Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

scientific article published on April 25, 2003

Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M212856200
P953full work available at URLhttp://www.jbc.org/article/S0021925820869890/pdf
https://api.elsevier.com/content/article/PII:S0021925820869890?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0021925820869890?httpAccept=text/xml
https://syndication.highwire.org/content/doi/10.1074/jbc.M212856200
P698PubMed publication ID12716910

P2093author name stringHideki Sumimoto
Noriko Ueno
Motoyuki Kohjima
Tomoko Izaki
Keiichiro Kami
Hiroyuki Nunoi
Ryu Takeya
Masahiko Taura
P2860cites workCell transformation by the superoxide-generating oxidase Mox1Q22010372
A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1Q22010993
Identification of renox, an NAD(P)H oxidase in kidneyQ22254385
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase CQ24290955
Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteinsQ34411802
Assembly of the neutrophil respiratory burst oxidase: a direct interaction between p67PHOX and cytochrome b558.Q34689181
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox).Q38336129
Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.Q40339903
Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cellsQ43660501
A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheismQ43918747
Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic systemQ43945169
NADH/NADPH Oxidase and Vascular FunctionQ63365800
The cytosolic component p47(phox) is not a sine qua non participant in the activation of NADPH oxidase but is required for optimal superoxide productionQ71825234
Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reactionQ73413711
Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophilsQ77863925
Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47(phox) may participate in forming this oxidase in vitro and in vivoQ77955201
The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558)Q78101657
Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactionsQ24291510
A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodesQ24291514
Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 functionQ24298671
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous diseaseQ24319232
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targetsQ24328957
Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phoxQ24534192
156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phoxQ24679525
Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activationQ24681540
Structure of the TPR domain of p67phox in complex with Rac.GTPQ27628646
Solution structure of the PX domain, a target of the SH3 domainQ27632043
Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13pQ27639477
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5Q28190953
Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidasesQ28213110
PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctionsQ28216382
Functional modules and expression of mouse p40(phox) and p67(phox), SH3-domain-containing proteins involved in the phagocyte NADPH oxidase complexQ28513581
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathwaysQ28571066
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1Q28585409
Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidaseQ28609613
pEF-BOS, a powerful mammalian expression vectorQ29547606
The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.Q30165057
Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidaseQ30175140
Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby actiQ30175312
Activation of the phagocyte NADPH oxidase protein p47(phox). Phosphorylation controls SH3 domain-dependent binding to p22(phox).Q30175411
Activation of the neutrophil respiratory burst oxidaseQ30175836
Roles for proline-rich regions of p47phox and p67phox in the phagocyte NADPH oxidase activation in vitroQ30176330
NADPH oxidase activity is independent of p47phox in vitroQ30176826
Interactions between the cytosolic components p47phox and p67phox of the human neutrophil NADPH oxidase that are not required for activation in the cell-free system.Q30193434
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidaseQ30194274
Molecular basis for Rac2 regulation of phagocyte NADPH oxidaseQ32063730
A novel superoxide-producing NAD(P)H oxidase in kidneyQ33921569
Novel homologs of gp91phox.Q34069745
An NAD(P)H oxidase regulates growth and transcription in melanoma cellsQ34127326
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectbiochemistryQ7094
cell biologyQ7141
human genomeQ720988
cytochrome b-245 beta chainQ4044986
P304page(s)25234-46
P577publication date2003-04-25
2003-07-04
P1433published inJournal of Biological ChemistryQ867727
P1476titleNovel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases
Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases
P478volume278

