Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

scientific article published on February 1997

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.11.4.463
P698PubMed publication ID9042860
P5875ResearchGate publication ID14167878

P2093author name stringBravo R
Lacal JC
Perona R
Saniger L
Montaner S
Sánchez-Pérez I
P433issue4
P304page(s)463-475
P577publication date1997-02-01
P1433published inGenes & DevelopmentQ1524533
P1476titleActivation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins
P478volume11

Reverse relations

cites work (P2860)
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Q36337932Anti-inflammatory effects of statins: clinical evidence and basic mechanisms
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Q33818687Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2.
Q38632892Breast cancer-associated gene 3 interacts with Rac1 and augments NF-κB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo
Q73155209CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin
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Q33753610Cdc42 and aging of hematopoietic stem cells
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Q28513614Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development
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Q38297271Chemoattractant-stimulated NF-kappaB activation is dependent on the low molecular weight GTPase RhoA.
Q37880077Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management
Q35570996Citron kinase, a RhoA effector, enhances HIV-1 virion production by modulating exocytosis
Q40649906Constitutively Activated Rho Guanosine Triphosphatases Regulate the Growth and Morphology of Hairy Cell Leukemia Cells
Q44650518Constitutively active Gq/11-coupled Receptors Enable Signaling by Co-expressed Gi/o-coupled Receptors
Q34736520Critical activities of Rac1 and Cdc42Hs in skeletal myogenesis: antagonistic effects of JNK and p38 pathways
Q36846434Critical role of Cdc42 in mediating endothelial barrier protection in vivo
Q35964491Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma.
Q36168835Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury
Q43780913Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB.
Q28382965DLC1 suppresses NF-κB activity in prostate cancer cells due to its stabilizing effect on adherens junctions
Q43597884Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways
Q37649660Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer
Q33960372Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation
Q37619425Detection of enteric pathogens by the nodosome
Q73691283Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation
Q39092880Dual lipidation of the brain-specific Cdc42 isoform regulates its functional properties.
Q51272863Effects of the Rho kinase inhibitor, hydroxyfasudil, on bladder dysfunction and inflammation in rats with HCl-induced cystitis.
Q35192592Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury.
Q64914219Engineering of Human Corneal Endothelial Cells In Vitro.
Q35995685Enhanced intrarenal oxidative stress and angiotensinogen in IgA nephropathy patients.
Q28565494Eotaxin induces migration of RBL-2H3 mast cells via a Rac-ERK-dependent pathway
Q42816126Expression of Rac1b stimulates NF-kappaB-mediated cell survival and G1/S progression
Q73359138Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways
Q36328224Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix
Q43628848Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor necrosis factor-alpha- and interleukin-1beta-induced NF-kappa B activation
Q35745964G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation
Q34359014G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling
Q24319756GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors
Q24554337Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1
Q35128385Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts
Q34244330Genome-wide analysis of Pax8 binding provides new insights into thyroid functions
Q42817431Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells
Q37828397Glutaminase: a hot spot for regulation of cancer cell metabolism?
Q38256963Granule protein processing and regulated secretion in neutrophils
Q35113720HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation
Q84232214HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients
Q47964174HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation
Q38121356Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders
Q35109696Hijacking Rho GTPases by protein toxins and apoptosis: molecular strategies of pathogenic bacteria.
Q38153177How does cancer cell metabolism affect tumor migration and invasion?
Q39595632Human immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKR
Q33714131IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion
Q35654383IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice
Q77581166Identification of a signaling pathway activated specifically in the somatodendritic compartment by a heparan sulfate that regulates dendrite growth
Q44203329Identification of the LIM kinase-1 as a ceramide-regulated gene in renal mesangial cells
Q30447293Identification of the deleted in liver cancer 1 gene, DLC1, as a candidate meningioma tumor suppressor.
