Lipid rafts and redox regulation of cellular signaling in cholesterol induced atherosclerosis

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Lipid rafts and redox regulation of cellular signaling in cholesterol induced atherosclerosis is …
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P356DOI10.2174/157340310793566181
P8608Fatcat IDrelease_esekz4uzsndn3m7cwapcy6uyiu
P724Internet Archive IDpubmed-PMC3083812
P932PMC publication ID3083812
P698PubMed publication ID22043207
P5875ResearchGate publication ID51760513

P2093author name stringBetul Catalgol
Nesrin Kartal Ozer
P2860cites workOxidized LDL regulates macrophage gene expression through ligand activation of PPARgammaQ24311702
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alphaQ24683359
Detergent-resistant membranes and the protein composition of lipid raftsQ24793091
Atherosclerosis — An Inflammatory DiseaseQ26776972
Functional rafts in cell membranesQ27860768
Lipid rafts and signal transductionQ28131735
Regulation of G protein-coupled receptor kinases by caveolinQ28139192
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5Q28190953
Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascadeQ28215821
Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activitiesQ28255025
Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cellsQ28286215
Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromesQ28359694
The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survivalQ28396081
A role for lipid rafts in B cell antigen receptor signaling and antigen targetingQ28504447
Dual role of peroxiredoxin I in macrophage-derived foam cellsQ28505046
Plasma Platelet-activating Factor Acetylhydrolase Is a Secreted Phospholipase A2 with a Catalytic TriadQ28505897
Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brainQ28575022
Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolaeQ28584954
Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenaseQ28587071
CD36 is palmitoylated on both N- and C-terminal cytoplasmic tailsQ28609742
Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivoQ28609900
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cellsQ29547331
Reactive oxygen species in cell signalingQ29615243
Physiological functions of thioredoxin and thioredoxin reductaseQ29615600
Functions of lipid rafts in biological membranesQ29616845
Role of oxidative modifications in atherosclerosisQ29617974
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiationQ29619212
Reactive oxygen species, antioxidants, and the mammalian thioredoxin systemQ29619367
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokinesQ29620217
Effects of membrane lipids on ion channel structure and function.Q30332910
Oxidized LDL induces a coordinated up-regulation of the glutathione and thioredoxin systems in human macrophagesQ33220393
Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomainsQ33292451
A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoproteinQ33379703
Caveolins, liquid-ordered domains, and signal transductionQ33752828
Regulation of macrophage gene expression by peroxisome-proliferator-activated receptor gamma: implications for cardiovascular diseaseQ33841047
Serum glutathione in adolescent males predicts parental coronary heart diseaseQ33881955
Protein pool maintenance during oxidative stress.Q37597225
The role of oxidative stress in atherosclerosis.Q37600512
Cellular oxidation of low-density lipoprotein by Chlamydia pneumoniaeQ37878008
Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteinsQ40548300
Ceramide in lipid particles enhances heparan sulfate proteoglycan and low density lipoprotein receptor-related protein-mediated uptake by macrophagesQ40573529
The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assemblyQ40591985
OxLDL induces macrophage gamma-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesisQ40806137
Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gammaQ40883227
G-protein palmitoylation: regulation and functional significance.Q40948983
Caveolae and caveolinsQ41099734
Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolaeQ41215934
Reversible palmitoylation of signaling proteinsQ41382874
SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.Q41466836
Inhibition of glutathione synthesis increases the toxicity of oxidized low-density lipoprotein to human monocytes and macrophagesQ41513930
Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione contentQ41666422
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membraneQ41715384
Regulation of ceramide production and apoptosisQ41748407
Isolation and characterization of a complement-activating lipid extracted from human atherosclerotic lesionsQ41954726
Compartmentation of cyclic adenosine 3',5'-monophosphate signaling in caveolaeQ42058344
The endothelial nitric-oxide synthase-caveolin regulatory cycleQ42450294
Inhibition of adenylyl cyclase by caveolin peptidesQ42453161
Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cellsQ42464570
Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cellsQ42474889
Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide productionQ42536735
PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammationQ42832963
27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cellsQ43706818
Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol.Q43716112
Scavenger receptor class B type I as a receptor for oxidized low density lipoproteinQ43717087
Expression of glutaredoxin in human coronary arteries: its potential role in antioxidant protection against atherosclerosisQ43738087
Apolipoprotein AI and HDL(3) inhibit spreading of primary human monocytes through a mechanism that involves cholesterol depletion and regulation of CDC42.Q43813812
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalitiesQ43819817
Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null miceQ44094465
Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytesQ44223897
Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilationQ44365406
Administration of tyrosyl radical-oxidized HDL inhibits the development of atherosclerosis in apolipoprotein E-deficient miceQ44509603
Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase.Q44725224
Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterolQ44895988
Contribution of lysosomal vesicles to the formation of lipid raft redox signaling platforms in endothelial cellsQ44930996
Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen speciesQ45005902
Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation propertiesQ45148001
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesisQ45165256
Serum thioredoxin and alpha-tocopherol concentrations in patients with major risk factorsQ45282785
Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cellsQ46417523
Mechanisms for suppressing NADPH oxidase in the vascular wallQ46552044
Vitamin E inhibits CD36 scavenger receptor expression in hypercholesterolemic rabbitsQ46567172
NADPH oxidase p22phox gene variants are associated with systemic oxidative stress biomarker responses to exercise trainingQ46588936
Fibroblasts that overexpress 15-lipoxygenase generate bioactive and minimally modified LDL.Q46686309
Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formationQ46693405
Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture.Q46709404
Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cellsQ46847918
OxLDL increases endothelial stiffness, force generation, and network formationQ46898081
E-LDL and Ox-LDL differentially regulate ceramide and cholesterol raft microdomains in human MacrophagesQ46945574
Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I.Q46960352
Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domainQ47881243
Dynamic regulation of endothelial nitric oxide synthase: complementary roles of dual acylation and caveolin interactions.Q52528653
Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide.Q52560750
Oxidation of low-density lipoprotein by hemoglobin stems from a heme-initiated globin radical: antioxidant role of haptoglobin.Q53875273
Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer.Q54056188
Formation of ceramide-enriched domains in lipid particles enhances the binding of apolipoprotein EQ57360759
CD95 Signaling via Ceramide-rich Membrane RaftsQ57371964
Ceramide: A Novel Player in Reactive Oxygen Species-Induced Signaling?Q57373628
CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated ReceptorsQ58150309
A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial WallQ60723097
Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolaeQ71070312
Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membraneQ71142838
Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitriteQ71199670
Dietary cholesterol-induced changes of protein kinase C and the effect of vitamin E in rabbit aortic smooth muscle cellsQ71746481
Oxidative tyrosylation of HDL enhances the depletion of cellular cholesteryl esters by a mechanism independent of passive sterol desorptionQ71853370
A method for defining the stages of low-density lipoprotein oxidation by the separation of cholesterol- and cholesteryl ester-oxidation products using HPLCQ72604244
Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activationQ73133867
Targeting of a G alpha subunit (Gi1 alpha) and c-Src tyrosine kinase to caveolae membranes: clarifying the role of N-myristoylationQ73438699
Induction of vascular endothelial growth factor in balloon-injured baboon arteries. A novel role for reactive oxygen species in atherosclerosisQ73454257
Dynamic Targeting of the Agonist-stimulated m2 Muscarinic Acetylcholine Receptor to Caveolae in Cardiac MyocytesQ73486030
Bradykinin Sequesters B2 Bradykinin Receptors and the Receptor-coupled Gα Subunits Gαq and Gαiin Caveolae in DDT1 MF-2 Smooth Muscle CellsQ73486047
Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cellsQ73954435
Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenalQ74024032
Effect of vitamin E and probucol on dietary cholesterol-induced atherosclerosis in rabbitsQ74060310
Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDLQ74648768
Ceramide-rich membrane rafts mediate CD40 clusteringQ77373931
Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenalQ77648460
Effects of lipid profile on forearm hyperemic response in young subjectsQ79969982
Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxinQ80076755
CSF-1 regulation of the wandering macrophage: complexity in actionQ35935793
Oxidative stress and vascular remodelling.Q36125357
New insights on oxidative stress in the artery wall.Q36230886
NADPH oxidase and endothelial cell functionQ36232155
Ceramide-enriched membrane domainsQ36286893
4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis.Q36306332
Colony-stimulating factor-1 in immunity and inflammation.Q36335789
Physiological and pathophysiological aspects of ceramideQ36341274
On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moietyQ36365606
Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects.Q36411963
Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fibroblasts and macrophage foam cellsQ36423053
Lipid rafts in T cell receptor signallingQ36447769
Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoproteinQ36501176
Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damageQ36584535
Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derived inflammatory mediators.Q36595292
S-nitrosylation: NO-related redox signaling to protect against oxidative stressQ36598832
Redox signalling involving NADPH oxidase-derived reactive oxygen speciesQ36628663
Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspectiveQ36801006
Lipid rafts and oxidative stress-induced cell deathQ36852080
Lipid rafts in membrane-cytoskeleton interactions and control of cellular biomechanics: actions of oxLDL.Q36852087
Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin-ceramide pathway in human macrophagesQ36852827
Role of redox regulation and lipid rafts in macrophages during Ox-LDL-mediated foam cell formationQ36864655
Lipid raft redox signaling platforms in endothelial dysfunctionQ36895553
The LDL modification hypothesis of atherogenesis: an updateQ37326175
The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transportQ37512515
Phospholipase A2 activity of low density lipoprotein: evidence for an intrinsic phospholipase A2 activity of apoprotein B-100.Q33925421
Lipid rafts and membrane dynamicsQ33985713
CD36 and atherosclerosisQ34069100
How cells handle cholesterol.Q34094514
Interactions between nitric oxide and lipid oxidation pathways: implications for vascular diseaseQ34119356
Redox regulation of cardiomyocyte survival and deathQ34211068
Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesionsQ34236265
Emerging themes in lipid rafts and caveolae.Q34348709
Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteinsQ34411802
The role of high-density lipoproteins in oxidation and inflammationQ34423104
Caveolin-deficient mice: insights into caveolar function human diseaseQ34457018
Cell signalling by oxidized lipids and the role of reactive oxygen species in the endotheliumQ34480588
Physiological and pathophysiological roles of oxygen radicals in the renal microvasculatureQ34495243
Biomarkers.Q34701833
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
ABCA1: regulation, trafficking and association with heteromeric proteinsQ35009337
Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors.Q35038907
Ceramide and cell death receptor clusteringQ35047148
Oxidized low-density lipoprotein-induced apoptosisQ35047186
Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review).Q35054306
Lipid rafts: bringing order to chaosQ35058353
Membrane dynamics and cell polarity: the role of sphingolipidsQ35086135
Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animalsQ35092592
Inflammatory Reactions in the Pathogenesis of AtherosclerosisQ35124954
ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathyQ35182347
Role of Monocytes in AtherogenesisQ35541858
Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages: contributions to atherosclerosisQ35549957
Raft ceramide in molecular medicineQ35559152
Redox regulation by thioredoxin in cardiovascular diseasesQ35572631
The biology of caveolae: lessons from caveolin knockout mice and implications for human diseaseQ35679599
Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitroQ35753181
A CD36-dependent signaling cascade is necessary for macrophage foam cell formationQ35758193
Lipids: potential regulators of nitric oxide generationQ35861877
Dual role of oxidized LDL on the NF-kappaB signaling pathway.Q35877997
Signal transduction of a G protein-coupled receptor in caveolae: colocalization of endothelin and its receptor with caveolinQ35933073
P433issue4
P921main subjectmembrane raftQ424178
atherosclerosisQ12252367
P304page(s)309-324
P577publication date2010-11-01
P1433published inCurrent cardiology reviewsQ26842280
P1476titleLipid rafts and redox regulation of cellular signaling in cholesterol induced atherosclerosis
P478volume6

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