Reverse relations

cites work (P2860)
Q34181387A Conserved Region between the TPR and Activation Domains of p67 Participates in Activation of the Phagocyte NADPH Oxidase
Q30164072A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase
Q24296133A region C-terminal to the proline-rich core of p47phox regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67phox
Q42496593A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation.
Q42447798Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation
Q24303790Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phox
Q34349277Analysis of mRNA transcripts from the NAD(P)H oxidase 1 (Nox1) gene. Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variant
Q30433144Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3.
Q39756367Anthrax edema toxin inhibits Nox1-mediated formation of reactive oxygen species by colon epithelial cells
Q38921494Association between NADPH oxidase (NOX) and lung cancer: a systematic review and meta-analysis
Q41859565Backbone 1H, 15N, and 13C resonance assignments for the NOXO1β PX domain
Q26991619Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system
Q48080421Calcium-dependent protein kinases regulate the production of reactive oxygen species by potato NADPH oxidase
Q42662658Characteristics of NADPH oxidase genes (Nox2, p22, p47, and p67) and Nox4 gene expressed in blood cells of juvenile Ciona intestinalis
Q35992729Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
Q34269250Comparative pharmacology of chemically distinct NADPH oxidase inhibitors
Q39646559Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain
Q24678301Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3
Q45246489Crucial role of two potential cytosolic regions of Nox2, 191TSSTKTIRRS200 and 484DESQANHFAVHHDEEKD500, on NADPH oxidase activation
Q27022012Detection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidases
Q37971795Differential roles of NADPH oxidases in vascular physiology and pathophysiology
Q24338017Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation
Q45345920Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1.
Q24306096Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity
Q24676778Dual oxidases
Q45086298Ecabet sodium inhibits Helicobacter pylori lipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells
Q33649841Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases
Q34046939Epidermal growth factor stimulates nuclear factor-κB activation and heme oxygenase-1 expression via c-Src, NADPH oxidase, PI3K, and Akt in human colon cancer cells
Q46527889Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells
Q36327246Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
Q34557682Expression and function of Noxo1gamma, an alternative splicing form of the NADPH oxidase organizer 1.
Q33745533Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues
Q42182273Expression of gp91phox/Nox2 in COS-7 cells: cellular localization of the protein and the detection of outward proton currents
Q92616828Fas-associated factor 1 mediates NADPH oxidase-induced reactive oxygen species production and proinflammatory responses in macrophages against Listeria infection
Q34623486Function and design of the Nox1 system in vascular smooth muscle cells
Q33906642Hydrogen sulfide regulates homocysteine-mediated glomerulosclerosis
Q28294861Identification of a novel partner of duox: EFP1, a thioredoxin-related protein
Q46853357Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction
Q34319871Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy.
Q34382679Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone
Q83317779Inhibition of ceramide-redox signaling pathway blocks glomerular injury in hyperhomocysteinemic rats
Q43074613Inhibition of human vascular NADPH oxidase by apocynin derived oligophenols
Q24655002Inhibitory action of NoxA1 on dual oxidase activity in airway cells
Q37968311Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease
Q37610011Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell
Q24319711Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1)
Q40373525Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells
Q24548021Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases
Q41172741Knockout of p47 phox uncovers a critical role of p40 phox in reactive oxygen species production in microvascular endothelial cells
Q34300862Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5).
Q40057005Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase
Q37475351Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding
Q36547056Modulation of vascular smooth muscle signaling by reactive oxygen species
Q33300608Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes
Q33290000Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes
Q28269693Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice
Q28296636Mutational analysis reveals distinct features of the Nox4-p22 phox complex
Q43232684NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways
Q37589114NADPH oxidase in brain injury and neurodegenerative disorders
Q37265507NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology
Q35301338NADPH oxidase: recent evidence for its role in erectile dysfunction
Q54216652NADPH oxidases and ROS signaling in the gastrointestinal tract.
Q37342232NADPH oxidases and angiotensin II receptor signaling
Q38394359NADPH oxidases and cancer
Q90576094NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Q27027435NADPH oxidases in lung health and disease
Q33632660NADPH oxidases: a perspective on reactive oxygen species production in tumor biology
Q36302873NADPH oxidases: an overview from structure to innate immunity-associated pathologies
Q35296159NADPH oxidases: not just for leukocytes anymore!