Q30540011Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury
Q33201904Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse
Q89599348Impairment of Membrane Lipid Homeostasis by Bichalcone Analog TSWU-BR4 Attenuates Function of GRP78 in Regulation of the Oxidative Balance and Invasion of Cancer Cells
Q30445152In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies
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Q34124356Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling
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Q46622473Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia
Q28365800Inhibition of cell transformation by sulindac sulfide is confined to specific oncogenic pathways
Q35491663Inhibition of geranylgeranyl transferase-I decreases cell viability of HTLV-1-transformed cells
Q97419380Inhibition of leucine-rich repeats and calponin homology domain containing 1 accelerates microglia-mediated neuroinflammation in a rat traumatic spinal cord injury model
Q43882525Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells
Q33872322Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
Q41024128Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling
Q40923131Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity
Q35545301Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts
Q64103582KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF
Q35641026Kaposi's sarcoma-associated herpesvirus microRNAs repress breakpoint cluster region protein expression, enhance Rac1 activity, and increase in vitro angiogenesis
Q37349989KiSS1 suppresses TNFalpha-induced breast cancer cell invasion via an inhibition of RhoA-mediated NF-kappaB activation.
Q77993726Lack of c-Jun activity increases survival to cisplatin
Q38739496Leucine Zipper Down-regulated in Cancer-1 (LDOC1) interacts with Guanine nucleotide binding protein-like 3-like (GNL3L) to modulate Nuclear Factor-kappa B (NF-κB) signaling during cell proliferation.
Q44614910Lovastatin causes sensitization of HeLa cells to ionizing radiation‐induced apoptosis by the abrogation of G2 blockage
Q38328981Lysophosphatidic acid activates NF-kappaB in fibroblasts. A requirement for multiple inputs
Q38044174Lysophospholipid receptor activation of RhoA and lipid signaling pathways
Q35055504MDA-9/syntenin is essential for factor VIIa-induced signaling, migration, and metastasis in melanoma cells
Q51630242Macrophages from lupus-prone MRL mice are characterized by abnormalities in Rho activity, cytoskeletal organization, and adhesiveness to extracellular matrix proteins.
Q38132108Mal, more than a bridge to MyD88.
Q28505657Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation
Q39574466Mas oncogene signaling and transformation require the small GTP-binding protein Rac
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Q44492984Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation
Q41785271Melanoma cell migration to type IV collagen requires activation of NF-kappaB
Q36304167Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth
Q36708704MicroRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C epsilon (PKCepsilon).
Q36780182Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?
Q24554281Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex
Q35619856Modulation of HIV-1 replication by a novel RhoA effector activity
Q35565668Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells
Q36561736Multifaceted role of Rho proteins in angiogenesis
Q46037226Myeloid Notch1 Deficiency Activates RhoA/ROCK Pathway and Aggravates Hepatocellular Damage In Mouse Ischemic Livers.
Q73916916NF-kappaB (p65/RelA) as a regulator of TNFalpha-mediated ML-1 cell differentiation
Q34088808NF-kappaB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment
Q33699422NF-kappaB and apoptosis in mammary epithelial cells
Q34225148NF-kappaB and cell-cycle regulation: the cyclin connection
Q28570506NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival
Q54941244NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation.
Q40397344NK cells are biologic and biochemical targets of 6-mercaptopurine in Crohn's disease patients
Q92987394NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer
Q40077398NOD1 and NOD2: Beyond Peptidoglycan Sensing.
Q24315893Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation
Q40671067Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways
Q38981722New Aspects on Bacterial Effectors Targeting Rho GTPases
Q38343521Number of expressed cancer/testis antigens identifies focal adhesion pathway genes as possible targets for multiple myeloma therapy.
Q35067751Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-κB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells
Q33969205Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase
Q88160419Oxidative stress as a possible mechanism of statin-induced myopathy
Q41750986Oxygen radicals and signaling
Q33670240PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart
Q43660533PYK2 links G(q)alpha and G(13)alpha signaling to NF-kappa B activation.
Q52963887Pathogenicity island-dependent activation of Rho GTPases Rac1 and Cdc42 in Helicobacter pylori infection.
Q33797174Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases
Q52668550Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis.
Q33782701Platelets and megakaryocytes contain functional nuclear factor-kappaB.
