Cytoskeletal Stability in the Auditory Organ In Vivo: RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development

scientific article published on 18 September 2017

Cytoskeletal Stability in the Auditory Organ In Vivo: RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/ENEURO.0149-17.2017
P932PMC publication ID5602105
P698PubMed publication ID28929130

P50authorCord BrakebuschQ30093323
Ilya BelevichQ53188227
Tommi AnttonenQ57510844
Ulla PirvolaQ89359129
Eija JokitaloQ40315053
P2093author name stringAnni Herranen
Maarja Laos
P2860cites workThe deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.Q24603825
How to bury the dead: elimination of apoptotic hair cells from the hearing organ of the mouseQ27318741
Microscopy Image Browser: A Platform for Segmentation and Analysis of Multidimensional DatasetsQ27345307
The quest for restoring hearing: Understanding ear development more completely.Q28083871
Distinct subdomain organization and molecular composition of a tight junction with adherens junction featuresQ28506754
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathwayQ28509023
Ciliary proteins link basal body polarization to planar cell polarity regulationQ28585995
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survivalQ28586935
The small GTPase Rac1 regulates auditory hair cell morphogenesisQ28591364
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammalsQ28591957
Responses to cell loss become restricted as the supporting cells in mammalian vestibular organs grow thick junctional actin bands that develop high stabilityQ30411696
The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organsQ30428318
Reinforcement of cell junctions correlates with the absence of hair cell regeneration in mammals and its occurrence in birds.Q30437837
Changes in the adult vertebrate auditory sensory epithelium after traumaQ30442292
Shape change controls supporting cell proliferation in lesioned mammalian balance epitheliumQ30443443
Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the CochleaQ30471081
Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear.Q30490970
Rapid hair cell loss: a mouse model for cochlear lesionsQ30490976
Damage-induced cell-cell communication in different cochlear cell types via two distinct ATP-dependent Ca wavesQ30495799
Integration of single and multicellular wound responsesQ30533865
Concentric zones of active RhoA and Cdc42 around single cell woundsQ33211372
Apical constriction: themes and variations on a cellular mechanism driving morphogenesisQ33570622
Expression patterns of FGF receptors in the developing mammalian cochlea.Q34104286
Cell control by membrane-cytoskeleton adhesionQ34238066
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytesQ34611649
Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferationQ34938112
Inner ear hair cells deteriorate in mice engineered to have no or diminished innervationQ35190077
The Rho GTPase Cdc42 regulates hair cell planar polarity and cellular patterning in the developing cochlea.Q35453418
Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epitheliaQ35546873
Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthoodQ36469565
NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometryQ36856200
Wound repair: toward understanding and integration of single-cell and multicellular wound responsesQ36929762
Non-sensory cells in the deafened organ of Corti: approaches for repairQ36950155
Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.Q37200935
RhoGTPases, actomyosin signaling and regulation of the epithelial Apical Junctional ComplexQ37319461
Rho GTPase function in development: how in vivo models change our viewQ38015643
Revisiting planar cell polarity in the inner ear.Q38096733
An Fgfr3-iCreER(T2) transgenic mouse line for studies of neural stem cells and astrocytes.Q38346456
Distribution of F-actin and fodrin in the hair cells of the guinea pig cochlea as revealed by confocal fluorescence microscopyQ42458316
Junctionally restricted RhoA activity is necessary for apical constriction during phase 2 inner ear placode invagination.Q42464828
Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shapeQ42469196
The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.Q42486077
A mechanism for sensing noise damage in the inner ear.Q44814019
Organization of cell junctions and cytoskeleton in the reticular lamina in normal and ototoxically damaged organ of CortiQ46230453
Outer hair cell loss and supporting cell expansion following chronic gentamicin treatmentQ46242957
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton.Q46854784
Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells.Q50425907
Scar formation after drug-induced cochlear insultQ50545792
Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development.Q50799044
P4510describes a project that usesImageJQ1659584
P433issue5
P921main subjectcytoskeletonQ154626
wound healingQ1509074
P577publication date2017-09-18
P1433published ineNeuroQ27726083
P1476titleCytoskeletal Stability in the Auditory Organ In Vivo: RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development
P478volume4

Reverse relations

cites work (P2860)
Q90078072Polarity during tissue repair, a multiscale problem
Q64244340Rho-Family Small GTPases: From Highly Polarized Sensory Neurons to Cancer Cells

Search more.