review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1007/S00018-010-0486-4 |
P2888 | exact match | https://scigraph.springernature.com/pub.10.1007/s00018-010-0486-4 |
P698 | PubMed publication ID | 20706766 |
P5875 | ResearchGate publication ID | 45641235 |
P50 | author | Gianluca Tell | Q39599984 |
P2093 | author name string | Franco Quadrifoglio | |
Damiano Fantini | |||
P2860 | cites work | Nucleolar proteome dynamics | Q21735921 |
Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation | Q24290624 | ||
Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism | Q24291085 | ||
Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter | Q24292228 | ||
Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1 | Q24303442 | ||
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). | Q24304919 | ||
Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals | Q24310136 | ||
Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1 | Q24310318 | ||
Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway | Q24313920 | ||
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. | Q24315064 | ||
Identification of redox/repair protein Ref-1 as a potent activator of p53 | Q24316161 | ||
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA | Q24319977 | ||
SIRT1 deacetylates APE1 and regulates cellular base excision repair | Q24320136 | ||
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. | Q24329154 | ||
A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells. | Q40461671 | ||
Loss of redox factor 1 decreases NF-kappaB activity and increases susceptibility of endothelial cells to apoptosis | Q40493108 | ||
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress | Q40704172 | ||
Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis | Q40726056 | ||
Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophages | Q40730456 | ||
TSH controls Ref-1 nuclear translocation in thyroid cells | Q40877307 | ||
A role of cyclin G in the process of apoptosis | Q40932309 | ||
Increase in Ref-1 mRNA and protein by thyrotropin in rat thyroid FRTL-5 cells | Q41099921 | ||
Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice | Q41664808 | ||
Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway | Q42007394 | ||
Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis | Q42169230 | ||
Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: a basis for its role in human disease | Q42465868 | ||
Key role of a downstream specificity protein 1 site in cell cycle-regulated transcription of the AP endonuclease gene APE1/APEX in NIH3T3 cells | Q42510086 | ||
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites | Q42631836 | ||
Characterization of the DNA-binding properties of the early growth response-1 (Egr-1) transcription factor: evidence for modulation by a redox mechanism | Q42810654 | ||
Probing conformational changes in Ape1 during the progression of base excision repair | Q43106181 | ||
Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo. | Q44126941 | ||
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion | Q44575257 | ||
Important role for Rac1 in regulating reactive oxygen species generation and pulmonary arterial smooth muscle cell growth | Q45065483 | ||
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor. | Q46472872 | ||
Drosophila DNA polymerase zeta interacts with recombination repair protein 1, the Drosophila homologue of human abasic endonuclease 1. | Q46968604 | ||
Purification and characterization of a Mg2+-dependent endonuclease (AN34) from etoposide-treated human leukemia HL-60 cells undergoing apoptosis | Q47944979 | ||
Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression | Q48171155 | ||
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death | Q48196301 | ||
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas. | Q48713531 | ||
Properties of a superoxide anion-generating microsomal NADH oxidoreductase, a potential pulmonary artery PO2 sensor. | Q50767301 | ||
Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation. | Q53430376 | ||
Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein. | Q54450406 | ||
Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme | Q70786873 | ||
Expression of a multifunctional DNA repair enzyme gene, apurinic/apyrimidinic endonuclease (APE; Ref-1) in the suprachiasmatic, supraoptic and paraventricular nuclei | Q71680548 | ||
Analysis of repair of abasic sites in early onset breast cancer patients | Q73237186 | ||
Endothelin-1 induces NAD(P)H oxidase in human endothelial cells | Q73556500 | ||
Evidence that the bifunctional redox factor / AP endonuclease Ref-1 is an anti-apoptotic protein associated with differentiation in the developing retina | Q73616948 | ||
Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells | Q73804432 | ||
Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity | Q74390472 | ||
Ref-1 controls pax-8 DNA-binding activity | Q77545510 | ||
Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB | Q78109651 | ||
Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium | Q78891508 | ||
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain | Q79278480 | ||
Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization | Q81326626 | ||
The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium | Q24336783 | ||
A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium | Q24337016 | ||
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A | Q24338600 | ||
XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions | Q24535921 | ||
Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1 | Q24543007 | ||
Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme | Q24555669 | ||
Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12 | Q24630184 | ||
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene | Q24634275 | ||
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells | Q24650179 | ||
APE1/Ref-1 regulates PTEN expression mediated by Egr-1 | Q24650473 | ||
NOPdb: Nucleolar Proteome Database | Q25257475 | ||
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected] | Q27621279 | ||
Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease | Q27650945 | ||
Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair | Q28138546 | ||
APE/Ref-1 and the mammalian response to genotoxic stress | Q28181946 | ||
Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 1 4q11.2 - 12) | Q28185401 | ||
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair | Q28198657 | ||
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death | Q28250070 | ||
Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA | Q28256454 | ||
Negative regulation of the major human AP-endonuclease, a multifunctional protein | Q28298283 | ||
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target | Q28305801 | ||
The intracellular localization of APE1/Ref-1: more than a passive phenomenon? | Q28307041 | ||
Mitochondrial localization of APE/Ref-1 in thyroid cells | Q28580188 | ||
DNA repair pathways as targets for cancer therapy | Q29615572 | ||
Radiation-induced cell cycle arrest compromised by p21 deficiency | Q29620237 | ||
Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. | Q30436649 | ||
Cellular antioxidant effects of atorvastatin in vitro and in vivo | Q30809431 | ||
Structural characterization of the 5' regions of the human phenylalanine hydroxylase gene | Q33189085 | ||
The SET complex acts as a barrier to autointegration of HIV-1 | Q33415459 | ||
Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era? | Q33558839 | ||
The many functions of APE1/Ref-1: not only a DNA repair enzyme | Q33609187 | ||
Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers. | Q33723639 | ||
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. | Q38302437 | ||
Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease | Q38307342 | ||
High-performance affinity beads for identifying drug receptors | Q38309653 | ||
Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding | Q38316481 | ||
Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo. | Q38319417 | ||
Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity | Q38330722 | ||
Regulation of blood calcium in humans | Q38688498 | ||
XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro | Q39718210 | ||
Downregulation of APE1/Ref-1 is involved in the senescence of mesenchymal stem cells. | Q39843440 | ||
Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration | Q39958626 | ||
A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity | Q39967163 | ||
NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases | Q40056077 | ||
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors | Q40358919 | ||
Hypocalcemia increases and hypercalcemia decreases the steady-state level of parathyroid hormone messenger RNA in the rat. | Q40379094 | ||
Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity | Q40393910 | ||
Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA. | Q40421214 | ||
Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop | Q40443160 | ||
Efficient repair of abasic sites in DNA by mitochondrial enzymes | Q33772134 | ||
Redox regulation of DNA repair: implications for human health and cancer therapeutic development | Q33830130 | ||
Rac1 disrupts p67phox/p40phox binding: a novel role for Rac in NADPH oxidase activation | Q33874052 | ||
Two essential but distinct functions of the mammalian abasic endonuclease | Q33936936 | ||
Going APE over ref-1. | Q34053099 | ||
Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology | Q34059645 | ||
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis | Q34132208 | ||
Thiols in cellular redox signalling and control | Q34263056 | ||
Subnuclear organization and trafficking of regulatory proteins: implications for biological control and cancer. | Q34271770 | ||
Selenomethionine regulation of p53 by a ref1-dependent redox mechanism | Q34394902 | ||
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells | Q34547595 | ||
Granzymes at a glance | Q34589497 | ||
The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains | Q34878594 | ||
Current molecular models for NADPH oxidase regulation by Rac GTPase | Q34915029 | ||
Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding | Q35019872 | ||
Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage | Q35576447 | ||
The base excision repair: mechanisms and its relevance for cancer susceptibility | Q35630334 | ||
Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins | Q35781797 | ||
Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance. | Q35795731 | ||
The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair | Q35829262 | ||
Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310 | Q35829268 | ||
Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase | Q35949648 | ||
Redox-dependent transcriptional regulation | Q36311782 | ||
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage | Q36509230 | ||
An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels | Q36568598 | ||
Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision | Q36726717 | ||
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells. | Q37242539 | ||
Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression | Q37332450 | ||
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. | Q37377727 | ||
