IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice

scientific article published on 5 June 2015

IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1029314G
P356DOI10.1371/JOURNAL.PONE.0129314
P932PMC publication ID4457730
P698PubMed publication ID26047140
P5875ResearchGate publication ID279213154

P50authorYusuf A. HannunQ87620042
Vincent W. YangQ112668235
P2093author name stringValentina A Schmidt
Ashley J Snider
Amr M Ghaleb
Agnieszka B Bialkowska
Dmitri V Gnatenko
P2860cites workgp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.Q53418407
Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis.Q54142966
Suppression of experimental colitis by intestinal mononuclear phagocytes.Q54588871
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function.Q55052541
IQ-motif peptides as novel anti-microbial agentsQ61781885
Strategic compartmentalization of Toll-like receptor 4 in the mouse gutQ73229779
Dextran sulfate sodium-induced murine colitis activates NF-kappaB and increases galanin-1 receptor expressionQ73761478
Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependentQ36483421
Restriction of intestinal stem cell expansion and the regenerative response by YAP.Q36508081
Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling.Q36755963
Bile acids activate YAP to promote liver carcinogenesisQ37651886
A molecular rheostat at the interface of cancer and diabetesQ38103727
IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.Q39163078
IQGAP2, A candidate tumour suppressor of prostate tumorigenesis.Q39382148
Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway.Q39534571
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cellsQ40063159
Quantitative measurement of cytokine mRNA in inflammatory bowel disease: relation to clinical and endoscopic activity and outcomeQ40430965
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathwayQ40819427
Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice.Q41418413
Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ.Q41878360
The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitisQ42454131
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteinsQ42803708
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitisQ42859669
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathwayQ21735927
IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganizationQ24338356
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesisQ24655426
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
A human homologue of the Drosophila Toll protein signals activation of adaptive immunityQ28131769
IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulinQ28209157
Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion frontsQ28215481
Activation of interleukin-6 gene expression through the NF-kappa B transcription factorQ28646310
Unravelling the pathogenesis of inflammatory bowel diseaseQ29547551
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosisQ29614481
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerQ29614594
Real time quantitative PCRQ29616373
Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influencesQ29617565
Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer.Q31059013
Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitisQ33475620
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18Q34044424
Tissue-specific signals control reversible program of localization and functional polarization of macrophagesQ34065482
Toll-like receptors in inflammatory bowel diseases: A decade laterQ34134813
The immunological and genetic basis of inflammatory bowel diseaseQ34216426
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration programQ34244244
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic interventionQ34595904
LPS/TLR4 signal transduction pathwayQ34756268
Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinomaQ34950738
Activation of nuclear factor kappa B inflammatory bowel diseaseQ35350256
IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.Q35804062
Watch the GAP: Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular CarcinomaQ36225463
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e0129314
P577publication date2015-06-05
P1433published inPLOS OneQ564954
P1476titleIQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice
P478volume10

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cites work (P2860)
Q55268850Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer.
Q90397006IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity
Q39612799IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway
Q38680003Proteomic profiling reveals crucial retinal protein alterations in the early phase of an experimental glaucoma model
Q61818340SENP3-mediated host defense response contains HBV replication and restores protein synthesis
Q54981845Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation.

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