| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Richard A Cerione | |
| Jon W Erickson | |||
| P2860 | cites work | A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis | Q24649156 |
| Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway | Q24649739 | ||
| Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability | Q24685610 | ||
| Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour | Q73415922 | ||
| Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer | Q80370519 | ||
| Pyruvate kinase M2 is a phosphotyrosine-binding protein | Q27650067 | ||
| Rho GTPases in cell biology | Q27860969 | ||
| On the Origin of Cancer Cells | Q27861025 | ||
| Genomic analysis of metastasis reveals an essential role for RhoC | Q28144278 | ||
| Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways | Q28274882 | ||
| DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma | Q28384558 | ||
| DLC1: a significant GAP in the cancer genome | Q28390592 | ||
| The biology of cancer: metabolic reprogramming fuels cell growth and proliferation | Q29547301 | ||
| The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth | Q29547680 | ||
| c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism | Q29617213 | ||
| Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis | Q29617613 | ||
| The ErbB signaling network: receptor heterodimerization in development and cancer | Q29617919 | ||
| ERBB receptors and cancer: the complexity of targeted inhibitors | Q29619520 | ||
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| Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation | Q33960372 | ||
| Evidence for an alternative glycolytic pathway in rapidly proliferating cells | Q34535762 | ||
| Targeting mitochondrial glutaminase activity inhibits oncogenic transformation | Q34807996 | ||
| Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes | Q35638972 | ||
| Altered Rho GTPase signaling pathways in breast cancer cells. | Q35681632 | ||
| Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas | Q36294989 | ||
| Epidermal growth factor receptor (EGFR) signaling in cancer | Q36353031 | ||
| Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters | Q36624071 | ||
| Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. | Q36710542 | ||
| Protein kinase inhibitors: structural insights into selectivity | Q36952328 | ||
| Rho GTPases in cancer cell biology | Q37156024 | ||
| Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer | Q37376029 | ||
| Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b | Q38310978 | ||
| Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth | Q39773538 | ||
| Regulation of glutaminase activity and glutamine metabolism | Q40926056 | ||
| Dbl family proteins | Q41374941 | ||
| Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins | Q42803708 | ||
| Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation | Q42812372 | ||
| A novel Cdc42Hs mutant induces cellular transformation | Q42834331 | ||
| Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways | Q43597884 | ||
| Bacterial expression, purification, and characterization of rat kidney-type mitochondrial glutaminase | Q44578001 | ||
| Rho GTPases are over-expressed in human tumors. | Q53423587 | ||
| P275 | copyright license | Creative Commons Attribution 2.5 Generic | Q18810333 |
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | neoplasm | Q1216998 |
| glutaminase | Q24773687 | ||
| energy metabolism | Q30225378 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 734-740 | |
| P577 | publication date | 2010-12-01 | |
| P1433 | published in | Oncotarget | Q1573155 |
| P1476 | title | Glutaminase: a hot spot for regulation of cancer cell metabolism? | |
| P478 | volume | 1 |
| Q49330394 | A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity. |
| Q38767151 | A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis |
| Q37673339 | Altered glutamine metabolism and therapeutic opportunities for lung cancer |
| Q30928926 | Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma |
| Q45328866 | BPTES inhibition of hGA(124-551), a truncated form of human kidney-type glutaminase. |
| Q37691088 | Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis. |
| Q38060693 | Cancer metabolism: what we can learn from proteomic analysis by mass spectrometry |
| Q50113187 | Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. |
| Q37176101 | Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies. |
| Q36074804 | Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate. |
| Q47812705 | Comparative study on microsampling techniques in metabolic fingerprinting studies applying gas chromatography-MS analysis |
| Q36517216 | Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. |
| Q34227609 | Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells |
| Q58589986 | Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism |
| Q47095381 | Endogenous glutamine decrease is associated with pancreatic cancer progression. |
| Q35899955 | ErbB2 activation upregulates glutaminase 1 expression which promotes breast cancer cell proliferation |
| Q37619803 | Expression of glutamine metabolism-related proteins in thyroid cancer |
