Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function

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Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M203993200
P698PubMed publication ID12042318

P2093author name stringMary C Dinauer
Lixin Yu
Andrew Cross
Shelley Bennett
Natalie Stull
Brendan LeRoy
Karla J Biberstine-Kinkade
P2860cites workPurified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000Q24297934
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous diseaseQ24307950
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targetsQ24328957
Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome bQ24650898
156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phoxQ24679525
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidaseQ30194274
Cloning and sequencing of the bovine flavocytochrome b subunit proteins, gp91-phox and p22-phox: comparison with other known flavocytochrome b sequences.Q32054101
Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (first update).Q33927706
Novel homologs of gp91phox.Q34069745
Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidaseQ36165558
Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phoxQ36616258
Prediction and comparison of the haem-binding sites in membrane haemoproteinsQ38729717
Biosynthesis of flavocytochrome b558 . gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum.Q40975170
Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytesQ41619617
Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase.Q41620128
Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunitsQ42835038
The association of FAD with the cytochrome b-245 of human neutrophilsQ42869175
Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox).Q43645354
Identification of a spectrally stable proteolytic fragment of human neutrophil flavocytochrome b composed of the NH2-terminal regions of gp91(phox) and p22(phox).Q43706806
Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic systemQ43945169
Cytochrome b-245 of the neutrophil superoxide-generating system contains two nonidentical hemes. Potentiometric studies of a mutant form of gp91phoxQ46652773
Processing and Maturation of Flavocytochromeb558Include Incorporation of Heme as a Prerequisite for Heterodimer AssemblyQ59942392
Cytochrome b558, a component of the phagocyte NADPH oxidase, is a flavoproteinQ67502906
Characterization of neutrophilb-type cytochrome in situ by electron paramagnetic resonance spectroscopyQ67915206
Characterization of the GTP-dependent activation of the superoxide-producing NADPH oxidase in a cell-free system of pig neutrophilsQ70464999
Generation of superoxide by purified and relipidated cytochrome b559 in the absence of cytosolic activatorsQ70466332
P433issue33
P407language of work or nameEnglishQ1860
P921main subjectcytochrome b-245 beta chainQ4044986
protein heterodimerization activityQ14762999
cytochrome b-245 alpha chainQ21109992
P304page(s)30368-74
P577publication date2002-08-16
P1433published inJournal of Biological ChemistryQ867727
P1476titleMutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function
P478volume277

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cites work (P2860)
Q28297425Activation and assembly of the NADPH oxidase: a structural perspective
Q26991619Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system
Q42662658Characteristics of NADPH oxidase genes (Nox2, p22, p47, and p67) and Nox4 gene expressed in blood cells of juvenile Ciona intestinalis
Q24678301Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3
Q28256579Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity
Q45345920Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1.
Q34992223Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease
Q33955281Invariant local conformation in p22phox p.Y72H polymorphisms suggested by mass spectral analysis of crosslinked human neutrophil flavocytochrome b.
Q37152350Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes
Q24300616Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases
Q37151978Nox enzymes in immune cells
Q28266171Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding
Q46940007Regulation of superoxide-producing NADPH oxidases in nonphagocytic cells
Q35792499Subcellular localization and function of alternatively spliced Noxo1 isoforms
Q33213948The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators
Q35828194The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems

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