Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination

scientific article

Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JNCI/DJV289
P932PMC publication ID4712681
P698PubMed publication ID26464464
P5875ResearchGate publication ID283213494

P50authorPahini PandyaQ83701654
Irene Rodríguez-HernándezQ87342354
Erik SahaiQ44050376
Fernando CalvoQ56449134
Jose L OrgazQ56958553
Cecilia Herraiz SerranoQ59142483
Victoria Sanz-MorenoQ64001565
P2093author name stringGaia Cantelli
NaRa Kang
Tinghine Chu
P2860cites workThree-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3Q24313288
A model for p53-induced apoptosisQ24313374
p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linkingQ24313690
Nox1-dependent reactive oxygen generation is regulated by Rac1Q24320021
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPPQ24339404
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen speciesQ74602438
Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranesQ79359469
Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescenceQ82021676
Redox mechanisms in hepatic chronic wound healing and fibrogenesisQ24656684
Reassembly of contractile actin cortex in cell blebsQ24682765
Rho GTPases, oxidation, and cell redox controlQ26823042
At the leading edge of three-dimensional cell migrationQ26823247
Regulation of small GTPases by GEFs, GAPs, and GDIsQ26825750
Cancer invasion and the microenvironment: plasticity and reciprocityQ27024382
Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cellsQ27310093
Structure of the TPR domain of p67phox in complex with Rac.GTPQ27628646
Cell migration: integrating signals from front to backQ27860670
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiologyQ27860991
ATM and ATR: networking cellular responses to DNA damageQ28143424
Genomic analysis of metastasis reveals an essential role for RhoCQ28144278
Myosin phosphatase: structure, regulation and functionQ28260078
Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivityQ28264544
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataQ28266682
H2AX: the histone guardian of the genomeQ28274279
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
Rac activation and inactivation control plasticity of tumor cell movementQ28299776
Mitochondria, oxidants, and agingQ29547594
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysisQ29615193
Modulation of oxidative stress as an anticancer strategyQ29615707
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular diseaseQ29616095
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokersQ29616096
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysisQ29616712
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)Q29620308
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activityQ33292285
Increasing burden of melanoma in the United StatesQ33836015
Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53Q33955442
Diverse matrix metalloproteinase functions regulate cancer amoeboid migrationQ33988511
The essence of senescenceQ34288983
The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4.Q34400804
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
p53, oxidative stress, and agingQ35151322
DNA damage induces phosphorylation of the amino terminus of p53Q35199554
Membrane transport of hydrogen peroxide.Q36432908
Applications for ROCK kinase inhibitionQ36649417
Oxyl radicals, redox-sensitive signalling cascades and antioxidantsQ36849942
Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging.Q37005075
ROS and p53: a versatile partnershipQ37085000
Imaging amoeboid cancer cell motility in vivoQ37255337
Cancer cell killing via ROS: to increase or decrease, that is the questionQ37316371
Mechanical modes of 'amoeboid' cell migration.Q37518200
PIG3: a novel link between oxidative stress and DNA damage response in cancerQ37969534
Oxidative stress in melanocyte senescence and melanoma transformationQ38171635
Drugging the p53 pathway: understanding the route to clinical efficacyQ38191796
Mutations in the TP53 gene in human malignant melanomas derived from sun-exposed skin and unexposed mucosal membranesQ38454708
Oxidative Stress Induced by MnSOD-p53 Interaction: Pro- or Anti-Tumorigenic?Q38658833
Dual inactivation of RB and p53 pathways in RAS-induced melanomasQ39458533
An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cellsQ39569182
p53 prevents progression of nevi to melanoma predominantly through cell cycle regulationQ39654655
The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damageQ39761186
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivoQ40247020
Rac GTPase interacts with GAPs and target proteins through multiple effector sites.Q40789809
DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerizationQ40960688
Lack of p53 mutations and loss of heterozygosity in non-cultured human melanocytic lesionsQ41249912
Estimation of H2O2 gradients across biomembranes.Q41742092
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesisQ41838620
Mitochondrial ROS production under cellular stress: comparison of different detection methods.Q42814380
Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species.Q42831305
Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transitionQ42919170
Trends in prognostic factors and survival from cutaneous melanoma in Yorkshire, UK and New South Wales, Australia between 1993 and 2003.Q43544136
Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventionsQ44050330
Redox-dependent downregulation of Rho by Rac.Q44323617
Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinaseQ44573111
Phase 1 clinical trials of a selective Rho kinase inhibitor, K-115.Q50890366
Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis.Q54655468
Antioxidant supplementation increases the risk of skin cancers in women but not in menQ56997126
ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and StromaQ58001139
Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanomaQ72234184
A promoter that acquired p53 responsiveness during primate evolutionQ73288922
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
DNA damageQ5205747
P577publication date2015-10-13
P1433published inJournal of the National Cancer InstituteQ400279
P1476titleReactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination
P478volume108

Reverse relations

cites work (P2860)
Q41328196Complementary ACSL isoforms contribute to a non-Warburg advantageous energetic status characterizing invasive colon cancer cells
Q92813709Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective
Q38852351Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth.
Q60936653Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation
Q90470152Membrane blebs play a critical role in a hybrid mode of cancer cell invasion in three-dimensional environments
Q44700286Microarray analyses reveal genes related to progression and prognosis of esophageal squamous cell carcinoma
Q39085737Modes of invasion during tumour dissemination.
Q92627552Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
Q64279054Overlapping and unique roles played by ROCK1 and 2 in the modulation of coding and long noncoding RNA expression
Q41895201Reactive oxygen species and tumor dissemination: Allies no longer.
Q91869776Recent advances in tissue imaging for cancer research
Q61797822Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment
Q26751189Rho, ROCK and actomyosin contractility in metastasis as drug targets
Q39710284So You Can Teach Old Fibroblasts New Tricks
Q37705443The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination.
Q27326718The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration.
Q57035038The p53-inducible gene 3 promotes cell migration and invasion via activating the FAK/Src pathway in lung adenocarcinoma
Q47326513The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.

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