074Effects of Aging and Hypercholesterolemia on Oxidative Stress and DNA Damage in Bone Marrow Mononuclear Cells in Apolipoprotein E-deficient Mice
Q36232203Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558
Q63351757Electrogeneration of O2 .− and H2 O2 Using Polymer-modified Microelectrodes in the Environment of Living Cells
Q36626877Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease
Q28392374Elevated hydrogen peroxide and decreased catalase and glutathione peroxidase protection are associated with aging sarcopenia
Q33649841Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases
Q36021231Endothelin-1 impairs coronary arteriolar dilation: Role of p38 kinase-mediated superoxide production from NADPH oxidase
Q30484229Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
Q24602743Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner
Q39103864Frontline Science: HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock
Q35743968Functional pseudogenes inhibit the superoxide production.
Q36913701Genome-wide gene expression profiles in antioxidant pathways and their potential sex differences and connections to vitamin C in mice
Q38963813HIV-1 Tat C modulates NOX2 and NOX4 expressions through miR-17 in a human microglial cell line
Q40226730Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice
Q33828715High-sodium intake aggravates myocardial injuries induced by aldosterone via oxidative stress in Sprague-Dawley rats
Q92700356Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second
Q36408593Hyperglycemia-induced oxidative stress is independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome
Q39655996Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium
Q42062495Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase
Q24311930Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism
Q24299772Identification of an actin-binding site in p47phox an organizer protein of NADPH oxidase
Q46795047Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid
Q37069112Impaired priming and activation of the neutrophil NADPH oxidase in patients with IRAK4 or NEMO deficiency
Q37212683Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation
Q46264023Independent trafficking of flavocytochrome b558 and myeloperoxidase to phagosomes during phagocytosis visualised by energy-filtering and energy-dispersive spectroscopy-scanning transmission electron microscopy.
Q39172470Induction of genes encoding NADPH oxidase components and activation of IFN regulatory factor-1 by prolactin in fish macrophages.
Q39705140Infection of macrophages with Mycobacterium tuberculosis induces global modifications to phagosomal function
Q37714376Inflammation in adult and neonatal stroke
Q36361383Inflammation in response to glucose ingestion is independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome
Q38349993Inflammatory responses in brain ischemia
Q57289123Inhibition of NADPH Oxidase Activation by Apocynin Rescues Seizure-Induced Reduction of Adult Hippocampal Neurogenesis
Q42629466Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A "peptide walking" study
Q43074613Inhibition of human vascular NADPH oxidase by apocynin derived oligophenols
Q34133685Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits
Q33925611Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets
Q37668153Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox
Q36305359Intermittent Hypoxia Affects the Spontaneous Differentiation In Vitro of Human Neutrophils into Long-Lived Giant Phagocytes
Q42138826Intraphagosomal measurement of the magnitude and duration of the oxidative burst.
Q34675951Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity
Q35851033Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice
Q40331243Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia
Q33955281Invariant local conformation in p22phox p.Y72H polymorphisms suggested by mass spectral analysis of crosslinked human neutrophil flavocytochrome b.
Q97568603Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
Q43281525Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia
Q45144190Liposomes comprising anionic but not neutral phospholipids cause dissociation of Rac(1 or 2) x RhoGDI complexes and support amphiphile-independent NADPH oxidase activation by such complexes
Q33706803Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes.
Q41265815Luminol-amplified chemiluminescence detects mainly superoxide anion produced by human neutrophils
Q35673745Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase
Q36261469MCPIP is induced by cholesterol and participated in cholesterol-caused DNA damage in HUVEC.
Q34165147Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs
Q33707270Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells
Q26864358Mechanisms and potential therapeutic applications of microglial activation after brain injury
Q36114951Mechanisms of angiotensin II-enhanced connecting tubule glomerular feedback
Q84272616Mechanisms regulating superoxide generation in experimental models of phenylketonuria: an essential role of NADPH oxidase
Q37794381Microglial activation in stroke: therapeutic targets
Q46567817Microglial cells and Parkinson's disease
Q101574119Molecular insights into the mechanisms of susceptibility of Labeo rohita against oomycete Aphanomyces invadans
Q35012732Mutation of ARHGAP9 in patients with coronary spastic angina
Q30157617Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation
Q30422587Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species
Q49422978NADPH Oxidase Deficiency: A Multisystem Approach.
Q42262002NADPH Oxidase Mediates β-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures
Q24299314NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin
Q33935056NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes
Q37088271NADPH oxidase has a directional response to shear stress
Q26859140NADPH oxidase in stroke and cerebrovascular disease
Q36001842NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells
Q54216652NADPH oxidases and ROS signaling in the gastrointestinal tract.
Q36302873NADPH oxidases: an overview from structure to innate immunity-associated pathologies
Q34285878NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice
Q37574976NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease
Q41128491NOX Inhibitors - A Promising Avenue for Ischemic Stroke.
Q28581584NOX2, p22phox and p47phox are targeted to the nuclear pore complex in ischemic cardiomyocytes colocalizing with local reactive oxygen species
Q36085162Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy.
Q35555862Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-α
Q36228786Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing.
Q40054491Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance
Q27004060New insights into the regulation of neutrophil NADPH oxidase activity in the phagosome: a focus on the role of lipid and Ca(2+) signaling
Q64934153Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke.
