| scholarly article | Q13442814 |
| P50 | author | Jarek Meller | Q57232718 |
| Edgar Pick | Q58829352 | ||
| Miroslaw Kordos | Q83513513 | ||
| P2093 | author name string | Yi Zheng | |
| Sachin Kumar | |||
| Ariel Mizrahi | |||
| Jacek Biesiada | |||
| Filippo Marchioni | |||
| Kathleen Szczur | |||
| Marie-Dominique Filippi | |||
| William Seibel | |||
| Emily E Bosco | |||
| P2860 | cites work | A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening | Q22251350 |
| In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days | Q22299205 | ||
| Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking" | Q24291961 | ||
| Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism | Q24311930 | ||
| High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis | Q24545304 | ||
| Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration | Q27323209 | ||
| Structure of the TPR domain of p67phox in complex with Rac.GTP | Q27628646 | ||
| ZINC--a free database of commercially available compounds for virtual screening | Q27656255 | ||
| Rho GTPases in cell biology | Q27860969 | ||
| The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology | Q27860991 | ||
| Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings | Q27861111 | ||
| Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox) | Q28273527 | ||
| Protein-binding assays in biological liquids using microscale thermophoresis | Q28296871 | ||
| The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity | Q42812047 | ||
| Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in mice. | Q43726340 | ||
| Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein | Q44741140 | ||
| Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. | Q44915718 | ||
| Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis. | Q50693285 | ||
| N-acetylcysteine suppression of the proliferative index in the colon of patients with previous adenomatous colonic polyps. | Q53413929 | ||
| Rho GTPase Rac1 is critical for neutrophil migration into the lung. | Q53597773 | ||
| Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1 | Q59053220 | ||
| EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups | Q73911065 | ||
| Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase | Q28609613 | ||
| Rho GTPases and signaling networks | Q28646215 | ||
| NOX enzymes and the biology of reactive oxygen | Q29547517 | ||
| AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility | Q29547658 | ||
| A semiempirical free energy force field with charge-based desolvation | Q29614316 | ||
| Rational design and characterization of a Rac GTPase-specific small molecule inhibitor | Q29616494 | ||
| Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability | Q29618122 | ||
| Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by "peptide walking". | Q30176152 | ||
| Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis | Q30483206 | ||
| Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity | Q33292285 | ||
| Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat | Q33689411 | ||
| Novel aspects of the roles of Rac1 GTPase in the cardiovascular system | Q33746458 | ||
| Rac1-mediated NADPH oxidase release of O2- regulates epithelial sodium channel activity in the alveolar epithelium | Q33784145 | ||
| Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis | Q33806023 | ||
| N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial | Q34012103 | ||
| Molecular properties that influence the oral bioavailability of drug candidates | Q34130727 | ||
| Comparative pharmacology of chemically distinct NADPH oxidase inhibitors | Q34269250 | ||
| Rac guanosine triphosphatases represent a potential target in AML | Q34290267 | ||
| P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils | Q34461899 | ||
| Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches | Q34777763 | ||
| Current molecular models for NADPH oxidase regulation by Rac GTPase | Q34915029 | ||
| Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations | Q35648421 | ||
| The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase | Q35974253 | ||
| Structure-function based design of small molecule inhibitors targeting Rho family GTPases | Q36536310 | ||
| NADPH oxidase inhibitors: new antihypertensive agents? | Q36897941 | ||
| NOX enzymes as novel targets for drug development | Q37176104 | ||
| Classical inhibitors of NOX NAD(P)H oxidases are not specific. | Q37294085 | ||
| Rac1 GTPase: a "Rac" of all trades. | Q37371665 | ||
| Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets | Q37421764 | ||
| Translating the oxidative stress hypothesis into the clinic: NOX versus NOS. | Q37615958 | ||
| Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells | Q38328188 | ||
| Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox). | Q38336129 | ||
| Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease | Q40053415 | ||
| The genetic basis of chronic granulomatous disease | Q40694865 | ||
| "Peptide walking" is a novel method for mapping functional domains in proteins. Its application to the Rac1-dependent activation of NADPH oxidase | Q42672926 | ||
| Neutrophil isolation protocol | Q42714579 | ||
| Virtual screening approach for the identification of new Rac1 inhibitors | Q42798189 | ||
| Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. | Q42809514 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | inflammation | Q101991 |
| P304 | page(s) | 228-242 | |
| P577 | publication date | 2012-02-01 | |
| P1433 | published in | Chemistry and Biology | Q15758410 |
| P1476 | title | Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation | |
| P478 | volume | 19 |
| Q51084718 | Access to oxoquinoline heterocycles by N-heterocyclic carbene catalyzed ester activation for selective reaction with an enone. |
| Q38257747 | Advances and strategies in NADPH oxidase inhibitors and activators patents |
| Q26851300 | Approaches of targeting Rho GTPases in cancer drug discovery |
| Q47671813 | Harnessing sunlight without a photosensitizer for highly efficient consecutive [3+2]/[4+2] annulation to synthesize fused benzobicyclic skeletons. |
| Q48507180 | Inhibition of Rac family protein impairs colitis and colitis-associated cancer in mice. |
| Q27336134 | Modeling host genetic regulation of influenza pathogenesis in the collaborative cross |
| Q35985407 | NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress |
| Q47361639 | Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases. |
| Q34416582 | Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. |
| Q31140123 | Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines. |
| Q35397776 | Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays |
| Q38145091 | RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis |
| Q28067937 | Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy |
| Q38839225 | Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms |
| Q27318713 | Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. |
| Q38780866 | Rho GTPases: Anti- or pro-neoplastic targets? |
| Q36146913 | RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets |
| Q38193605 | Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task |
| Q50057600 | SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure. |
| Q90201401 | Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation |
| Q59126461 | The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro |
| Q33632757 | The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls |
| Q38846822 | The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer |
| Q46263540 | Tumor suppressor NPRL2 induces ROS production and DNA damage response |
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