| scholarly article | Q13442814 |
| P50 | author | Noah W. Gray | Q56153307 |
| P2093 | author name string | Robert D Gerard | |
| Bruce F Horazdovsky | |||
| Justin D Topp | |||
| P2860 | cites work | A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 | Q24291755 |
| A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5 | Q24291960 | ||
| The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading | Q24292063 | ||
| P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac | Q24294423 | ||
| ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics | Q24306668 | ||
| Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1 | Q24311327 | ||
| Linkage of the gene for an autosomal dominant form of juvenile amyotrophic lateral sclerosis to chromosome 9q34. | Q24538838 | ||
| Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene | Q24612029 | ||
| Dynamin-dependent endocytosis of ionotropic glutamate receptors | Q24642585 | ||
| Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis | Q24681007 | ||
| Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation | Q24681205 | ||
| The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2 | Q27732195 | ||
| The 2.0 A crystal structure of a heterotrimeric G protein | Q27732250 | ||
| The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity | Q59097192 | ||
| The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller | Q27748937 | ||
| The Pfam protein families database | Q27860470 | ||
| Rho GTPases and the actin cytoskeleton | Q27860579 | ||
| Trk receptors: roles in neuronal signal transduction | Q27919636 | ||
| Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport | Q27937100 | ||
| The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5 | Q28138959 | ||
| Junctophilins: a novel family of junctional membrane complex proteins | Q28144094 | ||
| EPS8 and E3B1 transduce signals from Ras to Rac | Q28145106 | ||
| Structural principles for the propeller assembly of beta-sheets: the preference for seven-fold symmetry | Q28156101 | ||
| The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis | Q28190263 | ||
| The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings | Q28201827 | ||
| From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS | Q28206361 | ||
| Dbl family guanine nucleotide exchange factors | Q28209857 | ||
| Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins | Q28257012 | ||
| Cadherin regulates dendritic spine morphogenesis | Q28508197 | ||
| Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization | Q28571556 | ||
| The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation | Q28577018 | ||
| Cdk5 is essential for synaptic vesicle endocytosis | Q28579572 | ||
| Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function | Q28579954 | ||
| Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer | Q28581004 | ||
| JPred: a consensus secondary structure prediction server | Q29614378 | ||
| Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting | Q29615874 | ||
| Neurotrophins and their receptors: a convergence point for many signalling pathways | Q29616108 | ||
| Evidence for a role of dendritic filopodia in synaptogenesis and spine formation | Q29616333 | ||
| Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors | Q29617999 | ||
| Amyotrophic lateral sclerosis | Q29619516 | ||
| A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function | Q29620529 | ||
| Genetic disorders of motor neurons. | Q33862558 | ||
| Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. | Q33926842 | ||
| The role of Rho in G protein-coupled receptor signal transduction | Q33932175 | ||
| Ligand-gated ion channel interactions with cytoskeletal and signaling proteins | Q33938793 | ||
| Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. | Q33953572 | ||
| Neurotrophins and the dynamic regulation of the neuronal cytoskeleton | Q33996747 | ||
| Molecular links between endocytosis and the actin cytoskeleton. | Q34023649 | ||
| Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. | Q34101310 | ||
| Spine motility. Phenomenology, mechanisms, and function | Q34152295 | ||
| Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded | Q34175381 | ||
| Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton | Q34394543 | ||
| Familial amyotrophic lateral sclerosis | Q34547620 | ||
| Contribution of cytoskeleton to the internalization of AMPA receptors | Q34658722 | ||
| Retrograde signaling by the neurotrophins follows a well-worn trk. | Q34750195 | ||
| Current molecular models for NADPH oxidase regulation by Rac GTPase | Q34915029 | ||
| Phosphoinositide 3-kinase-dependent activation of Rac. | Q35163957 | ||
| Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis | Q35580300 | ||
| Internalization of metabotropic glutamate receptor in C6 cells through clathrin-coated vesicles | Q38291585 | ||
| Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase | Q38330900 | ||
| The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis | Q38353980 | ||