| Q45059950 | Fluorination at the 4 position alters the substrate behavior of L-glutamine and L-glutamate: Implications for positron emission tomography of neoplasias |
| Q35078436 | Follicular adenomas exhibit a unique metabolic profile. ¹H NMR studies of thyroid lesions |
| Q38456915 | Glutaminase 1 is a potential biomarker for chronic post-surgical pain in the rat dorsal spinal cord using differential proteomics |
| Q34437004 | Glutaminase 1 is essential for the differentiation, proliferation, and survival of human neural progenitor cells |
| Q52655642 | Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate. |
| Q37688120 | Glutamine deprivation plus BPTES alters etoposide- and cisplatin-induced apoptosis in triple negative breast cancer cells |
| Q38692702 | Glutathione in metastases: From mechanisms to clinical applications |
| Q39261665 | Hopefully devoted to Q: targeting glutamine addiction in cancer |
| Q54978523 | Inhibition of Glycolysis and Glutaminolysis: Emerging Drug Discovery Approach to Combat Cancer. |
| Q36729484 | Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer |
| Q37921677 | Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death. |
| Q26749556 | Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function |
| Q88761261 | Lipid metabolism reprogramming and its potential targets in cancer |
| Q30391992 | Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS |
| Q90642651 | Metabolic Plasticity in Chemotherapy Resistance |
| Q37908233 | Metabolic alterations in cancer cells and therapeutic implications |
| Q36994631 | Metabolic host responses to infection by intracellular bacterial pathogens |
| Q37620679 | Metabolism addiction in pancreatic cancer |
| Q38926653 | Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction |
| Q36484135 | Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype |
| Q39114289 | Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation |
| Q50041769 | Multiplatform plasma metabolic and lipid fingerprinting of breast cancer: A pilot control-case study in Colombian Hispanic women. |
| Q38061832 | NRF2 and p53: Januses in cancer? |
| Q36392145 | Phospho-ΔNp63α/SREBF1 protein interactions: bridging cell metabolism and cisplatin chemoresistance |
| Q52668550 | Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis. |
| Q39448621 | Proteomic analysis reveals Warburg effect and anomalous metabolism of glutamine in pancreatic cancer cells |
| Q47134230 | Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer. |
| Q36463007 | R(h)oads to microvesicles |
| Q90440765 | Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma |
| Q89401928 | Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase |
| Q36736358 | Recent discoveries in the cycling, growing and aging of the p53 field |
| Q35740782 | Recent progress in targeting cancer |
| Q27003967 | Rho GTPases and their roles in cancer metabolism |
| Q35006405 | STAT1 regulates human glutaminase 1 promoter activity through multiple binding sites in HIV-1 infected macrophages |
| Q57812966 | Selective usage of isozymes for stress response |
| Q37745850 | Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells |
| Q33587667 | Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration |
| Q35009910 | Small angle X-ray scattering studies of mitochondrial glutaminase C reveal extended flexible regions, and link oligomeric state with enzyme activity |
| Q24337478 | Structural insights into the catalytic active site and activity of human Nit2/ω-amidase: kinetic assay and molecular dynamics simulation |
| Q38084744 | Sum of the parts: mass spectrometry-based metabolomics |
| Q49367042 | Targeted inhibition of glutaminase as a potential new approach for the treatment of NF1 associated soft tissue malignancies. |
| Q38592248 | Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach |
| Q49632469 | Targeting Glutamine Metabolism for Cancer Treatment. |
| Q38121980 | Targeting SREBP-1-driven lipid metabolism to treat cancer |
| Q24596727 | Targeting cellular metabolism to improve cancer therapeutics |
| Q97525253 | The Glutamate System as a Crucial Regulator of CNS Toxicity and Survival of HIV Reservoirs |
| Q36189879 | The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells |
| Q98386432 | The combination of orlistat, lonidamine and 6-diazo-5-oxo-L-norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells |
| Q28391040 | Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells |
| Q38436428 | Transcriptomic comparison of primary bovine horn core carcinoma culture and parental tissue at early stage |
| Q38553827 | Uncovering metabolism in rhabdomyosarcoma. |
| Q50084978 | [RhoA/Rho-kinase contributes to chronic pain following thoracotomy by up-regulating glutaminase 1 expression in rat spinal dorsal cord]. |
| Q52312423 | [The cancer paradigm in pulmonary arterial hypertension: towards anti-remodeling therapies targeting metabolic dysfunction?] |
| Q26865272 | α-Ketoglutaramate: an overlooked metabolite of glutamine and a biomarker for hepatic encephalopathy and inborn errors of the urea cycle |
| Q38563900 | ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases. |
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