Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability

scientific article published on August 2002

Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1091/MBC.E02-01-0022
P932PMC publication ID117953
P698PubMed publication ID12181357
P5875ResearchGate publication ID11206729

P50authorSalvador Aznar BenitahQ39033088
Juan Carlos LacalQ40430195
P2093author name stringRosario Perona
Isabel Sánchez-Pérez
Montserrat Martínez-Gomariz
P2860cites workMechanism of NF-kappa B translocation in macrophages treated in vitro with cisplatinQ77157629
Lack of c-Jun activity increases survival to cisplatinQ77993726
Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activationQ78069508
Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitationQ93607580
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoformsQ24312029
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2Q24313872
The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expressionQ24548310
NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosisQ24554454
Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuliQ24568220
CREB-binding protein/p300 are transcriptional coactivators of p65Q24569596
Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequenceQ24598724
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradationQ24650561
MEKK1 activates both IkappaB kinase alpha and IkappaB kinase betaQ24681806
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICADQ28258328
Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activationQ28277712
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1Q28302936
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesisQ28505039
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300Q28619230
Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa BQ28645847
Activation of interleukin-6 gene expression through the NF-kappa B transcription factorQ28646310
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
NF-kappaB in cancer: from innocent bystander to major culpritQ29614603
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylationQ29614709
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-betaQ29617188
The stress-activated protein kinase subfamily of c-Jun kinasesQ29620001
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domainQ29620169
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptorsQ31169174
Loss of IkappaB alpha-mediated control over nuclear import and DNA binding enables oncogenic activation of c-RelQ33778864
Control of apoptosis by Rel/NF-kappaB transcription factorsQ33797163
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.Q33860531
Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformationQ33948297
The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).Q33962748
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.Q34131747
I kappa B-independent control of NF-kappa B activity by modulatory phosphorylationsQ34179362
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activationQ35156450
N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activityQ36555088
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinasesQ36667357
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.Q36967719
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.Q39451375
CBP/p300 and muscle differentiation: no HAT, no muscleQ39646212
Mechanistic aspects of NF-kappa B regulation: the emerging role of phosphorylation and proteolysisQ40410066
Regulation of the DNA binding activity of NF-kappa B.Q40429561
Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.Q40767950
Fos is an essential component of the mammalian UV responseQ40789823
Cisplatin inhibits the expression of X-chromosome-linked inhibitor of apoptosis protein in an oral carcinoma cell lineQ40815035
Stimulation of p300-mediated transcription by the kinase MEKK1.Q40817286
The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrestQ40834838
PI3-K/AKT regulation of NF-kappaB signaling events in suppression of TNF-induced apoptosisQ40881979
Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand systemQ40942580
Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cellsQ40996842
The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression.Q41049409
Cisplatin induces a persistent activation of JNK that is related to cell deathQ41062943
Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosisQ41239719
Induction of apoptosis by the transcription factor c-JunQ42614297
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteinsQ42803708
HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathwayQ42804558
Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.Q42830960
Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF-kappaB inhibitionQ43614760
Inhibition of JNK activation through NF-kappaB target genesQ43802523
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.Q45971622
DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.Q46784718
c-Jun is essential for normal mouse development and hepatogenesisQ57083732
Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitroQ57888777
Functional Interplay Between Nuclear Factor-κB and c-Jun Integrated by Coactivator p300 Determines the Survival of Nerve Growth Factor-Dependent PC12 CellsQ58661830
Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteinsQ64380181
The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferationQ71833616
A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell deathQ72232625
Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cellsQ72350511
The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP)Q73083269
CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatinQ73155209
NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa BQ74244990
Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPasesQ74531638
P433issue8
P304page(s)2933-2945
P577publication date2002-08-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleCell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability
P478volume13