| Rab5 induces Rac-independent lamellipodia formation and cell migration | Q38613714 | ||
| Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. | Q39064480 | ||
| Distribution of soluble N-ethylmaleimide fusion protein attachment proteins (SNAPs) in the rat nervous system | Q39750209 | ||
| Agonist-induced internalization of the metabotropic glutamate receptor 1a is arrestin- and dynamin-dependent | Q40788728 | ||
| Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization | Q40885683 | ||
| Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures | Q41663908 | ||
| Role of AMPA receptor cycling in synaptic transmission and plasticity | Q41707244 | ||
| Hereditary motor system diseases (chronic juvenile amyotrophic lateral sclerosis). Conditions combining a bilateral pyramidal syndrome with limb and bulbar amyotrophy | Q41809526 | ||
| SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling | Q42816235 | ||
| Molecular determinants of NMDA receptor internalization | Q43690729 | ||
| Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors | Q43770953 | ||
| Biochemical and morphological characterization of an intracellular membrane compartment containing AMPA receptors. | Q43770958 | ||
| Internalization of ionotropic glutamate receptors in response to mGluR activation | Q43785653 | ||
| Remodeling of synaptic actin induced by photoconductive stimulation | Q43815517 | ||
| Regulation of rho GTPases by crosstalk and neuronal activity in vivo. | Q43906183 | ||
| Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice | Q43977943 | ||
| Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases | Q44170949 | ||
| Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. | Q44222198 | ||
| The metabotropic glutamate receptor mGluR5 is endocytosed by a clathrin-independent pathway. | Q44279238 | ||
| Glycine binding primes NMDA receptor internalization | Q44368770 | ||
| Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers | Q46153622 | ||
| Actin-dependent regulation of neurotransmitter release at central synapses | Q46191605 | ||
| Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation. | Q47380769 | ||
| Actin disassembles reversibly during electrically induced recycling of synaptic vesicles in cultured neurons. | Q48487560 | ||
| Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. | Q52169062 | ||
| AnALS2gene mutation causes hereditary spastic paraplegia in a Pakistani kindred | Q57239710 | ||
| P433 | issue | 23 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | guanine | Q169313 |
| Alsin Rho guanine nucleotide exchange factor | Q21982984 | ||
| P1104 | number of pages | 12 | |
| P304 | page(s) | 24612-24623 | |
| P577 | publication date | 2004-03-19 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor | |
| P478 | volume | 279 |
| Q90644155 | A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility |
| Q40484912 | A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death |
| Q34005076 | A screen to identify cellular modulators of soluble levels of an amyotrophic lateral sclerosis (ALS)-causing mutant SOD1. |
| Q36915829 | ALS2/alsin knockout mice and motor neuron diseases |
| Q24293687 | ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics |
| Q36608848 | Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms |
| Q28066333 | Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies |
| Q38668630 | Advances in understanding the role of disease-associated proteins in spinal muscular atrophy. |
| Q51954003 | Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish. |
| Q28510453 | Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities |
| Q35562672 | Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity |
| Q36625827 | Alsin and the molecular pathways of amyotrophic lateral sclerosis |
| Q24313283 | Alsin is partially associated with centrosome in human cells |
| Q56531747 | Amyotrophic lateral sclerosis |
| Q28513282 | Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking |
| Q46235070 | An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin |
| Q36565653 | Anti-ALS activity of alsin, the product of the ALS2 gene, and activity-dependent neurotrophic factor |
| Q24297917 | Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation |
| Q52329270 | Autophagy as a common pathway in amyotrophic lateral sclerosis. |
| Q82533353 | Biochemical characterization of Alsin, a Rab5 and Rac1 guanine nucleotide exchange factor |
| Q24337586 | C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking |
| Q34442081 | Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit |
| Q46353167 | Chapter 15 Juvenile amyotrophic lateral sclerosis |
| Q59544323 | Chapter 4 Molecular mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis |
| Q24303566 | Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31 |
| Q63406572 | Clinical presentation and natural history of infantile-onset ascending spastic paralysis from three families with an ALS2 founder variant |
| Q33910597 | Complex genetics of amyotrophic lateral sclerosis |