Nuclear organization in the 3D space of the nucleus - cause or consequence? | Q37486041 | ||
Redox effector factor-1 regulates the activity of thyroid transcription factor 1 by controlling the redox state of the N transcriptional activation domain | Q38292215 | ||
Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1. | Q38293786 | ||
Characterization of the promoter region of the human apurinic endonuclease gene (APE). | Q38297816 | ||
P433 | issue | 21 | |
P304 | page(s) | 3589-3608 | |
P577 | publication date | 2010-08-13 | |
P1433 | published in | Cellular and Molecular Life Sciences | Q5058352 |
P1476 | title | Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment | |
P478 | volume | 67 |
Q33956183 | A polymorphism in the DNA repair domain of APEX1 is associated with the radiation-induced pneumonitis risk among lung cancer patients after radiotherapy. |
Q91899753 | APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma |
Q37295649 | APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation |
Q33887146 | APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans |
Q36186953 | APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer. |
Q38698133 | An in vitro study ascertaining the role of H2O2 and glucose oxidase in modulation of antioxidant potential and cancer cell survival mechanisms in glioblastoma U-87 MG cells |
Q42410417 | Apoptosis-Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction |
Q37657335 | Association between APE1 Single Nucleotide Polymorphism (rs1760944) and Cancer Risk: a Meta-Analysis Based on 6,419 Cancer Cases and 6,781 Case-free Controls |
Q43185639 | Base excision DNA repair and cancer |
Q27025537 | Base excision repair and cancer |
Q35955906 | Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms |
Q33734782 | Cardiac Cell Senescence and Redox Signaling |
Q91260488 | Decreased APE-1 by Nitroxoline Enhances Therapeutic Effect in a Temozolomide-resistant Glioblastoma: Correlation with Diffusion Weighted Imaging |
Q39133838 | Down-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) in spinal motor neurones under oxidative stress |
Q91084556 | Effects of APE1 Asp148Glu polymorphisms on OPMD malignant transformation, and on susceptibility to and overall survival of oral cancer in Taiwan |
Q57115103 | Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1 |
Q34470985 | Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1. |
Q39129437 | Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology. |
Q90088035 | Genetic polymorphisms and gastric cancer risk: a comprehensive review synopsis from meta-analysis and genome-wide association studies |
Q26863138 | Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis risk |
Q90223370 | Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence |
Q39397332 | Human apurinic/apyrimidinic endonuclease 1 translocalizes to mitochondria after photodynamic therapy and protects cells from apoptosis |
Q36502969 | Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients |
Q37390615 | In silico prediction of antimalarial drug target candidates |
Q35599868 | Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties |
Q35340740 | Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function |
Q49892078 | Lead facilitates foci formation in a Balb/c-3T3 two-step cell transformation model: role of Ape1 function. |
Q42127225 | Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism |
Q30420636 | Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells |
Q26739704 | Nucleophosmin: from structure and function to disease development |
Q54979850 | Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes. |
Q37706156 | Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells |
Q41999364 | Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression |
Q37286470 | Pharmacogenetics Biomarkers and Their Specific Role in Neoadjuvant Chemoradiotherapy Treatments: An Exploratory Study on Rectal Cancer Patients. |
Q37718793 | Predicted for greatness: 1994 molecule of the year--the DNA repair enzyme |
Q53155527 | Prognostic significance of APE1 cytoplasmic localization in human epithelial ovarian cancer. |
Q38968023 | Protective effect of myokine IL-15 against H2O2-mediated oxidative stress in skeletal muscle cells |
Q36436106 | Rad9 protein contributes to prostate tumor progression by promoting cell migration and anoikis resistance |
Q37225608 | Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation. |
Q35534130 | Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis |
Q44740203 | Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin). |
Q37582544 | SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements. |
Q61803551 | Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma |
Q34963206 | Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines |
Q36837710 | Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease |
Q48111990 | The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel. |
Q27010959 | The association of APE1 -656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies |
Q43830895 | The association of APE1 Asp148Glu gene polymorphisms and lung cancer risk: an updated meta-analysis |
Q38206321 | The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once |
Q46140928 | The impacts of genetic polymorphisms in genes of base excision repair pathway on the efficacy and acute toxicities of (chemo)radiotherapy in patients with nasopharyngeal carcinoma |
Q35106907 | The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate. |
Q30430399 | Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5. |
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