Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment

scientific article published on 13 August 2010

Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00018-010-0486-4
P2888exact matchhttps://scigraph.springernature.com/pub.10.1007/s00018-010-0486-4
P698PubMed publication ID20706766
P5875ResearchGate publication ID45641235

P50authorGianluca TellQ39599984
P2093author name stringFranco Quadrifoglio
Damiano Fantini
P2860cites workNucleolar proteome dynamicsQ21735921
Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiationQ24290624
Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanismQ24291085
Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoterQ24292228
Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1Q24303442
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).Q24304919
Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicalsQ24310136
Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1Q24310318
Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathwayQ24313920
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.Q24315064
Identification of redox/repair protein Ref-1 as a potent activator of p53Q24316161
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNAQ24319977
SIRT1 deacetylates APE1 and regulates cellular base excision repairQ24320136
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.Q24329154
A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells.Q40461671
Loss of redox factor 1 decreases NF-kappaB activity and increases susceptibility of endothelial cells to apoptosisQ40493108
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stressQ40704172
Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosisQ40726056
Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophagesQ40730456
TSH controls Ref-1 nuclear translocation in thyroid cellsQ40877307
A role of cyclin G in the process of apoptosisQ40932309
Increase in Ref-1 mRNA and protein by thyrotropin in rat thyroid FRTL-5 cellsQ41099921
Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in miceQ41664808
Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathwayQ42007394
Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosisQ42169230
Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: a basis for its role in human diseaseQ42465868
Key role of a downstream specificity protein 1 site in cell cycle-regulated transcription of the AP endonuclease gene APE1/APEX in NIH3T3 cellsQ42510086
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sitesQ42631836
Characterization of the DNA-binding properties of the early growth response-1 (Egr-1) transcription factor: evidence for modulation by a redox mechanismQ42810654
Probing conformational changes in Ape1 during the progression of base excision repairQ43106181
Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo.Q44126941
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesionQ44575257
Important role for Rac1 in regulating reactive oxygen species generation and pulmonary arterial smooth muscle cell growthQ45065483
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.Q46472872
Drosophila DNA polymerase zeta interacts with recombination repair protein 1, the Drosophila homologue of human abasic endonuclease 1.Q46968604
Purification and characterization of a Mg2+-dependent endonuclease (AN34) from etoposide-treated human leukemia HL-60 cells undergoing apoptosisQ47944979
Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expressionQ48171155
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal deathQ48196301
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.Q48713531
Properties of a superoxide anion-generating microsomal NADH oxidoreductase, a potential pulmonary artery PO2 sensor.Q50767301
Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation.Q53430376
Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein.Q54450406
Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzymeQ70786873
Expression of a multifunctional DNA repair enzyme gene, apurinic/apyrimidinic endonuclease (APE; Ref-1) in the suprachiasmatic, supraoptic and paraventricular nucleiQ71680548
Analysis of repair of abasic sites in early onset breast cancer patientsQ73237186
Endothelin-1 induces NAD(P)H oxidase in human endothelial cellsQ73556500
Evidence that the bifunctional redox factor / AP endonuclease Ref-1 is an anti-apoptotic protein associated with differentiation in the developing retinaQ73616948
Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cellsQ73804432
Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activityQ74390472
Ref-1 controls pax-8 DNA-binding activityQ77545510
Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREBQ78109651
Implication of Ref-1 in the repression of renin gene transcription by intracellular calciumQ78891508
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domainQ79278480
Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerizationQ81326626
The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calciumQ24336783
A redox factor protein, ref1, is involved in negative gene regulation by extracellular calciumQ24337016
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme AQ24338600
XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactionsQ24535921
Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1Q24543007
Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzymeQ24555669
Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12Q24630184
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone geneQ24634275
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cellsQ24650179
APE1/Ref-1 regulates PTEN expression mediated by Egr-1Q24650473
NOPdb: Nucleolar Proteome DatabaseQ25257475
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]Q27621279
Evolution of the redox function in mammalian apurinic/apyrimidinic endonucleaseQ27650945
Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repairQ28138546
APE/Ref-1 and the mammalian response to genotoxic stressQ28181946
Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 1 4q11.2 - 12)Q28185401
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repairQ28198657
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell deathQ28250070
Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNAQ28256454
Negative regulation of the major human AP-endonuclease, a multifunctional proteinQ28298283
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive targetQ28305801
The intracellular localization of APE1/Ref-1: more than a passive phenomenon?Q28307041
Mitochondrial localization of APE/Ref-1 in thyroid cellsQ28580188
DNA repair pathways as targets for cancer therapyQ29615572
Radiation-induced cell cycle arrest compromised by p21 deficiencyQ29620237
Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1.Q30436649
Cellular antioxidant effects of atorvastatin in vitro and in vivoQ30809431
Structural characterization of the 5' regions of the human phenylalanine hydroxylase geneQ33189085
The SET complex acts as a barrier to autointegration of HIV-1Q33415459
Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?Q33558839
The many functions of APE1/Ref-1: not only a DNA repair enzymeQ33609187
Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.Q33723639
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.Q38302437
Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonucleaseQ38307342
High-performance affinity beads for identifying drug receptorsQ38309653
Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA bindingQ38316481
Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.Q38319417
Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activityQ38330722
Regulation of blood calcium in humansQ38688498
XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitroQ39718210
Downregulation of APE1/Ref-1 is involved in the senescence of mesenchymal stem cells.Q39843440
Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migrationQ39958626
A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activityQ39967163
NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatasesQ40056077
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumorsQ40358919
Hypocalcemia increases and hypercalcemia decreases the steady-state level of parathyroid hormone messenger RNA in the rat.Q40379094
Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activityQ40393910
Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA.Q40421214
Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loopQ40443160
Efficient repair of abasic sites in DNA by mitochondrial enzymesQ33772134
Redox regulation of DNA repair: implications for human health and cancer therapeutic developmentQ33830130
Rac1 disrupts p67phox/p40phox binding: a novel role for Rac in NADPH oxidase activationQ33874052
Two essential but distinct functions of the mammalian abasic endonucleaseQ33936936
Going APE over ref-1.Q34053099
Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiologyQ34059645
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesisQ34132208
Thiols in cellular redox signalling and controlQ34263056
Subnuclear organization and trafficking of regulatory proteins: implications for biological control and cancer.Q34271770
Selenomethionine regulation of p53 by a ref1-dependent redox mechanismQ34394902
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cellsQ34547595
Granzymes at a glanceQ34589497
The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domainsQ34878594
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA bindingQ35019872
Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damageQ35576447
The base excision repair: mechanisms and its relevance for cancer susceptibilityQ35630334
Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteinsQ35781797
Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance.Q35795731
The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repairQ35829262
Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310Q35829268
Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidaseQ35949648
Redox-dependent transcriptional regulationQ36311782
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damageQ36509230
An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levelsQ36568598
Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incisionQ36726717
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.Q37242539
Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expressionQ37332450
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.Q37377727
Nuclear organization in the 3D space of the nucleus - cause or consequence?Q37486041
Redox effector factor-1 regulates the activity of thyroid transcription factor 1 by controlling the redox state of the N transcriptional activation domainQ38292215
Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.Q38293786
Characterization of the promoter region of the human apurinic endonuclease gene (APE).Q38297816
P433issue21
P304page(s)3589-3608
P577publication date2010-08-13
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleUnderstanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
P478volume67

Reverse relations

cites work (P2860)
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