Q24304310Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region
Q24316184Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity
Q35824748Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors
Q36174261Nucleotide receptor signalling and the generation of reactive oxygen species
Q38959357Oxidized phagosomal NOX2 complex is replenished from lysosomes.
Q41888445Oxygen radicals elicit paralysis and collapse of spinal cord neuron growth cones upon exposure to proinflammatory cytokines
Q34032604P21-activated kinase in inflammatory and cardiovascular disease
Q37447260Pattern recognition receptor-dependent mechanisms of acute lung injury
Q37866915Phagosome dynamics during phagocytosis by neutrophils
Q38853680Pharmacological Modulation of Proton Channel Hv1 in Cancer Therapy: Future Perspectives.
Q30512379Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion.
Q28266171Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding
Q41627538Phosphorylation of p47phox is required for receptor-mediated NADPH oxidase/NOX2 activation in Epstein-Barr virus-transformed human B lymphocytes.
Q30156016Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase
Q58861402Physiologie des polynucléaires neutrophiles humains
Q91646764Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins
Q37341777Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia
Q37415313Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase
Q37184540Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane
Q37219375Proinflammatory cytokines provoke oxidative damage to actin in neuronal cells mediated by Rac1 and NADPH oxidase
Q35080194Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst
Q40216978Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils.
Q30514916PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils
Q35065819PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation
Q28475859Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats
Q38101029ROS production in phagocytes: why, when, and where?
Q37097141Reactive oxygen species and glucocorticoid-induced hypertension
Q36449410Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia
Q34939523Reactive oxygen species and the brain in sleep apnea
Q36801016Reactive oxygen species in phagocytic leukocytes
Q92871439Redox responses in skeletal muscle following denervation
Q35941498Redox-active cysteines of a membrane electron transporter DsbD show dual compartment accessibility
Q39535308Reduction of Sb(V) in a human macrophage cell line measured by HPLC-ICP-MS.
Q30156868Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.
Q64060576Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension
Q37179987Regulation of superoxide production in neutrophils: role of calcium influx
Q37139780Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox
Q34127988Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions.
Q36146913RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets
Q36814775Role of T cells in a gp91phox knockout murine model of acute allergic asthma
Q41080044Role of nucleotides and phosphoinositides in the stability of electron and proton currents associated with the phagocytic NADPH oxidase.
Q38193605Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task
Q35543506SNARE-mediated rapid lysosome fusion in membrane raft clustering and dysfunction of bovine coronary arterial endothelium.
Q30476034Single-cell Raman and fluorescence microscopy reveal the association of lipid bodies with phagosomes in leukocytes
Q36119968Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.
Q64259857Small GTPases and Their Role in Vascular Disease
Q30014849Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction
Q39466811Stable accumulation of p67phox at the phagosomal membrane and ROS production within the phagosome
Q36512248Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice
Q38007895Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or "all that you did and did not want to know about Nox inhibitory peptides".
Q28282131Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species
Q42427499Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin
Q36999104Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors.
Q46302495Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation
Q35070983Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease
Q35608083Systemic lupus erythematosus-associated neutrophil cytosolic factor 2 mutation affects the structure of NADPH oxidase complex
Q33584615TLR Cross-Talk Mechanism of Hemorrhagic Shock-Primed Pulmonary Neutrophil Infiltration
Q46743007TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils.
Q91955668Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies
Q38128187Taurine chloramine produced from taurine under inflammation provides anti-inflammatory and cytoprotective effects
Q92822569The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells
Q35607447The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications.
Q38018554The NADPH oxidase family and its inhibitors.
Q60944020The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation
Q35641633The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity
Q26766479The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts
Q39453649The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages.
Q30374610The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma.
Q27329515The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria
Q39348762The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration.
Q36138367The chemokines secretion and the oxidative stress are targets of low-level laser therapy in allergic lung inflammation
Q43276969The cytosolic subunit p67phox of the NADPH-oxidase complex does not bind NADPH.
Q43131424The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67 (phox.).
Q37156566The importance of myeloperoxidase in apocynin-mediated NADPH oxidase inhibition
Q36692346The inflammatory response in stroke
Q41986947The intimate and mysterious relationship between proton channels and NADPH oxidase.
Q38936522The life cycle of phagosomes: formation, maturation, and resolution
Q38169252The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury
Q90117180The p22phox Polymorphism C242T Is Not Associated with Peripheral Malondialdehyde and Superoxide Dismutase Levels in Healthy Korean Adults
Q30159700The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis
Q34541535The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils
Q33632757The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls
Q39123397The recruitment of p47(phox) and Rac2G12V at the phagosome is transient and phosphatidylserine dependent
Q92970041The role of NOX inhibitors in neurodegenerative diseases
Q34266689The role of the microglia in acute CNS injury
Q27693871The yin and yang of microglia
Q57785309Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension
Q47193242Tks adaptor proteins at a glance.
Q38007896Towards specific NADPH oxidase inhibition by small synthetic peptides
Q30157954Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phosph
Q39717376Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.
Q35976528Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages
Q84170482Two X-linked chronic granulomatous disease patients with unusual NADPH oxidase properties
Q28681630Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family
Q42814296Volume-sensitive NADPH oxidase activity and taurine efflux in NIH3T3 mouse fibroblasts
Q36717731beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway
Q58609392iPLAβ and its role in male fertility, neurological disorders, metabolic disorders, and inflammation
Q30497179p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation
Q30157297p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases

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