Q37574976NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease
Q35977261NOX Modifiers-Just a Step Away from Application in the Therapy of Airway Inflammation?
Q37169101NOX enzymes and Toll-like receptor signaling.
Q29547517NOX enzymes and the biology of reactive oxygen
Q36832562NOX in liver fibrosis
Q39546057NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction
Q50299245NOX1 complex:RAC1:GTP generates superoxide from oxygen
Q100153175NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen
Q64079428NOX5: Molecular biology and pathophysiology
Q30164408NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain
Q26829513Natural compounds as modulators of NADPH oxidases
Q64934153Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke.
Q35745857Novel NAD(P)H oxidases in the cardiovascular system
Q24316184Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity
Q28483560Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy
Q33744942Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries
Q28282472Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract
Q37151978Nox enzymes in immune cells
Q40145596Nox1 redox signaling mediates oncogenic Ras-induced disruption of stress fibers and focal adhesions by down-regulating Rho.
Q24320021Nox1-dependent reactive oxygen generation is regulated by Rac1
Q35486123Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2
Q34324985Nox3 regulation by NOXO1, p47phox, and p67phox.
Q90260610Oxidative Stress in Pulmonary Fibrosis
Q35903570Oxygen free radicals and redox biology of organelles
Q36374150Periaqueductal gray neuroplasticity following chronic morphine varies with age: role of oxidative stress.
Q30008984Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration
Q24318670Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1
Q28266171Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding
Q37976066Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme
Q34430784Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.
Q37184946Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase
Q50299244RAC1:GTP binds NOX1 complex
Q30499365Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics
Q35949648Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase
Q37774919Reactive oxygen species in TNFalpha-induced signaling and cell death.
Q28396273Reactive oxygen species in inflammation and tissue injury
Q34322148Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells
Q36450264Reactive oxygen species signaling in vascular smooth muscle cells
Q46280851Redox Signaling and Persistent Pulmonary Hypertension of the Newborn
Q34623471Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets
Q46280869Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD.
Q38294991Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells
Q30156868Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.
Q36865824Regulation of Nox and Duox enzymatic activity and expression
Q35849697Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms
Q37461363Regulation of reactive oxygen species generation in cell signaling
Q36666637Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases
Q46940007Regulation of superoxide-producing NADPH oxidases in nonphagocytic cells
Q30163832Regulation of the NADPH-oxidase complex of phagocytic leukocytes. Recent insights from structural biology, molecular genetics, and microscopy
Q37445914Role of NADPH oxidase in atherosclerosis
Q35955745Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress
Q43061685Role of the NADPH oxidase systems Nox and Duox in host defense and inflammation
Q37732032Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2.
Q36000866Sorting nexins--unifying trends and new perspectives
Q58075704Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Q28282131Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species
Q26852739Study designs to investigate Nox1 acceleration of neoplastic progression in immortalized human epithelial cells by selection of differentiation resistant cells
Q35792499Subcellular localization and function of alternatively spliced Noxo1 isoforms
Q33825619T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus
Q37095205TNFalpha and reactive oxygen species in necrotic cell death
Q35572079TRAIL promotes caspase-dependent pro-inflammatory responses via PKCδ activation by vascular smooth muscle cells
Q30491877Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases
Q35104682Tea polyphenols alleviate high fat and high glucose-induced endothelial hyperpermeability by attenuating ROS production via NADPH oxidase pathway
Q46250017The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice
Q33213948The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators
Q36060782The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Q41882353The NOXO1β PX domain preferentially targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
Q35886272The Nox family of NAD(P)H oxidases: host defense and beyond
Q39836858The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases
Q36739856The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1.
Q36597976The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation
Q36424627The role of Nox-mediated oxidation in the regulation of cytoskeletal dynamics
Q42487257The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells
Q30824712The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
Q38007896Towards specific NADPH oxidase inhibition by small synthetic peptides
Q30457630Traumatic noise activates Rho-family GTPases through transient cellular energy depletion
Q34361024c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells
Q100153172ppDVL:RAC1:GTP binds NOX1 complex

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