Reverse relations

cites work (P2860)
Q28547392A Central Role for JNK/AP-1 Pathway in the Pro-Oxidant Effect of Pyrrolidine Dithiocarbamate through Superoxide Dismutase 1 Gene Repression and Reactive Oxygen Species Generation in Hematopoietic Human Cancer Cell Line U937
Q47942760Activation of TWIST1 by COL11A1 promotes chemoresistance and inhibits apoptosis in ovarian cancer cells by modulating NF-κB-mediated IKKβ expression.
Q42022163Activation of nuclear factor-kappaB in human prostate carcinogenesis and association to biochemical relapse
Q38899892Alpha-Tomatine Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated Macrophages
Q37580192Androgen receptor activity modulates responses to cisplatin treatment in bladder cancer
Q35100882Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-kappaB inactivation
Q39870887Bis-(3-hydroxyphenyl) diselenide inhibits LPS-stimulated iNOS and COX-2 expression in RAW 264.7 macrophage cells through the NF-kappaB inactivation
Q64915016CUEDC2 Contributes to Cisplatin-Based Chemotherapy Resistance in Ovarian Serious Carcinoma by Regulating p38 MAPK Signaling.
Q36621547Cassia tora L. (Jue-ming-zi) has anticancer activity in TCA8113 cells in vitro and exerts anti-metastatic effects in vivo
Q37729428Common Chemical Inductors of Replication Stress:  Focus on Cell-Based Studies
Q35647850Control of oncogenesis and cancer therapy resistance
Q59330226Cyclophilin A as a target in the treatment of cytomegalovirus infections
Q34347854D. candidum has in vitro anticancer effects in HCT-116 cancer cells and exerts in vivo anti-metastatic effects in mice
Q33962641Dendrobium candidum Wall. ex Lindl. attenuates CCl4-induced hepatic damage in imprinting control region mice
Q39034883Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer.
Q40631549Early events in the induction of apoptosis in ovarian carcinoma cells by CD437: activation of the p38 MAP kinase signal pathway
Q39414094Euscaphic acid isolated from roots of Rosa rugosa inhibits LPS-induced inflammatory responses via TLR4-mediated NF-κB inactivation in RAW 264.7 macrophages
Q37535542Increased preventive effect on colon carcinogenesis by use of resistant starch (RS3) as the carrier for polysaccharide of Larimichthys crocea swimming bladder
Q33758201Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan
Q40173444Kaposi's sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression
Q40552652MEKK1 signaling through p38 leads to transcriptional inactivation of E47 and repression of skeletal myogenesis
Q45045445Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1.
Q43110174Nuclear Factor-kappa B as a Resistance Factor to Platinum-Based Antineoplasic Drugs
Q36085634Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
Q39835063Over-expression of mitogen-activated protein kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells
Q37714637Preventive Effect of Polysaccharide of Larimichthys crocea Swim Bladder on Reserpine Induced Gastric Ulcer in ICR Mice
Q85696582Preventive effects of the polysaccharide of Larimichthys crocea swim bladder on carbon tetrachloride (CCl4)-induced hepatic damage
Q28572424RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells
Q35177662Role of Jun and Jun kinase in resistance of cancer cells to therapy
Q39929809Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin
Q39514532Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration
Q97905063Serum deprivation initiates adaptation and survival to oxidative stress in prostate cancer cells
Q37160973Shift from apoptotic to necrotic cell death during human papillomavirus-induced transformation of keratinocytes
Q36987488Signalling pathways involved in clinical responses to chemotherapy.
Q33803307Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals
Q38306038Styraxoside A isolated from the stem bark of Styrax japonica inhibits lipopolysaccharide-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cells by suppressing nuclear factor-kappa B activation
Q43133462TNF-alpha reduces the Na+/K+ ATPase activity in LLC-PK1 cells by activating caspases and JNK and inhibiting NF-kappaB.
Q40751673Targeting nuclear factor-kappa B to overcome resistance to chemotherapy.
Q42631227The role of calcium, NF-κB and NFAT in the regulation of CXCL8 and IL-6 expression in Jurkat T-cells
Q39470179Toll-like receptor 4 activates NF-κB and MAP kinase pathways to regulate expression of proinflammatory COX-2 in renal medullary collecting duct cells
Q37001622Transglutaminase 2 expression predicts progression free survival in non-small cell lung cancer patients treated with epidermal growth factor receptor tyrosine kinase inhibitor
Q24804943Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells
Q42316245c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas

Search more.