Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins

scientific article published on 29 November 2019

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/CELLS8121545
P932PMC publication ID6952946
P698PubMed publication ID31795496

P2093author name stringTomoichiro Asano
Hideyuki Sakoda
Akifumi Kushiyama
Hiraku Ono
Midori Fujishiro
Yusuke Nakatsu
Yasuka Matsunaga
Masa-Ki Inoue
Takeshi Yamamotoya
Mayu Kanamoto
Miki Naitou
Shun Hasei
P2860cites workNADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunitsQ88661890
NF-κB signaling in inflammationQ89348733
TGF-β1-PML SUMOylation-peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosisQ91674217
Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16Q92505602
The AMP-activated protein kinase--fuel gauge of the mammalian cell?Q24315074
The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancerQ24317638
Receptor-associated Mad homologues synergize as effectors of the TGF-beta responseQ24318330
Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.Q24535558
The importance of metabolic factors for the increasing prevalence of fatty liver in Shanghai factory workersQ80183316
Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activityQ80466945
Can serum pin1 level be regarded as an indicative marker of nonalcoholic steatohepatitis and fibrotic stages?Q85212712
The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1Q87356475
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2Q24563807
Contribution of the toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinomaQ26781477
Regulation of nuclear factor-κB in autoimmunityQ26860148
Structural basis for phosphoserine-proline recognition by group IV WW domainsQ27626138
A Smad action turnover switch operated by WW domain readers of a phosphoserine codeQ27670475
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway ModulationsQ28079712
The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signallingQ28139111
Signal transduction by the JNK group of MAP kinasesQ28142592
NF-kappaB regulation in the immune systemQ28205043
Pinning down proline-directed phosphorylation signalingQ28215887
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisQ28242612
Fatty acid metabolism, the central nervous system, and feedingQ28267045
Activation and assembly of the NADPH oxidase: a structural perspectiveQ28297425
Cross talk between mitochondria and NADPH oxidasesQ28391403
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functionsQ29547189
Steatohepatitis: a tale of two "hits"?Q29547771
Missing pieces in the NF-kappaB puzzleQ29547864
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationQ29614227
Cyclin-dependent kinases: engines, clocks, and microprocessorsQ29614786
Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adultsQ29614911
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stressQ29615562
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expressionQ29615644
Adipocyte differentiation from the inside outQ29615690
Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesisQ29619888
Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob miceQ31045022
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitisQ33563333
Pin1 promotes transforming growth factor-beta-induced migration and invasionQ33581891
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.Q34285636
The metabolic syndrome as a predictor of nonalcoholic fatty liver diseaseQ34467576
The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophilsQ34541535
Hepatic stellate cells secretes type I collagen to trigger epithelial mesenchymal transition of hepatoma cells.Q34704882
Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meaningsQ34815796
Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinaseQ35003564
STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis posttranscriptionally, and is essential for lung myofibroblast differentiationQ47398620
Structure and function of the human parvulins Pin1 and Par14/17.Q47640105
Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamilyQ48064097
Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults.Q51491016
Association of nonalcoholic fatty liver disease with insulin resistance.Q51559831
The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils.Q52034778
Prolyl-isomerase Pin1 impairs trastuzumab sensitivity by up-regulating fatty acid synthase expression.Q53241324
PIN1, the cell cycle and cancer.Q53561253
Pin1 induction in the fibrotic liver and its roles in TGF-β1 expression and Smad2/3 phosphorylation.Q54222587
Stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbates liver injury and fibrosis.Q54332913
Development of Pin1 inhibitors and their potential as therapeutic agentsQ58609893
Prolyl isomerase Pin1: a promoter of cancer and a target for therapyQ58695611
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for TreatmentQ58799997
Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferationQ64102551
Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measuresQ80119138
Non-alcoholic steatohepatitis: definitions and pathogenesisQ35020857
Minireview: malonyl CoA, AMP-activated protein kinase, and adiposityQ35538672
Is weight reduction an effective therapy for nonalcoholic fatty liver? A systematic reviewQ35576405
A critical step for JNK activation: isomerization by the prolyl isomerase Pin1Q35657377
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD).Q35907960
Pin1 protein regulates Smad protein signaling and pulmonary fibrosisQ36078699
Integrins: molecular targets in cancer therapyQ36409214
Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent modelQ36492869
Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority PopulationsQ36818424
Prevalence and risk factors of fatty liver disease in the Shuiguohu district of Wuhan city, central ChinaQ37008567
How the Smads regulate transcriptionQ37025325
Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB familyQ37341168
The peptidyl-prolyl isomerase, Pin1, facilitates NF-kappaB binding in hepatocytes and protects against hepatic ischemia/reperfusion injuryQ37355290
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylationQ37356550
Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment.Q37362755
The NF-kappaB family of transcription factors and its regulationQ37672294
Nonalcoholic fatty liver disease: pathology and pathogenesisQ37676210
Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.Q37683419
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathwayQ37743477
Prevalence, gender, ethnic variations, and prognosis of NASH.Q37789173
Non-canonical NF-κB signaling pathwayQ37822660
Transforming growth factor (TGF)-β expression and activation mechanisms as potential targets for anti-tumor therapy and tumor imaging.Q38010271
PtdIns5P and Pin1 in oxidative stress signalingQ38100465
Cellular and molecular mechanisms of endothelial dysfunction in diabetesQ38134022
The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretionQ38288031
Control of protein function by prolyl isomerizationQ38301243
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitisQ38310080
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesisQ38336218
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.Q38680300
The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastomaQ39814307
Prolyl isomerase: enzymatic catalysis of slow protein-folding reactionsQ40488942
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.Q41157114
Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunitQ41456327
Role of Pin1 in neointima formation: down-regulation of Nrf2-dependent heme oxygenase-1 expression by Pin1.Q42469114
Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stressQ42678633
Pin1 enhances adipocyte differentiation by positively regulating the transcriptional activity of PPARγ.Q42808575
Outcome after liver transplantation for NASH cirrhosisQ43888512
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathwayQ44967749
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P577publication date2019-11-29
P1433published inCellsQ27724621
P1476titlePin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins
P478volume8

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