Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2.

scientific article

Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1159/000110451
P698PubMed publication ID17982273
P5875ResearchGate publication ID5864942

P2093author name stringPin-Lan Li
Fan Yi
Si Jin
Qi-Zheng Chen
P2860cites workCell transformation by the superoxide-generating oxidase Mox1Q22010372
Rho GTPases in cell biologyQ27860969
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiologyQ27860991
Homocysteine enhances TIMP-1 expression and cell proliferation associated with NADH oxidase in rat mesangial cellsQ28565638
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factorsQ29547630
Rho family proteins in cell adhesion and cell migration.Q33959704
NAD(P)H oxidases and their relevance to atherosclerosisQ34423077
Rho family proteins: coordinating cell responsesQ34446303
Sphingolipids in mammalian cell signallingQ34507788
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
GTPases and reactive oxygen species: switches for killing and signalingQ35607959
Regulation of NADPH oxidases: the role of Rac proteinsQ36412266
Regulation of novel superoxide-producing NAD(P)H oxidasesQ36598785
NADPH oxidases in the kidneyQ36598811
Podocyte injury and glomerulosclerosis in hyperhomocysteinemic ratsQ44928199
Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cellsQ45116558
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1Q59053220
P433issue6
P921main subjectmesangial cellQ3331086
P304page(s)909-918
P577publication date2007-01-01
P1433published inCellular Physiology and BiochemistryQ2229420
P1476titleMechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2.
P478volume20

Reverse relations

cites work (P2860)
Q37622159Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia
Q45052622Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia
Q37151470Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats
Q37066900Cross talk between ceramide and redox signaling: implications for endothelial dysfunction and renal disease
Q36894381Inhibition of hyperhomocysteinemia-induced inflammasome activation and glomerular sclerosis by NLRP3 gene deletion
Q35101890Lipid raft redox signaling: molecular mechanisms in health and disease
Q39798053Lysosomal ceramide mediates gemcitabine-induced death of glioma cells
Q36731427NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia
Q34222583NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats
Q89920236Podocyte Lysosome Dysfunction in Chronic Glomerular Diseases
Q88532146RACking up ceramide-induced islet β-cell dysfunction
Q36970633Redox control of renal function and hypertension.
Q33733309Redox signaling via lipid raft clustering in homocysteine-induced injury of podocytes
Q45072496Sphingolipids and Redox Signaling in Renal Regulation and Chronic Kidney Diseases
Q39484880TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2.
Q34055584Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells.
Q30493665Triggering role of acid sphingomyelinase in endothelial lysosome-membrane fusion and dysfunction in coronary arteries.
Q38705395Upregulated Vav2 in gastric cancer tissues promotes tumor invasion and metastasis

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