Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells

scientific article

Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/IMR.12119
P932PMC publication ID3830525
P698PubMed publication ID24117826

P50authorKyung-Hee ChangQ95981466
P2093author name stringRamesh C Nayak
Jose A Cancelas
Nataraja-Sarma Vaitinadin
P2860cites workSignaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinaseQ22010473
Circulating stem cell collection in lymphoma and myeloma after mobilization with cyclophosphamide and granulocyte colony-stimulating factor for autologous transplantationQ71685182
ADP-ribosylation of Rho enhances actin polymerization-coupled shape oscillations in human neutrophilsQ71736240
Engraftment of embryonic hematopoietic cells in conditioned newborn recipientsQ73128552
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID miceQ73827359
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4Q77952550
Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine TriphosphatasesQ79176492
Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblikeQ80358443
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localizationQ80385968
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loopQ22011174
FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodellingQ24297925
A novel ras-related gene familyQ24300094
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complexQ24301883
The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18Q24303678
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilinQ24316148
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylationQ24316282
Bcr encodes a GTPase-activating protein for p21racQ24318326
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASPQ24318478
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Characterization of RAC3, a novel member of the Rho familyQ24321818
rac, a novel ras-related family of proteins that are botulinum toxin substratesQ24339158
Signal-dependent membrane targeting by pleckstrin homology (PH) domainsQ24532099
Regulation of myeloid leukaemia by the cell-fate determinant MusashiQ24634359
The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodiaQ24648605
Rho GTPases in hematopoiesis and hemopathiesQ24652636
Rho-stimulated contractility drives the formation of stress fibers and focal adhesionsQ24671788
RhoE binds to ROCK I and inhibits downstream signalingQ24675619
Microinjection of recombinant p21rho induces rapid changes in cell morphologyQ24678787
Rho GTPase regulation by miRNAs and covalent modificationsQ26999290
Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domainsQ27626998
High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASPQ27649039
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsQ27860467
Rho GTPases: biochemistry and biologyQ27860645
Rho GTPases in cell biologyQ27860969
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.Q27930376
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cellsQ28114982
Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16Q28142648
Regulation of cell polarity and protrusion formation by targeting RhoA for degradationQ28189565
Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liverQ28210389
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170Q28213976
Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouseQ28214473
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activityQ28214812
The oncoprotein 18/stathmin family of microtubule destabilizersQ28215619
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and NckQ28218186
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1Q28219213
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene productQ28250279
Cdc42--the centre of polarityQ28250444
GDIs: central regulatory molecules in Rho GTPase activationQ28253312
Identification of a putative target for Rho as the serine-threonine kinase protein kinase NQ28273890
Stem cell niche: structure and functionQ28276131
A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcrQ28288509
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complexQ28293934
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migrationQ28295800
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase RhoQ28511023
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cellsQ28586410
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defenseQ28609612
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2Q28609631
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assemblyQ28609843
Rho and Rac take center stageQ28645748
Actin dynamics control SRF activity by regulation of its coactivator MALQ28646140
Inhibition of myosin light chain kinase by p21-activated kinaseQ28678502
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblastsQ29614253
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1Q29614256
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathwayQ29614258
Regulation of actin filament assembly by Arp2/3 complex and forminsQ29615161
Mesenchymal and haematopoietic stem cells form a unique bone marrow nicheQ29616602
Guanine nucleotide exchange factors for Rho GTPases: turning on the switchQ29618403
Spatiotemporal dynamics of RhoA activity in migrating cellsQ29618433
Stem cells and niches: mechanisms that promote stem cell maintenance throughout lifeQ29620450
Imaging hematopoietic precursor division in real timeQ30481466
Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cellsQ30500982
The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.Q30538230
The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascadeQ31141260
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activityQ33292285
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.Q33292328
The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilamentsQ33388915
The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.Q33562723
Functions of unconventional myosinsQ33840306
The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleenQ33859887
Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathwayQ33872322
Kit signal transductionQ33979008
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemiaQ34157874
Endosteal marrow: a rich source of hematopoietic stem cellsQ34295180
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptorQ34567286
The journey of developing hematopoietic stem cellsQ34652843
Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing.Q34988228
Unleashing formins to remodel the actin and microtubule cytoskeletonsQ35016805
Phosphoinositide regulation of the actin cytoskeletonQ35019759
Rho GTPase-activating proteins in cell regulationQ35024821
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formationQ35049173
The whys and hows of hematopoietic progenitor and stem cell mobilizationQ35084569
Molecular mechanism for activation of superoxide-producing NADPH oxidases.Q35638899
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrowQ35691159
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilizationQ35730965
Noncanonical Wnt signaling maintains hematopoietic stem cells in the nicheQ35821670
Increased hematopoietic stem cell mobilization in aged miceQ35849168
EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF.Q35863768
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilizationQ35888155
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenationQ35947877
Bacterial cytotoxins: targeting eukaryotic switchesQ36094307
A role for Cdc42 in macrophage chemotaxisQ36264673
Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblastsQ36293793
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytesQ36380848
The hematopoietic stem cell in its placeQ36426799
Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cellsQ36478420
The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.Q36547690
Epidermal growth factor regulates hematopoietic regeneration after radiation injuryQ36674536
Current knowledge of the large RhoGAP family of proteinsQ36707513
Actin nucleation and elongation factors: mechanisms and interplayQ37164608
RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitorsQ37246480
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potentialQ37398312
Asymmetric cell division: recent developments and their implications for tumour biologyQ37811896
Off the beaten paths: alternative and crosstalk regulation of Rho GTPasesQ37950870
Development of hematopoietic stem cell activity in the mouse embryoQ38306839
Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathwayQ39540274
Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin traffickingQ39871471
Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure.Q40449994
The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flowQ40857641
Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreadingQ40918517
Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytesQ40918897
Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motilityQ40948867
The Rho GTPases in macrophage motility and chemotaxisQ40993544
Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytesQ41063804
Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophagesQ41123408
Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form.Q41378313
ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motilityQ41660150
Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.Q41700895
ADP-ribosylation of the GTP-binding protein Rho by Clostridium limosum exoenzyme affects basal, but not N-formyl-peptide-stimulated, actin polymerization in human myeloid leukaemic (HL60) cellsQ41956158
Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases.Q42805134
Isolation of a new human oncogene from a diffuse B-cell lymphoma.Q42814928
Timing of cyclin D1 expression within G1 phase is controlled by Rho.Q42823589
ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.Q43594596
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cellsQ43842022
Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactionsQ44099207
Redox-dependent downregulation of Rho by Rac.Q44323617
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.Q44357555
Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region.Q44684690
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.Q44915718
Role of citron kinase as a target of the small GTPase Rho in cytokinesisQ47713471
Pleckstrin homology domains: a common fold with diverse functionsQ47910921
Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphomaQ47951335
Recombinant rat stem cell factor synergizes with recombinant human granulocyte colony-stimulating factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential.Q52222892
Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment.Q53622126
First protozoa-trapping plant foundQ55953622
Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1Q57011019
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1Q59053220
Niche retreats for stem cellsQ59057890
Domains of rasGAP and rhoGAP are relatedQ59072519
Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell DifferentiationQ62818376
Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemiaQ62927037
A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cellsQ68513257
The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1Q70870969
Diffuse intraembryonic hemopoiesis in normal and chimeric avian developmentQ70941976
Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse EmbryoQ71621442
P433issue1
P921main subjectcytoskeletonQ154626
P304page(s)255-268
P577publication date2013-11-01
P1433published inImmunological ReviewsQ15724582
P1476titleRho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells
P478volume256

