The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro

scientific article published in PLoS ONE

The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0204271
P932PMC publication ID6161897
P698PubMed publication ID30265686

P50authorNils WelshQ59691737
P2093author name stringXuan Wang
Per-Ola Carlsson
Per Wikström
Erik Walum
Andris Elksnis
P2860cites workExpression of NADPH oxidase in human pancreatic islets.Q54299839
Antioxidative effects of phenylethanoids from Cistanche deserticolaQ71976537
Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitroQ78086387
Roles of Reactive Oxygen Species on Insulin Resistance in Adipose TissueQ26746340
Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target EngagementQ26861119
NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of actionQ30155581
Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK ratQ33501717
A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cellsQ33660799
Free fatty acids and pathogenesis of type 2 diabetes mellitusQ34066567
Cytokines suppress human islet function irrespective of their effects on nitric oxide generationQ34143253
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunctionQ34268169
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?Q35034481
Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic isletQ35404856
The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse EmbryosQ35647604
Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 InhibitorQ35984159
Oxidative stress and impaired insulin secretion in type 2 diabetesQ36625437
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expressionQ36855830
Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activityQ36856230
NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?Q37269522
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophagesQ37548406
Src tyrosine kinase mediates platelet-derived growth factor BB-induced and redox-dependent migration in metanephric mesenchymal cellsQ37579198
Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severityQ37596130
NOX4 downregulation leads to senescence of human vascular smooth muscle cells.Q37687002
Type 2 diabetes mellitus: a metabolic autoinflammatory diseaseQ38119302
A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretionQ38271856
The human Nox4: gene, structure, physiological function and pathological significanceQ38464231
Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell deathQ38849033
Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signalingQ39719190
Determination of drug permeability and prediction of drug absorption in Caco-2 monolayersQ40081558
Expression of isoforms of NADPH oxidase components in rat pancreatic isletsQ40231191
Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cellsQ40683693
NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistanceQ42380553
Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.Q42609911
Pancreatic beta-cells express phagocyte-like NAD(P)H oxidaseQ44453013
ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesisQ46380661
NADPH Oxidase-Dependent Reactive Oxygen Species Stimulate β-Cell Regeneration Through Differentiation of Endocrine Progenitors in Murine PancreasQ46655021
The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 miceQ46708553
EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium.Q48144907
NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice.Q50219280
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcell deathQ2383867
P304page(s)e0204271
P577publication date2018-01-01
P1433published inPLOS OneQ564954
P1476titleThe novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
P478volume13

Reverse relations

cites work (P2860)
Q90260794GPCRs, G Proteins, and Their Impact on β-cell Function
Q64264027Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass
Q89487277Inhibiting the Activity of NADPH Oxidase in Cancer
Q90576094NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Q96111449NADPH oxidases: Current aspects and tools
Q92079223Pharmacological characterization of the seven human NOX isoforms and their inhibitors
Q99579274The pandemic COVID-19: a tale of viremia, cellular oxidation and immune dysfunction

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