Microbial toxins and the glycosylation of rho family GTPases

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Microbial toxins and the glycosylation of rho family GTPases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0959-440X(00)00126-3
P698PubMed publication ID11042449

P2093author name stringAktories K
Busch C
P2860cites workExpression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucinQ22010456
A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similaritiesQ24530447
pH-induced conformational changes in Clostridium difficile toxin BQ24548768
Structure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed formsQ27618381
Crystal structures of the bovine beta 4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactoseQ27618915
Crystal structure of RhoA-GDP and its functional implicationsQ27743848
Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.Q42814014
A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinaseQ47239880
A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxinsQ47792278
Genetic rearrangements in the pathogenicity locus of Clostridium difficile strain 8864--implications for transcription, expression and enzymatic activity of toxins A and B.Q47915521
Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.Q47954843
Clostridium difficile toxin B induces reorganization of actin, vinculin, and talin in cultured cells.Q52490693
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1Q59053220
Hydrophobic cluster analysis: an efficient new way to compare and analyse amino acid sequencesQ69445009
Molecular mimicry in the recognition of glycosphingolipids by Gal alpha 3 Gal beta 4 GlcNAc beta-binding Clostridium difficile toxin A, human natural anti alpha-galactosyl IgG and the monoclonal antibody Gal-13: characterization of a binding-activeQ71787158
Characterization of chitin synthase 2 of Saccharomyces cerevisiae. Implication of two highly conserved domains as possible catalytic sitesQ72298744
A Rho-related GTPase is involved in Ca(2+)-dependent neurotransmitter exocytosisQ73538373
Inhibition of calcium release-activated calcium current by Rac/Cdc42-inactivating clostridial cytotoxins in RBL cellsQ73631031
Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxinQ74247337
Clostridium difficile infectionQ74333323
Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector couplingQ74457062
Structure-function analysis of the UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Essential residues lie in a predicted active site cleft resembling a lactose repressor foldQ74485219
Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogueQ27749065
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsQ27860467
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
Activity of the yeast MNN1 alpha-1,3-mannosyltransferase requires a motif conserved in many other families of glycosyltransferasesQ27935328
The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRFQ28292490
Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipidsQ28583613
Rho GTPases and signaling networksQ28646215
Rho GTPases and their effector proteinsQ29547740
Rho GTPases control polarity, protrusion, and adhesion during cell movementQ29614244
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPasesQ29614245
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblastsQ29614253
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1Q29614256
Clostridium difficile toxins A and B are cation-dependent UDP-glucose hydrolases with differing catalytic activitiesQ30472216
Polarization of chemoattractant receptor signaling during neutrophil chemotaxisQ30493167
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).Q33737854
Structure/function studies of glycosyltransferasesQ33745420
Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulatorsQ33855240
The role of local actin instability in axon formationQ33855372
Neurotoxins affecting neuroexocytosisQ33881286
Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.Q33953572
The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteinsQ34312684
Glucosylation of Rho proteins by Clostridium difficile toxin B.Q34312765
Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B. Role of Rho proteinsQ34372893
Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylationQ34378935
Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteinsQ34397543
Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteinsQ34405601
Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxinQ34422333
Evidence for a modular structure of the homologous repetitive C-terminal carbohydrate-binding sites of Clostridium difficile toxins and Streptococcus mutans glucosyltransferasesQ36139965
Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A.Q37358133
Impact of amino acids 22-27 of Rho-subfamily GTPases on glucosylation by the large clostridial cytotoxins TcsL-1522, TcdB-1470 and TcdB-8864.Q38317914
A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxinsQ38326211
Characterization of the glycosyltransferase enzyme from the Escherichia coli K5 capsule gene cluster and identification and characterization of the glucuronyl active site.Q38336699
Inhibition of Fc epsilon-RI-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B (monoglucosyltransferase)Q41213243
Rho proteins: targets for bacterial toxinsQ41542894
Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas.Q41726718
Cellular internalisation of Clostridium difficile toxin A.Q41913662
Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferasesQ42625252
Capsular polysaccharide synthesis in Streptococcus pneumoniae serotype 14: molecular analysis of the complete cps locus and identification of genes encoding glycosyltransferases required for the biosynthesis of the tetrasaccharide subunitQ42668248
Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cyclingQ42810333
P433issue5
P921main subjectglycosylationQ898365
P304page(s)528-535
P577publication date2000-10-01
P1433published inCurrent Opinion in Structural BiologyQ15758416
P1476titleMicrobial toxins and the glycosylation of rho family GTPases
P478volume10

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cites work (P2860)
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Q45071227A phosphatidylserine-binding site in the cytosolic fragment of Clostridium sordellii lethal toxin facilitates glucosylation of membrane-bound Rac and is required for cytotoxicity.
Q40715854Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway
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Q40910110EhRho1, a RhoA-like GTPase of Entamoeba histolytica, is modified by clostridial glucosylating cytotoxins
Q46479800Evidence for dual receptor-binding sites in Clostridium difficile toxin A.
Q46939948GEF and glucosylation assays on liposome-bound Rac.
Q42072153Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons
Q33632189Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins
Q43888109Interaction of the Rho-ADP-ribosylating C3 exoenzyme with RalA.
Q35784070Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media
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Q34131204Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds
Q44132578Rac GTPase plays an essential role in exocytosis by controlling the fusion competence of release sites.
Q37781061Recent insights into Pasteurella multocida toxin and other G-protein-modulating bacterial toxins
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Q35544342Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT
Q33789728Structure determination by MALDI-IRMPD mass spectrometry and exoglycosidase digestions of O-linked oligosaccharides from Xenopus borealis egg jelly
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