| review article | Q7318358 |
| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1001144013 |
| P356 | DOI | 10.1186/1742-2094-3-30 |
| P2888 | exact match | https://scigraph.springernature.com/pub.10.1186/1742-2094-3-30 |
| P932 | PMC publication ID | 1637099 |
| P698 | PubMed publication ID | 17094809 |
| P5875 | ResearchGate publication ID | 6702213 |
| P2093 | author name string | Gary E Landreth | |
| Brandy L Wilkinson | |||
| P2860 | cites work | Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes | Q24321387 |
| Pleiotropic effects of statins | Q24647863 | ||
| NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo | Q24679444 | ||
| Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies | Q24681261 | ||
| Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration | Q24815912 | ||
| Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo | Q27860578 | ||
| Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product | Q28114879 | ||
| Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. | Q53232489 | ||
| Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease. | Q53241047 | ||
| Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. | Q53324593 | ||
| Activation of NADPH oxidase in Alzheimer's disease brains. | Q53341731 | ||
| Transient activation of the NADPH oxidase through Fc gamma RI. Oxidase deactivation precedes internalization of cross-linked receptors. | Q54342782 | ||
| Lipid peroxidation and oxidative imbalance: early functional events in Alzheimer's disease. | Q54486088 | ||
| Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease | Q57782086 | ||
| Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase | Q62003460 | ||
| Inactivation of alpha 1-proteinase inhibitor by peroxynitrite | Q68017549 | ||
| Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide | Q68255434 | ||
| Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma | Q70865140 | ||
| beta-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity | Q71473378 | ||
| Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK | Q71743139 | ||
| Priming of monocyte respiratory burst by beta-amyloid fragment (25-35) | Q71911494 | ||
| Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes | Q73221688 | ||
| NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons | Q73338159 | ||
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| Microglia and astrocytes in the adult rat brain: comparative immunocytochemical analysis demonstrates the efficacy of lipocortin 1 immunoreactivity | Q73466564 | ||
| Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase | Q73520876 | ||
| Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase | Q74121518 | ||
| Vitamin E induces ramification and downregulation of adhesion molecules in cultured microglial cells | Q74429505 | ||
| alpha-tocopherol inhibits the respiratory burst in human monocytes. Attenuation of p47(phox) membrane translocation and phosphorylation | Q77604560 | ||
| Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia | Q83853842 | ||
| Inflammation and Alzheimer's disease | Q28138617 | ||
| Role of the rac1 p21-GDP-dissociation inhibitor for rho heterodimer in the activation of the superoxide-forming NADPH oxidase of macrophages | Q28255637 | ||
| Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease | Q28268162 | ||
| Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors | Q28293826 | ||
| Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study | Q28366850 | ||
| NADPH oxidase: an update | Q28611494 | ||
| The reaction of no with superoxide | Q28611742 | ||
| NOX enzymes and the biology of reactive oxygen | Q29547517 | ||
| ATP mediates rapid microglial response to local brain injury in vivo | Q29547872 | ||
| Reactive oxygen species in cell signaling | Q29615243 | ||
| Microglia: a sensor for pathological events in the CNS | Q29620556 | ||
| Proteomic identification of nitrated proteins in Alzheimer's disease brain | Q31144652 | ||
| NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. | Q31148000 | ||
| beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. | Q31840031 | ||
| Molecular basis for Rac2 regulation of phagocyte NADPH oxidase | Q32063730 | ||
| Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity | Q33187378 | ||
| Chemistry, physiology and pathology of free radicals | Q33781599 | ||
| Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. | Q33921362 | ||
| Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures | Q34032447 | ||
| 1alpha,25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase | Q34084410 | ||
| Vitamin E and donepezil for the treatment of mild cognitive impairment | Q34411313 | ||
| Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins | Q34411802 | ||
| Statins and the risk of dementia | Q34511970 | ||
| Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach | Q34727547 | ||
| Current molecular models for NADPH oxidase regulation by Rac GTPase | Q34915029 | ||
| Evidence of neuronal oxidative damage in Alzheimer's disease. | Q35782389 | ||
| How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes | Q35842732 | ||
| Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism | Q36099893 | ||
| The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides | Q36328369 | ||
| Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms | Q36394129 | ||
| Iron toxicity and oxygen radicals | Q38648352 | ||
| Risk of Alzheimer's disease and duration of NSAID use. | Q39457609 | ||
| A key role for the microglial NADPH oxidase in APP-dependent killing of neurons | Q40356252 | ||
| Mechanisms of statin-mediated inhibition of small G-protein function | Q40387534 | ||
| A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. | Q40657503 | ||
| Vitamin E suppression of microglial activation is neuroprotective | Q40776019 | ||
| Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]. | Q40946540 | ||
| Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins | Q40977784 | ||
| TNF-alpha mediates inducible nitric oxide synthase expression in human neuroblastoma cell line by cisplatin | Q41114913 | ||
| Nitric oxide neurotoxicity | Q41115083 | ||
| Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages | Q41239810 | ||
| Oxidative stress hypothesis in Alzheimer's disease | Q41482152 | ||
| Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. | Q41712816 | ||
| Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. | Q41749781 | ||
| Expression and modulation of an NADPH oxidase in mammalian astrocytes. | Q42484955 | ||
| Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. | Q43638880 | ||
| Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease | Q43664433 | ||
| A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity | Q43793656 | ||
| Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1. | Q43809961 | ||
| Modulation of microglial superoxide production by alpha-tocopherol in vitro: attenuation of p67(phox) translocation by a protein phosphatase-dependent pathway | Q43830033 | ||
| Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice | Q43832213 | ||
| Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. | Q43918731 | ||
| Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system | Q43945169 | ||
| Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. | Q43972731 | ||
| Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial | Q44121424 | ||
| Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. | Q44208857 | ||
| Akt Phosphorylates p47phoxand Mediates Respiratory Burst Activity in Human Neutrophils | Q44432151 | ||
| Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex | Q44545624 | ||
| Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. | Q44557611 | ||
| Pravastatin at 10 mg/day does not decrease plasma levels of either amyloid-β (Aβ) 40 or Aβ 42 in humans | Q44612866 | ||
| Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. | Q44728755 | ||
| Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study | Q44734509 | ||
| Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes | Q45115168 | ||
| 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. | Q45221796 | ||
| Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia | Q46414453 | ||
| Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease | Q46691404 | ||
| Adult mouse astrocytes degrade amyloid-beta in vitro and in situ | Q46779933 | ||
| Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease | Q46942969 | ||
| Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia | Q47764327 | ||
| Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide | Q47903820 | ||
| Hematopoietic origin of microglial and perivascular cells in brain | Q47937973 | ||
| Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease | Q48125251 | ||
| A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced | Q48179910 | ||
| beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease | Q48205438 | ||
| The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages | Q48221009 | ||
| RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. | Q48270446 | ||
| Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture. | Q48290847 | ||
| Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease | Q48307804 | ||
| Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. | Q48380256 | ||
| Production of nitrite by neonatal rat microglial cells/brain macrophages | Q48492805 | ||
| 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. | Q48723281 | ||
| A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. | Q48725577 | ||
| Widespread peroxynitrite-mediated damage in Alzheimer's disease. | Q48728343 | ||
| Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. | Q48910103 | ||
| Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. | Q49149683 | ||
| Nonsteroidal anti-inflammatory drugs in Alzheimer's disease. | Q52020137 | ||
| Tyrosine phosphorylation systems in Alzheimer's disease pathology | Q52238097 | ||
| Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. | Q53189340 | ||
| Activation of microglial cells by beta-amyloid protein and interferon-gamma. | Q53202007 | ||
| P921 | main subject | Alzheimer's disease | Q11081 |
| microglia | Q1622829 | ||
| P304 | page(s) | 30 | |
| P577 | publication date | 2006-11-09 | |
| P1433 | published in | Journal of Neuroinflammation | Q15716679 |
| P1476 | title | The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease | |
| P478 | volume | 3 |
| Q45334506 | Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis |
| Q91928338 | Acid- and Volume-Sensitive Chloride Currents in Microglial Cells |
| Q28390090 | Age-related alterations in the expression of genes and synaptic plasticity associated with nitric oxide signaling in the mouse dorsal striatum |
| Q24681412 | Alzheimer's disease; taking the edge off with cannabinoids? |
| Q83799854 | Angiotensin II and aldosterone-induced neuronal damage in neurons through an astrocyte-dependent mechanism |
| Q34914124 | Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease |
| Q46725218 | Association of the p22phox polymorphism C242T with the risk of late-onset Alzheimer's disease in a northern Han Chinese population |
| Q99635814 | Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice |
| Q26865295 | Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system |
| Q46262329 | CLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia. |
| Q37729392 | Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress |
| Q27339727 | Chronic apocynin treatment attenuates beta amyloid plaque size and microglial number in hAPP(751)(SL) mice |
| Q55505826 | Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress. |
| Q35671697 | Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's Disease |
| Q36907446 | Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase. |
| Q24609123 | Cobalamin deficiency, hyperhomocysteinemia, and dementia |
| Q38609997 | Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation. |
| Q28391403 | Cross talk between mitochondria and NADPH oxidases |
| Q36156588 | Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase |
| Q37362105 | DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain. |
| Q58565150 | Distinct cytokine profiles in human brains resilient to Alzheimer's pathology |
| Q43022563 | Effect of 1400W on blocking lipopolysaccharide-induced microglial toxicity to preoligodendrocytes |
| Q89731185 | Efficacy of probiotics on cognition, and biomarkers of inflammation and oxidative stress in adults with Alzheimer's disease or mild cognitive impairment - a meta-analysis of randomized controlled trials |
| Q37425292 | Expression of gp91phox and p22phox, catalytic subunits of NADPH oxidase, on microglia in Nasu-Hakola disease brains |
| Q37352823 | Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification |
| Q26782894 | Implications of glial nitric oxide in neurodegenerative diseases |
| Q34547897 | Inflammasomes as therapeutic targets for Alzheimer's disease |
| Q36067388 | Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation |
| Q37734352 | Long-Term Effects of Maternal Deprivation on Redox Regulation in Rat Brain: Involvement of NADPH Oxidase. |
| Q36421994 | Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease |
| Q38742072 | Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury |
| Q35677056 | Markers of Oxidative Stress and Neuroprogression in Depression Disorder. |
| Q37849615 | Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer's disease |
| Q46298977 | Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1). |
| Q59335641 | Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? |
| Q38109630 | Metal dyshomeostasis and inflammation in Alzheimer's and Parkinson's diseases: possible impact of environmental exposures |
| Q42794541 | Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures. |
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| Q39435384 | NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa |
| Q55228929 | NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation. |
| Q35028232 | NADPH-oxidase activation and cognition in Alzheimer disease progression |
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| Q38974360 | Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions. |
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| Q89475158 | Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging |
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