Reverse relations

cites work (P2860)
Q31110460A data-driven network model of primary myelofibrosis: transcriptional and post-transcriptional alterations in CD34+ cells.
Q43083337CEP2 attenuates myoblast differentiation but does not affect proliferation
Q45816321Cytoskeletal function in the immune system.
Q90426322Cytoskeletal tension regulates mesodermal spatial organization and subsequent vascular fate
Q42656462Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy
Q52725556Elevated Expression of miR302-367 in Endothelial Cells Inhibits Developmental Angiogenesis via CDC42/CCND1 Mediated Signaling Pathways.
Q41173866Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells
Q47280922Hematopoietic defects in response to reduced Arhgap21.
Q26823123Integrin cytoplasmic tail interactions
Q55717745Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment.
Q64108626Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway
Q59126829Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase
Q64961781PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.
Q35242581Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity
Q92420783Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics
Q51321906Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes.
Q59052275Rho-GTPase Signalling in the Pathogenesis of Nephrotic Syndrome
Q42128160Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission
Q43187995Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation
Q37056963Suppressive action of miRNAs to ARP2/3 complex reduces cell migration and proliferation via RAC isoforms in Hirschsprung disease
Q38718455The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner
Q58580925The Mechanobiology of the Actin Cytoskeleton in Stem Cells during Differentiation and Interaction with Biomaterials
Q47319422The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients
Q42321447p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

Search more.