Q33720590Potential drug targets: small GTPases that regulate leukocyte function
Q74127433Potentiation of Rho-A-mediated lysophosphatidic acid activity by hyperinsulinemia
Q36158964Prostanoid EP₁ receptors mediate up-regulation of the orphan nuclear receptor Nurr1 by cAMP-independent activation of protein kinase A, CREB and NF-κB.
Q40565710Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis
Q37036685Protein kinase D protects against oxidative stress-induced intestinal epithelial cell injury via Rho/ROK/PKC-delta pathway activation
Q23918164Protein phosphorylation cascades associated with methamphetamine-induced glial activation
Q36156141ROCK I-mediated activation of NF-kappaB by RhoB
Q50066730ROCK as a therapeutic target for ischemic stroke.
Q39089381ROCK2/rasHa co-operation induces malignant conversion via p53 loss, elevated NF-κB and tenascin C-associated rigidity, but p21 inhibits ROCK2/NF-κB-mediated progression
Q26853214ROCKs as immunomodulators of stroke
Q36779662Rac GTPase instructs nuclear factor-kappaB activation by conveying the SCF complex and IkBalpha to the ruffling membranes
Q40230078Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling.
Q40927177Rac-dependent anti-apoptotic signaling by the insulin receptor cytoplasmic domain
Q37371665Rac1 GTPase: a "Rac" of all trades.
Q34695267Rac1 activity regulates proliferation of aggressive metastatic melanoma
Q28216113Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB
Q36310904Rac1 augments Wnt signaling by stimulating β-catenin-lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import
Q36733195Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging
Q24303862Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kappaB p65 trans activation plays a novel role
Q40803889Rac1 protects epithelial cells against anoikis
Q39159284Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death
Q40301555Rac1, but not Rac1B, stimulates RelB-mediated gene transcription in colorectal cancer cells
Q38678046Rac1-mediated cardiac damage causes diastolic dysfunction in a mouse model of subacute doxorubicin-induced cardiotoxicity
Q27316142Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors
Q39456448Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
Q34073399Ras and Rho GTPases: a family reunion
Q37061781Ras and rheb signaling in survival and cell death
Q36291656Ras-like family small GTPases genes in Nilaparvata lugens: Identification, phylogenetic analysis, gene expression and function in nymphal development
Q31523965Ras-related GTPase Rhob represses NF-kappaB signaling
Q33957447Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity
Q22010208Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways
Q44413736Reduction of serum C-reactive protein by statin therapy may reflect decreased isoprenylation of Rac-1, a mediator of the IL-6 signal transduction pathway
Q74734362Reduction of tumor necrosis factor-alpha (TNF-alpha) related nuclear factor-kappaB (NF-kappaB) translocation but not inhibitor kappa-B (Ikappa-B)-degradation by Rho protein inhibition in human endothelial cells
Q28566136Regulated shuttling of Slit-Robo-GTPase activating proteins between nucleus and cytoplasm during brain development
Q44077300Regulation of GRIP1 and CBP Coactivator activity by Rho GDI modulates estrogen receptor transcriptional enhancement
Q38325239Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells
Q48000569Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells
Q22254209Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands
Q42828450Regulation of c-myc expression by PDGF through Rho GTPases.
Q37041713Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1.
Q38249102Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42
Q40400674Regulation of p21-activated kinase-independent Rac1 signal transduction by nischarin
Q40890957Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling
Q28208539Regulation of proto-Dbl by intracellular membrane targeting and protein stability
Q28576263Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha
Q34612747Rho GTPase signalling pathways in the morphological changes associated with apoptosis.
Q36903028Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology
Q29547740Rho GTPases and their effector proteins
Q27003967Rho GTPases and their roles in cancer metabolism
Q35537884Rho GTPases as therapeutic targets for the treatment of inflammatory diseases
Q38119740Rho GTPases in neurodegeneration diseases
Q92816177Rho GTPases in the Physiology and Pathophysiology of Peripheral Sensory Neurons
Q26782005Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?
Q28257230Rho GTPases: functions and association with cancer
Q24301188Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis
Q43530084Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.
Q33802112Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology
Q34149118Rho protein inactivation induced apoptosis of cultured human endothelial cells
Q34180592Rho signals to cell growth and apoptosis
Q90975446Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells
Q34869485RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts
Q40114788RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.
