| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/J.CCR.2007.10.015 |
| P8608 | Fatcat ID | release_eqjevepz65b73obphfmzg6odsm |
| P698 | PubMed publication ID | 17996650 |
| P5875 | ResearchGate publication ID | 5849575 |
| P50 | author | Brian Druker | Q373427 |
| P2093 | author name string | Adrienne D Cox | |
| Yi Zheng | |||
| David A Williams | |||
| Jose A Cancelas | |||
| Danilo Perrotti | |||
| Kenneth D R Setchell | |||
| Hee-Don Chae | |||
| Paolo Neviani | |||
| Chad E Harris | |||
| Patricia J Keller | |||
| Emily K Thomas | |||
| P433 | issue | 5 | |
| P304 | page(s) | 467-478 | |
| P577 | publication date | 2007-11-01 | |
| P1433 | published in | Cancer Cell | Q280018 |
| P1476 | title | Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease | |
| P478 | volume | 12 |
| Q36139665 | A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis |
| Q46264202 | A key role for Rac and Pak signaling in neutrophil extracellular traps (NETs) formation defines a new potential therapeutic target |
| Q39101349 | A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility |
| Q47275250 | ABR, a novel inducer of transcription factor C/EBPα, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia. |
| Q39145182 | Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction |
| Q34168766 | Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia |
| Q34055929 | Adhesion, migration, and homing of murine hematopoietic stem cells and progenitors |
| Q39665460 | BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells |
| Q35669231 | Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells |
| Q90608661 | CAMSAP2-mediated noncentrosomal microtubule acetylation drives hepatocellular carcinoma metastasis |
| Q34086837 | Cancer stem cells: a stride towards cancer cure? |
| Q35921528 | Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase |
| Q37836936 | Chronic myeloid leukemia stem cells and developing therapies |
| Q41971118 | Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression |
| Q61800494 | Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells |
| Q33667686 | Current status and perspectives of patient-derived xenograft models in cancer research |
| Q37214445 | Deregulation of Rho GTPases in cancer |
| Q38230630 | Development of EHop-016: a small molecule inhibitor of Rac. |
| Q35381542 | ELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML. |
| Q35885308 | Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice. |
| Q37103609 | Experimental non-ATP-competitive therapies for chronic myelogenous leukemia |
| Q50337087 | FMNL1 promotes proliferation and migration of leukemia cells. |
| Q47744553 | Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression |
| Q33777707 | Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor. |
| Q35553586 | Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia |
| Q35664324 | Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination |
| Q46529000 | Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice |
| Q27004027 | Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia |
| Q89126918 | Inhibition of semaphorin-3a suppresses lipopolysaccharide-induced acute kidney injury |
| Q39433276 | Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia |
| Q58585276 | KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia |
| Q36793806 | Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia |
| Q27305153 | Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2 |
| Q37283128 | Molecular biology of bcr-abl1-positive chronic myeloid leukemia |
| Q33834313 | NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases |
| Q38810768 | New alternative splicing BCR/ABL-OOF shows an oncogenic role by lack of inhibition of BCR GTPase activity and an increased of persistence of Rac activation in chronic myeloid leukemia. |
| Q37843769 | New drugs for chronic myelogenous leukemia |
| Q37549702 | Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells |
| Q28550876 | Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases |
| Q39919462 | PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells |
| Q37200848 | Pak and Rac GTPases promote oncogenic KIT-induced neoplasms |
| Q91869736 | Perspective: Biophysical regulation of cancerous and normal blood cell lineages in hematopoietic malignancies |
| Q47113181 | Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines |
| Q40089044 | Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis. |
| Q38145091 | RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis |
| Q57120110 | RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2 |
| Q35730978 | Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis |
| Q60955103 | Rac GTPases in Hematological Malignancies |
| Q34290267 | Rac guanosine triphosphatases represent a potential target in AML |
| Q35692020 | Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development |
| Q43103589 | Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo |
| Q39159284 | Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death |
| Q33806023 | Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis |
| Q92916866 | Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome |
| Q33997238 | Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo |
| Q35986641 | Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors |
| Q42609911 | Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. |
| Q43159277 | Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells |
| Q39283279 | Rho GTPases and cancer |
| Q37122081 | Rho GTPases and regulation of hematopoietic stem cell localization |
| Q24652636 | Rho GTPases in hematopoiesis and hemopathies |
| Q37471296 | Rho GTPases in hematopoietic stem cell functions |
| Q38230951 | Rho GTPases modulate malignant transformation of tumor cells |
| Q38841623 | Ruxolitinib induces autophagy in chronic myeloid leukemia cells. |
| Q36057903 | Signaling and cytoskeletal requirements in erythroblast enucleation |
| Q90723175 | Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells |
| Q93167001 | Targeting Rac and Cdc42 GEFs in Metastatic Cancer |
| Q88954473 | Targeting Rac and Cdc42 GTPases in Cancer |
| Q37272565 | Targeting the leukemic stem cell: the Holy Grail of leukemia therapy |
| Q34478364 | The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model |
| Q41459669 | The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease |
| Q37863400 | The diverse roles of Rac signaling in tumorigenesis |
| Q64972523 | The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic. |
| Q60920983 | The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors |
| Q33613165 | Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling |
| Q36637506 | Transforming mutations of RAC guanosine triphosphatases in human cancers |
| Q96302801 | Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor |
| Q36141909 | Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival |
| Q36825803 | p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix |
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