Bacterial cytotoxins: targeting eukaryotic switches

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Bacterial cytotoxins: targeting eukaryotic switches is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/NRMICRO1150
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/nrmicro1150
P8608Fatcat IDrelease_s7zidnl4ozdzhbxkwl7qasofmu
P698PubMed publication ID15821726
P5875ResearchGate publication ID7914528

P50authorKlaus AktoriesQ1740773
P2093author name stringJoseph T Barbieri
P2860cites workWAVE, a novel WASP-family protein involved in actin reorganization induced by RacQ22008483
Direct interaction of two polarity complexes implicated in epithelial tight junction assemblyQ24293221
Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneriQ24533240
Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayersQ24561503
Rho protein regulates tight junctions and perijunctional actin organization in polarized epitheliaQ24563849
The integrin-actin connection, an eternal love affairQ24676735
Chemoattractant-stimulated NF-kappaB activation is dependent on the low molecular weight GTPase RhoA.Q38297271
Activation of rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxinQ38315380
A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxinsQ38326211
Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.Q38334527
Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile.Q38341499
Pseudomonas aeruginosa ExoT is a Rho GTPase-activating proteinQ39537017
Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cellsQ39573446
Cooperation between actin-binding proteins of invasive Salmonella: SipA potentiates SipC nucleation and bundling of actinQ39644435
Proteasomal degradation of cytotoxic necrotizing factor 1-activated rac.Q39655801
Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathwayQ39831970
Salmonella modulates vesicular traffic by altering phosphoinositide metabolismQ40531614
The RickA protein of Rickettsia conorii activates the Arp2/3 complexQ40594520
Characterization of YopT effects on Rho GTPases in Yersinia enterocolitica-infected cells.Q40641826
VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigrationQ40654707
RhoA and ROCK promote migration by limiting membrane protrusionsQ40672013
Clostridium difficile colitisQ40679117
Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosisQ40708723
Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectinQ40728754
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathwayQ40819427
The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophagesQ40826483
Cytolysin-mediated translocation (CMT): a functional equivalent of type III secretion in gram-positive bacteriaQ40829555
Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanismsQ40832397
Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheetsQ40868085
A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimuriumQ41178388
Inhibition of Fc epsilon-RI-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B (monoglucosyltransferase)Q41213243
The Yersinia pseudotuberculosis cytotoxic necrotizing factor (CNFY) selectively activates RhoA.Q41463935
A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis.Q41471661
The Yersinia Ser/Thr protein kinase YpkA/YopO directly interacts with the small GTPases RhoA and Rac-1.Q41478052
YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells.Q41485138
Protein tyrosine phosphatase activity of an essential virulence determinant in YersiniaQ41511214
Induction of phagocytic behaviour in human epithelial cells by Escherichia coli cytotoxic necrotizing factor type 1.Q41532053
Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function.Q42436011
RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actinQ42459171
Direct nucleation and bundling of actin by the SipC protein of invasive SalmonellaQ42680869
Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1.Q42799773
Microinjection of recombinant p21rho induces rapid changes in cell morphologyQ24678787
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodiaQ24682164
Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complexQ27619816
Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizing factor 1Q27632787
Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxinQ27640212
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsQ27860467
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaQ27861126
The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoAQ28145375
Activation of phospholipase D1 by ADP-ribosylated RhoAQ28210496
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and NckQ28218186
The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesionsQ28239729
In vivo covalent cross-linking of cellular actin by the Vibrio cholerae RTX toxinQ28485730
Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammationQ28590843
Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cellsQ28590934
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defenseQ28609612
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assemblyQ28609843
Rho and Rac take center stageQ28645748
Rho GTPases and signaling networksQ28646215
The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell ContactsQ29042060
Rho GTPases control polarity, protrusion, and adhesion during cell movementQ29614244
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPasesQ29614245
Cell migration: Rho GTPases lead the wayQ29616711
Crk family adaptors-signalling complex formation and biological rolesQ30167857
Polarization of chemoattractant receptor signaling during neutrophil chemotaxisQ30493167
Identification of the region of rho involved in substrate recognition by Escherichia coli cytotoxic necrotizing factor 1 (CNF1).Q30782754
Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.Q30973103
Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxinQ31082589
Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 regulator of kinase (Crk) proteinsQ31146461
Ras-related GTPase Rhob represses NF-kappaB signalingQ31523965
A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3.Q31743399
Actin is ADP-ribosylated by the Salmonella enterica virulence-associated protein SpvB.Q31906961
S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells.Q32060838
Pseudomonas aeruginosa cystic fibrosis isolates induce rapid, type III secretion-dependent, but ExoU-independent, oncosis of macrophages and polymorphonuclear neutrophilsQ33180176
Ezrin/radixin/moesin proteins are high affinity targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS.Q33204721
The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.Q33562723
Evidence for contribution of tripartite hemolysin BL, phosphatidylcholine-preferring phospholipase C, and collagenase to virulence of Bacillus cereus endophthalmitisQ33599928
Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3.Q33899706
GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structureQ33904931
T cell activation and the cytoskeletonQ33932683
Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteinsQ34006206
Mutation of the gene encoding cytotoxic necrotizing factor type 1 (cnf(1)) attenuates the virulence of uropathogenic Escherichia coliQ34007961
Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis modelQ34009471
Microbial toxins and the glycosylation of rho family GTPasesQ34066508
ERM proteins: from cellular architecture to cell signalingQ34079082
In vivo rho GTPase-activating protein activity of Pseudomonas aeruginosa cytotoxin ExoSQ34116489
Yersinia pseudotuberculosis produces a cytotoxic necrotizing factorQ34121877
Surfing pathogens and the lessons learned for actin polymerization.Q34123309
Role of Yops and adhesins in resistance of Yersinia enterocolitica to phagocytosisQ34127164
Rho protein inactivation induced apoptosis of cultured human endothelial cellsQ34149118
Mechanism of Clostridium difficile toxin A-induced apoptosis in T84 cellsQ34156582
Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxinsQ34157039
Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitroQ34214675
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42Q34284892
Rho-family GTPases: it's not only Rac and Rho (and I like it).Q34305856
The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteinsQ34312684
Glucosylation of Rho proteins by Clostridium difficile toxin B.Q34312765
Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPasesQ34328046
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complexQ34334221
Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B. Role of Rho proteinsQ34372893
Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteinsQ34397543
Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteinsQ34405601
Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxinQ34422333
Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivoQ34422633
p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritisQ34432263
Cellular control of actin nucleationQ34762557
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathwaysQ35064957
Hijacking Rho GTPases by protein toxins and apoptosis: molecular strategies of pathogenic bacteria.Q35109696
Cytoskeletal remodeling in lymphocyte activationQ35145758
Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibersQ35199228
Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytesQ35589374
Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa.Q35620528
Role of the cytoskeleton during leukocyte responsesQ35709644
Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complexQ35709932
Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytesQ35775396
Regulation of actin dynamics by WASP and WAVE family proteins.Q35795887
Characterization of translation termination mutations in the spv operon of the Salmonella virulence plasmid pSDL2Q36138955
Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPasesQ36256190
Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flowQ36324917
RhoA is required for monocyte tail retraction during transendothelial migrationQ36377962
Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho.Q36604031
ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III systemQ36809802
Evidence for two types of cytotoxic necrotizing factor in human and animal clinical isolates of Escherichia coliQ37181270
Clostridium difficile toxin A and its effects on cellsQ37406518
Cellular and molecular actions of binary toxins possessing ADP-ribosyltransferase activityQ37505427
CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxinQ37558354
Cytotoxic necrotizing factor-1 contributes to Escherichia coli K1 invasion of the central nervous systemQ38291521
Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complexQ42801719
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteinsQ42803708
Difference in protein substrate specificity between hemorrhagic toxin and lethal toxin from Clostridium sordelliiQ42806187
Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cyclingQ42810333
Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.Q42814014
The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cellsQ43548955
CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasionQ44220432
Rho-specific Bacillus cereus ADP-ribosyltransferase C3cer cloning and characterizationQ44544856
Temporal regulation of salmonella virulence effector function by proteasome-dependent protein degradationQ44668051
How bacterial ADP-ribosylating toxins recognize substratesQ45018408
Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleationQ46673303
The low molecular weight GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcriptionQ47309729
Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.Q47954843
Control of actin turnover by a salmonella invasion proteinQ48018016
Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell.Q50119973
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.Q50124353
Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis.Q51024811
Clostridium difficile toxin B induces reorganization of actin, vinculin, and talin in cultured cells.Q52490693
NAD+-glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci.Q54546984
Escherichia coli cytotoxic necrotizing factor 1 (CNF1), a toxin that activates the Rho GTPase.Q54561665
Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine.Q54564124
Molecular localization of the Escherichia coli cytotoxic necrotizing factor CNF1 cell-binding and catalytic domains.Q54564776
The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3.Q54734829
Requirement of Rac1 and Rac2 Expression by Mature Dendritic Cells for T Cell PrimingQ58862030
Botulinum C2 toxin ADP-ribosylates actinQ59065931
ADP-ribosylation of actin isoforms by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxinQ68624073
A cell division-active protein from E. coliQ70330559
The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPasesQ73263462
LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachmentQ73508884
Clostridium difficile toxin A causes early damage to mitochondria in cultured cellsQ73977795
Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expressionQ74240730
Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector couplingQ74457062
Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in miceQ74477573
Complement c3a and c5a induce different signal transduction cascades in endothelial cellsQ74583305
Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin AQ77309148
C3stau, a new member of the family of C3-like ADP-ribosyltransferasesQ77384524
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytesQ77801010
Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epitheliumQ78319031
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)397-410
P577publication date2005-05-01
P1433published inNature Reviews MicrobiologyQ1071797
P1476titleBacterial cytotoxins: targeting eukaryotic switches
P478volume3

Reverse relations

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