Q42639509RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.
Q33649134RhoA interacts with the fusion glycoprotein of respiratory syncytial virus and facilitates virus-induced syncytium formation
Q31052568RhoA of the Rho family small GTPases is essential for B lymphocyte development
Q24310745RhoG signals in parallel with Rac1 and Cdc42
Q39697053STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA
Q34348449Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors
Q34412353Serine-71 phosphorylation of Rac1 modulates downstream signaling
Q35546502Serum response factor function and dysfunction in smooth muscle
Q41724478Signal transduction through NF-kappa B.
Q33948297Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation
Q39644202Simvastatin inhibits glucose-stimulated vascular smooth muscle cell migration involving increased expression of RhoB and a block of Ras/Akt signal
Q38451651Small GTPase Rap1 regulates cell migration through regulation of small GTPase RhoA activity in response to transforming growth factor-β1.
Q34704519SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma
Q35365005Statin use and risk of pancreatic cancer: results from a large, clinic-based case-control study
Q39012650Statins in anthracycline-induced cardiotoxicity: Rac and Rho, and the heartbreakers
Q36259633Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells
Q40711853Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases
Q54281504Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1α-induced invasion of human esophageal carcinoma cells.
Q33959056Suppression of Ras-induced apoptosis by the Rac GTPase
Q55032216Suppression of phospho-p85α-GTP-Rac1 lipid raft interaction by bichalcone analog attenuates cancer cell invasion.
Q37086576Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response
Q27335272Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-κB activation
Q24322063TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner
Q34542205TNF ligands and receptors--a matter of life and death
Q34565473TNF receptor subtype signalling: differences and cellular consequences
Q34807996Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
Q35892052Targeting of host-cell ubiquitin and ubiquitin-like pathways by bacterial factors
Q45070460Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha
Q55207637The Pharmacological Targets and Clinical Evidence of Natural Products With Anti-hepatic Inflammatory Properties.
Q26864271The Rac1 hypervariable region in targeting and signaling: a tail of many stories
Q39411440The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion.
Q36744824The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases
Q36401482The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing
Q38129243The cytotoxic necrotizing factor 1 from E. coli: a janus toxin playing with cancer regulators.
Q87593562The diamond anniversary of tissue transglutaminase: a protein of many talents
Q28190692The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element
Q24292225The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function
Q33967934The insert region of Rac1 is essential for membrane ruffling but not cellular transformation
Q35011136The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein
Q36515597The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease?
Q35595431The many roles of statins in ischemic stroke
Q35946550The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset
Q34594213The role of Rho GTPases in disease development
Q28608947The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death
Q30989694The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways
Q34695835Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway
Q30413746Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61.
Q39759604Thyroid hormone antagonizes tumor necrosis factor-alpha signaling in pituitary cells through the induction of dual specificity phosphatase 1.
Q28362213Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA
Q40819427Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway
Q34296477Toll-like receptors and innate immunity.
Q40329297Transcriptomal profiling of the cellular transformation induced by Rho subfamily GTPases
Q34033409Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin
Q40648585Tumor necrosis factor-alpha promotes survival of opossum kidney cells via Cdc42-induced phospholipase C-gamma1 activation and actin filament redistribution
Q40631985Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling
Q42729185Unraveling the mechanism of action of a new type III secretion system effector AexU from Aeromonas hydrophila
Q28610652Vav2 is an activator of Cdc42, Rac1, and RhoA
Q40494842Wave2 activates serum response element via its VCA region and functions downstream of Rac.
Q64928290Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Q33632074Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation
Q36400558Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production.
Q41114017hCLOCK Causes Rho-Kinase-Mediated Endothelial Dysfunction and NF-κB-Mediated Inflammatory Responses
Q24647606p120-catenin mediates inflammatory responses in the skin
Q34432263p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
Q42813127p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr.
Q36894019rhoB encoding a UV-inducible Ras-related small GTP-binding protein is regulated by GTPases of the Rho family and independent of JNK, ERK, and p38 MAP kinase
Q37580248β-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation.

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