| Q33242003 | Components of the antigen processing and presentation pathway revealed by gene expression microarray analysis following B cell antigen receptor (BCR) stimulation |
| Q38492623 | Compromised autophagy and neurodegenerative diseases |
| Q64945919 | Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease. |
| Q24339422 | Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation |
| Q37830720 | Dysregulation of axonal transport and motorneuron diseases. |
| Q21285051 | Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases |
| Q38684233 | Endocytic membrane trafficking and neurodegenerative disease |
| Q33725465 | Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function |
| Q43734721 | Evaluation of the Golgi trafficking protein VPS54 (wobbler) as a candidate for ALS. |
| Q38833377 | Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers. |
| Q34633785 | GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor |
| Q24338228 | Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes |
| Q36211097 | Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences. |
| Q48106083 | Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. |
| Q24298929 | Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking |
| Q83231035 | In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation |
| Q41912714 | Inhibition of Rab5a exchange activity is a key step for Listeria monocytogenes survival. |
| Q38789426 | Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions |
| Q24295258 | Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance |
| Q47108927 | Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease? |
| Q34328577 | Long-distance retrograde neurotrophic factor signalling in neurons |
| Q28511013 | Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress |
| Q35633071 | Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function. |
| Q28505562 | Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking |
| Q36565597 | Mitochondria in amyotrophic lateral sclerosis: a trigger and a target |
| Q36573336 | Molecular biology of amyotrophic lateral sclerosis: insights from genetics |
| Q40719087 | Nd6p, a novel protein with RCC1-like domains involved in exocytosis in Paramecium tetraurelia |
| Q35351477 | Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades |
| Q81395356 | Novel homozygous ALS2 nonsense mutation (p.Gln715X) in sibs with infantile-onset ascending spastic paralysis: the first cases from northwestern Europe |
| Q33621868 | Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities? |
| Q41991266 | Proteostasis disturbance in amyotrophic lateral sclerosis |
| Q38315974 | Purification and analysis of RIN family-novel Rab5 GEFs |
| Q38315963 | Purification and functional analyses of ALS2 and its homologue |
| Q106518954 | RAC1 GEFs activate RAC1 |
| Q37301164 | RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndrome |
| Q35278147 | Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities |
| Q36090727 | Rab GTPases implicated in inherited and acquired disorders |
| Q38236498 | Rab proteins: the key regulators of intracellular vesicle transport |
| Q37031233 | Rab-mediated endocytosis: linking neurodegeneration, neuroprotection, and synaptic plasticity? |
| Q52690498 | Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. |
| Q28586055 | RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells |
| Q34148669 | Rac1 at the crossroad of actin dynamics and neuroinflammation in Amyotrophic Lateral Sclerosis |
| Q33742737 | Redox modifier genes and pathways in amyotrophic lateral sclerosis |
| Q52617275 | Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins. |
| Q30489444 | Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin |
| Q48547144 | Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival. |
| Q27027490 | Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration |
| Q26853181 | Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease |
| Q36447580 | Rho-linked genes and neurological disorders |
| Q24301513 | Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation |
| Q92265603 | SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis |
| Q30489942 | Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages |
| Q92534799 | Swimming in Deep Water: Zebrafish Modeling of Complicated Forms of Hereditary Spastic Paraplegia and Spastic Ataxia |
| Q39274901 | The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration? |
| Q39662062 | The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy |
| Q57372624 | The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis |
| Q34159126 | The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases. |
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| Q36861432 | Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration |
| Q37510748 | Vinculin and Rab5 complex is required [correction of requited]for uptake of Staphylococcus aureus and interleukin-6 expression |
| Q38140444 | Zebrafish as a model system for mitochondrial biology and diseases |
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